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Bromelain 500 mg

California Gold Nutrition
4.7
★ ★ ★ ★ ★
(6368 ratings)
Bromelain 500 mg
Product Image
Score78
A substantial 500 mg serving is simple and economical, but weight without enzyme-activity units cannot establish potency.
How scoring works
Quantity:30 Capsule(s) • (30 servings)
Goals:
Digestive Health
Anti-Inflammatory Support
Joint Health

Score 78

A substantial 500 mg serving is simple and economical, but weight without enzyme-activity units cannot establish potency.
How scoring works

Also available as

1 option
90 servings Bromelain 500 mg • 90 Capsule(s) • 90 servings $15.16 ($0.16 per serving)
$5.56($0.18 per serving)
iHerb
$ 5.56
Amazon
$ 0.00
Report prices

Analysis

The single-active formula supplies 500 mg bromelain in one serving. The absence of GDU, MCU, or other enzyme-activity units leaves potency uncertain despite the substantial weight.

The source material is not specified. The standard capsule or tablet has no stated acid protection, so delivery for non-digestive use is not specifically optimized.

Timing should match the intended use: a meal-linked serving fits digestive support, while between-meal use is commonly chosen for systemic goals. Value is favorable, and the concise formula makes label assessment easy.

Who is it for
  • Adults seeking a single-ingredient bromelain product
  • People who prefer one active over a large enzyme blend
  • Users not taking medicines that raise bleeding risk
Best for
  • Bromelain supplementation
  • Meal-linked digestive enzyme use
  • A simple enzyme formula

Pros

  • Provides 500 mg bromelain
  • Uses a focused single-active design
  • Avoids unrelated botanical blends
  • Offers favorable value

Cons

  • Does not disclose enzyme-activity units
  • Potency cannot be compared from weight alone
  • Meal-timing directions are not supplied
  • Source material is not identified

Warnings

  • Bromelain may increase bleeding tendency with anticoagulant or antiplatelet medicines.
  • Bromelain should be reviewed before a planned procedure because its bleeding effect may be relevant.
  • Bromelain may cause nausea, diarrhea, or stomach discomfort in sensitive users.

Nutrient quality

79 High impact

A substantial bromelain weight gives the formula useful substance. Missing activity, source, and release details limit quality confidence.

.

Ingredient transparency

72 High impact

Active weights are listed and no proprietary blend hides the supplied doses. Missing enzyme activity, timing, excipients, and some source details keep disclosure incomplete.

.

Customer satisfaction

73 High impact

A very strong supplied average is supported by an exceptionally large review base. Specific review comments were not provided, so repeated complaints and purpose-specific experiences cannot be assessed.

.

Value for money

91 Highest impact

A substantial amount and favorable serving economics create strong value. Unknown enzyme activity remains the main potency gap.

.
Report analysis

Goals

Digestive Health
Digestive Health
Impact
High effect
B- Goal FitC Strength of SupportD- CoverageA- Formula Quality
Bromelain · 500 mg

Bromelain is directly relevant to protein digestion and may reduce discomfort linked to protein-heavy meals. The 500 mg capsule supplies a substantial enzyme weight in a simple formula.

Confidence in digestive potency is limited because no GDU or MCU activity units, meal-timing directions, or enzyme-protective delivery details are provided. Bromelain may raise bleeding risk with anticoagulant or antiplatelet medicines and may trigger reactions in people allergic to pineapple.

Study evidence
Bromelain Supportive 2 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Moderate effect
B- Goal FitC- Strength of SupportD- CoverageB+ Formula Quality

The substantial bromelain amount may support acute swelling and tissue comfort through proteolytic enzyme activity. Its role is more situation-specific than broad daily inflammatory support.

The label gives only weight and does not state enzyme activity units, so true potency cannot be confirmed. Missing source, timing, and delayed-release details further limit confidence in systemic use.

