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Hair Skin & Nails

Nature Made
4.7
★ ★ ★ ★ ★
(159 ratings)
Vitamin A 2500 IU
Biotin 2500 mcg
Copper 0.9 mg
Product Image
Score78
A practical hair, skin, and nail softgel with broad basic nutrient coverage. Mineral oxide forms and biotin-related laboratory interference are the main trade-offs.
How scoring works
Quantity:120 Softgel(s) • (120 servings)
Goals:
Skin Health
Nail Health
Hair Health
Vision Support

Score 78

A practical hair, skin, and nail softgel with broad basic nutrient coverage. Mineral oxide forms and biotin-related laboratory interference are the main trade-offs.
How scoring works
$13.18($0.10 per serving)
Walmart
$ 13.18
Vitacost
$ 14.69
Report prices

Analysis

Biotin, zinc, copper, vitamin A, and vitamin C cover keratin production, connective tissue, antioxidant defense, and deficiency-related shedding. Benefits are most likely when one of these nutrients is inadequate.

Beta-carotene is well suited to softgel delivery, but zinc oxide and copper oxide are less favorable mineral forms. The formula does not include collagen, cysteine, silicon, ceramides, or other direct structural ingredients.

The once-daily format and long serving supply make routine use simple. High-dose biotin can distort thyroid, hormone, and cardiac laboratory results, so timing around bloodwork needs attention.

Who is it for
  • Adults with possible nutrient-related hair or nail concerns
  • Users wanting a once-daily beauty supplement
  • People seeking biotin with zinc and copper
Best for
  • Hair and nail nutrition
  • Skin antioxidant support
  • Deficiency-focused beauty support

Pros

  • Compact multi-nutrient formula
  • Softgel supports beta-carotene delivery
  • Balanced zinc and copper amounts
  • Long serving supply

Cons

  • Zinc oxide has weaker absorption
  • Copper oxide has poor bioavailability
  • No direct structural proteins or lipids
  • Biotin helps mainly when status is low

Warnings

  • The 2,500 mcg biotin amount may interfere with thyroid, hormone, and cardiac laboratory tests.
  • Tell the testing clinician about biotin use and follow their guidance on pausing it before bloodwork.
  • Extra biotin is unlikely to improve hair or nails when biotin status is already adequate.

Nutrient quality

75 High impact

Beta-carotene suits the softgel, but zinc oxide and copper oxide have weak absorption. Biotin and vitamin C are meaningful, while zinc and copper provide maintenance support.

.

Ingredient transparency

78 High impact

All meaningful active amounts are clearly disclosed. The supplied data does not include a complete inactive ingredient list.

.

Customer satisfaction

65 Moderate impact

The aggregate satisfaction measure is strong, but the limited volume reduces confidence. Missing feedback themes leave recurring complaints and purpose fit uncertain.

.

Value for money

92 Highest impact

The price is very well matched to the formula quality and dose. Each serving provides excellent cost efficiency.

.
Report analysis

Goals

Skin Health
Skin Health
Impact
High effect
B+ Goal FitB- Strength of SupportB CoverageA- Formula Quality
Zinc · 11 mgVitamin C · 100 mgCopper · 0.9 mg

Vitamins A and C, zinc, copper, and biotin provide a focused nutrient base for skin structure and antioxidant defense. Benefits from biotin are most likely when intake is inadequate.

The softgel suits beta-carotene, but zinc and copper oxides are less favorable mineral forms. The biotin amount can interfere with some laboratory tests, so it should be disclosed before bloodwork.

Study evidence
Biotin Supportive 10 studies
Copper Supportive 16 studies
Vitamin A Supportive 106 studies
Vitamin C Supportive 53 studies
Zinc Supportive 66 studies
Nail Health
Nail Health
Impact
High effect
A- Goal FitB- Strength of SupportC CoverageA- Formula Quality
Biotin · 2500 mcg

Biotin at 2,500 mcg provides a strong keratin-support foundation, with vitamin C and zinc adding useful connective-tissue and deficiency coverage. The amount is relevant for brittle nails, though the specific d-biotin form is not confirmed.

