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Calcium Magnesium Zinc

Solaray
4.8
★ ★ ★ ★ ★
(22215 ratings)
Glutamic Acid 100 mg
Zinc 25 mg
Calcium 1000 mg
Magnesium 500 mg
Product Image
Score76
High mineral coverage is useful, but mixed forms, unclear splits, and unbalanced long-term zinc reduce everyday appeal.
How scoring works
Quantity:100 VegCap(s) • (25 servings)
Goals:
Bone Health
General Health
Immunity
Energy
Digestive Health
Testosterone Support
Productivity Boost
Skin Health

Score 76

High mineral coverage is useful, but mixed forms, unclear splits, and unbalanced long-term zinc reduce everyday appeal.
How scoring works

Also available as

1 option
250 servings Magnesium 500 mg, Calcium 1000 mg +2 more • 250 VegCap(s) • 62 servings $24.90 ($0.40 per serving)
$12.69($0.50 per serving)
Vitacost
$ 12.69
Amazon
$ 12.69
Walmart
$ 12.69
iHerb
$ 12.69
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Analysis

The formula combines calcium, magnesium, zinc, and glutamic acid for bone and general mineral support. Citrate and amino-acid chelate components improve some of the form profile.

Carbonate, hydroxide, and oxide forms lower average absorption quality, and the supplied label repeats amounts across sources without showing the true split. Zinc reaches 25 mg without listed copper, while magnesium reaches a level that may challenge digestive tolerance.

Four capsules provide a high mineral serving with moderate value. It fits users who need substantial minerals and can monitor dietary calcium and zinc from other products.

Who is it for
  • Adults seeking combined calcium, magnesium, and zinc
  • Users with a defined high mineral need
  • People comfortable with four capsules daily
Best for
  • Bone mineral support
  • High-dose calcium and magnesium
  • Combined mineral convenience

Pros

  • Provides substantial calcium
  • Includes substantial magnesium
  • Uses some citrate and chelate forms
  • Adds 25 mg zinc

Cons

  • Includes oxide, carbonate, and hydroxide forms
  • Does not include copper
  • Mineral splits are unclear
  • Requires four capsules

Warnings

  • Long-term 25 mg zinc intake may reduce copper status
  • The 500 mg magnesium amount may cause loose stools
  • High supplemental calcium should be counted with diet and separated from medicines whose absorption it can reduce

Nutrient quality

73 High impact

Several weaker or vague forms limit ingredient quality. Aggressive dosing is the main concern.

.

Ingredient transparency

80 High impact

Most active amounts are clearly disclosed. Missing directions and inactive ingredients keep disclosure incomplete.

.

Customer satisfaction

72 High impact

The supplied average is strong and rests on a large review count. No review text was provided to assess recurring complaints or firsthand experiences.

.

Value for money

78 High impact

Serving efficiency is favorable for the disclosed formula. A focused active profile supports value.

.
Report analysis

Goals

Bone Health
Bone Health
Impact
High effect
A Goal FitC+ Strength of SupportB- CoverageB Formula Quality
Magnesium · 500 mgCalcium · 1000 mgZinc · 25 mg

Calcium and magnesium provide major structural minerals, while zinc contributes to matrix enzymes. The formula has meaningful skeletal breadth but omits vitamin D and vitamin K support for absorption and calcium placement.

The mineral servings are large, and both calcium and magnesium include a mix of better and weaker forms. Dividing the serving may improve calcium use and reduce the chance of digestive discomfort from the high magnesium amount.

Study evidence
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
Zinc Supportive 33 studies
General Health
General Health
Impact
High effect
A Goal FitC- Strength of SupportB- CoverageB- Formula Quality
Magnesium · 500 mgZinc · 25 mg

Calcium, magnesium, and zinc support foundational bone, muscle, nerve, and immune functions. The combination covers skeletal, muscular, nervous-system, and immune mineral needs.

The mineral amounts are substantial, but magnesium is above a typical supplemental target and zinc is relatively high for daily use. The 500 mg magnesium serving may cause diarrhea, and the 25 mg zinc amount warrants attention to copper intake during extended daily use.

Study evidence
Magnesium Supportive 114 studies
Zinc Supportive 60 studies
Immunity
Immunity
Impact
High effect
B Goal FitB- Strength of SupportC- CoverageC Formula Quality
Magnesium · 500 mgZinc · 25 mg

The mineral formula provides 25 mg zinc, a meaningful amount for immune function, alongside calcium and magnesium. Chelate and citrate sources improve part of the mineral profile.

