Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis.
Barkhidarian B; Khorshidi M; Shab-Bidar S; Hashemi B · Avicenna journal of phytomedicine · 2022
Meta-analysis8 studies pooledflagHeart Health forscienceCitrulline
- Citrulline supplementation in postmenopausal women: a systematic review of vascular, muscular, and metabolic effects.
Bahari H; Ramezani E; Malekahmadi M · BMC women's health · 2026
Systematic review360 participants12 studies pooledflagHeart Health forscienceCitrulline
- Maternal Betaine and Methylation Potential during Pregnancy Are Associated with Child Growth at Birth and Early Childhood: Results of the Chilean Maternal & Infant Cohort Study-II.
Trujillo-González I; Barisione G; Bottiglieri T; Reyes M; Garmendia ML; Mujica-Coopman MF · The Journal of nutrition · 2026
Cohort study150 participantsflagWeight Gain forscienceBetaine Anhydrous
- Betaine supplementation fails to improve body composition: a systematic review and meta-analysis.
Ashtary-Larky D; Bagheri R; Tinsley GM; Asbaghi O; Salehpour S; Kashkooli S; Kooti W; Wong A · The British journal of nutrition · 2023
Meta-analysisflagWeight Gain forscienceBetaine Anhydrous
- Effect of Long-Term L-Arginine Supplementation on Arterial Compliance and Metabolic Parameters in Patients with Multiple Cardiovascular risk Factors: Randomized, Placebo-Controlled Study.
Guttman H; Zimlichman R; Boaz M; Matas Z; Shargorodsky M · Journal of cardiovascular pharmacology · 2024
Randomized trial90 participantsflagCardiovascular Support forscienceArginine
- Atorvastatin but not L-arginine improves endothelial function in type I diabetes mellitus: a double-blind study.
Mullen MJ; Wright D; Donald AE; Thorne S; Thomson H; Deanfield JE · Journal of the American College of Cardiology · 2000
Randomized trial84 participantsflagCardiovascular Support forscienceArginine
- Oral L-citrulline supplementation attenuates blood pressure response to cold pressor test in young men.
Figueroa A; Trivino JA; Sanchez-Gonzalez MA; Vicil F · American journal of hypertension · 2010
Randomized trial17 participantsflagCardiovascular Support forscienceCitrulline
- Oral citrulline supplementation in pregnancies with preeclampsia: a multicenter, randomized, double-blind clinical trial.
Winer N; Misbert E; Masson D; Girault A; Alexandre-Gouabau MC; Ducarme G; Dochez V; Thubert T; Boivin M; Ferchaud-Roucher V; Péré M; Darmaun D · The American journal of clinical nutrition · 2025
Randomized trial115 participantsflagCardiovascular Support forscienceCitrulline
- Reassessment of the effect of oral l-arginine on blood pressure: A systematic review and meta-analysis based on ambulatory blood pressure monitoring.
Shi Y; Liu Y; Zhou Z; Xu S; Luo P · Nitric oxide : biology and chemistry · 2026
Meta-analysis202 participants5 studies pooledflagCardiovascular Support forscienceArginine
- Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials.
Bai Y; Sun L; Yang T; Sun K; Chen J; Hui R · The American journal of clinical nutrition · 2009
Meta-analysis492 participants13 studies pooledflagCardiovascular Support forscienceArginine
- L-arginine improves endothelial function and reduces LDL oxidation in patients with stable coronary artery disease.
Yin WH; Chen JW; Tsai C; Chiang MC; Young MS; Lin SJ · Clinical nutrition (Edinburgh, Scotland) · 2006
Randomized trial31 participantsflagCardiovascular Support forscienceArginine
- Oral L-Arginine Administration Improves Anthropometric and Biochemical Indices Associated With Cardiovascular Diseases in Obese Patients: A Randomized, Single Blind Placebo Controlled Clinical Trial.
Dashtabi A; Mazloom Z; Fararouei M; Hejazi N · Research in cardiovascular medicine · 2016
Randomized trial90 participantsflagCardiovascular Support forscienceArginine
- Does l-citrulline supplementation and watermelon intake reduce blood pressure in middle-aged and older adults? A systematic review and meta-analysis of randomized controlled trials.
Luo P; Chen J; Liu K; Zhang J · Clinical nutrition ESPEN · 2025
Meta-analysis415 participants15 studies pooledflagCardiovascular Support forscienceCitrulline
- Micronutrient Supplementation to Reduce Cardiovascular Risk.