Zinc oxide and copper oxide are less favorable mineral forms, and the formula lacks collagen, cysteine, or silicon for direct structural support. High-dose biotin can interfere with thyroid, hormone, and cardiac laboratory tests, so the dose should be disclosed before bloodwork.

Study evidence
Biotin Supportive 8 studies
Vitamin C Supportive 1 study
Zinc No effect 1 study
Hair Health
Hair Health
Impact
High effect
B Goal FitB- Strength of SupportB- CoverageB+ Formula Quality
Biotin · 2500 mcgZinc · 11 mgVitamin C · 100 mg

Biotin, zinc, copper, vitamin A, and vitamin C create a hair-focused nutrient blend spanning keratin support, follicle function, and connective tissue. Benefits remain more certain when a nutritional gap is present.

The biotin amount is meaningful, while zinc and copper are clearly balanced but use lower-quality oxide forms. High-dose biotin may interfere with thyroid, hormone, or cardiac blood tests and should be disclosed before testing.

Study evidence
Biotin Supportive 4 studies
Copper Adverse 4 studies
Vitamin A Disputed 13 studies
Vitamin C Mixed 5 studies
Zinc Supportive 22 studies
Vision Support
Vision Support
Impact
High effect
B+ Goal FitC+ Strength of SupportC+ CoverageB+ Formula Quality
Zinc · 11 mgVitamin C · 100 mgCopper · 0.9 mgVitamin A · 2500 IU

Beta-carotene, vitamin C, zinc, and copper provide a credible base for retinal antioxidant support and vitamin A function. The combination is relevant but falls short of a complete vision formula because lutein, zeaxanthin, and vitamin E are absent.

The softgel supports beta-carotene absorption, while zinc oxide and copper oxide are less preferred mineral forms. Biotin is prominent but does not materially improve ocular coverage.

Study evidence
Copper Supportive 7 studies
Vitamin A Supportive 65 studies
Vitamin C Disputed 24 studies
Zinc Supportive 39 studies

Ingredients

IngredientAmount per serving
Vitamin A (Beta-Carotene)
 2500 IU
Vitamin C (Ascorbic Acid)
 100 mg
Biotin
2500 mcg
Zinc (Zinc Oxide)
 11 mg
Copper (Copper Oxide)
 0.9 mg
Gluten Free Adults 18–50
Report overview
Vitamin A (Beta-Carotene) · 2500 IU OverallScore84
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

The softgel combines a useful beta-carotene dose with a lipid-friendly delivery format. Its source is not disclosed, so natural origin cannot be confirmed. Clear form labeling, efficient cost, and a focused supporting formula make it a good practical fit with a modest sourcing limitation.

View ingredientView products
Biotin · 2500 mcg OverallScore78
B+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyC Value

The softgel provides a clearly disclosed, moderately high biotin dose alongside several supporting nutrients. The specific d-Biotin isomer is not confirmed, and the dose falls below the collection's top potency range. The 2,500 mcg dose may interfere with some laboratory tests, so users should disclose it before bloodwork.

View ingredientView products
Copper (Copper Oxide) · 0.9 mg OverallScore66
F Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyA+ Value

Copper oxide is clearly disclosed but has very poor bioavailability. The 0.9 mg dose covers routine adult maintenance without approaching excessive intake. The very low serving cost makes the formula highly economical for copper delivery.

View ingredientView products
Loading alternative details
68 Performance

Keratin Hair Booster

Reserveage Nutrition
<p>A meaningful keratin amount plus biotin directly strengthens the hair-and-nail focus beyond the original vitamin-only formula. Zinc oxide and copper sulfate remain basic forms, and a small longevity blend is not fully disclosed.</p>
66 Performance

Tres Beauty 3

Reserveage Beauty
<p>Collagen and soluble keratin provide direct structural ingredients for hair and nails that the original lacks. Basic zinc and copper forms, incomplete blend detail, and a high serving cost are important trade-offs.</p>
74 Performance