Magnesium oxide and calcium carbonate are less favorable forms, and the large calcium load may compete with magnesium absorption. The product lacks vitamin C or vitamin D, so its immunity coverage rests mostly on zinc.

Study evidence
Magnesium Supportive 8 studies
Zinc Supportive 73 studies
Energy
Energy
Impact
High effect
B Goal FitC Strength of SupportD+ CoverageC+ Formula Quality
Magnesium · 500 mg

Magnesium supports ATP-dependent reactions, while zinc and calcium contribute to general mineral function rather than direct alertness. The amounts are substantial, but the mixed forms include magnesium oxide and do not disclose how much comes from each source.

The formula has depth in basic mineral support but does not cover mitochondrial, stimulant, or stress-resilience pathways. The high magnesium amount may cause diarrhea, and prolonged use of the zinc amount without copper may impair copper balance.

Study evidence
Magnesium Supportive 4 studies
Digestive Health
Digestive Health
Impact
Moderate effect
B- Goal FitB- Strength of SupportC- CoverageD Formula Quality
Zinc · 25 mgMagnesium · 500 mg

Magnesium may support motility and zinc can contribute to intestinal repair when intake is inadequate. The large calcium emphasis and mixed mineral forms make the product less targeted than a digestive-specific formula.

Magnesium includes citrate but also oxide, while zinc is not supplied as zinc carnosine. The high mineral load may cause constipation, loose stools, or cramping depending on individual response.

Study evidence
Magnesium Supportive 50 studies
Zinc Supportive 130 studies
Testosterone Support
Testosterone Support
Impact
Moderate effect
C+ Goal FitC Strength of SupportD CoverageC+ Formula Quality
Magnesium · 500 mgZinc · 25 mg

Zinc and magnesium provide foundational endocrine nutrients, but calcium dominates the formula. The product lacks vitamin D, boron, or a stress-modulating botanical.

Magnesium mixes useful citrate and chelate forms with oxide, while large mineral amounts may compete for absorption. The 500 mg supplemental magnesium amount may cause diarrhea, and prolonged 25 mg zinc use may lower copper status.

Study evidence
Magnesium Disputed 5 studies
Zinc Disputed 7 studies

Ingredients

IngredientAmount per serving
Total Carbohydrates
1 Gram(s)
Calcium (Calcium Amino Acid Chelate Complex, Calcium Carbonate, Calcium Citrate, Calcium Hydroxide)
 1000 mg
Magnesium (Magnesium Amino Acid Chelate Complex, Magnesium Citrate, Magnesium Oxide)
 500 mg
Zinc (Zinc Amino Acid Chelate Complex)
 25 mg
Glutamic Acid Hydrochloride
100 mg
Adults 18–50
Report overview
Glutamic Acid · 100 mg OverallScore82
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB- Value

The clearly disclosed glutamic acid hydrochloride provides an adequate supplemental amount and suits the multi-mineral formula. The label does not confirm the biologically active L-isomer, limiting confidence in isomer specificity. Value is moderate, with four capsules required for the full serving.

View ingredientView products
Zinc (Zinc Amino Acid Chelate Complex) · 25 mg OverallScore68
D+ Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyD+ Value
+3

The generic zinc amino acid chelate complex source offers limited form quality, while the vegetable capsule format is well suited to use. Its 25 mg elemental serving is clearly stated and fits the preferred effective range. Copper omission poses little concern at this amount, while value is mixed because it falls into an unlisted middle price band.

View ingredientView products
Calcium (Calcium Amino Acid Chelate Complex, Calcium Carbonate, Calcium Citrate, Calcium Hydroxide) · 1000 mg OverallScore67
B Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyD+ Value

Chelated and citrate calcium improve the blend, but carbonate and hydroxide make absorption quality mixed. The 1000 mg serving is larger than the amount usually absorbed most efficiently at once, so dividing it may improve use. The cost is moderate, and no flagged additives appear in the supplied ingredient data.