An P; Wan S; Luo Y; Luo J; Zhang X; Zhou S; Xu T; He J; Mechanick JI; Wu WC; Ren F; Liu S · Journal of the American College of Cardiology · 2022
Meta-analysis883,627 participants884 studies pooledflagCardiovascular Support forscienceCitrulline
- l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.
Bailey SJ; Blackwell JR; Lord T; Vanhatalo A; Winyard PG; Jones AM · Journal of applied physiology (Bethesda, Md. : 1985) · 2016
Randomized trial10 participantsflagCardiovascular Support forscienceCitrulline
- Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women.
Maharaj A; Fischer SM; Dillon KN; Kang Y; Martinez MA; Figueroa A · Nutrients · 2022
Randomized trial25 participantsflagCardiovascular Support flagHeart Health forscienceCitrulline
- Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men.
Ochiai M; Hayashi T; Morita M; Ina K; Maeda M; Watanabe F; Morishita K · International journal of cardiology · 2012
Randomized trial15 participantsflagCardiovascular Support forscienceCitrulline
- Investigation of the effect of nitrate and L-arginine intake on aerobic, anaerobic performance, balance, agility, and recovery in elite taekwondo athletes.
Kavcı Z; Ozan M; Buzdağlı Y; Savaş A; Uçar H · Journal of the International Society of Sports Nutrition · 2024
Randomized trial15 participantsflagEnergy forscienceArginine
- The Effects of Arginine-Based Supplements on Fatigue Levels following COVID-19 Infection: A Prospective Study in Romania.
Turcu-Stiolica A; Ionele CM; Ungureanu BS; Subtirelu MS · Healthcare (Basel, Switzerland) · 2023
Non-randomized trial505 participantsflagEnergy forscienceArginine
- Isolated but not combined ergogenic effects of caffeine and L-arginine during an isokinetic knee extension.
Zart S; Brachtendorf M; Becker S; Fröhlich M · Frontiers in nutrition · 2024
Randomized trial29 participantsflagEnergy forscienceArginine
- L-Arginine but not L-glutamine likely increases exogenous carbohydrate oxidation during endurance exercise.
Rowlands DS; Clarke J; Green JG; Shi X · European journal of applied physiology · 2012
Randomized trial8 participantsflagEnergy forscienceArginine
- Effect of L-arginine on energy metabolism, skeletal muscle and brown adipose tissue in South Asian and Europid prediabetic men: a randomised double-blinded crossover study.
Boon MR; Hanssen MJW; Brans B; Hülsman CJM; Hoeks J; Nahon KJ; Bakker C; van Klinken JB; Havekes B; Schaart G; Jazet IM; Rensen PCN; van Marken Lichtenbelt WD · Diabetologia · 2019
Randomized trial20 participantsflagEnergy forscienceArginine
- Acute Effect of Citrulline Malate on Repetition Performance During Strength Training: A Systematic Review and Meta-Analysis.
Vårvik FT; Bjørnsen T; Gonzalez AM · International journal of sport nutrition and exercise metabolism · 2021
Meta-analysis137 participants8 studies pooledflagEnergy forscienceCitrulline
- Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study.
Suzuki T; Morita M; Kobayashi Y; Kamimura A · Journal of the International Society of Sports Nutrition · 2016
Randomized trial22 participantsflagEnergy forscienceCitrulline
- Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness.
Pérez-Guisado J; Jakeman PM · Journal of strength and conditioning research · 2010
Randomized trial41 participantsflagEnergy forscienceCitrulline
- Citrulline/malate promotes aerobic energy production in human exercising muscle.
Bendahan D; Mattei JP; Ghattas B; Confort-Gouny S; Le Guern ME; Cozzone PJ · British journal of sports medicine · 2002
Single-arm trial18 participantsflagEnergy forscienceCitrulline
- The Effect of Citrulline Malate Supplementation on Muscle Fatigue Among Healthy Participants.
Farney TM; Bliss MV; Hearon CM; Salazar DA · Journal of strength and conditioning research · 2019
Randomized trial12 participantsflagEnergy forscienceCitrulline
- Effect of oral L-citrulline on brachial and aortic blood pressure defined by resting status: evidence from randomized controlled trials.
Yang HH; Li XL; Zhang WG; Figueroa A; Chen LH; Qin LQ · Nutrition & metabolism · 2022
Meta-analysis8 studies pooledflagHeart Health forscienceCitrulline
- Impact of L-Citrulline Supplementation and HIIT on Lipid Profile, Arterial Stiffness, and Fat Mass in Obese Adolescents with Metabolic-Dysfunction-Associated Fatty Liver Disease: A Randomized Clinical Trial.
Rodríguez-Carrillo AA; Espinoza-Vargas MR; Vargas-Ortiz K; Ibarra-Reynoso LDR; Olvera-Juárez M; Gómez-Ojeda A; Garay-Sevilla ME; Figueroa A · Nutrients · 2025
Randomized trial44 participantsflagHeart Health forscienceCitrulline
- Vascular effects of l-citrulline supplementation in healthy adults are largely influenced by the prehypertensive range of blood pressure: A double-blind, randomized, placebo-controlled, parallel-group study.
Nogimura D; Nagaoka K; Ogino K; Ogino N; Moriyasu K; Morita M · Nutrition research (New York, N.Y.) · 2026
Randomized trial66 participantsflagHeart Health forscienceCitrulline
- The Assessment of short-term effect of L-Citrulline on endothelial function via FMD to NMD ratio in known CAD patients: A randomized, cross-over clinical trial (Clinical trial number: NCT02638727).
Safi M; Mahjoob MP; Nateghi S; Khaheshi I; Akbarzadeh MA; Naderian M · Romanian journal of internal medicine = Revue roumaine de medecine interne · 2017
Randomized trial30 participantsflagHeart Health forscienceCitrulline
- Oral Arginine Supplementation in Healthy Individuals Performing Regular Resistance Training.
Busnatu ȘS; Andronic O; Pană MA; Stoian AP; Scafa-Udriște A; Păun N; Stanciu S · Healthcare (Basel, Switzerland) · 2023
Randomized trial70 participantsflagMuscle Gain forscienceArginine
- l-Arginine and Beetroot Extract Supplementation in the Prevention of Sarcopenia.
Córdova-Martínez A; Caballero-García A; Bello HJ; Pons-Biescas A; Noriega DC; Roche E · Pharmaceuticals (Basel, Switzerland) · 2023
Randomized trial66 participantsflagMuscle Gain forscienceArginine
- Influence of nitric oxide in the improvement of muscle power.
Bernardo DN; Bryk FF; Fucs PM · Acta ortopedica brasileira · 2016
Randomized trial36 participantsflagMuscle Gain forscienceArginine
- Serum betaine is inversely associated with low lean mass mainly in men in a Chinese middle-aged and elderly community-dwelling population.
Huang BX; Zhu YY; Tan XY; Lan QY; Li CL; Chen YM; Zhu HL · The British journal of nutrition · 2017
Cohort study1,996 participantsflagMuscle Gain flagWeight Gain forscienceBetaine Anhydrous
- Dietary betaine intake is associated with skeletal muscle mass change over 3 years in middle-aged adults: the Guangzhou Nutrition and Health Study.
Long JA; Zhong RH; Chen S; Wang F; Luo Y; Lu XT; Yishake D; Chen YM; Fang AP; Zhu HL · The British journal of nutrition · 2021
Cohort study1,242 participantsflagMuscle Gain flagWeight Gain forscienceBetaine Anhydrous
- Higher serum choline and betaine levels are associated with better body composition in male but not female population.
Gao X; Randell E; Zhou H; Sun G · PloS one · 2018
Cross-sectional study1,081 participantsflagMuscle Gain forscienceBetaine Anhydrous
- Betaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exercise.
Apicella JM; Lee EC; Bailey BL; Saenz C; Anderson JM; Craig SA; Kraemer WJ; Volek JS; Maresh CM · European journal of applied physiology · 2013
Randomized trial12 participantsflagMuscle Gain forscienceBetaine Anhydrous
- Ergogenic effects of betaine supplementation on strength and power performance.
Lee EC; Maresh CM; Kraemer WJ; Yamamoto LM; Hatfield DL; Bailey BL; Armstrong LE; Volek JS; McDermott BP; Craig SA · Journal of the International Society of Sports Nutrition · 2011
Randomized trial12 participantsflagMuscle Gain forscienceBetaine Anhydrous
- Effects of Citrulline alone or combined with exercise on muscle mass, muscle strength, and physical performance among older adults: a systematic review.
Aubertin-Leheudre M; Buckinx F · Current opinion in clinical nutrition and metabolic care · 2021
Systematic review250 participants6 studies pooledflagMuscle Gain forscienceCitrulline
- Impact of L-citrulline supplementation and whole-body vibration training on arterial stiffness and leg muscle function in obese postmenopausal women with high blood pressure.
Figueroa A; Alvarez-Alvarado S; Ormsbee MJ; Madzima TA; Campbell JC; Wong A · Experimental gerontology · 2015
Randomized trial41 participantsflagMuscle Gain forscienceCitrulline
- Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type 2 Diabetes.
Figueroa A; Dillon KN; Levitt DE; Kang Y · Nutrients · 2025
Randomized trial16 participantsflagMuscle Gain forscienceCitrulline
- Citrulline stimulates muscle protein synthesis in the post-absorptive state in healthy people fed a low-protein diet - A pilot study.
Jourdan M; Nair KS; Carter RE; Schimke J; Ford GC; Marc J; Aussel C; Cynober L · Clinical nutrition (Edinburgh, Scotland) · 2016
Randomized trial8 participantsflagMuscle Gain forscienceCitrulline
- Effect of High-Intensity Interval Training Combined with L-Citrulline Supplementation on Functional Capacities and Muscle Function in Dynapenic-Obese Older Adults.
Buckinx F; Gouspillou G; Carvalho LP; Marcangeli V; El Hajj Boutros G; Dulac M; Noirez P; Morais JA; Gaudreau P; Aubertin-Leheudre M · Journal of clinical medicine · 2020
Randomized trial56 participantsflagMuscle Gain forscienceCitrulline
- Effects of betaine on body composition, performance, and homocysteine thiolactone.
Cholewa JM; Wyszczelska-Rokiel M; Glowacki R; Jakubowski H; Matthews T; Wood R; Craig SA; Paolone V · Journal of the International Society of Sports Nutrition · 2013
Randomized trial23 participantsflagWeight Gain forscienceBetaine Anhydrous
- Effects of Betaine Supplementation on Markers of Metabolic Flexibility, Body Composition, and Anaerobic Performance in Active College-Age Females.
Waldman HS; Bryant AR; McAllister MJ · Journal of dietary supplements · 2023
Randomized trial23 participantsflagWeight Gain forscienceBetaine Anhydrous
- Effects of Citrulline Supplementation on Body Weight in Patients With Hepatobiliary Pancreatic Surgery.
Yang JA; Lee KE; Park JH; Yee J; Kim JY; Gwak HS · Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2020
Cohort study138 participantsflagWeight Gain forscienceCitrulline
- Impact of high-intensity interval training with or without l-citrulline on physical performance, skeletal muscle, and adipose tissue in obese older adults.
Marcangeli V; Youssef L; Dulac M; Carvalho LP; Hajj-Boutros G; Reynaud O; Guegan B; Buckinx F; Gaudreau P; Morais JA; Mauriège P; Noirez P; Aubertin-Leheudre M; Gouspillou G · Journal of cachexia, sarcopenia and muscle · 2022
Clinical trial81 participantsflagWeight Gain forscienceCitrulline
- Synergistic effect of long-term L-citruline supplementation combined with exercise on body composition in adults: A systematic review and meta-analysis of randomized controlled trials.
Wang W; Cai S; Liu K; Luo P · Complementary therapies in medicine · 2026
Meta-analysis9 studies pooledflagWeight Gain forscienceCitrulline
- Effects of Citrulline or Watermelon Supplementation on Body Composition: A Systematic Review and Dose-Response Meta-Analysis.
Ashtary-Larky D; Mohammadi S; Mousavi SAH; Hajizadeh L; Candow DG; Forbes SC; Afrisham R; Farrokhi V; Antonio J; Suzuki K · Nutrients · 2025
Meta-analysis21 studies pooledflagWeight Gain forscienceCitrulline
- Impact of 3-week citrulline supplementation on postprandial protein metabolism in malnourished older patients: The Ciproage randomized controlled trial.
Bouillanne O; Melchior JC; Faure C; Paul M; Canouï-Poitrine F; Boirie Y; Chevenne D; Forasassi C; Guery E; Herbaud S; Le Corvoisier P; Neveux N; Nivet-Antoine V; Astier A; Raynaud-Simon A; Walrand S; Cynober L; Aussel C · Clinical nutrition (Edinburgh, Scotland) · 2020
Randomized trial24 participantsflagWeight Gain forscienceCitrulline