$23.69 $0.78 per serving
Product analysis
5-HTP Plus 200 mg may offer limited sleep support in people who sleep poorly, while benefits for everyday mood remain uncertain.
AI assessment of the formula, label and price. How scoring works
Nutrient Quality25
The vitamin B6 form is stated, but the other main preparations are not. The available information does not establish the quality of the complete mix.
Ingredient Transparency70
Amounts are given for all listed ingredients, helping compare servings. Most forms are missing, making the different preparations harder to compare.
Value For Money47
The 5-HTP contribution offers reasonable value in the comparison available. Reliable cost comparisons for the other ingredients are unavailable, so value for the full mix remains uncertain.
Customer Satisfaction72
Customer ratings are very favorable across a modest review pool. They indicate satisfaction without confirming mood or sleep benefits.
Product Focus64
The formula centers on 5-HTP for mood and sleep-related purposes, but routine benefits remain uncertain. Vitamin B6 is most relevant when intake is low, and the additions do not establish a stronger combined effect.
- Format
Capsule - Container
- 60 Capsule(s)
- Per serving
- $0.78
- Customer rating
- 4.7 · 106 ratings
Goals
Impact
Highest effect
Vitamin B6 · 10 mg5-HTP · 200 mgSAMe · 20 mg
Impact
Moderate effect
Impact
Moderate effect
SAMe · 20 mgVitamin B6 · 10 mgTryptophan · 20 mg
SAMe Not classified
No linked studies yet.
Tryptophan Not classified
No linked studies yet.
Impact
Moderate effect
Ingredients
| Ingredient | Amount per serving | Score |
|---|---|---|
Total Carbohydrates | 1 Gram(s) | |
Vitamin B6 (Pyridoxine Hydrochloride) | 10 mg | |
5-Hydroxytryptophan | 200 mg | |
L-Tryptophan | 20 mg | |
SAMe | 20 mg |
5-HTP · 200 mg OverallScore60
A serving provides 200 mg of 5-HTP, at a moderate cost per 100 mg. 5-HTP is named, but its botanical source is not specified. General warnings are present, but a specific warning about serotonin-related medications is not stated.
How this ingredient is rated
Active Ingredient Quality & Bioavailability40
5-HTP is named, but its botanical source is not specified.
Botanical Source & Standardization
5-HTP is named, but its botanical source is not specified.
Dose, Safety & Label Transparency81
The serving provides 200 mg of 5-HTP. General warnings are present, but a specific warning about serotonin-related medications is not stated.
Dosage Potency & Range
The serving provides 200 mg of 5-HTP.
Safety Warnings & Label Clarity
General warnings are present, but a specific warning about serotonin-related medications is not stated.
Value60
The cost per 100 mg of 5-HTP is moderate.
Price per 100mg 5-HTP
The cost per 100 mg of 5-HTP is moderate.
Alternative products
Report alternatives
Sources
Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
- The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
- Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
- Tryptophan and 5-hydroxytryptophan for depression.
- 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
- Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies.
- A double-blind, randomized parallel-group, efficacy and safety study of intramuscular S-adenosyl-L-methionine 1,4-butanedisulphonate (SAMe) versus imipramine in patients with major depressive disorder.
- Preliminary results of a randomized controlled trial carried out with a fixed combination of S-adenosyl-L-methionine and betaine versus amitriptyline in patients with mild depression.
- S-adenosylmethionine blood levels in major depression: changes with drug treatment.
- Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses.
- A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning
- High Dose Vitamin B6 Reduces Depression Symptoms.
- Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
- Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
- Associations of dietary B vitamins intakes with depression in adults.
- Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
- The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
- The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression
- Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
- Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.