$21.99 $0.24 per serving
Product analysis
5-HTP 200 mg pairs 5-HTP with vitamin B6 for mood and stress support. Benefits remain uncertain, particularly for people already getting enough vitamin B6.
AI assessment of the formula, label and price. How scoring works
Nutrient Quality68
Vitamin B6 is supplied in a clearly identified form. The plant source of 5-HTP is named, but its preparation quality cannot be fully assessed here.
Ingredient Transparency100
Ingredient amounts and forms are clearly disclosed. That makes serving contents easier to compare with other options.
Value For Money100
Both the vitamin B6 and 5-HTP contributions compare favorably for value. Affordable ingredients do not resolve the uncertainty about their expected benefits.
Customer Satisfaction79
Customer ratings indicate high satisfaction across 771 reviews. Those opinions do not establish effectiveness or safety.
Product Focus70
The formula concentrates on 5-HTP and related vitamin B6 functions. Support for stress, fullness and sleep remains limited or specific to certain groups.
- Format
Capsule - Container
- 90 Capsule(s)
- Per serving
- $0.24
- Customer rating
- 4.7 · 771 ratings
Goals
Impact
Highest effect
Vitamin B6 · 50 mg5-HTP · 200 mg
vitamin b6 can help fill nutritional gaps associated with depressed mood, irritability or apathy; extra mood benefit is not established when intake is adequate. Serotonin-precursor activity does not establish a general mood benefit from the supplied human findings.
How this product is rated for Mood Support
Ingredient fit95
5-HTP and Vitamin B6 provide the recorded ingredient connection. The declared amounts reach the saved comparison’s reference range; this does not establish an effective mood dose.
Goal fit
The relevant ingredients give this formula a clear connection to mood support, subject to their individual limitations.
Dose adequacy
The declared amounts reach the saved comparison’s reference range; this does not establish an effective mood dose.
Pathways60
The strongest recorded connection is monoamine signalling, without establishing a corresponding improvement in mood.
Depth
The strongest recorded connection is monoamine signalling, without establishing a corresponding improvement in mood.
Breadth
The recorded contribution is concentrated in one functional area, rather than broad mood support.
Evidence96
The leading ingredient is recognized in the saved findings, but its population and outcome limitations constrain expectations for general mood support.
Evidence strength
The leading ingredient is recognized in the saved findings, but its population and outcome limitations constrain expectations for general mood support.
Studied preparation
The saved findings recognize the declared preparations; this does not establish interchangeable extracts or routine mood benefit.
Formulation logic100
The supplied facts show no configured conflicts or missing required partners. Amount thresholds describe the saved comparison, rather than proven mood efficacy.
Partner coverage
The recognized ingredients do not lack a required partner in the supplied findings; this does not establish added benefit from combining them.
Conflicts
No configured ingredient conflict was identified in the supplied facts.
Effective doses
All counted ingredients meet the saved amount threshold, which is not a proven effective mood dose.
Impact
Moderate effect
5-HTP may offer a limited, population-specific contribution to sleep through the serotonin–melatonin precursor route. The 200 mg amount is above the lower sleep-context reference, but that does not establish a stronger benefit at this level.
The formula focuses on a single pathway, without separate support for sleep timing or relaxation. Vitamin B6 is included, but its normal metabolic role does not establish an added sleep contribution.
How this product is rated for Sleep Support
Ingredient fit95
5-HTP is the main potential sleep contributor; vitamin B6 is included without an established independent sleep role.
Goal fit
The blend's potential sleep contribution is concentrated in 5-HTP, with B6 adding no clear separate benefit.
Dose adequacy
The 200 mg 5-HTP amount is above the lower supplied reference, but this does not establish added benefit.
Pathways60
The product's only substantial sleep route is the serotonin–melatonin precursor pathway.
Depth
5-HTP provides the clearest route through sleep-related precursors.
Breadth
It focuses on one pathway and does not add notable coverage for timing, calming, or stress regulation.
Evidence58
5-HTP has a limited, population-specific potential role; B6 does not establish a separate sleep benefit.
Evidence strength
5-HTP is the strongest sleep-related ingredient here, although its role is narrow and uncertain.
Studied preparation
The listed forms are considered in the supplied context, but B6's added sleep benefit is not established.
Formulation logic100
5-HTP and B6 need no missing partner, and no listed activating ingredient conflicts with sleep.
Partner coverage
The credited ingredients do not rely on a missing partner to be considered for their potential roles.
Conflicts
No listed caffeine or activating ingredient works against the sleep-focused approach.
Effective doses
Both listed amounts reach the range considered for potential contributions, but that does not establish added benefit from B6.
Impact
High effect
Vitamin B6 · 50 mg
5-HTP connects to mood and neurotransmitter synthesis, with conditional findings in selected anxiety and stress settings. Vitamin B6 supports related neurotransmitter functions, but its stress findings often involve combinations and do not establish a broad individual benefit. Both amounts make a meaningful contribution within the supplied comparison. The product concentrates on this one aspect of stress relief, with less support for calming or sleep recovery.
How this product is rated for Stress Relief
Ingredient fit95
Vitamin B6 and 5-HTP anchors the stress connection. The relevant amount matches the supplied comparison.
Goal fit
The relevant ingredients give the formula a clear connection to stress relief, though its uses extend to other goals.
Dose adequacy
The selected serving reaches the full supplied comparison amount for the relevant ingredients.
Pathways60
Mood and neurotransmitter synthesis dominate; sleep recovery is smaller and other roles lack meaningful coverage.
Depth
Mood and neurotransmitter synthesis is the strongest role in the saved findings; this indicates emphasis, not a measured benefit.
Breadth
Mood and neurotransmitter synthesis dominate; sleep recovery is smaller and other roles lack meaningful coverage.
Evidence70
Vitamin B6 and 5-HTP provides the leading supported contribution. Both have conditional applicability to everyday stress relief.
Evidence strength
Vitamin B6 and 5-HTP provides the leading supported contribution. Both have conditional applicability to everyday stress relief.
Studied preparation
The relevant preparations are recognized in the supplied comparison; that does not guarantee the same benefit in every setting.
Formulation logic90
Vitamin B6 lacks a partner specified in the supplied comparison, so its contribution remains limited to its independent role. No conflict among the combinations evaluated was identified in the supplied findings.
Partner coverage
Vitamin B6 lacks a partner specified in the supplied comparison, so its contribution remains limited to its independent role.
Conflicts
No conflict among the combinations evaluated was identified in the supplied findings.
Effective doses
Every retained ingredient provides a meaningful comparison amount, though that is not proof of clinical effectiveness.
Impact
Moderate effect
5-HTP may help with feeling full and eating less. The supporting weight-loss findings come from small trials, so reliable long-term results remain uncertain.
How this product is rated for Weight Loss
Ingredient fit71
5-HTP targets appetite and fullness.
Goal fit
5-HTP targets appetite and fullness.
Dose adequacy
The 5-HTP serving provides partial support against the saved dose reference.
Pathways14
Appetite and fullness are the main relevant route, with limited coverage.
Depth
Appetite and fullness are the main relevant route, with limited coverage.
Breadth
No direct weight-management route reaches the saved level for broad coverage.
Evidence62
Small trials support appetite effects, but confidence in lasting weight loss is limited.
Evidence strength
Small trials support appetite effects, but confidence in lasting weight loss is limited.
Studied preparation
The preparations assessed at useful amounts match those recognized in the saved review.
Formulation logic100
The assessed ingredients do not require a missing partner, and no configured ingredient conflict was found.
Partner coverage
The assessed ingredients can contribute without an additional missing partner.
Conflicts
No configured ingredient conflict was found in the supplied facts.
Effective doses
All ingredients counted for this finding reach the saved minimum amount.
Ingredients
| Ingredient | Amount per serving | Score |
|---|---|---|
Vitamin B6 (Pyridoxine Hydrochloride) | 50 mg | |
5-HTP (Griffonia simplicifolia) | 200 mg |
5-HTP (Griffonia simplicifolia) · 200 mg OverallScore80
Each serving supplies 200 mg of 5-HTP from Griffonia simplicifolia. The available information records a general warning but no specific warning about interactions with serotonin-affecting medicines.
How this ingredient is rated
Active Ingredient Quality & Bioavailability70
The available information identifies Griffonia simplicifolia as the source but does not give a 5-HTP standardization percentage.
Botanical Source & Standardization
The available information identifies Griffonia simplicifolia as the source but does not give a 5-HTP standardization percentage.
Dose, Safety & Label Transparency81
Each serving supplies 200 mg of 5-HTP. The available information records a general warning but no specific warning about interactions with serotonin-affecting medicines.
Dosage Potency & Range
Each serving supplies 200 mg of 5-HTP.
Safety Warnings & Label Clarity
The available information records a general warning but no specific warning about interactions with serotonin-affecting medicines.
Value100
Whole-product servings cost about $0.12 per 100 mg of 5-HTP, a low cost on this ingredient-based measure.
Price per 100mg 5-HTP
Whole-product servings cost about $0.12 per 100 mg of 5-HTP, a low cost on this ingredient-based measure.
Vitamin B6 (Pyridoxine Hydrochloride) · 50 mg OverallScore75
The 50 mg of vitamin B6 per serving is a high amount, making ongoing intake a safety consideration. The identified form is pyridoxine hydrochloride.
How this ingredient is rated
Ingredient Form & Label Quality100
The B6 source is identified as pyridoxine hydrochloride.
Vitamin B6 Form Identification
The B6 source is identified as pyridoxine hydrochloride.
Clean Label and Excipient Purity
The evaluation flags no configured artificial colors, titanium dioxide or hydrogenated oils, or talc or flow agents.
Dose, Safety & Label Transparency37
The 50 mg of B6 per serving is a high amount; the evaluation treats it as a safety concern for ongoing intake. The source is identified.
Vitamin B6 Dose & Safety Policy
The 50 mg of B6 per serving is a high amount; the evaluation treats it as a safety concern for ongoing intake.
Label Transparency
The B6 source is identified as pyridoxine hydrochloride.
Value100
The whole product costs about $0.24 per serving with 50 mg of B6; the price covers its other ingredients too.
Vitamin B6 Price Efficiency
The whole product costs about $0.24 per serving with 50 mg of B6; the price covers its other ingredients too.
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Sources
Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
- The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
- Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
- Tryptophan and 5-hydroxytryptophan for depression.
- 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
- High Dose Vitamin B6 Reduces Depression Symptoms.
- Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
- Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
- Associations of dietary B vitamins intakes with depression in adults.
- Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
- The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
- Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
- Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
- Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
- Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
- The effect of pyridoxine administration on melatonin secretion in normal men.
- Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
- Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
- Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
- Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.