Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Efficacy and Tolerability of Topical 0.1% Stabilized Bioactive Retinol for Photoaging: A Vehicle-Controlled Integrated Analysis.
Farris P; Berson D; Bhatia N; Goldberg D; Lain E; Mariwalla K; Zeichner J; Miller D; McGuire T; Kizoulis M · Journal of drugs in dermatology : JDD · 2024
Meta-analysis471 participants6 studies pooledflagSkin Health forscienceVitamin A
- Biomarkers of Tretinoin Precursors and Tretinoin Efficacy in Patients With Moderate to Severe Facial Photodamage: A Randomized Clinical Trial.
Chien AL; Kim DJ; Cheng N; Shin J; Leung SG; Nelson AM; Zang J; Suh H; Rainer B; Wallis L; Okoye GA; Loss M; Kang S · JAMA dermatology · 2022
Randomized trial24 participantsflagSkin Health forscienceVitamin A
- Photodecomposition of vitamin A and photobiological implications for the skin.
Fu PP; Xia Q; Yin JJ; Cherng SH; Yan J; Mei N; Chen T; Boudreau MD; Howard PC; Wamer WG · Photochemistry and photobiology · 2007
Narrative reviewflagSkin Health forscienceVitamin A
- Effect of short-term, high-dose retinol on dark adaptation in aging and early age-related maculopathy.
Owsley C; McGwin G; Jackson GR; Heimburger DC; Piyathilake CJ; Klein R; White MF; Kallies K · Investigative ophthalmology & visual science · 2006
Randomized trial104 participantsflagVision Support forscienceVitamin A
- Vitamin A and fish oils for retinitis pigmentosa.
Rayapudi S; Schwartz SG; Wang X; Chavis P · The Cochrane database of systematic reviews · 2014
Systematic review866 participants3 studies pooledflagVision Support forscienceVitamin A
- Long-term effects of fenretinide on retinal function.
Decensi A; Fontana V; Fioretto M; Rondanina G; Torrisi R; Orengo MA; Costa A · European journal of cancer (Oxford, England : 1990) · 1997
Clinical trial42 participantsflagVision Support forscienceVitamin A
- The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial.
Ito N; Seki S; Ueda F · Nutrients · 2018
Randomized trial23 participantsflagSkin Health forscienceAstaxanthin
- Supplementating with dietary astaxanthin combined with collagen hydrolysate improves facial elasticity and decreases matrix metalloproteinase-1 and -12 expression: a comparative study with placebo.
Yoon HS; Cho HH; Cho S; Lee SR; Shin MH; Chung JH · Journal of medicinal food · 2015
Randomized trial44 participantsflagSkin Health forscienceAstaxanthin
- Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers.
Chalyk NE; Klochkov VA; Bandaletova TY; Kyle NH; Petyaev IM · Nutrition research (New York, N.Y.) · 2018
Single-arm trial31 participantsflagSkin Health forscienceAstaxanthin
- The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity.
Phetcharat L; Wongsuphasawat K; Winther K · Clinical interventions in aging · 2016
Randomized trial34 participantsflagSkin Health forscienceAstaxanthin
- Cosmetic benefits of astaxanthin on humans subjects.
Tominaga K; Hongo N; Karato M; Yamashita E · Acta biochimica Polonica · 2012
Other66 participantsflagSkin Health forscienceAstaxanthin
- Systemic and skin-targeting beneficial effects of lycopene-enriched ice cream: A pilot study.
Chernyshova MP; Pristenskiy DV; Lozbiakova MV; Chalyk NE; Bandaletova TY; Petyaev IM · Journal of dairy science · 2019
Randomized trialflagSkin Health forscienceLycopene
- Topical lycopene emulgel significantly improves biophysical parameters of human skin.
Sohail M; Muhammad Faran Ashraf Baig M; Akhtar N; Chen Y; Xie B; Li B · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2022
Clinical trialflagSkin Health forscienceLycopene
- Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema.
Aust O; Stahl W; Sies H; Tronnier H; Heinrich U · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2005
Randomized trialflagSkin Health forscienceLycopene
- Association of Vitamin A Intake With Cutaneous Squamous Cell Carcinoma Risk in the United States.