View ingredientView products
Loading alternative details
80 Performance

Magnesium & Calcium

NOW
<p>Calcium citrate, magnesium citrate, glycinate, and taurate plus vitamin D3 and monomethionine zinc provide broader form quality than a mostly carbonate-and-oxide blend. The listed magnesium amount is unusually high and still includes oxide, creating a substantial tolerance concern.</p>
80 Performance

Calcium Magnesium plus Zinc

Solgar
<p>Citrate and gluconate forms improve calcium, magnesium, and zinc coverage while keeping the formula focused. Calcium carbonate and magnesium oxide remain, but the zinc amount is less aggressive than several original formulas.</p>
76 Performance

Calcium Magnesium Plus Zinc

Bluebonnet
<p>Calcium, magnesium, zinc, copper, and several useful forms create broader trace-mineral coverage than a basic three-mineral formula. Magnesium remains high enough to cause loose stools, while horsetail and tiny boron additions contribute little.</p>
78 Budget

Calcium Magnesium Zinc + Vitamin D3

Best Naturals
<p>Lower serving cost keeps substantial calcium, magnesium, zinc, and vitamin D3 with some citrate and gluconate forms. Carbonate and oxides remain, and the zinc amount is assertive for routine use.</p>
79 Budget

Calcium Magnesium & Zinc

Sundown
<p>Economical calcium, magnesium, and zinc coverage preserves the core mineral purpose. Carbonate and oxide forms limit absorption quality, though zinc citrate and mineral gluconates add some form variety.</p>
78 Budget

Chelated Calcium Magnesium Zinc

American Health
<p>Very low serving cost retains the same three core minerals at substantial amounts. Carbonate and oxide forms dominate, so value rather than form quality is the main advantage.</p>
77 Value

Calcium Magnesium Zinc + Vitamin D3

AN Amazing Nutrition Amazing Formulas
<p>A very low serving cost adds vitamin D3 to substantial calcium, magnesium, and zinc coverage. Repeated form entries obscure source contributions, and the zinc amount is aggressive for long-term routine use.</p>
80 Value

Natural Calcium Magnesium & Zinc with Vitamin D3

Spring Valley
<p>Very low routine cost preserves calcium, magnesium, zinc, and vitamin D3 with a simpler label. Mineral forms are not identified, so absorption quality cannot be compared confidently.</p>
85 Value

