Astaxanthin

non-nutrient_non-botanical

Astaxanthin is a keto-carotenoid within the terpene class of phytochemicals. Primarily sourced from the microalga Haematococcus pluvialis, this pigment gives salmon and shrimp their characteristic hue. Its molecular structure allows it to span cell membranes, providing cellular protection against free radical damage. Its antioxidant capacity is significantly higher than that of several familiar antioxidants, including vitamin E and beta-carotene. This allows the compound to neutralize free radicals and singlet oxygen without becoming a pro-oxidant. It also has anti-inflammatory effects through its influence on signaling pathways involved in inflammation. Supplementation is often used to support eye health, skin elasticity, reduced UV damage, and cardiovascular function. It may also assist with muscle recovery and athletic performance by contributing to cellular protection and reducing oxidative stress.

Natural sources
Haematococcus pluvialis microalgaeSalmonTroutKrillShrimpCrabLobster

No public comparison lists found.

Optimal Dosage
Minimum4 mg
Maximum12 mg
Safety & Toxicity
Upper Limit (UL)40 mg
Toxicity Threshold80 mg
Toxicity EffectSkin discoloration, stomach pain
4 safety notes
  • Pregnant or nursing women should consult a healthcare professional before use.
  • Individuals with allergies to shellfish should exercise caution if the astaxanthin source is not specified as algae-derived.
  • Individuals with certain medical conditions (e.g., autoimmune disorders, low blood pressure) should consult a healthcare professional.
  • May affect blood pressure readings.
Goals
Anti-Aging
Impact
High effect
Typical dose:4–12 mg
Astaxanthin's unique molecular structure allows it to span the entire cell membrane, providing comprehensive protection against free radical damage. It can cross the blood-brain and blood-retinal barriers, offering targeted antioxidant support to these critical tissues.

Study evidence

4 studies

Astaxanthin may improve skin moisture and elasticity, but the available research does not establish that it slows aging overall. Evidence for reducing wrinkles is less consistent, and changes in antioxidant markers do not demonstrate longer life or protection from age-related decline.

View goal
Anti-Inflammatory Support
Impact
High effect
Typical dose:4–12 mg
Astaxanthin is a unique antioxidant that can span the entire cell membrane, offering superior protection against oxidative damage. By reducing oxidative stress, it helps lower key inflammatory markers like C-reactive protein (CRP) and is particularly beneficial for skin, eye, and joint health.

Study evidence

18 studies

Astaxanthin may reduce selected inflammatory markers, particularly in people with certain health conditions, but findings are inconsistent. Benefits are less clear in healthy exercisers, and changes in blood markers do not by themselves establish broad protection from inflammatory illness.

View goal
Cardiovascular Support
Impact
High effect
Typical dose:4–12 mg
Astaxanthin is a carotenoid with a unique molecular structure that allows it to span cell membranes, providing superior antioxidant protection. It has been shown in clinical studies to reduce oxidative stress, improve blood rheology (flow), and lower lipid peroxidation, making it a highly effective cardiovascular protector.

Study evidence

12 studies

Astaxanthin may improve some cholesterol and inflammation markers, particularly in people with metabolic or heart conditions, but findings are inconsistent. The available research does not establish that these changes prevent cardiovascular events or reliably improve heart health.

View goal
Cognitive Support
Impact
High effect
Typical dose:4–12 mg
Astaxanthin is a unique carotenoid with exceptionally potent antioxidant activity. Its ability to cross the blood-brain barrier allows it to directly protect brain cells from free radical damage and inflammation, which are key factors in age-related cognitive decline.

Study evidence

6 studies

Astaxanthin has shown possible benefits for some memory and thinking measures, but overall improvements over placebo are inconsistent. The available human research does not establish a reliable cognitive benefit, and favorable results from combination supplements cannot be attributed to astaxanthin alone.

View goal
Heart Health
Impact
High effect
Typical dose:4–12 mg
As a potent lipid-soluble antioxidant, astaxanthin integrates into cell membranes, offering superior protection against peroxidation. It has been shown to reduce markers of inflammation and oxidation, lower triglycerides, and improve circulation by enhancing the flexibility of red blood cells.

Study evidence

16 studies

Astaxanthin may improve some blood fats and markers related to heart health, particularly in people with metabolic conditions, but results vary. The available research does not establish that these changes prevent heart attacks or other major cardiovascular problems.

View goal
Skin Health
Impact
High effect
Typical dose:4–12 mg
Astaxanthin is a potent carotenoid that accumulates in the skin, providing protection against UVA-induced oxidative stress. Clinical studies have shown it can improve skin texture, elasticity, and moisture content while reducing the appearance of wrinkles and age spots.

Study evidence

12 studies

Astaxanthin may modestly improve skin moisture and elasticity, but evidence for reducing wrinkles or protecting against sun-related aging is inconsistent. Small human studies provide promising signals, while broader reviews leave uncertainty about how reliable and noticeable these benefits are.