Kim J; Park MK; Li WQ; Qureshi AA; Cho E · JAMA dermatology · 2024
Cohort study123,570 participantsflagSkin Health forscienceLycopene
- β-Carotene and other carotenoids in protection from sunlight.
Stahl W; Sies H · The American journal of clinical nutrition · 2013
Narrative reviewflagSkin Health forscienceLycopene
- Tensile properties and contours of aging facial skin. A controlled double-blind comparative study of the effects of retinol, melibiose-lactose and their association.
Piérard-Franchimont C; Castelli D; Cromphaut IV; Bertin C; Ries G; Cauwenbergh G; Piérard GE · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2016
Randomized trial120 participantsflagSkin Health forscienceVitamin A
- Antiaging action of retinol: from molecular to clinical.
Bellemère G; Stamatas GN; Bruère V; Bertin C; Issachar N; Oddos T · Skin pharmacology and physiology · 2009
Randomized trial48 participantsflagSkin Health forscienceVitamin A
- An Updated Review of Topical Tretinoin in Dermatology: From Acne and Photoaging to Skin Cancer.
Balado-Simó P; Morgado-Carrasco D; Gómez-Armayones S; López-Ferrer A; Barco D; Ferrándiz-Pulido C; Podlipnik S · Journal of clinical medicine · 2025
Narrative reviewflagSkin Health forscienceVitamin A
- Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial.
Chang H; Tao K; Yang Y; Wang Y; Ge M; Wang X; Tang S; Yu H · Journal of cosmetic dermatology · 2025
Randomized trialflagSkin Health forscienceVitamin A
- Benefits and Safety of Astaxanthin in the Treatment of Mild-To-Moderate Dry Eye Disease.
Tian L; Wen Y; Li S; Zhang P; Wang Y; Wang J; Cao K; Du L; Wang N; Jie Y · Frontiers in nutrition · 2022
Single-arm trial60 participantsflagVision Support forscienceAstaxanthin
- Astaxanthin (AstaReal®) Improved Acute and Chronic Digital Eye Strain in Children: A Randomized Double-Blind Placebo-Controlled Trial.
Hecht KA; Marwah M; Wood V; Nishida Y; Bach AE; Gerson J; Hom MM; Schnackenberg J; Raote S; Srivastava S; Negi P; Caston E · Advances in therapy · 2025
Randomized trial64 participantsflagVision Support forscienceAstaxanthin
- Effects of diet containing astaxanthin on visual function in healthy individuals: a randomized, double-blind, placebo-controlled, parallel study.
Sekikawa T; Kizawa Y; Li Y; Miura N · Journal of clinical biochemistry and nutrition · 2023
Randomized trial60 participantsflagVision Support forscienceAstaxanthin
- Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential.
Kidd P · Alternative medicine review : a journal of clinical therapeutic · 2012
Narrative reviewflagVision Support forscienceAstaxanthin
- Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
Martinez-Perez C; Oliveira AP · Nutrients · 2026
Systematic review9 studies pooledflagVision Support forscienceAstaxanthin
- A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa.
Berson EL; Rosner B; Sandberg MA; Hayes KC; Nicholson BW; Weigel-DiFranco C; Willett W · Archives of ophthalmology (Chicago, Ill. : 1960) · 1993
Randomized trial601 participantsflagVision Support forscienceVitamin A
- Efficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese Phase II clinical trial.
Toshida H; Funaki T; Ono K; Tabuchi N; Watanabe S; Seki T; Otake H; Kato T; Ebihara N; Murakami A · Drug design, development and therapy · 2018
Randomized trial66 participantsflagVision Support forscienceVitamin A
- Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age.
Imdad A; Mayo-Wilson E; Haykal MR; Regan A; Sidhu J; Smith A; Bhutta ZA · The Cochrane database of systematic reviews · 2022
Meta-analysis1,223,856 participants47 studies pooledflagVision Support forscienceVitamin A
- Vitamin A supplementation improves retinal function in infants at risk of retinopathy of prematurity.
Mactier H; McCulloch DL; Hamilton R; Galloway P; Bradnam MS; Young D; Lavy T; Farrell L; Weaver LT · The Journal of pediatrics · 2012
Randomized trial89 participantsflagVision Support forscienceVitamin A