Longer Stronger Hair and Nails

Irwin Naturals
<p>Buffered vitamin C, zinc picolinate, chelated copper, biotin, horsetail, amino acids, and flax oil create broader hair-and-nail support than the original. Lysine and proline are modest, horsetail lacks a fully specified silica yield, and concentrated biotin may distort laboratory results.</p>
80 Budget

One Daily Women's

21st Century
<p>A lower serving cost adds broad vitamins and minerals while retaining biotin, beta-carotene, vitamin C, zinc, and copper. Biotin is lower than in the original, but zinc remains an oxide and supplemental iron is unnecessary for people without increased iron needs.</p>
77 Budget

One Daily Women's

Equate
<p>Broad vitamins, minerals, biotin, beta-carotene, zinc, and copper come at a lower serving cost than the focused original. Most chemical forms are unspecified and the biotin amount is lower, while iron is appropriate only when needed.</p>
78 Budget

One Daily Men's Health

Equate
<p>A very low-cost multivitamin provides beta-carotene, vitamin C, zinc, selenium, and copper for general skin and hair nutrition. Its biotin amount is far below the original and most forms are undisclosed, so it is a budget multi rather than a close beauty formula.</p>
75 Value

Longer Stronger Hair and Nails

Irwin Naturals
<p>Useful mineral forms, buffered vitamin C, biotin, horsetail, amino acids, and flax oil provide a broader hair-and-nail formula than the original. The serving costs more, lysine and proline are modest, and concentrated biotin may interfere with laboratory tests, so the value gain depends on wanting the added ingredients.</p>
69 Value

Longer Stronger Hair & Nails

Applied Nutrition
<p>Zinc citrate, chelated copper, biotin, horsetail, and gotu kola improve ingredient targeting while keeping the serving cost moderate for a specialty formula. Collagen is only a token amount, preformed vitamin A is high, and biotin may distort laboratory results.</p>
74 Value