View goal
Showing 6 of 9 goals

Studies

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Interactions
Sources

Up to five highest-ranked published examples per goal. Study counts and charts include all published studies for the connection.

  1. Markers of Hypoxia and Oxidative Stress in Aging Volunteers Ingesting Lycosomal Formulation of Dark Chocolate Containing Astaxanthin.
    Petyaev IM; Klochkov VA; Chalyk NE; Pristensky DV; Chernyshova MP; Kyle NH; Bashmakov YK · The journal of nutrition, health & aging · 2019
    Randomized trial32 participantsAnti-Aging
  2. The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity.
    Phetcharat L; Wongsuphasawat K; Winther K · Clinical interventions in aging · 2016
    Randomized trial34 participantsAnti-AgingSkin Health
  3. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential.
    Kidd P · Alternative medicine review : a journal of clinical therapeutic · 2012
    Narrative reviewVision SupportAnti-Aging
  4. Systematic Review and Meta-Analysis on the Effects of Astaxanthin on Human Skin Ageing.
    Zhou X; Cao Q; Orfila C; Zhao J; Zhang L · Nutrients · 2021
    Meta-analysis11 studies pooledAnti-Aging
  5. The anti-inflammatory and antioxidant effects of astaxanthin as an adjunctive therapy in community-acquired pneumonia: a randomized controlled trial.
    Youssef FM; Ateyya H; Hanna Samy AE; Elmokadem EM · Frontiers in pharmacology · 2025
    Randomized trial80 participantsAnti-Inflammatory Support
  6. The Role of Astaxanthin as an Antioxidant and Anti-Inflammatory Agent in Human Health: A Systematic Review.
    Malcangi G; Inchingolo AM; Casamassima L; Trilli I; Ferrante L; Longo M; Inchingolo F; Marinelli G; Palermo A; Dipalma G; Inchingolo AD · International journal of molecular sciences · 2026
    Systematic review15 studies pooledAnti-Inflammatory Support
  7. Astaxanthin ameliorates inflammation, oxidative stress, and reproductive outcomes in endometriosis patients undergoing assisted reproduction: A randomized, triple-blind placebo-controlled clinical trial.
    Rostami S; Alyasin A; Saedi M; Nekoonam S; Khodarahmian M; Moeini A; Amidi F · Frontiers in endocrinology · 2023
    Randomized trial50 participantsAnti-Inflammatory Support
  8. Astaxanthin Modulates Inflammation in Type 2 Diabetes via Regulation of microRNAs, Lysophosphatidylcholine, and α-Hydroxybutyrate.
    Sharifi-Rigi A; Zal F; Aarabi MH; Dehghani M; Roustaei Rad N; Taghiyar S · International journal of endocrinology · 2025
    Randomized trial50 participantsAnti-Inflammatory Support
  9. Redox-sensitive miRNAs and Humanin could mediate effects of exercise and astaxanthin on oxidative stress and inflammation in type 2 diabetes.
    Basereh A; Khoramipour K; Hosseini N; HajHosseini M; Khodabakhshi A; Amirkhosravi L; Khoramipour K · Scientific reports · 2025
    Randomized trial90 participantsAnti-Inflammatory Support
  10. Astaxanthin, a natural antioxidant, lowers cholesterol and markers of cardiovascular risk in individuals with prediabetes and dyslipidaemia.
    Ciaraldi TP; Boeder SC; Mudaliar SR; Giovannetti ER; Henry RR; Pettus JH · Diabetes, obesity & metabolism · 2023
    Randomized trial34 participantsCardiovascular Support
  11. Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
    Wan S; Wu W; Zhang Y; He J; Wang X; An P; Luo J; Zhu Y; Luo Y · Nutrients · 2024
    Meta-analysisHeart HealthCardiovascular Support
  12. Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia.
    Yoshida H; Yanai H; Ito K; Tomono Y; Koikeda T; Tsukahara H; Tada N · Atherosclerosis · 2010
    Randomized trial61 participantsCardiovascular SupportHeart Health
  13. Effects of Astaxanthin Supplementation on Glycemic Control and Lipid Profile in Patients With Prediabetes and Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials.
    Molani-Gol R; Bohlouli Sardroudi S; Rafraf M · Nutrition and metabolic insights · 2026
    Meta-analysis403 participants9 studies pooledCardiovascular SupportHeart Health
  14. Astaxanthin Supplemented with High-Intensity Functional Training Decreases Adipokines Levels and Cardiovascular Risk Factors in Men with Obesity.
    Saeidi A; Nouri-Habashi A; Razi O; Ataeinosrat A; Rahmani H; Mollabashi SS; Bagherzadeh-Rahmani B; Aghdam SM; Khalajzadeh L; Al Kiyumi MH; Hackney AC; Laher I; Heinrich KM; Zouhal H · Nutrients · 2023
    Randomized trial68 participantsCardiovascular Support
