Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Accelerated biological aging, mediating amino acids, and risk of incident type 2 diabetes: a prospective cohort study.
Zhang Z; Wang J; Yu B; Sun Y; Chen Y; Lu Y; Wang N; Xia F · Journal of endocrinological investigation · 2025
Cohort study95,773 participantsflagAnti-Aging forscienceGlycine
- Dietary protein and amino acid intakes for mitigating sarcopenia in humans.
He W; Connolly ED; Cross HR; Wu G · Critical reviews in food science and nutrition · 2025
Narrative reviewflagAnti-Aging forscienceGlycine
- Age-Related Neurochemical Changes in the Vestibular Nuclei.
Smith PF · Frontiers in neurology · 2016
Narrative reviewflagAnti-Aging forscienceGlycine
- SHMT2 regulates CD8+ T cell senescence via the reactive oxygen species axis in HIV-1 infected patients on antiretroviral therapy.
Zhang QS; Wang JN; Yang TL; Li SY; Li JQ; Liu DN; Shang H; Zhang ZN · EBioMedicine · 2025
Observational studyflagAnti-Aging forscienceGlycine
- Metabolomics and incident dementia in older Chinese adults: The Shanghai Aging Study.
Cui M; Jiang Y; Zhao Q; Zhu Z; Liang X; Zhang K; Wu W; Dong Q; An Y; Tang H; Ding D; Chen X · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
Cohort studyflagAnti-Aging forscienceGlycine
- Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes.
Cruz M; Maldonado-Bernal C; Mondragón-Gonzalez R; Sanchez-Barrera R; Wacher NH; Carvajal-Sandoval G; Kumate J · Journal of endocrinological investigation · 2009
Randomized trial74 participantsflagAnti-Inflammatory Support forscienceGlycine
- Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: a pilot randomized trial.
Vargas MH; Del-Razo-Rodríguez R; López-García A; Lezana-Fernández JL; Chávez J; Furuya MEY; Marín-Santana JC · BMC pulmonary medicine · 2018
Randomized trial13 participantsflagAnti-Inflammatory Support forscienceGlycine
- Subgingival air polishing (glycine powder) versus minocycline hydrochloride: efficacy in residual periodontal pockets following endoscope-assisted scaling and root planing.
Guo X; Bai H; Lu X; Guo J; Qi Y; Huo X; Li S · Clinical oral investigations · 2026
Randomized trial80 participantsflagAnti-Inflammatory Support forscienceGlycine
- Long-term Implant Maintenance: A Systematic Review of Home and Professional Care Strategies in Supportive Implant Therapy.
Araújo TG; Moreira CS; Neme RA; Luan H; Bertolini M · Brazilian dental journal · 2024
Systematic review13 studies pooledflagAnti-Inflammatory Support forscienceGlycine
- Analysis of the factors influencing the occurrence of peri-implantitis in patients with implant-supported restoration and study on the maintenance effect of subgingival sandblasting.
Pan T; Meng W; Zhang M; Xie Y; Chen Z; Zhou M; Yin L; Xie H · BMC oral health · 2026
Randomized trial198 participantsflagAnti-Inflammatory Support forscienceGlycine
- [Cross-sectional association between the amino acid intake and episodic memory in middle- and old-aged community dwellers].
Kinoshita K; Otsuka R; Takada M; Tsukamoto-Yasui M; Nishita Y; Tange C; Tomida M; Shimokata H; Imaizumi A; Arai H · Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics · 2021
Cross-sectional study2,082 participantsflagBrain Health forscienceHistidine flagBrain Health forsciencePhenylalanine
- The effect of histidine on mental fatigue and cognitive performance in subjects with high fatigue and sleep disruption scores.
Sasahara I; Fujimura N; Nozawa Y; Furuhata Y; Sato H · Physiology & behavior · 2016
Randomized trial20 participantsflagBrain Health forscienceHistidine
- The Association between Dietary Amino Acid Intake and Cognitive Decline 8 Years Later in Japanese Community-Dwelling Older Adults.
Kinoshita K; Otsuka R; Takada M; Tsukamoto-Yasui M; Nishita Y; Tange C; Tomida M; Shimokata H; Kuzuya M; Imaizumi A; Arai H · The journal of nutrition, health & aging · 2021
Cohort study427 participantsflagBrain Health forsciencePhenylalanine
- Magnetic resonance imaging in phenylketonuria: reversal of cerebral white matter change.
Cleary MA; Walter JH; Wraith JE; White F; Tyler K; Jenkins JP · The Journal of pediatrics · 1995
Non-randomized trial41 participantsflagBrain Health forsciencePhenylalanine
- Improved dietary control results in improvements in indices of white matter structure in adults with phenylketonuria: the ReDAPT study.
Kang MJY; Adamson C; Malpas CB; Winton-Brown T; Burgess N; Fazio T; Velakoulis D; Desmond P; Venkatraman V; De Jong G; Walterfang M · Acta neuropsychiatrica · 2026
Single-arm trial7 participantsflagBrain Health forsciencePhenylalanine
- [Brain white matter lesions of children with phenylketonuria before and after treatment].