PreserVision AREDS Soft Gels

Bausch & Lomb
<p>Substantial antioxidant vitamins, zinc, and copper provide better vision-focused coverage than the original and retain beta-carotene as a shared ingredient. Hair and nail support is weak, the mineral forms are basic, and current or former smokers should avoid concentrated beta-carotene supplements.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Evidence for the Efficacy of Over-the-counter Vitamin A Cosmetic Products in the Improvement of Facial Skin Aging: A Systematic Review.
    Spierings NMK · The Journal of clinical and aesthetic dermatology · 2022
    Systematic review9 studies pooledSkin Health forVitamin A
  2. A stabilized 0.1% retinol facial moisturizer improves the appearance of photodamaged skin in an eight-week, double-blind, vehicle-controlled study.
    Tucker-Samaras S; Zedayko T; Cole C; Miller D; Wallo W; Leyden JJ · Journal of drugs in dermatology : JDD · 2009
    Randomized trial64 participantsSkin Health forVitamin A
  3. Anti-pollution cosmetic-based one-step formation of w/o/w multiple emulsion containing D-biotin for skin protection: fabrication and in vitro and in vivo evaluation.
    Ali A; Iqbal S; Ilyas A; Khan H; Asad MHHB; Fatima N; Akhtar N · Drug delivery and translational research · 2020
    Non-randomized trial15 participantsSkin Health forBiotin
  4. Final report on the safety assessment of biotin.
    Fiume MZ; Cosmetic Ingredient Review Expert Panel · International journal of toxicology · 2002
    Narrative reviewSkin Health forBiotin
  5. Improvement of facial skin characteristics using copper oxide containing pillowcases: a double-blind, placebo-controlled, parallel, randomized study.
    Borkow G; Gabbay J; Lyakhovitsky A; Huszar M · International journal of cosmetic science · 2010
    Randomized trial57 participantsSkin Health forCopper
  6. Zinc, Copper, and Iron in Selected Skin Diseases.
    Podgórska A; Kicman A; Naliwajko S; Wacewicz-Muczyńska M; Niczyporuk M · International journal of molecular sciences · 2024
    Narrative reviewSkin Health forCopper
  7. Alopecia and Associated Toxic Agents: A Systematic Review.
    Yu V; Juhász M; Chiang A; Atanaskova Mesinkovska N · Skin appendage disorders · 2022
    Systematic review47 studies pooledHair Health forVitamin A
  8. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  9. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsSkin Health Hair Health Nail Health forBiotin
  10. Trace element levels in alopecia areata.
    Bhat YJ; Manzoor S; Khan AR; Qayoom S · Indian journal of dermatology, venereology and leprology · 2009
    Case-control study100 participantsHair Health forCopper
  11. Menkes disease and response to copper histidine: An Indian case series.
    Yoganathan S; Sudhakar SV; Arunachal G; Thomas M; Subramanian A; George R; Danda S · Annals of Indian Academy of Neurology · 2022
    Case series4 participantsHair Health forCopper
  12. Biotin for the treatment of nail disease: what is the evidence?
    Lipner SR; Scher RK · The Journal of dermatological treatment · 2018
    Narrative reviewNail Health forBiotin
  13. Brittle nails: response to daily biotin supplementation.
    Hochman LG; Scher RK; Meyerson MS · Cutis · 1993
    Case series35 participantsNail Health forBiotin
  14. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health Skin Health forBiotin
  15. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  16. UV damage to hair and the effect of antioxidants and metal chelators.
    Millington KR; Marsh JM · International journal of cosmetic science · 2021
    In vitro / ex vivo studyHair Health forCopper
  17. Preserving fibre health: reducing oxidative stress throughout the life of the hair fibre.
    Marsh JM; Davis MG; Lucas RL; Reilman R; Styczynski PB; Li C; Mamak M; McComb DW; Williams RE; Godfrey S; Navqi KR; Chechik V · International journal of cosmetic science · 2016
    In vitro / ex vivo studyHair Health forCopper
  18. Topical tretinoin for hair growth promotion.
    Bazzano GS; Terezakis N; Galen W · Journal of the American Academy of Dermatology · 1986
    Non-randomized trial56 participantsHair Health forVitamin A
  19. A review of isotretinoin in the treatment of frontal fibrosing alopecia.
    Shahpar A; Nezhad NZ; Sahaf AS; Ahramiyanpour N · Journal of cosmetic dermatology · 2024
    Systematic review232 participants15 studies pooledHair Health forVitamin A
  20. Efficacy of Isotretinoin and Acitretin in Treatment of Frontal Fibrosing Alopecia: Retrospective Analysis of 54 Cases.
    Rakowska A; Gradzińska A; Olszewska M; Rudnicka L · Journal of drugs in dermatology : JDD · 2018
    Cohort study54 participantsHair Health forVitamin A
  21. Systemic Treatments for Lichen Planopilaris and Frontal Fibrosing Alopecia: A Retrospective Study of 315 Patients.
    Willaert M; Van Dongen T; Dikrama P; Nijsten T; Hijnen D; Waalboer-Spuij R · Acta dermato-venereologica · 2025
    Cohort study315 participantsHair Health forVitamin A
  22. Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes.