Cal/Mag 500 mg/250 mg

NaturesPlus
<p>Chelated calcium and magnesium provide a lower, more balanced mineral load with strong serving value. Zinc and glutamic acid are absent, but the simpler formula may be easier to tolerate than high-dose combinations.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Associations of dietary calcium intake with metabolic syndrome and bone mineral density among the Korean population: KNHANES 2008-2011.
    Kim MK; Chon SJ; Noe EB; Roh YH; Yun BH; Cho S; Choi YS; Lee BS; Seo SK · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Cross-sectional study14,705 participantsBone Health forCalcium
  2. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  3. The effects of zinc supplementation on serum zinc, alkaline phosphatase activity and fracture healing of bones.
    Sadighi A; Roshan MM; Moradi A; Ostadrahimi A · Saudi medical journal · 2009
    Randomized trial60 participantsBone Health forZinc
  4. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  5. Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years.
    Imdad A; Rogner J; Sherwani RN; Sidhu J; Regan A; Haykal MR; Tsistinas O; Smith A; Chan XHS; Mayo-Wilson E; Bhutta ZA · The Cochrane database of systematic reviews · 2023
    Meta-analysis219,584 participants96 studies pooledDigestive Health forZinc
  6. Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta-analysis.
    Tihtonen K; Korhonen P; Isojärvi J; Ojala R; Ashorn U; Ashorn P; Tammela O · Annals of the New York Academy of Sciences · 2022
    Meta-analysis1,566 participants7 studies pooledBone Health forCalcium
  7. Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study.
    Orchard TS; Larson JC; Alghothani N; Bout-Tabaku S; Cauley JA; Chen Z; LaCroix AZ; Wactawski-Wende J; Jackson RD · The American journal of clinical nutrition · 2014
    Cohort study73,684 participantsBone Health forMagnesium
  8. Excess serum zinc concentration is associated with incident fracture in men: Tehran lipid and glucose study.
    Bahadoran Z; Hadaegh F; Azizi F; Ghasemi A · Scientific reports · 2026
    Cohort study1,968 participantsBone Health forZinc
  9. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  10. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  11. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  12. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  13. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  14. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  15. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  16. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  17. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  18. Increased incidence of fractures in middle-aged and elderly men with low intakes of phosphorus and zinc.
    Elmståhl S; Gullberg B; Janzon L; Johnell O; Elmståhl B · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 1999
    Cohort study6,576 participantsBone Health forZinc
  19. Zinc Supplementation Increases Procollagen Type 1 Amino-Terminal Propeptide in Premenarcheal Girls: A Randomized Controlled Trial.
    Berger PK; Pollock NK; Laing EM; Chertin V; Bernard PJ; Grider A; Shapses SA; Ding KH; Isales CM; Lewis RD · The Journal of nutrition · 2016
    Randomized trial147 participantsBone Health forZinc
  20. Randomized controlled trial of prenatal zinc supplementation and fetal bone growth.
    Merialdi M; Caulfield LE; Zavaleta N; Figueroa A; Costigan KA; Dominici F; Dipietro JA · The American journal of clinical nutrition · 2004
    Randomized trial242 participantsBone Health forZinc
  21. Is Zinc an Important Trace Element on Bone-Related Diseases and Complications? A Meta-analysis and Systematic Review from Serum Level, Dietary Intake, and Supplementation Aspects.
    Ceylan MN; Akdas S; Yazihan N · Biological trace element research · 2021
    Meta-analysis40 studies pooledBone Health forZinc
  22. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  23. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  24. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  25. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  26. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  27. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  28. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  29. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  30. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  31. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  32. Oral zinc supplementation for the treatment of acute diarrhea in children: a systematic review and meta-analysis.
    Lamberti LM; Walker CL; Chan KY; Jian WY; Black RE · Nutrients · 2014
    Meta-analysis18,822 participants104 studies pooledDigestive Health forZinc
  33. Zinc with oral rehydration therapy reduces stool output and duration of diarrhea in hospitalized children: a randomized controlled trial.
    Bhatnagar S; Bahl R; Sharma PK; Kumar GT; Saxena SK; Bhan MK · Journal of pediatric gastroenterology and nutrition · 2004
    Randomized trial287 participantsDigestive Health forZinc
  34. Lower-Dose Zinc for Childhood Diarrhea - A Randomized, Multicenter Trial.
    Dhingra U; Kisenge R; Sudfeld CR; Dhingra P; Somji S; Dutta A; Bakari M; Deb S; Devi P; Liu E; Chauhan A; Kumar J; Semwal OP; Aboud S; Bahl R; Ashorn P; Simon J; Duggan CP; Sazawal S; Manji K · The New England journal of medicine · 2020
    Randomized trial4,500 participantsDigestive Health forZinc
  35. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsDigestive Health General Health forZinc
  36. Short-course prophylactic zinc supplementation for diarrhea morbidity in infants of 6 to 11 months.
    Malik A; Taneja DK; Devasenapathy N; Rajeshwari K · Pediatrics · 2013
    Randomized trial272 participantsDigestive Health forZinc