Study evidence
Bromelain Supportive 12 studies
Joint Health
Joint Health
Impact
Moderate effect
C Goal FitD Strength of SupportD- CoverageA- Formula Quality

Bromelain may support joint comfort through proteolytic and inflammation-modulating effects. Human evidence is limited and depends strongly on enzyme activity, which is not disclosed.

The 500 mg weight appears substantial, but no GDU or FIP activity value is provided, so functional potency cannot be determined. Bromelain may increase bleeding tendency with anticoagulant or antiplatelet medicines and may trigger reactions in people allergic to pineapple.

Study evidence
Bromelain Mixed 5 studies

Ingredients

IngredientAmount per serving
Bromelain
500 mg
Gluten Free Adults 18–50 Dairy Free No Allergies
Report overview
Bromelain · 500 mg OverallScore53
F Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyA+ Value

The standalone capsule supplies a substantial 500 mg bromelain dose with excellent cost efficiency. Enzyme activity units are absent, so the true potency cannot be confirmed from weight alone. Source, timing, and delayed-release details are also missing, limiting confidence for systemic use.

View ingredientView products
Loading alternative details
86 Performance

Bromelain 2400 GDU/g - 500 mg

NOW
<p>A 500 mg pineapple bromelain serving with clearly stated high activity makes potency easier to assess, improving ingredient clarity and performance compared with Bromelain 500 mg. Meal timing is not stated, and bromelain may increase bleeding tendency with anticoagulant or antiplatelet medicines.</p>
83 Performance

High Potency Bromelain 3000 GDU 500 mg

Doctor's Best
<p>A 500 mg serving with clearly disclosed high enzyme activity provides a potent focused option, improving ingredient clarity and performance compared with Bromelain 500 mg. Standard capsule delivery and missing meal timing limit confidence about systemic use.</p>
82 Performance

Bromelain 2400 GDU/g 500 mg

Protocol For Life Balance
<p>A 500 mg pineapple bromelain serving with disclosed high activity provides clear enzyme potency, improving ingredient clarity and performance compared with Bromelain 500 mg. Meal timing is missing, and bromelain may increase bleeding tendency with anticoagulant or antiplatelet medicines.</p>
81 Budget

Bromelain 500 mg

AN Amazing Nutrition Amazing Formulas
<p>A lower serving cost makes Bromelain 500 mg an economical alternative to Bromelain 500 mg. A focused 500 mg pineapple bromelain serving keeps the formula simple. Activity units and meal timing are not disclosed, and bromelain may increase bleeding tendency with anticoagulant or antiplatelet medicines.</p>
81 Budget

Bromelain 500 mg

The Vitamin Shoppe
<p>A lower serving cost makes Bromelain 500 mg an economical alternative to Bromelain 500 mg. A focused 500 mg pineapple bromelain serving provides a substantial enzyme weight. Activity units and meal timing are not disclosed, and bromelain may increase bleeding tendency with anticoagulant or antiplatelet medicines.</p>
74 Budget

Turmeric & Bromelain 450 mg

Natural Factors
<p>A lower serving cost makes Turmeric & Bromelain 450 mg an economical alternative to Bromelain 500 mg. Turmeric and 150 mg of pineapple bromelain broaden the formula beyond a single enzyme. Neither botanical is standardized, and both may increase bleeding tendency with anticoagulant or antiplatelet medicines.</p>
82 Value

Bromelain 500 mg

Natural Factors
<p>A substantial 500 mg pineapple-extract serving combines a focused formula with economical routine use, providing a favorable serving cost relative to Bromelain 500 mg. Activity units and meal timing are not disclosed, so the formula is not fully characterized.</p>
82 Value

Specially-Coated Bromelain 500 mg

Life Extension
<p>A protected tablet and 500 mg of pineapple bromelain support delivery beyond a basic uncoated product, providing stronger ingredient quality for the added cost relative to Bromelain 500 mg. Activity units and meal timing remain undisclosed, so the formula is not fully characterized.</p>
82 Value