  15. Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomised, double-blind, placebo-controlled study.
    Katagiri M; Satoh A; Tsuji S; Shirasawa T · Journal of clinical biochemistry and nutrition · 2012
    Randomized trial96 participantsCognitive Support
  16. Effect of astaxanthin-rich extract derived from Paracoccus carotinifaciens on cognitive function in middle-aged and older individuals.
    Hayashi M; Ishibashi T; Maoka T · Journal of clinical biochemistry and nutrition · 2020
    Clinical trial54 participantsCognitive Support
  17. The Effects of Astaxanthin on Cognitive Function and Neurodegeneration in Humans: A Critical Review.
    Queen CJJ; Sparks SA; Marchant DC; McNaughton LR · Nutrients · 2024
    Narrative reviewCognitive Support
  18. Effects of Astaxanthin Supplementation on Fatigue, Motor Function and Cognition: A Meta-Analysis of Randomized Controlled Trials.
    Liu C; Dong X; Jia J; Ha M · Biological research for nursing · 2024
    Meta-analysis346 participants11 studies pooledCognitive Support
  19. Astaxanthin and improvement of dementia: A systematic review of current clinical trials.
    Utomo NP; Pinzon RT; Latumahina PK; Damayanti KRS · Cerebral circulation - cognition and behavior · 2024
    Systematic reviewCognitive Support
  20. Impact of astaxanthin on oxidative markers, uric acid, and clinical symptoms in heart failure: a randomized clinical trial.
    Mohammadi SG; Shafie D; Feizi A; Bagherniya M; Ahmadi AR; Kafeshani M · BMC cardiovascular disorders · 2025
    Randomized trial80 participantsHeart Health
  21. Astaxanthin Influence on Health Outcomes of Adults at Risk of Metabolic Syndrome: A Systematic Review and Meta-Analysis.
    Leung LY; Chan SM; Tam HL; Wong ES · Nutrients · 2022
    Meta-analysis321 participants7 studies pooledHeart Health
  22. The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial.
    Ito N; Seki S; Ueda F · Nutrients · 2018
    Randomized trial23 participantsSkin Health
  23. Supplementating with dietary astaxanthin combined with collagen hydrolysate improves facial elasticity and decreases matrix metalloproteinase-1 and -12 expression: a comparative study with placebo.
    Yoon HS; Cho HH; Cho S; Lee SR; Shin MH; Chung JH · Journal of medicinal food · 2015
    Randomized trial44 participantsSkin Health
  24. Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers.
    Chalyk NE; Klochkov VA; Bandaletova TY; Kyle NH; Petyaev IM · Nutrition research (New York, N.Y.) · 2018
    Single-arm trial31 participantsSkin Health
  25. Cosmetic benefits of astaxanthin on humans subjects.
    Tominaga K; Hongo N; Karato M; Yamashita E · Acta biochimica Polonica · 2012
    Other66 participantsSkin Health
  26. Benefits and Safety of Astaxanthin in the Treatment of Mild-To-Moderate Dry Eye Disease.
    Tian L; Wen Y; Li S; Zhang P; Wang Y; Wang J; Cao K; Du L; Wang N; Jie Y · Frontiers in nutrition · 2022
    Single-arm trial60 participantsVision Support
  27. Astaxanthin (AstaReal®) Improved Acute and Chronic Digital Eye Strain in Children: A Randomized Double-Blind Placebo-Controlled Trial.
    Hecht KA; Marwah M; Wood V; Nishida Y; Bach AE; Gerson J; Hom MM; Schnackenberg J; Raote S; Srivastava S; Negi P; Caston E · Advances in therapy · 2025
    Randomized trial64 participantsVision Support
  28. Effects of diet containing astaxanthin on visual function in healthy individuals: a randomized, double-blind, placebo-controlled, parallel study.
    Sekikawa T; Kizawa Y; Li Y; Miura N · Journal of clinical biochemistry and nutrition · 2023
    Randomized trial60 participantsVision Support
  29. Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
    Martinez-Perez C; Oliveira AP · Nutrients · 2026
    Systematic review9 studies pooledVision Support
  30. Astaxanthin supplement improves clinical outcomes, quality of life, and inflammatory factors in patients with rheumatoid arthritis: a randomized clinical trial.
    Grigorian A; Tabatabaeyan A; Salesi M; Feizi A; Ahmadi AR; Kafeshani M · Food & function · 2025
    Randomized trial60 participantsJoint Health
  31. A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of a Krill Oil, Astaxanthin, and Oral Hyaluronic Acid Complex on Joint Health in People with Mild Osteoarthritis.
    Hill WS; Dohnalek MH; Ha Y; Kim SJ; Jung JC; Kang SB · Nutrients · 2023
    Randomized trial100 participantsJoint Health