    Sharma A; Goren A; Dhurat R; Agrawal S; Sinclair R; Trüeb RM; Vañó-Galván S; Chen G; Tan Y; Kovacevic M; Situm M; McCoy J · Dermatologic therapy · 2020
    Single-arm trialHair Health forVitamin A
  23. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  24. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  25. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  26. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  27. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
    Case reportHair Health forVitamin C
  28. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  29. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  30. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  31. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  32. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  33. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy.
    Colombo VE; Gerber F; Bronhofer M; Floersheim GL · Journal of the American Academy of Dermatology · 1991
    Other32 participantsNail Health forBiotin
  34. Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial.
    Chiavetta A; Mazzurco S; Secolo MP; Tomarchio G; Milani M · Dermatologic therapy · 2020
    Randomized trial50 participantsNail Health forBiotin
  35. Vitamins and minerals: their role in nail health and disease.
    Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
    Narrative reviewNail Health forBiotin Nail Health forZinc
  36. Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten Micronutrient.
    Dunleavy KA; Ungaro RC; Manning L; Gold S; Novak J; Colombel JF · Crohn's & colitis 360 · 2023
    Other20 participantsNail Health forVitamin C
  37. Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters.
    Aksac SE; Bilgili SG; Yavuz GO; Yavuz IH; Aksac M; Karadag AS · International journal of dermatology · 2021
    Non-randomized trial60 participantsSkin Health forBiotin
  38. Generalized seborrhoeic dermatitis. Clinical and therapeutic data of 25 patients.
    Messaritakis J; Kattamis C; Karabula C; Matsaniotis N · Archives of disease in childhood · 1976
    Non-randomized trial25 participantsSkin Health forBiotin
  39. Holocarboxylase synthetase deficiency: novel clinical and molecular findings.
    Tammachote R; Janklat S; Tongkobpetch S; Suphapeetiporn K; Shotelersuk V · Clinical genetics · 2010
    Case series4 participantsSkin Health forBiotin
  40. Noninferiority of Copper Dressings Than Negative Pressure Wound Therapy in Healing Diabetic Wounds: A Randomized Clinical Trial.
    Melamed E; Dabbah J; Israel T; Kan I; Pinzur MS; Roth T; Borkow G · Advances in wound care · 2026
    Randomized trialSkin Health forCopper
  41. Radially Electrospun Fibrous Membrane Incorporated with Copper Peroxide Nanodots Capable of Self-Catalyzed Chemodynamic Therapy for Angiogenesis and Healing Acceleration of Diabetic Wounds.
    Huang Y; Qi L; Liu Z; Jiang Y; Wang J; Liu L; Li Y; Zhang L; Feng G · ACS applied materials & interfaces · 2023
    Animal experimentSkin Health forCopper
  42. Engineering copper nanoparticle/polysaccharide-immobilized cotton gauze for accelerated healing of Staphylococcus aureus-infected dermal wounds.
    Sahoo M; Banerjee T; Virkar S; Das S; Biswas S; Mitra D · Journal of materials chemistry. B · 2026
    Animal experimentSkin Health forCopper
  43. Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings.
    Melamed E; Rovitsky A; Roth T; Assa L; Borkow G · Medicina (Kaunas, Lithuania) · 2021
    Single-arm trialSkin Health forCopper
  44. Efficacy and Tolerability of Topical 0.1% Stabilized Bioactive Retinol for Photoaging: A Vehicle-Controlled Integrated Analysis.
    Farris P; Berson D; Bhatia N; Goldberg D; Lain E; Mariwalla K; Zeichner J; Miller D; McGuire T; Kizoulis M · Journal of drugs in dermatology : JDD · 2024
    Meta-analysis471 participants6 studies pooledSkin Health forVitamin A
  45. Tensile properties and contours of aging facial skin. A controlled double-blind comparative study of the effects of retinol, melibiose-lactose and their association.
    Piérard-Franchimont C; Castelli D; Cromphaut IV; Bertin C; Ries G; Cauwenbergh G; Piérard GE · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2016
    Randomized trial120 participantsSkin Health forVitamin A
  46. Antiaging action of retinol: from molecular to clinical.
    Bellemère G; Stamatas GN; Bruère V; Bertin C; Issachar N; Oddos T · Skin pharmacology and physiology · 2009
    Randomized trial48 participantsSkin Health forVitamin A
  47. An Updated Review of Topical Tretinoin in Dermatology: From Acne and Photoaging to Skin Cancer.
    Balado-Simó P; Morgado-Carrasco D; Gómez-Armayones S; López-Ferrer A; Barco D; Ferrándiz-Pulido C; Podlipnik S · Journal of clinical medicine · 2025
    Narrative reviewSkin Health forVitamin A
  48. Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial.
    Chang H; Tao K; Yang Y; Wang Y; Ge M; Wang X; Tang S; Yu H · Journal of cosmetic dermatology · 2025
    Randomized trialSkin Health forVitamin A
