SAMe

SAMe

Metabolic Maintenance4.5 (31 ratings)
Format:Capsule Quantity: 30 Capsule(s) · 30 servings
Goals
$70.00 $2.33 per serving
iHerb$70.00

About this product

The capsule supplies a starting amount of SAMe plus modest calcium and magnesium. The minerals do not solve the product's main SAMe stability and delivery questions.

No stabilizing salt, enteric coating, or net active yield is disclosed. A regular capsule may allow substantial exposure to stomach acid before absorption.

The serving is expensive relative to more fully characterized options. Users seeking SAMe should favor a named stable salt with protected delivery.

Who is it for
  • Adults seeking low-dose SAMe with minerals
  • Users who tolerate standard capsules
  • People willing to accept limited form detail
Best for
  • Starting-dose experimentation
  • Combined SAMe and magnesium
  • Simple daily capsule use

Pros

  • SAMe amount is disclosed
  • Includes magnesium citrate
  • Includes calcium citrate and malate
  • No proprietary blend

Cons

  • SAMe salt is unspecified
  • No enteric protection
  • Net active yield is unclear
  • High serving cost

Warnings

  • SAMe can provoke mania in bipolar disorder
  • Combining SAMe with serotonergic antidepressants or triptans may raise serotonin-syndrome risk
  • SAMe may cause digestive upset, anxiety, or sleep disruption

Product analysis

60 out of 100
Modest mineral additions cannot offset an unspecified SAMe form, unprotected capsule, and poor value.

AI assessment of the formula, label and price. How scoring works

Nutrient quality70

Neither a stabilized salt nor acid-resistant delivery is identified. A common starting amount is practical, although net SAMe yield remains unclear.

Ingredient transparency72

Most active quantities are stated without a hidden blend. Repeated entries, unclear net SAMe yield, missing directions, and absent excipients reduce transparency.

Customer satisfaction59

The supplied average rating is strong and the rating volume is limited. No specific experience details were provided to judge repeated complaints or purpose alignment.

Value for money34

Delivery limitations or high cost weaken practical value. Better-protected or more efficiently priced alternatives are more competitive.

Format
Capsule
Container
30 Capsule(s)
Per serving
$2.33
Customer rating
4.5 · 31 ratings
Report analysis

Goals

Detoxification
Detoxification
Impact
High effect
C+ Ingredient FitF PathwaysA- EvidenceA+ Formulation Logic
Magnesium · 75 mgSAMe · 200 mg
Study evidence
Magnesium Supportive 19 studies
SAMe Supportive 30 studies

Ingredients

IngredientAmount per servingScore
Calcium (Calcium Citrate, Calcium Malate)
 75 mg
Magnesium (Magnesium Citrate)
 75 mg
SAMe
200 mg 59
Adults 18–50
Report overview
SAMe · 200 mg OverallScore59
B Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyF Value
SAMe lists S-adenosylmethionine disulfate tosylate, a stabilized salt, and a 200 mg amount per serving. The saved facts do not clarify whether that amount is salt weight or active SAMe. Individually sealed foil blisters and enteric coating are not recorded, and the cost is high.
How this ingredient is rated

Active Ingredient Quality & Bioavailability77

A stabilized salt is listed, but the saved facts do not identify individually sealed foil blisters.
Stabilized Salt Form
It lists S-adenosylmethionine disulfate tosylate, a stabilized salt form.
Packaging Integrity
The saved facts do not identify individually sealed foil blister packs.

Dose, Safety & Label Transparency60

The label states 200 mg, but the facts do not say whether this is salt weight or active SAMe.
Active Dosage Strength
The saved facts list 200 mg per serving.
Net SAMe Yield Transparency
Only one amount is listed; the facts do not clarify net SAMe versus salt weight.

Value20

The cost for a 400 mg comparison amount is very high, and enteric coating is not recorded.
Price Per 400mg Active Dose
The normalized cost for a 400 mg comparison amount is very high; enteric coating is not recorded.
View ingredientView products
Loading alternative details
85 Performance

SAMe 400 mg

Lake Avenue Nutrition

A stabilized salt and enteric coating protect a full SAMe amount during storage and passage through the stomach. Its balance of dose, stabilization, or gastric protection is stronger than less protected eligible formulas. Net active yield and moisture-resistant packaging remain unclear.

84 Performance

SAMe 400 mg

Life Extension

Enteric coating protects a full SAMe amount from stomach acid and supports purposeful delivery. Its balance of dose, stabilization, or gastric protection is stronger than less protected eligible formulas. The stabilized salt, net active yield, and moisture protection are not identified.

84 Performance

SAMe 400 mg

NOW

A stabilized disulfate tosylate salt supplies a full SAMe amount in one tablet. Its balance of dose, stabilization, or gastric protection is stronger than less protected eligible formulas. Enteric and sealed moisture protection are not stated, and net active yield remains unclear.

