SAMe (S-Adenosylmethionine)

SAMe (S-Adenosylmethionine)

Pure Encapsulations4.7 (24 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 60 servings
Goals
$84.50 $1.40 per serving
VitacostLowest$84.50Pure Formulas$84.50Vitacost$84.50

About this product

The focused capsule uses a clearly named stable SAMe salt at a common starting amount. Its single-ingredient design is easy to understand.

No enteric or delayed-release feature is stated, and the label does not distinguish salt-complex weight from active SAMe. Packaging protection against moisture is also not identified.

The product may suit users beginning at a lower amount, but it is expensive for uncertain delivery. More protected options provide a stronger balance.

Who is it for
  • Adults starting with lower-dose SAMe
  • Users wanting a named stable salt
  • People preferring a single active ingredient
Best for
  • Cautious SAMe initiation
  • Simple capsule routines
  • Detoxification-oriented use

Pros

  • Stabilized salt is identified
  • Practical starting amount
  • Single active ingredient
  • Exact serving weight disclosed

Cons

  • No enteric protection
  • Net SAMe yield is unclear
  • No blister packaging identified
  • High normalized cost

Warnings

  • SAMe may provoke mania in bipolar disorder
  • Serotonergic medicines and supplements can create a serotonin-syndrome risk with SAMe
  • Possible adverse effects include nausea, anxiety, and insomnia

Product analysis

73 out of 100
A stable low-dose SAMe salt in a simple capsule, held back by no stated acid protection and high cost.

AI assessment of the formula, label and price. How scoring works

Nutrient quality86

A stabilized salt supports shelf stability, but no acid-resistant delivery is stated. A common starting amount is practical, although net SAMe yield remains unclear.

Ingredient transparency82

The active amount is disclosed without a hidden blend, and the stabilizing salt is named. Missing net active yield, complete directions, and non-active ingredients leave important gaps.

Customer satisfaction62

The supplied average rating is very strong and the rating volume is limited. No specific experience details were provided to judge repeated complaints or purpose alignment.

Value for money57

Delivery limitations or high cost weaken practical value. Better-protected or more efficiently priced alternatives are more competitive.

Format
Capsule
Container
60 Capsule(s)
Per serving
$1.40
Customer rating
4.7 · 24 ratings
Report analysis

Goals

Detoxification
Detoxification
Impact
High effect
B+ Ingredient FitF PathwaysA- EvidenceA+ Formulation Logic
SAMe · 200 mg

SAMe supplies methyl groups used in normal body processes, which gives it a biochemical connection to this goal. That role doesn't show that taking it improves routine removal of toxins. The declared 200 mg serving also doesn't by itself identify a toxin-clearance benefit you can expect.

How this product is rated for Detoxification

Ingredient fit80

SAMe provides 200 mg per serving; the amount alone does not demonstrate a routine toxin-clearance benefit.
Goal fit
SAMe is the sole relevant active ingredient.
Dose adequacy
SAMe provides 200 mg per serving; the amount alone does not demonstrate a routine toxin-clearance benefit.

Pathways19

SAMe supplies methyl groups, a normal metabolic role rather than a demonstrated routine toxin-removal effect.
Depth
SAMe supplies methyl groups, a normal metabolic role rather than a demonstrated routine toxin-removal effect.
Breadth
The connection is limited to methyl-group supply, without demonstrating broad toxin removal.

Evidence86

SAMe has a metabolic role, but a routine toxin-clearance benefit at this serving is unclear.
Evidence strength
SAMe has a metabolic role, but a routine toxin-clearance benefit at this serving is unclear.
Studied preparation
The declared SAMe amount identifies the ingredient, without resolving whether it improves routine toxin clearance.

Formulation logic100

No required companion ingredient or particular ingredient conflict is identified.
Partner coverage
No required companion ingredient is missing for the relevant ingredient roles.
Conflicts
No particular ingredient conflict is identified.
Effective doses
SAMe provides 200 mg per serving; the amount alone does not demonstrate a routine toxin-clearance benefit.
Study evidence
SAMe Supportive 30 studies

Ingredients

IngredientAmount per servingScore
SAMe (S-Adenosyl-L-Methionine Disulfate Tosylate)
 200 mg 59
Adults 18–50
Report overview
SAMe (S-Adenosyl-L-Methionine Disulfate Tosylate) · 200 mg OverallScore59
B Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyF Value
The label lists 200 mg of SAMe per serving, and the saved facts indicate a stabilized-salt claim without naming the specific salt. They also indicate delayed release, but do not distinguish the salt weight from net active SAMe. No blister claim appears, and cost is high relative to the listed amount.
How this ingredient is rated

Active Ingredient Quality & Bioavailability77

A stabilized-salt claim and delayed-release feature are indicated, but the specific salt name is not available.
Stabilized Salt Form
The saved facts indicate a stabilized salt form, though they do not identify the specific salt.
Packaging Integrity
No individual blister-pack claim is recorded, so the packaging type remains unclear.