Quercetin 880 mg with Bromelain

Nutricost
<p>A substantial quercetin dihydrate amount and 165 mg of bromelain provide broader antioxidant-enzyme coverage, providing stronger ingredient quality for the added cost relative to Bromelain 500 mg. Bromelain activity and source details are missing, so the formula is not fully characterized.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Therapeutic efficacy of bromelain in impacted third molar surgery: a randomized controlled clinical study.
    Ordesi P; Pisoni L; Nannei P; Macchi M; Borloni R; Siervo S · Quintessence international (Berlin, Germany : 1985) · 2016
    Randomized trial80 participantsAnti-Inflammatory Support forBromelain
  2. Efficacy of proteolytic enzyme bromelain on health outcomes after third molar surgery. Systematic review and meta-analysis of randomized clinical trials.
    Mendes ML; do Nascimento-Júnior EM; Reinheimer DM; Martins-Filho PR · Medicina oral, patologia oral y cirugia bucal · 2019
    Meta-analysis6 studies pooledAnti-Inflammatory Support forBromelain
  3. Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain.
    Müller S; März R; Schmolz M; Drewelow B; Eschmann K; Meiser P · Phytotherapy research : PTR · 2013
    Randomized trial12 participantsAnti-Inflammatory Support forBromelain
  4. An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study.
    Colletti A; Procchio C; Pisano M; Martelli A; Pellizzato M; Cravotto G · Nutrients · 2024
    Randomized trial42 participantsAnti-Inflammatory Support forBromelain
  5. Therapeutic uses of pineapple-extracted bromelain in surgical care - A review.
    Muhammad ZA; Ahmad T · JPMA. The Journal of the Pakistan Medical Association · 2019
    Narrative reviewAnti-Inflammatory Support forBromelain
  6. The role of enzyme supplementation in digestive disorders.
    Roxas M · Alternative medicine review : a journal of clinical therapeutic · 2009
    Narrative reviewDigestive Health forBromelain
  7. Effects of bromelain supplementation on disease activity and quality of life in patients with ulcerative colitis: a randomized, triple-blind, placebo-controlled study.
    Delgarm P; Mokhtare M; Ebrahimi Daryani N; Abolghasemi J; Rahideh ST · Scientific reports · 2025
    Randomized trial70 participantsDigestive Health forBromelain
  8. Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies.
    Brien S; Lewith G; Walker A; Hicks SM; Middleton D · Evidence-based complementary and alternative medicine : eCAM · 2024
    Narrative reviewJoint Health forBromelain
  9. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis.
    Kasemsuk T; Saengpetch N; Sibmooh N; Unchern S · Clinical rheumatology · 2017
    Randomized trial40 participantsJoint Health forBromelain
  10. Oral enzyme combination therapy reduces systemic inflammation, urinary CTXII and pain in knee osteoarthritis: a proof-of-mechanism, randomised, crossover, double-blind, placebo-controlled trial.
    Henrotin Y; Pap T; Lieten S; Badot V; Dubuc JE; Urbin-Choffray D; von Eynatten M; Johansen OE; Rau S; Brabants K · RMD open · 2025
    Randomized trial45 participantsJoint Health forBromelain
  11. Efficacy, tolerability, and safety of an oral enzyme combination vs diclofenac in osteoarthritis of the knee: results of an individual patient-level pooled reanalysis of data from six randomized controlled trials
    Ueberall MA, Mueller-Schwefe GH, Wigand R, Essner U · Journal of Pain Research · 2016
    Meta-analysis697 participants6 studies pooledJoint Health forBromelain
  12. The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults: a randomized, double-blind, placebo-controlled trial
    Bolten WW, Glade MJ, Raum S, Ritz BW · Arthritis · 2015
    Randomized trial150 participantsJoint Health forBromelain