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Bromelain 2400 GDU/g 500 mg

Protocol For Life Balance
4.9
★ ★ ★ ★ ★
(235 ratings)
Bromelain 500 mg
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Score82
Clearly stated 2,400 GDU per gram activity and a substantial amount are major strengths; delivery and goal-specific timing remain the practical gaps.
How scoring works
Quantity:90 Capsule(s) • (90 servings)
Goals:
Digestive Health
Anti-Inflammatory Support
Joint Health

Score 82

Clearly stated 2,400 GDU per gram activity and a substantial amount are major strengths; delivery and goal-specific timing remain the practical gaps.
How scoring works
$34.00($0.37 per serving)
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Analysis

The 500 mg amount and 2,400 GDU per gram activity provide a well-characterized enzyme dose. Bromelain directly supports protein digestion and may also support short-term tissue-comfort pathways when used away from food.

A regular capsule does not provide the protection of an enteric-coated tablet. The supplied label data also do not say whether to take it with meals for digestion or between meals for systemic use.

The mid-sized supply supports regular use without committing to the largest bottle. The formula remains narrow, so it does not address fiber, the microbiome, cartilage structure, or broader inflammatory pathways.

Who is it for
  • Adults who want a measurable bromelain dose
  • People seeking help digesting protein-rich meals
  • Users considering focused short-term tissue support
Best for
  • Protein digestion
  • Activity-standardized enzyme use
  • A simple single-ingredient routine

Pros

  • High bromelain amount
  • Activity disclosed at 2,400 GDU per gram
  • No unrelated active ingredients

Cons

  • No enteric coating
  • Meal timing is not provided
  • Single-enzyme coverage is narrow

Warnings

  • Bromelain may increase bruising or bleeding when combined with anticoagulant or antiplatelet medicines.
  • People planning surgery should ask the surgical team when to stop bromelain because of its effect on bleeding tendency.
  • People with pineapple allergy may also react to pineapple-derived bromelain.

Nutrient quality

91 Highest impact

High-activity bromelain provides a strong standalone enzyme serving. Its potency is clear, but standard capsule delivery and missing meal timing limit systemic-use confidence.

Ingredient transparency

82 Highest impact

Listed active ingredients have specific amounts and no proprietary blend hides their doses. Bromelain activity, meal timing, full source details, or non-active ingredients remain incompletely disclosed.

Customer satisfaction

71 High impact

The aggregate rating is strong and is supported by a moderate review sample. No review comments are supplied, so recurring complaints and fit with the intended use cannot be checked.

Value for money

80 Highest impact

The effective serving offers good value relative to formula quality. A focused or coherent ingredient list supports efficient spending.

Report analysis

Goals

Digestive Health
Impact
Highest effect
A- Goal FitA+ Strength of SupportC- CoverageA+ Formula Quality
Bromelain · 500 mg

High-activity bromelain directly supports protein breakdown and may ease digestive work around protein-rich meals. The 500 mg amount and 2400 GDU per gram activity are clearly specified.

The single-enzyme formula provides strong depth but no fiber, probiotic, or mucosal support. Bromelain may increase bleeding tendency when combined with anticoagulant or antiplatelet medicines.

Study evidence
Bromelain Supportive 2 studies
Anti-Inflammatory Support
Impact
High effect
B- Goal FitA- Strength of SupportC- CoverageA Formula Quality

Bromelain provides a focused enzyme approach that may help with acute swelling and tissue stress. Its evidence is more situational than the evidence for broad daily inflammatory balance.

The stated enzyme potency and substantial amount make the active exposure unusually clear. Systemic use may depend on taking it away from meals, and bromelain can raise bleeding risk with anticoagulants or around surgery.

Study evidence
Bromelain Supportive 12 studies
Joint Health
Impact
High effect
C+ Goal FitA- Strength of SupportC- CoverageA+ Formula Quality

A full-strength bromelain serving with declared 2400 GDU per gram activity offers focused support for joint-comfort pathways. Human evidence is promising but less established than for the leading structural and botanical joint ingredients.

The capsule lacks enteric protection and the supplied directions do not explain between-meal use for systemic effects. Bromelain may increase bleeding tendency in people using anticoagulant or antiplatelet medicines.

Study evidence
Bromelain Mixed 5 studies

Ingredients

IngredientAmount per serving
Bromelain (Pineapple)
500 mg
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
A Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyB+ Value

The label provides a strong standalone bromelain dose with clearly stated high enzyme activity. A standard capsule is only partly aligned for systemic use, and the available data do not specify meal timing. Cost efficiency is good, while the exact pineapple plant part remains undisclosed.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of Oral Administration of Bromelain on Postoperative Discomfort After Third Molar Surgery.
    Ghensi P; Cucchi A; Creminelli L; Tomasi C; Zavan B; Maiorana C · The Journal of craniofacial surgery · 2018
    Randomized trial84 participantsAnti-Inflammatory Support forBromelain
  2. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis.
    Kasemsuk T; Saengpetch N; Sibmooh N; Unchern S · Clinical rheumatology · 2017
    Randomized trial40 participantsJoint Health forBromelain
  3. The role of enzyme supplementation in digestive disorders.
    Roxas M · Alternative medicine review : a journal of clinical therapeutic · 2009
    Narrative reviewDigestive Health forBromelain
  4. Is bromelain an effective drug for the control of pain and inflammation associated with impacted third molar surgery? Systematic review and meta-analysis.
    de A C Almeida R; de Sousa Lima FCM; do E Vasconcelos BC · International journal of oral and maxillofacial surgery · 2019
    Meta-analysis252 participants5 studies pooledAnti-Inflammatory Support forBromelain
  5. Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies.
    Brien S; Lewith G; Walker A; Hicks SM; Middleton D · Evidence-based complementary and alternative medicine : eCAM · 2024
    Narrative reviewAnti-Inflammatory Support Joint Health forBromelain
  6. Therapeutic efficacy of bromelain in impacted third molar surgery: a randomized controlled clinical study.
    Ordesi P; Pisoni L; Nannei P; Macchi M; Borloni R; Siervo S · Quintessence international (Berlin, Germany : 1985) · 2016
    Randomized trial80 participantsAnti-Inflammatory Support forBromelain
  7. Efficacy of proteolytic enzyme bromelain on health outcomes after third molar surgery. Systematic review and meta-analysis of randomized clinical trials.
    Mendes ML; do Nascimento-Júnior EM; Reinheimer DM; Martins-Filho PR · Medicina oral, patologia oral y cirugia bucal · 2019
    Meta-analysis6 studies pooledAnti-Inflammatory Support forBromelain
  8. Bromelain supplementation and inflammatory markers: A systematic review of clinical trials.
    Pereira IC; Sátiro Vieira EE; de Oliveira Torres LR; Carneiro da Silva FC; de Castro E Sousa JM; Torres-Leal FL · Clinical nutrition ESPEN · 2023
    Systematic review7 studies pooledAnti-Inflammatory Support forBromelain
  9. Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain.
    Müller S; März R; Schmolz M; Drewelow B; Eschmann K; Meiser P · Phytotherapy research : PTR · 2013
    Randomized trial12 participantsAnti-Inflammatory Support forBromelain
  10. Prospective double-blind clinical trial evaluating the effectiveness of Bromelain in the third molar extraction postoperative period.
    de la Barrera-Núñez MC; Yáñez-Vico RM; Batista-Cruzado A; Heurtebise-Saavedra JM; Castillo-de Oyagüe R; Torres-Lagares D · Medicina oral, patologia oral y cirugia bucal · 2014
    Randomized trial34 participantsAnti-Inflammatory Support forBromelain
  11. Therapeutic uses of pineapple-extracted bromelain in surgical care - A review.
    Muhammad ZA; Ahmad T · JPMA. The Journal of the Pakistan Medical Association · 2019
    Narrative reviewAnti-Inflammatory Support forBromelain
  12. An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study.
    Colletti A; Procchio C; Pisano M; Martelli A; Pellizzato M; Cravotto G · Nutrients · 2024
    Randomized trial42 participantsAnti-Inflammatory Support forBromelain
  13. Effects of bromelain supplementation on disease activity and quality of life in patients with ulcerative colitis: a randomized, triple-blind, placebo-controlled study.
    Delgarm P; Mokhtare M; Ebrahimi Daryani N; Abolghasemi J; Rahideh ST · Scientific reports · 2025
    Randomized trial70 participantsDigestive Health forBromelain
  14. Oral enzyme combination therapy reduces systemic inflammation, urinary CTXII and pain in knee osteoarthritis: a proof-of-mechanism, randomised, crossover, double-blind, placebo-controlled trial.
    Henrotin Y; Pap T; Lieten S; Badot V; Dubuc JE; Urbin-Choffray D; von Eynatten M; Johansen OE; Rau S; Brabants K · RMD open · 2025
    Randomized trial45 participantsJoint Health forBromelain
  15. Efficacy, tolerability, and safety of an oral enzyme combination vs diclofenac in osteoarthritis of the knee: results of an individual patient-level pooled reanalysis of data from six randomized controlled trials
    Ueberall MA, Mueller-Schwefe GH, Wigand R, Essner U · Journal of Pain Research · 2016
    Meta-analysis697 participants6 studies pooledJoint Health forBromelain
  16. The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults: a randomized, double-blind, placebo-controlled trial
    Bolten WW, Glade MJ, Raum S, Ritz BW · Arthritis · 2015
    Randomized trial150 participantsJoint Health forBromelain