Dose, Safety & Label Transparency60

The ingredient amount is clear, but the label does not state net active SAMe separately from salt weight.
Active Dosage Strength
The label lists 200 mg of SAMe per serving, the common starting amount described in the supplied context.
Net SAMe Yield Transparency
Only one SAMe amount is listed, so salt-complex weight and net active SAMe are not distinguished.

Value20

The normalized cost is high relative to the collection reference.
Price Per 400mg Active Dose
The cost for a 400 mg reference amount is high, although a delayed-release claim is recorded.
View ingredientView products
Loading alternative details
85 Performance

SAMe 400 mg

Lake Avenue Nutrition

A stabilized salt and enteric coating protect a full SAMe amount during storage and passage through the stomach. Its balance of dose, stabilization, or gastric protection is stronger than less protected eligible formulas. Net active yield and moisture-resistant packaging remain unclear.

84 Performance

SAMe 400 mg

Life Extension

Enteric coating protects a full SAMe amount from stomach acid and supports purposeful delivery. Its balance of dose, stabilization, or gastric protection is stronger than less protected eligible formulas. The stabilized salt, net active yield, and moisture protection are not identified.

84 Performance

SAMe 400 mg

NOW

A stabilized disulfate tosylate salt supplies a full SAMe amount in one tablet. Its balance of dose, stabilization, or gastric protection is stronger than less protected eligible formulas. Enteric and sealed moisture protection are not stated, and net active yield remains unclear.

74 Budget

SAMe 200

Jarrow Formulas

A common starting SAMe amount provides a simple, low-cost option. It lowers routine cost versus the original. Neither a stabilized salt nor acid-resistant delivery is identified, so protected active yield is uncertain.

83 Budget

SAMe 200 mg

NOW

A stabilized disulfate tosylate salt provides a credible common starting amount at efficient routine value. It lowers routine cost versus the original. Enteric protection, net active yield, and moisture-resistant packaging are not stated.

84 Budget

SAMe 400 mg

Nutricost

A stabilized salt provides a full SAMe amount with efficient dose value. It lowers routine cost versus the original. The two-capsule serving has no stated acid resistance, and moisture protection is unclear.

84 Value

SAMe 400 mg

NOW

A stabilized disulfate tosylate salt provides a full SAMe amount with favorable dose value. Compared with the original, its delivery design and routine economics offer a useful value trade-off. Enteric protection and sealed moisture protection are not stated.

80 Value

SAMe 400 mg

Swanson

A stable disulfate tosylate form provides a full SAMe amount in one tablet. Compared with the original, its delivery design and routine economics offer a useful value trade-off. Enteric protection, net active yield, and moisture-resistant packaging are not stated.

78 Value

SAMe 200 mg S-Adenosyl-Methionine

Life Extension

Enteric coating protects a common starting SAMe amount from stomach acid. Compared with the original, its delivery design and routine economics offer a useful value trade-off. The salt form, net active yield, and moisture protection are not identified.

Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review.
    Noureddin M; Sander-Struckmeier S; Mato JM · World journal of hepatology · 2020
    Systematic review9 studies pooledDetoxification forSAMe
  2. Ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy: a multi-centered randomized controlled trial.
    Zhang L; Liu XH; Qi HB; Li Z; Fu XD; Chen L; Shao Y · European review for medical and pharmacological sciences · 2016
    Randomized trial120 participantsDetoxification forSAMe
  3. S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis.
    Guo T; Chang L; Xiao Y; Liu Q · PloS one · 2015
    Meta-analysis705 participants11 studies pooledDetoxification forSAMe
  4. Protective effect of S-adenosylmethionine on hepatic ischemia-reperfusion injury during hepatectomy in HCC patients with chronic HBV infection.
    Liu GY; Wang W; Jia WD; Xu GL; Ma JL; Ge YS; Yu JH; Sun QK; Meng FL · World journal of surgical oncology · 2014
    Non-randomized trial81 participantsDetoxification forSAMe
  5. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial.
    Mato JM; Cámara J; Fernández de Paz J; Caballería L; Coll S; Caballero A; García-Buey L; Beltrán J; Benita V; Caballería J; Solà R; Moreno-Otero R; Barrao F; Martín-Duce A; Correa JA; Parés A; Barrao E; García-Magaz I; Puerta JL; Moreno J; Boissard G; Ortiz P; Rodés J · Journal of hepatology · 1999
    Randomized trial123 participantsDetoxification forSAMe