74 Budget

SAMe 200

Jarrow Formulas

A common starting SAMe amount provides a simple, low-cost option. It lowers routine cost versus the original. Neither a stabilized salt nor acid-resistant delivery is identified, so protected active yield is uncertain.

83 Budget

SAMe 200 mg

NOW

A stabilized disulfate tosylate salt provides a credible common starting amount at efficient routine value. It lowers routine cost versus the original. Enteric protection, net active yield, and moisture-resistant packaging are not stated.

84 Budget

SAMe 400 mg

Nutricost

A stabilized salt provides a full SAMe amount with efficient dose value. It lowers routine cost versus the original. The two-capsule serving has no stated acid resistance, and moisture protection is unclear.

84 Value

SAMe 400 mg

NOW

A stabilized disulfate tosylate salt provides a full SAMe amount with favorable dose value. Compared with the original, its delivery design and routine economics offer a useful value trade-off. Enteric protection and sealed moisture protection are not stated.

80 Value

SAMe 400 mg

Swanson

A stable disulfate tosylate form provides a full SAMe amount in one tablet. Compared with the original, its delivery design and routine economics offer a useful value trade-off. Enteric protection, net active yield, and moisture-resistant packaging are not stated.

78 Value

SAMe 200 mg S-Adenosyl-Methionine

Life Extension

Enteric coating protects a common starting SAMe amount from stomach acid. Compared with the original, its delivery design and routine economics offer a useful value trade-off. The salt form, net active yield, and moisture protection are not identified.

Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Oral magnesium supplementation improves metabolic variables and muscle strength in alcoholics.
    Gullestad L; Dolva LO; Søyland E; Manger AT; Falch D; Kjekshus J · Alcoholism, clinical and experimental research · 1992
    Randomized trial49 participantsDetoxification forMagnesium
  2. Magnesium Sulfate Administration in Moderate Coronary Artery Disease Patients Improves Atherosclerotic Risk Factors: A Double-Blind Clinical Trial Study.
    Farshidi H; Sobhani AR; Eslami M; Azarkish F; Eftekhar E; Keshavarz M; Soltani N · Journal of cardiovascular pharmacology · 2021
    Randomized trialDetoxification forMagnesium
  3. Effects of Synbiotic Food Consumption on Serum Minerals, Liver Enzymes, and Blood Pressure in Patients with Type 2 Diabetes: A Double-blind Randomized Cross-over Controlled Clinical Trial.
    Asemi Z; Aarabi MH; Hajijafari M; Alizadeh SA; Razzaghi R; Mazoochi M; Esmaillzadeh A · International journal of preventive medicine · 2020
    Randomized trialDetoxification forMagnesium
  4. Clinical experience with 781 cases of alcoholism evaluated and treated on an inpatient basis by various methods.
    Daus AT; Freeman WM; Wilson J; Aponte C · The International journal of the addictions · 1985
    Observational study781 participantsDetoxification forMagnesium
  5. Ionized hypomagnesemia in patients undergoing orthotopic liver transplantation: a complication of citrate intoxication.
    Scott VL; De Wolf AM; Kang Y; Altura BT; Virji MA; Cook DR; Altura BM · Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 1997
    Single-arm trialDetoxification forMagnesium
  6. Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review.
    Noureddin M; Sander-Struckmeier S; Mato JM · World journal of hepatology · 2020
    Systematic review9 studies pooledDetoxification forSAMe
  7. Ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy: a multi-centered randomized controlled trial.
    Zhang L; Liu XH; Qi HB; Li Z; Fu XD; Chen L; Shao Y · European review for medical and pharmacological sciences · 2016
    Randomized trial120 participantsDetoxification forSAMe
  8. S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis.
    Guo T; Chang L; Xiao Y; Liu Q · PloS one · 2015
    Meta-analysis705 participants11 studies pooledDetoxification forSAMe
  9. Protective effect of S-adenosylmethionine on hepatic ischemia-reperfusion injury during hepatectomy in HCC patients with chronic HBV infection.
    Liu GY; Wang W; Jia WD; Xu GL; Ma JL; Ge YS; Yu JH; Sun QK; Meng FL · World journal of surgical oncology · 2014
    Non-randomized trial81 participantsDetoxification forSAMe
  10. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial.
    Mato JM; Cámara J; Fernández de Paz J; Caballería L; Coll S; Caballero A; García-Buey L; Beltrán J; Benita V; Caballería J; Solà R; Moreno-Otero R; Barrao F; Martín-Duce A; Correa JA; Parés A; Barrao E; García-Magaz I; Puerta JL; Moreno J; Boissard G; Ortiz P; Rodés J · Journal of hepatology · 1999
    Randomized trial123 participantsDetoxification forSAMe