  37. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  38. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  39. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  40. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  41. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  42. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  43. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  44. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  45. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  46. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  47. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  48. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  49. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  50. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  51. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  52. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  53. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  54. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  55. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  56. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  57. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  58. Hypomagnesemia Is a Risk Factor for Infections after Kidney Transplantation: A Retrospective Cohort Analysis.
    Odler B; Deak AT; Pregartner G; Riedl R; Bozic J; Trummer C; Prenner A; Söllinger L; Krall M; Höflechner L; Hebesberger C; Boxler MS; Berghold A; Schemmer P; Pilz S; Rosenkranz AR · Nutrients · 2021
    Cohort study376 participantsImmunity forMagnesium
  59. Higher Intake of Dietary Magnesium Is Inversely Associated With COVID-19 Severity and Symptoms in Hospitalized Patients: A Cross-Sectional Study.
    Nouri-Majd S; Ebrahimzadeh A; Mousavi SM; Zargarzadeh N; Eslami M; Santos HO; Taghizadeh M; Milajerdi A · Frontiers in nutrition · 2022
    Cross-sectional study250 participantsImmunity forMagnesium
  60. Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D.
    Chaigne-Delalande B; Li FY; O'Connor GM; Lukacs MJ; Jiang P; Zheng L; Shatzer A; Biancalana M; Pittaluga S; Matthews HF; Jancel TJ; Bleesing JJ; Marsh RA; Kuijpers TW; Nichols KE; Lucas CL; Nagpal S; Mehmet H; Su HC; Cohen JI; Uzel G; Lenardo MJ · Science (New York, N.Y.) · 2013
    Single-arm trialImmunity forMagnesium
  61. Effect of magnesium on granulocyte function and on the exercise induced inflammatory response.
    Mooren FC; Golf SW; Völker K · Magnesium research · 2003
    Randomized trialImmunity forMagnesium
  62. Maternal and neonatal outcomes following magnesium sulfate in the setting of chorioamnionitis: a meta-analysis.
    Pergialiotis V; Sapantzoglou I; Rodolaki K; Varthaliti A; Theodora M; Antsaklis P; Thomakos N; Stavros S; Daskalakis G; Papapanagiotou A · Archives of gynecology and obstetrics · 2024
    Meta-analysis6,559 participants8 studies pooledImmunity forMagnesium
  63. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  64. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  65. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  66. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  67. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc
  68. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
    Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
    Meta-analysis4,049 participants52 studies pooledMood Support forMagnesium
  69. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsMood Support Stress Relief forMagnesium
  70. Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsMood Support forMagnesium
  71. The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
    Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
    Randomized trial46 participantsMood Support forMagnesium
  72. Dietary magnesium intake and risk of depression.
    Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
    Cross-sectional study17,730 participantsMood Support forMagnesium
  73. Zinc in depression: From development to treatment: A comparative/ dose response meta-analysis of observational studies and randomized controlled trials.
    Yosaee S; Clark CCT; Keshtkaran Z; Ashourpour M; Keshani P; Soltani S · General hospital psychiatry · 2022
    Meta-analysisMood Support forZinc
  74. Dietary zinc and iron intake and risk of depression: A meta-analysis.
    Li Z; Li B; Song X; Zhang D · Psychiatry research · 2017
    Meta-analysis9 studies pooledMood Support forZinc
  75. Zinc sulphate: A reasonable choice for depression management in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial.
    Salari S; Khomand P; Arasteh M; Yousefzamani B; Hassanzadeh K · Pharmacological reports : PR · 2016
    Randomized trial43 participantsMood Support forZinc
  76. Comparative efficacy and tolerability of nutraceuticals for depressive disorder: A systematic review and network meta-analysis.
    Cheng YC; Huang WL; Chen WY; Huang YC; Kuo PH; Tu YK · Psychological medicine · 2025
    Meta-analysis17,437 participants192 studies pooledMood Support forZinc
  77. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce.
    Sarris J; Ravindran A; Yatham LN; Marx W; Rucklidge JJ; McIntyre RS; Akhondzadeh S; Benedetti F; Caneo C; Cramer H; Cribb L; de Manincor M; Dean O; Deslandes AC; Freeman MP; Gangadhar B; Harvey BH; Kasper S; Lake J; Lopresti A; Lu L; Metri NJ; Mischoulon D; Ng CH; Nishi D; Rahimi R; Seedat S; Sinclair J; Su KP; Zhang ZJ; Berk M · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2022
    Guideline / consensusMood Support forZinc
  78. Predictive Model of Nail Consistency Using Scanning Electron Microscopy with Energy-Dispersive X-Ray.
    Mingorance Álvarez E; Martínez Quintana R; Pérez Pico AM; Mayordomo R · Biology · 2021
    Cross-sectional study57 participantsNail Health forCalcium
  79. Vitamins and minerals: their role in nail health and disease.
    Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
    Narrative reviewNail Health forZinc