Wang ZX; Zhou ZS; Yu WM · Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2006
Single-arm trial19 participantsflagBrain Health forsciencePhenylalanine
- Combined L-carnosine and L-tyrosine supplementation as an ergogenic strategy for physical and cognitive performance under fatigue in professional football players.
Bilgin S; Bozyılan E; Buzdağlı Y; Karaç Öcal Y; Gürkan O; Toktaş S; İnan H; Egil İ; Yarayan YE · Frontiers in nutrition · 2026
Randomized trial24 participantsflagBrain Health forscienceTyrosine
- Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands--A review.
Jongkees BJ; Hommel B; Kühn S; Colzato LS · Journal of psychiatric research · 2016
Narrative reviewflagBrain Health forscienceTyrosine
- Influence of nutritional tyrosine on cognition and functional connectivity in healthy old humans.
Hensel C; Becker M; Düzel S; Demuth I; Norman K; Steinhagen-Thiessen E; Gallinat J; Lindenberger U; Kühn S · NeuroImage · 2019
Cross-sectional study286 participantsflagBrain Health forscienceTyrosine
- Dietary Tyrosine Intake (FFQ) Is Associated with Locus Coeruleus, Attention and Grey Matter Maintenance: An MRI Structural Study on 398 Healthy Individuals of the Berlin Aging Study-II.
Plini ERG; Melnychuk MC; Harkin A; Dahl MJ; McAuslan M; Kühn S; Boyle RT; Whelan R; Andrews R; Düzel S; Drewelies J; Wagner GG; Lindenberger U; Norman K; Robertson IH; Dockree PM · The journal of nutrition, health & aging · 2023
Cross-sectional study398 participantsflagBrain Health forscienceTyrosine
- Baseline-dependent effect of dopamine's precursor L-tyrosine on working memory gating but not updating.
Jongkees BJ · Cognitive, affective & behavioral neuroscience · 2021
Randomized trial45 participantsflagBrain Health forscienceTyrosine
- Metabolomic profiling reveals novel biomarkers of alcohol intake and alcohol-induced liver injury in community-dwelling men.
Harada S; Takebayashi T; Kurihara A; Akiyama M; Suzuki A; Hatakeyama Y; Sugiyama D; Kuwabara K; Takeuchi A; Okamura T; Nishiwaki Y; Tanaka T; Hirayama A; Sugimoto M; Soga T; Tomita M · Environmental health and preventive medicine · 2016
Cross-sectional study896 participantsflagDetoxification forscienceGlutamic Acid
- The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.
Tan HC; Hsu JW; Tai ES; Chacko S; Kovalik JP; Jahoor F · Frontiers in endocrinology · 2024
Cohort study42 participantsflagDetoxification forscienceGlycine
- Metabolic impact of dietary glycine supplementation in individuals with severe obesity.
Tan HC; Hsu JW; Tai ES; Chacko S; Wu V; Yen PM; Kovalik JP; Jahoor F · Scientific reports · 2025
Single-arm trial19 participantsflagDetoxification forscienceGlycine
- Contribution towards a Metabolite Profile of the Detoxification of Benzoic Acid through Glycine Conjugation: An Intervention Study.
Irwin C; van Reenen M; Mason S; Mienie LJ; Westerhuis JA; Reinecke CJ · PloS one · 2017
Non-randomized trial21 participantsflagDetoxification forscienceGlycine
- Glycine conjugation of para-aminobenzoic acid (PABA): a quantitative test of liver function.
Furuya KN; Durie PR; Roberts EA; Soldin SJ; Verjee Z; Yung-Jato L; Giesbrecht E; Ellis L · Clinical biochemistry · 1996
Methods validation study74 participantsflagDetoxification forscienceGlycine
- The treatment of isovaleric acidemia with glycine supplement
M Naglak, R Salvo, K Madsen, P Dembure, L Elsas · Pediatric research · 1988
Non-randomized trial2 participantsflagDetoxification forscienceGlycine
- Causes of hair loss and the developments in hair rejuvenation.
Rushton DH; Norris MJ; Dover R; Busuttil N · International journal of cosmetic science · 2010
Narrative reviewflagHair Health forscienceLysine
- The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review.
Soh J; Raventhiran S; Lee JH; Lim ZX; Goh J; Kennedy BK; Maier AB · GeroScience · 2024
Systematic reviewflagSleep Support forscienceGlycine
- New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep.
Bannai M; Kawai N · Journal of pharmacological sciences · 2012
Narrative reviewflagSleep Support forscienceGlycine
- The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers.
Bannai M; Kawai N; Ono K; Nakahara K; Murakami N · Frontiers in neurology · 2012
Clinical trial7 participantsflagSleep Support forscienceGlycine
- The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression
Clarinda N Sutanto, Wen Wei Loh, Jung Eun Kim · Nutrition Reviews · 2022
Meta-analysis4 studies pooledflagSleep Support forscienceTryptophan
- Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure.
Díaz-Flores M; Cruz M; Duran-Reyes G; Munguia-Miranda C; Loza-Rodríguez H; Pulido-Casas E; Torres-Ramírez N; Gaja-Rodriguez O; Kumate J; Baiza-Gutman LA; Hernández-Saavedra D · Canadian journal of physiology and pharmacology · 2014
Randomized trial60 participantsflagStress Relief forscienceGlycine