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Wellness ImmuNitric

Source Naturals
4.6
★ ★ ★ ★ ★
(26 ratings)
Arginine 2250 mg
Citrulline 750 mg
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Score74
A focused, economical circulation formula supplies useful arginine, with modest citrulline and a three-tablet burden.
How scoring works
Quantity:90 Tablet(s) • (30 servings)
Goals:
Cardiovascular Support
Energy

Score 74

A focused, economical circulation formula supplies useful arginine, with modest citrulline and a three-tablet burden.
How scoring works
$13.08($0.43 per serving)
iHerb
$ 13.08
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Analysis

Three tablets supply 2.25 g of arginine hydrochloride and 750 mg of L-citrulline. Folate and vitamin B6 add a related homocysteine-metabolism pathway without making the formula unnecessarily broad.

Arginine reaches a useful amount, while citrulline sits only at the low end and remains below common performance use. Compressed tablets offer no extended delivery and may be sizable given the total ingredient load.

The ongoing cost is favorable for the disclosed arginine amount. It fits users who prefer tablets and value clear dosing, provided a three-tablet serving is acceptable.

Who is it for
  • Adults seeking tablet-based circulation support
  • People wanting amino acids with B vitamins
  • Users comfortable taking three tablets
Best for
  • Arginine-led nitric-oxide support
  • Clear fixed-dose routines
  • Exercise blood-flow support

Pros

  • Useful 2.25 g arginine amount
  • Pure citrulline is clearly disclosed
  • Favorable cost for the core dose

Cons

  • Requires three tablets
  • Citrulline remains below a strong performance amount
  • No sustained-release delivery

Warnings

  • Arginine and citrulline may add to nitrates, blood-pressure medicines, or PDE-5 inhibitors and cause dizziness or excessive blood-pressure lowering.
  • Arginine can trigger herpes simplex recurrences in some susceptible users.
  • Higher amino-acid intake may cause nausea, cramping, or diarrhea.

Nutrient quality

85 Highest impact

A substantial arginine amount and relevant cofactors provide good vascular-support depth. Modest citrulline and ambiguous duplicate folate entries prevent a stronger assessment.

Ingredient transparency

69 High impact

Core amino-acid quantities are clear and no proprietary blend is used. Duplicate folate entries, missing directions, and absent excipients reduce label clarity.

Customer satisfaction

61 Moderate impact

The supplied average rating is strong and the rating volume is limited. No specific experience details were provided to judge repeated complaints or purpose alignment.

Value for money

81 Highest impact

The formula provides fair value for its cost. It compares favorably within the category despite remaining limitations.

Report analysis

Goals

Cardiovascular Support
Blood Flow and Circulation
Cardiovascular Support
Impact
High effect
B+ Goal FitB Strength of SupportC+ CoverageA- Formula Quality
Arginine · 2250 mgVitamin B6 · 7.5 mgFolate · 420 mcg DFECitrulline · 750 mg

Arginine provides a substantial nitric-oxide precursor dose, while citrulline and B vitamins add supporting roles. The formula is focused on endothelial function rather than lipid or cardiac-energy support.

Every active amount is disclosed and the powder or tablet serving makes the core dose easy to assess. Citrulline remains below the range commonly used for strong standalone vasodilation.

Study evidence
Arginine Supportive 47 studies
Citrulline Supportive 33 studies
Folate Supportive 93 studies
Energy
Physical Stamina
Energy
Impact
High effect
B- Goal FitB- Strength of SupportC CoverageA- Formula Quality

Arginine and citrulline support nitric oxide production and exercise blood flow, which can contribute to workout stamina. The formula does not address alertness, mitochondrial fuel, or stress resilience.

Arginine is supplied at a useful amount, while citrulline is below common performance levels. Both amino acids are clearly disclosed and the formula remains compact.

Study evidence
Arginine No effect 7 studies
Citrulline No effect 14 studies

Ingredients

IngredientAmount per serving
Calories
20 Calorie(s)
Vitamin B6 (Pyridoxine Hydrochloride)
 7.5 mg
Folate (Calcium Folinate, Folic Acid)
 420 mcg DFE
Sodium
10 mg
L-Arginine (L-Arginine Hydrochloride)
 2250 mg
L-Citrulline
750 mg
Adults 18–50
Report overview
Arginine (L-Arginine Hydrochloride) · 2250 mg OverallScore71
C- Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyB+ Value
A clearly identified hydrochloride form supplies a strong dose, though it requires several tablets. Basic compressed tablets offer no sustained-release advantage and add a moderate pill burden. Cost per gram is favorable for the disclosed arginine amount.
View ingredientView products
Citrulline · 750 mg OverallScore54
B- Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyF Value

Pure L-Citrulline is named and its individual amount is disclosed. The 750 mg serving is below the common performance range but may offer modest support. Citrulline-specific value is poor because the cost per active gram is high.

View ingredientView products
Loading alternative details
67 Performance

Pump-Ocalypse Blue Raz

Bucked Up
Glycerol, citrulline, arginine, and agmatine form a coherent stimulant-free pump formula, but several amounts are moderate rather than full strength. An opaque mushroom blend and low betaine amount weaken dose quality and disclosure. Compared with the original, its Arginine and Citrulline coverage and stronger formulation depth make it a better quality-focused match.
73 Performance

Wellness ImmuNitric

Source Naturals
A substantial arginine amount with modest citrulline and B-vitamin support creates a coherent vascular formula at reasonable value. Duplicate folate entries reduce label clarity, and the vasodilating combination may add to nitrates or blood-pressure medicines. Compared with the original, its Arginine and Citrulline coverage and stronger formulation depth make it a better quality-focused match.
78 Performance

Arginine & Citrulline 500 mg / 250 mg

NOW Sports
A large supply of clearly disclosed L-arginine and L-citrulline offers efficient routine value. Very low serving amounts mean targeted nitric-oxide or exercise use would require many capsules. Compared with the original, its Arginine and Citrulline coverage and stronger formulation depth make it a better quality-focused match.
79 Budget

L-Arginine + L-Citrulline 750 mg

Nutricost
A large supply of clearly separated L-arginine and L-citrulline provides economical but basic nitric-oxide support. Both amounts are too low for targeted performance use without taking multiple capsules. Compared with the original, its lower serving cost improves affordability while retaining Arginine and Citrulline support.
78 Budget

L-Arginine L-Citrulline Complex 1000 mg

Best Naturals
L-arginine hydrochloride and free-form citrulline provide a focused combination with good supply economy. The arginine amount is only moderate and the citrulline amount is far below targeted performance use. Compared with the original, its lower serving cost improves affordability while retaining Arginine and Citrulline support.
78 Budget

L-Arginine L-Citrulline Complex

Source Naturals
A large supply of focused arginine and citrulline offers reasonable routine value. The arginine amount is modest, the citrulline amount is far below targeted use, and arginine may add to blood-pressure-lowering medicines. Compared with the original, its lower serving cost improves affordability while retaining Arginine and Citrulline support.
78 Value

L-Arginine L-Citrulline Complex

Source Naturals
A focused arginine-citrulline tablet provides moderate arginine at reasonable value. The citrulline amount is far below targeted performance use, and arginine may add to the effects of nitrates or blood-pressure medicines. Compared with the original, its Arginine and Citrulline coverage and balance of formula depth and serving cost provide better practical value.
77 Value

Arginine & Citrulline 500 mg/250 mg

NOW Sports
Clearly disclosed L-arginine and L-citrulline provide a focused nitric-oxide formula at a low serving cost. Both amounts are far below targeted performance ranges, so meaningful use would require many capsules. Compared with the original, its Arginine and Citrulline coverage and balance of formula depth and serving cost provide better practical value.
80 Value