  80. Cross-sectional and longitudinal associations of magnesium intake and cognition in the Healthy Aging Longitudinal Study in Taiwan.
    Tao MH; Chuang SC; Wu IC; Chan HT; Cheng CW; Chen HL; Lee MM; Chang HY; Hsiung CA; Hsu CC · European journal of nutrition · 2024
    Cohort study5,663 participantsProductivity Boost forMagnesium
  81. Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients.
    Tu X; Qiu H; Lin S; He W; Huang G; Zhang X; Wu Y; He J · Neuropsychiatric disease and treatment · 2022
    Cohort study327 participantsProductivity Boost forMagnesium
  82. The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
    Lopresti AL; Smith SJ · Frontiers in nutrition · 2026
    Randomized trial100 participantsProductivity Boost forMagnesium
  83. Hypomagnesemia and Acute Cognitive Decline in Older Adults: An Evaluation of Clinical Practice and Cognitive Outcomes at a National Health Service (NHS) Trust in England.
    Lai XN; Sadhwani V; Ng WM; Gani A · Cureus · 2025
    Cohort study667 participantsProductivity Boost forMagnesium
  84. Magnesium Depletion Score as a Novel Predictor of Cognitive Impairment: A Population-Based Cross-Sectional Study From NHANES.
    Chen M; Xue R; Zhang M; Zhang J; Zheng J; Ye D; Sun J · Journal of the American Medical Directors Association · 2025
    Cross-sectional study2,768 participantsProductivity Boost forMagnesium
  85. Zinc supplementation improved cognitive performance and taste acuity in Indian adolescent girls.
    Tupe RP; Chiplonkar SA · Journal of the American College of Nutrition · 2010
    Randomized trial180 participantsProductivity Boost forZinc
  86. Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Meli AM; Ali A; Mhd Jalil AM; Mohd Yusof H; Tan MMC · Medicina (Kaunas, Lithuania) · 2022
    Meta-analysisProductivity Boost forZinc
  87. Linkages of biomarkers of zinc with cognitive performance and taste acuity in adolescent girls.
    Chiplonkar SA; Kawade R · International journal of food sciences and nutrition · 2015
    Cross-sectional study403 participantsProductivity Boost forZinc
  88. Associations Between Serum Selenium, Zinc, and Copper Levels and Cognitive Function in the Elderly.
    Charernwat P; Chansirikarnjana S; Panpunuan P; Sritara P; Sirivarasai J · Nutrients · 2025
    Cross-sectional study854 participantsProductivity Boost forZinc
  89. Comparative analysis of methyl-donor nutrient intakes and RCPM cognitive performance among school-aged children.
    Apprey C; Asamoah-Boakye O; Annaful VT; Annan RA · Clinical nutrition ESPEN · 2022
    Cross-sectional study2,073 participantsProductivity Boost forZinc
  90. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  91. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  92. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  93. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc
  94. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forZinc
  95. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  96. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  97. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  98. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  99. Investigating the effect of zinc supplementation on probability of relapse and mental health in patients with opioid use disorder undergoing methadone maintenance treatment.
    Amini Z; HeidariFarsani E · Substance abuse treatment, prevention, and policy · 2023
    Randomized trial68 participantsStress Relief forZinc
  100. A systematic review of the association between zinc and anxiety.
    Azargoonjahromi A · Nutrition reviews · 2024
    Systematic review9 studies pooledStress Relief forZinc
  101. Zinc acutely and temporarily inhibits adrenal cortisol secretion in humans. A preliminary report.
    Brandão-Neto J; de Mendonça BB; Shuhama T; Marchini JS; Pimenta WP; Tornero MT · Biological trace element research · 1991
    Clinical trial27 participantsStress Relief forZinc
  102. Low Zinc, Copper, and Manganese Intake is Associated with Depression and Anxiety Symptoms in the Japanese Working Population: Findings from the Eating Habit and Well-Being Study.
    Nakamura M; Miura A; Nagahata T; Shibata Y; Okada E; Ojima T · Nutrients · 2019
    Cross-sectional study2,089 participantsStress Relief forZinc
  103. Mediation effects of thyroid hormones in the associations between essential metal elements and anxiety or depression symptoms in the elderly.
    Li J; Wang W; Peng Y; Qin N; Li J; Wei Y; Wang B; Zeng H; Li H; Cheng L · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Observational study416 participantsStress Relief forZinc
  104. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  105. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  106. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  107. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  108. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium
  109. Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum.
    Meeker JD; Rossano MG; Protas B; Padmanahban V; Diamond MP; Puscheck E; Daly D; Paneth N; Wirth JJ · Fertility and sterility · 2010
    Cross-sectional study219 participantsTestosterone Support forZinc
  110. Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review.
    Santos HO; Cadegiani FA; Forbes SC · Clinical therapeutics · 2022
    Scoping reviewTestosterone Support forZinc
  111. Zinc is an Essential Element for Male Fertility: A Review of Zn Roles in Men's Health, Germination, Sperm Quality, and Fertilization.
    Fallah A; Mohammad-Hasani A; Colagar AH · Journal of reproduction & infertility · 2020
    Narrative reviewTestosterone Support forZinc
  112. Clinical, endocrinological and biochemical effects of zinc deficiency.
    Prasad AS · Clinics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc
  113. Clinical, endocrinologic, and biochemical effects of zinc deficiency.
    Prasad AS · Special topics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc