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Dr. Derrick DeSilva's Liposomal Vitamin C Natural Citrus Flavor

4.6
★ ★ ★ ★ ★
(160 ratings)
Vitamin C 1000 mg
Sodium 125 mg
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Score63
A focused liposomal vitamin C liquid with a useful amount, but premium cost and limited carrier detail are notable trade-offs.
How scoring works
Liquid
Quantity:5 Liquid(s) • (30 servings)
Goals:
Immunity
General Health
Skin Health
Vision Support
Anti-Inflammatory Support

Score 63

A focused liposomal vitamin C liquid with a useful amount, but premium cost and limited carrier detail are notable trade-offs.
How scoring works
$50.49($1.68 per serving)
iHerb
$ 50.49
iHerb
$ 50.49
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Analysis

The liquid supplies 1,000 mg of vitamin C through ascorbic acid and sodium ascorbate. Partial buffering may improve comfort, while the liposomal carrier is designed to support uptake.

Vitamin C, sodium, and the total liposome blend are quantified, but the blend's full composition is not disclosed. The formula therefore has a clear active dose without complete carrier transparency.

People who specifically prefer a liquid liposomal format may find the design useful. Value is weak compared with simpler buffered powders or capsules, and the 125 mg sodium contribution is not meaningful for exercise hydration.

Who is it for
  • Adults seeking liquid vitamin C
  • People who prefer a partly buffered formula
  • Users willing to pay more for liposomal delivery
Best for
  • Vitamin C supplementation
  • Antioxidant support
  • People avoiding tablets

Pros

  • Target-range vitamin C amount
  • Partly buffered with sodium ascorbate
  • Liposomal delivery format

Cons

  • Relatively costly per serving
  • Proprietary carrier composition is incomplete
  • Not a balanced electrolyte formula

Warnings

  • The 125 mg sodium contribution may matter on a strict sodium restriction
  • High vitamin C intake can cause loose stools or stomach discomfort
  • People prone to oxalate kidney stones should discuss sustained high-dose vitamin C use with a clinician

Nutrient quality

88 Highest impact

The ingredient form and serving amount provide solid nutritional support. The formula remains reasonably focused without obvious excessive dosing.

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Ingredient transparency

59 Moderate impact

Conflicting or repeated amount presentation makes the active breakdown difficult to assess. An unspecified blend or support base and missing inactive ingredients limit full label clarity.

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Customer satisfaction

59 Moderate impact

The aggregate rating is favorable but less consistent with a limited review base. No specific feedback is supplied to confirm recurring complaints or purpose-related experiences.

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Value for money

40 Lower impact

The format and short supply weaken value relative to simpler vitamin C products. Most of the cost appears directed toward the core active formula.

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Report analysis

Goals

Immunity
Immunity
Impact
Highest effect
A Goal FitA+ Strength of SupportB- CoverageA- Formula Quality
Vitamin C · 1000 mg

A 1,000 mg Vitamin C serving provides strong direct antioxidant and immune-cell support. Liposomal delivery may improve uptake, and sodium ascorbate partially buffers the acidic form.

Vitamin C and sodium are separately quantified, but the phospholipid ingredients inside the liposomal blend are not identified. The product supports one immune pathway deeply rather than offering broad multi-pathway coverage.

Study evidence
Vitamin C Supportive 53 studies
General Health
General Health
Impact
Highest effect
A- Goal FitA Strength of SupportC CoverageA- Formula Quality
Vitamin C · 1000 mg

A full target-range vitamin C serving and liposomal carrier provide strong antioxidant and collagen-support relevance. Partial buffering with sodium ascorbate may improve comfort compared with plain ascorbic acid alone.

The active amount and liposomal blend are clearly quantified, although the complete carrier composition is not shown. The formula is focused, but the sodium contribution may matter for people following a medically prescribed sodium restriction.

Study evidence
Vitamin C Supportive 56 studies
Skin Health
Skin Health
Impact
High effect
B Goal FitA- Strength of SupportC- CoverageA- Formula Quality
Vitamin C · 1000 mg

Vitamin C directly supports collagen synthesis and antioxidant defense. The high daily amount provides strong depth for this focused pathway.

Combining ascorbic acid with sodium ascorbate and a liposomal carrier may improve comfort and uptake. The formula remains narrow because it supplies no collagen, barrier lipid, or hydration active.

Study evidence
Vitamin C Supportive 53 studies
Vision Support
Macular and Blue Light Defense
Vision Support
Impact
High effect
C- Goal FitA- Strength of SupportD CoverageA- Formula Quality
Vitamin C · 1000 mg

Vitamin C provides useful antioxidant support for the lens and other ocular tissues. A single antioxidant cannot replace a broader vision formula built around macular carotenoids, zinc, or structural lipids.

The 1,000 mg amount is clearly disclosed and reaches a meaningful supplemental range. Liposomal delivery may improve uptake, but the proprietary lipid blend prevents a full assessment of composition and quality.

Study evidence
Vitamin C Disputed 24 studies
Anti-Inflammatory Support
Cellular Defense
Anti-Inflammatory Support
Impact
High effect
D+ Goal FitB Strength of SupportD- CoverageA Formula Quality
Vitamin C · 1000 mg

Vitamin C supports antioxidant defenses and may modestly influence inflammatory signaling. It is less direct than established botanical or omega-3 anti-inflammatory actives.

The substantial amount and liposomal positioning support useful exposure, although the exact lipid delivery details are limited. The single-active design provides depth in one antioxidant pathway without broader coverage.

Study evidence
Vitamin C Supportive 50 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid, Sodium Ascorbate)
 1000 mg
Sodium (Sodium Ascorbate)
 125 mg
Liposome Proprietary Blend
500 mg
Adults 18–50
Report overview
Vitamin C (Ascorbic Acid, Sodium Ascorbate) · 1000 mg OverallScore76
A- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyF Value

Liposomal delivery is designed to improve uptake, although the vitamin C combines acidic and buffered forms. The 1,000 mg serving falls within the preferred intake range. Vitamin C, sodium from sodium ascorbate, and the liposomal blend are separately quantified, while the cost per gram is high even after accounting for the premium liposomal delivery.

View ingredientView products
Sodium (Sodium Ascorbate) · 125 mg OverallScore57
D+ Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyD+ Value

Its 125 mg sodium amount is too low for dependable replacement during intense exercise. Sodium ascorbate identifies the source, but the formula provides no supporting electrolytes or recognized buffering mineral. The liquid is designed for vitamin C delivery rather than exercise hydration, and it lacks supporting electrolytes.

View ingredientView products
Loading alternative details
82 Performance

Liposomal Vitamin C 1000 mg

SunLipid
A disclosed phospholipid complex, MCT, and 1000 mg sodium ascorbate serving provide a clear liposomal design. It retains buffered delivery while improving on the proprietary liposome blend and duplicate source-level vitamin C amounts.
86 Performance

Ester-C Plus 1000 mg Vitamin C

Solgar
Buffered calcium ascorbate and 200 mg of citrus bioflavonoids provide a focused 1000 mg vitamin C option without sodium. It does not preserve the proprietary liposome blend and duplicate source-level vitamin C amounts, but may better suit someone prioritizing buffering and a sodium-free formula.
89 Performance

Pure Buffered Calcium Ascorbate

NOW
An 890 mg calcium ascorbate serving offers full buffering, clear mineral disclosure, and no sodium contribution. It lacks the proprietary liposome blend and duplicate source-level vitamin C amounts, while incomplete inactive-ingredient and use details remain a limitation.
85 Budget

C-500 With Rose Hips

NOW
A lower listed serving cost comes with a practical 500 mg ascorbic acid amount and a small rose-hip addition. It gives up liposomal delivery and buffering, so people with a sensitive stomach may prefer the original format.
83 Budget

C 500 mg

21st Century
A lower listed serving cost and a simple 500 mg ascorbic acid amount make this an economical basic option. Calcium carbonate adds little buffering, and the simpler tablet does not retain the proprietary liposome blend and duplicate source-level vitamin C amounts.
85 Budget

Gold C Vitamin C 1000 mg

California Gold Nutrition
A lower listed serving cost preserves a substantial 1000 mg vitamin C amount in a very simple formula. Plain ascorbic acid removes the proprietary liposome blend and duplicate source-level vitamin C amounts and may be less comfortable for sensitive users.
82 Value

Meta-C 1000 mg Tablets

NutriBiotic Immunity
Favorable listed value comes with a more informative or better-buffered formula than the original. The 1000 mg vitamin C complex names calcium, active metabolites, and spirulina, although spirulina adds limited clarity to the core purpose.
86 Value

C

Swanson
Favorable listed value comes with a more informative or better-buffered formula than the original. A 1000 mg calcium ascorbate amount and 200 mg of citrus bioflavonoids provide buffering without the original sodium contribution.
84 Value

Ester-C 24 Hour Immune Support 1000 mg

NatureSmart
Favorable listed value comes with a more informative or better-buffered formula than the original. Buffered calcium ascorbate and a disclosed citrus bioflavonoid complex keep the formula focused and may improve stomach comfort.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  2. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  3. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  4. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  5. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  6. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  7. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  8. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  9. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  10. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  11. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  12. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  13. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  14. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  15. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  16. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  17. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  18. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  19. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  20. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  21. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsVision Support forVitamin C
  22. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyVision Support forVitamin C
  23. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewVision Support forVitamin C
  24. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin C
  25. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsVision Support forVitamin C