Vitamin D3 & K2

Vitamin D3 & K2

The Vitamin Shoppe4.8 (128 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 60 servings
Goals
$16.99 $0.28 per serving

Product analysis

79 out of 100

Vitamin D3 & K2 supplies nutrients involved in calcium use and normal bone maintenance, particularly when vitamin D intake is low. Their combination does not by itself establish extra bone or heart protection.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality86

Vitamin D3 and clearly identified MK-7 are strengths of the ingredient selection. Calcium carbonate is named, although a firm conclusion about its form quality is unavailable.

Ingredient Transparency100

All ingredient amounts and forms are disclosed. Those details make the serving straightforward to compare with other D and K supplements.

Value For Money62

The MK-7 contribution offers favorable value, while vitamin D offers more moderate value. The calcium contribution has no firm value conclusion.

Customer Satisfaction74

Customer feedback is strongly positive. The relatively small review base provides useful buying context, without establishing bone or heart effects.

Product Focus65

The compact formula has a clear central purpose in bone and mineral nutrition. Its wider heart and longevity uses have more limited or preparation-specific support.

Format
Capsule
Container
60 Capsule(s)
Per serving
$0.28
Customer rating
4.8 · 128 ratings
Report analysis

Goals

Everyday Health
Impact
High effect
B+ Ingredient FitC PathwaysB+ EvidenceA+ Formulation Logic
Vitamin D · 2500 IUVitamin K · 90 mcg
Study evidence
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Bone Health
Impact
Highest effect
B+ Ingredient FitB+ PathwaysA+ EvidenceA Formulation Logic
Vitamin K · 90 mcgCalcium · 100 mgVitamin D · 2500 IU
Study evidence
Calcium Supportive 144 studies
Vitamin D Supportive 202 studies
Vitamin K Supportive 78 studies
Cardiovascular Support
Impact
Moderate effect
C+ Ingredient FitF PathwaysC+ EvidenceA+ Formulation Logic
Vitamin K · 90 mcgVitamin D · 2500 IU
Study evidence
Vitamin D Mixed 170 studies
Vitamin K Supportive 40 studies
Immunity
Impact
High effect
C+ Ingredient FitC PathwaysA+ EvidenceA+ Formulation Logic
Vitamin D · 2500 IU
Study evidence
Vitamin D Supportive 85 studies
Longevity
Impact
High effect
B Ingredient FitF PathwaysB- EvidenceA+ Formulation Logic
Vitamin K · 90 mcgVitamin D · 2500 IU
Study evidence
Vitamin D Supportive 50 studies
Vitamin K Supportive 27 studies
Heart Health
Impact
Moderate effect
C+ Ingredient FitF PathwaysB EvidenceA+ Formulation Logic
Vitamin K · 90 mcgVitamin D · 2500 IU
Study evidence
Vitamin D Mixed 164 studies
Vitamin K Mixed 62 studies

Ingredients

IngredientAmount per servingScore
Vitamin D3 (Cholecalciferol)
2500 IU 72
Vitamin K2 (Menaquinone-7)
90 mcg 93
Calcium (Calcium Carbonate)
100 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value
A serving provides 90 mcg of vitamin K at a low cost per serving. It uses vitamin K2 as MK-7. The MK-7 isomer is not specified as trans or all-trans.
How this ingredient is rated

Active Ingredient Quality & Bioavailability82

The vitamin K includes MK-7. Its trans or all-trans isomer is not specified.
Vitamin K Form (MK-7 vs. MK-4 vs. K1)
MK-7 is a form of vitamin K2 that remains in the bloodstream longer than other forms.
MK-7 Isomer Disclosure
The MK-7 isomer is not specified as trans or all-trans.

Dose, Safety & Label Transparency100

The label states 90 mcg of MK-7 per serving.
Vitamin K2 (MK-7) Dosage Efficacy
The serving provides 90 mcg of MK-7.
Form and Subtype Transparency
The amount and MK-7 subtype are stated.

Value100

The cost per serving is low.
Price per Effective MK-7 Serving
The cost per serving is low.
A- Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyD+ Value
+2
A serving provides 2500 IU of vitamin D per serving at a high cost per 1,000 IU. The vitamin D is cholecalciferol, or D3. Independent certification or batch-specific testing is not documented.
How this ingredient is rated

Active Ingredient Quality & Bioavailability87

The vitamin D is cholecalciferol, or D3. The raw material source is not specified.
Vitamin D3 vs. D2 Superiority
The vitamin D is cholecalciferol, or D3.
Sourcing and Active Marker Disclosure
The raw material source is not specified.

Dose, Safety & Label Transparency68

The serving provides 2500 IU of vitamin D per serving. No qualifying independent certification or batch-specific testing is documented.
Daily Dosage Appropriateness
The serving provides 2500 IU of vitamin D per serving.
Excipient and Additive Purity
Titanium dioxide, artificial colors and hydrogenated oils are not listed.
Purity and Quality Certification
No qualifying independent certification or batch-specific testing is documented.

Value50

The cost per 1,000 IU of vitamin D is high, and vitamin K2 as MK-7 is included.
Price per 1,000 IU Efficiency
The cost per 1,000 IU of vitamin D is high, and vitamin K2 as MK-7 is included.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  2. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  3. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  4. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  5. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  6. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  7. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  8. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  9. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  10. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  11. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  12. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  13. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  14. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  15. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  16. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forVitamin D
  17. A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.
    Kumar V; Yadav AK; Lal A; Kumar V; Singhal M; Billot L; Gupta KL; Banerjee D; Jha V · Journal of the American Society of Nephrology : JASN · 2017
    Randomized trial120 participantsCardiovascular Support forVitamin D
  18. Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk.
    Porto C; Petribu K; Barbosa N; Magalhães R; Lira C; Porto AB; Markman-Filho B; Lordsleem A; Calado E; Magalhães J; Sougey E; Silva T; Junio A; Bandeira F; Leão R · American heart journal plus : cardiology research and practice · 2025
    Randomized trial224 participantsCardiovascular Support forVitamin D
  19. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial.
    Raed A; Bhagatwala J; Zhu H; Pollock NK; Parikh SJ; Huang Y; Havens R; Kotak I; Guo DH; Dong Y · PloS one · 2017
    Randomized trial70 participantsCardiovascular Support forVitamin D
  20. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsCardiovascular Support Heart Health forVitamin D