  49. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  50. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  51. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  52. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  53. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  54. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  55. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  56. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  57. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc
  58. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forZinc
  59. What did we learn in 35 years of research on nutrition and supplements for age-related macular degeneration: a systematic review.
    Pameijer EM; Heus P; Damen JAA; Spijker R; Hooft L; Ringens PJ; Imhof SM; van Leeuwen R · Acta ophthalmologica · 2023
    Systematic review27 studies pooledVision Support forCopper
  60. Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2.
    Agrón E; Mares J; Clemons TE; Swaroop A; Chew EY; Keenan TDL; AREDS and AREDS2 Research Groups · Ophthalmology · 2021
    Cohort study8,242 participantsVision Support forCopper
  61. Association between late age-related macular degeneration and dietary intake of copper, iron, zinc and selenium: a 2005-2008 NHANES cross-sectional observational study.
    Lu Y; Li C; Liu Y; Wu T; Lu P · BMC ophthalmology · 2025
    Observational study4,996 participantsVision Support forCopper
  62. Associations between dietary nutrient intake and the risk of multiple age-related ocular diseases: evidence from longitudinal analysis.
    Yang Y; Zou H · The journal of nutrition, health & aging · 2026
    Cohort study103,192 participantsVision Support forCopper
  63. Dietary habits and dietary nutrient intake in patients with age-related macular degeneration: A case-control study.
    Šalková Kráľová J; Kolář P; Kapounová Z; Veselý P; Derflerová Brázdová Z · Central European journal of public health · 2023
    Case-control study151 participantsVision Support forCopper
  64. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa.
    Berson EL; Rosner B; Sandberg MA; Hayes KC; Nicholson BW; Weigel-DiFranco C; Willett W · Archives of ophthalmology (Chicago, Ill. : 1960) · 1993
    Randomized trial601 participantsVision Support forVitamin A
  65. Efficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese Phase II clinical trial.
    Toshida H; Funaki T; Ono K; Tabuchi N; Watanabe S; Seki T; Otake H; Kato T; Ebihara N; Murakami A · Drug design, development and therapy · 2018
    Randomized trial66 participantsVision Support forVitamin A
  66. Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age.
    Imdad A; Mayo-Wilson E; Haykal MR; Regan A; Sidhu J; Smith A; Bhutta ZA · The Cochrane database of systematic reviews · 2022
    Meta-analysis1,223,856 participants47 studies pooledVision Support forVitamin A
  67. Vitamin A supplementation improves retinal function in infants at risk of retinopathy of prematurity.
    Mactier H; McCulloch DL; Hamilton R; Galloway P; Bradnam MS; Young D; Lavy T; Farrell L; Weaver LT · The Journal of pediatrics · 2012
    Randomized trial89 participantsVision Support forVitamin A
  68. Effect of short-term, high-dose retinol on dark adaptation in aging and early age-related maculopathy.
    Owsley C; McGwin G; Jackson GR; Heimburger DC; Piyathilake CJ; Klein R; White MF; Kallies K · Investigative ophthalmology & visual science · 2006
    Randomized trial104 participantsVision Support forVitamin A
  69. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsVision Support forVitamin C
  70. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyVision Support forVitamin C
  71. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewVision Support forVitamin C
  72. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin C
  73. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsVision Support forVitamin C
  74. Antioxidant vitamin and mineral supplements for age-related macular degeneration.
    Evans JR · The Cochrane database of systematic reviews · 2002
    Systematic review170 participants7 studies pooledVision Support forZinc
  75. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration.
    Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2023
    Meta-analysis3,790 participants5 studies pooledVision Support forZinc
  76. Oral zinc in macular degeneration.
    Newsome DA; Swartz M; Leone NC; Elston RC; Miller E · Archives of ophthalmology (Chicago, Ill. : 1960) · 1988
    Randomized trial151 participantsVision Support forZinc
  77. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.
    Age-Related Eye Disease Study Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2001
    Randomized trial3,640 participantsVision Support forZinc
  78. Effect of vitamin A and zinc supplementation on the nutriture of children in Northeast Thailand.
    Udomkesmalee E; Dhanamitta S; Sirisinha S; Charoenkiatkul S; Tuntipopipat S; Banjong O; Rojroongwasinkul N; Kramer TR; Smith JC · The American journal of clinical nutrition · 1992
    Randomized trial133 participantsVision Support forZinc