Nitric Oxide Booster

Nutricost Performance
Three arginine forms provide a moderate combined amount and clear nitric-oxide focus at favorable value. Citrulline remains underdosed, and the undisclosed citrulline-malate ratio makes its active contribution uncertain. Compared with the original, its Arginine and Citrulline coverage and balance of formula depth and serving cost provide better practical value.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Reassessment of the effect of oral l-arginine on blood pressure: A systematic review and meta-analysis based on ambulatory blood pressure monitoring.
    Shi Y; Liu Y; Zhou Z; Xu S; Luo P · Nitric oxide : biology and chemistry · 2026
    Meta-analysis202 participants5 studies pooledCardiovascular Support forArginine
  2. Effect of Long-Term L-Arginine Supplementation on Arterial Compliance and Metabolic Parameters in Patients with Multiple Cardiovascular risk Factors: Randomized, Placebo-Controlled Study.
    Guttman H; Zimlichman R; Boaz M; Matas Z; Shargorodsky M · Journal of cardiovascular pharmacology · 2024
    Randomized trial90 participantsCardiovascular Support forArginine
  3. Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials.
    Bai Y; Sun L; Yang T; Sun K; Chen J; Hui R · The American journal of clinical nutrition · 2009
    Meta-analysis492 participants13 studies pooledCardiovascular Support forArginine
  4. L-arginine improves endothelial function and reduces LDL oxidation in patients with stable coronary artery disease.
    Yin WH; Chen JW; Tsai C; Chiang MC; Young MS; Lin SJ · Clinical nutrition (Edinburgh, Scotland) · 2006
    Randomized trial31 participantsCardiovascular Support forArginine
  5. Oral L-Arginine Administration Improves Anthropometric and Biochemical Indices Associated With Cardiovascular Diseases in Obese Patients: A Randomized, Single Blind Placebo Controlled Clinical Trial.
    Dashtabi A; Mazloom Z; Fararouei M; Hejazi N · Research in cardiovascular medicine · 2016
    Randomized trial90 participantsCardiovascular Support forArginine
  6. Does l-citrulline supplementation and watermelon intake reduce blood pressure in middle-aged and older adults? A systematic review and meta-analysis of randomized controlled trials.
    Luo P; Chen J; Liu K; Zhang J · Clinical nutrition ESPEN · 2025
    Meta-analysis415 participants15 studies pooledCardiovascular Support forCitrulline
  7. Micronutrient Supplementation to Reduce Cardiovascular Risk.
    An P; Wan S; Luo Y; Luo J; Zhang X; Zhou S; Xu T; He J; Mechanick JI; Wu WC; Ren F; Liu S · Journal of the American College of Cardiology · 2022
    Meta-analysis883,627 participants884 studies pooledCardiovascular Support forCitrulline
  8. l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.
    Bailey SJ; Blackwell JR; Lord T; Vanhatalo A; Winyard PG; Jones AM · Journal of applied physiology (Bethesda, Md. : 1985) · 2016
    Randomized trial10 participantsCardiovascular Support forCitrulline
  9. Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women.
    Maharaj A; Fischer SM; Dillon KN; Kang Y; Martinez MA; Figueroa A · Nutrients · 2022
    Randomized trial25 participantsCardiovascular Support forCitrulline
  10. Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men.
    Ochiai M; Hayashi T; Morita M; Ina K; Maeda M; Watanabe F; Morishita K · International journal of cardiology · 2012
    Randomized trial15 participantsCardiovascular Support forCitrulline
  11. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  12. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  13. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  14. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  15. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  16. Investigation of the effect of nitrate and L-arginine intake on aerobic, anaerobic performance, balance, agility, and recovery in elite taekwondo athletes.
    Kavcı Z; Ozan M; Buzdağlı Y; Savaş A; Uçar H · Journal of the International Society of Sports Nutrition · 2024
    Randomized trial15 participantsEnergy forArginine
  17. The Effects of Arginine-Based Supplements on Fatigue Levels following COVID-19 Infection: A Prospective Study in Romania.
    Turcu-Stiolica A; Ionele CM; Ungureanu BS; Subtirelu MS · Healthcare (Basel, Switzerland) · 2023
    Non-randomized trial505 participantsEnergy forArginine
  18. Isolated but not combined ergogenic effects of caffeine and L-arginine during an isokinetic knee extension.
    Zart S; Brachtendorf M; Becker S; Fröhlich M · Frontiers in nutrition · 2024
    Randomized trial29 participantsEnergy forArginine
  19. L-Arginine but not L-glutamine likely increases exogenous carbohydrate oxidation during endurance exercise.
    Rowlands DS; Clarke J; Green JG; Shi X · European journal of applied physiology · 2012
    Randomized trial8 participantsEnergy forArginine
  20. Effect of L-arginine on energy metabolism, skeletal muscle and brown adipose tissue in South Asian and Europid prediabetic men: a randomised double-blinded crossover study.
    Boon MR; Hanssen MJW; Brans B; Hülsman CJM; Hoeks J; Nahon KJ; Bakker C; van Klinken JB; Havekes B; Schaart G; Jazet IM; Rensen PCN; van Marken Lichtenbelt WD · Diabetologia · 2019
    Randomized trial20 participantsEnergy forArginine
  21. Acute Effect of Citrulline Malate on Repetition Performance During Strength Training: A Systematic Review and Meta-Analysis.
    Vårvik FT; Bjørnsen T; Gonzalez AM · International journal of sport nutrition and exercise metabolism · 2021
    Meta-analysis137 participants8 studies pooledEnergy forCitrulline
  22. Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study.
    Suzuki T; Morita M; Kobayashi Y; Kamimura A · Journal of the International Society of Sports Nutrition · 2016
    Randomized trial22 participantsEnergy forCitrulline
  23. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness.
    Pérez-Guisado J; Jakeman PM · Journal of strength and conditioning research · 2010
    Randomized trial41 participantsEnergy forCitrulline
  24. Citrulline/malate promotes aerobic energy production in human exercising muscle.
    Bendahan D; Mattei JP; Ghattas B; Confort-Gouny S; Le Guern ME; Cozzone PJ · British journal of sports medicine · 2002
    Single-arm trial18 participantsEnergy forCitrulline
  25. The Effect of Citrulline Malate Supplementation on Muscle Fatigue Among Healthy Participants.
    Farney TM; Bliss MV; Hearon CM; Salazar DA · Journal of strength and conditioning research · 2019
    Randomized trial12 participantsEnergy forCitrulline