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Specially-Coated Bromelain 500 mg

Life Extension
4.6
★ ★ ★ ★ ★
(2627 ratings)
Bromelain 500 mg
Product Image
Score82
Coated delivery and a high ingredient weight are useful, but the missing enzyme-activity value keeps potency uncertain.
How scoring works
Quantity:60 Tablet(s) • (60 servings)
Goals:
Anti-Inflammatory Support
Digestive Health
Joint Health

Score 82

Coated delivery and a high ingredient weight are useful, but the missing enzyme-activity value keeps potency uncertain.
How scoring works
$15.75($0.26 per serving)
iHerb
$ 15.75
Amazon
$ 15.75
Vitacost
$ 15.75
Pure Formulas
$ 15.75
Report prices

Analysis

The 500 mg bromelain weight is substantial for protein digestion or focused tissue-comfort support. A coated tablet may protect more enzyme through the stomach than a standard capsule.

The label does not provide GDU or FIP activity, so the functional strength cannot be compared reliably. Pineapple is named, but the plant part and between-meal directions are not supplied.

The serving value is strong for a protected tablet, and the small calcium addition does not materially affect the formula. Buyers who prioritize delivery may prefer it over plain capsules, while activity-focused shoppers still lack key data.

Who is it for
  • Adults prioritizing protected bromelain delivery
  • People considering between-meal systemic use
  • Users who prefer tablets
Best for
  • Systemic enzyme routines
  • Protein digestion
  • Users wanting more protection from stomach acid

Pros

  • Substantial bromelain amount
  • Specially coated tablet
  • Good serving value

Cons

  • No enzyme activity units
  • Pineapple plant part is not listed
  • Timing instructions are absent

Warnings

  • Bromelain may increase bruising or bleeding when combined with anticoagulant or antiplatelet medicines.
  • People planning surgery should ask the surgical team when to stop bromelain because of its effect on bleeding tendency.
  • People with pineapple allergy may also react to pineapple-derived bromelain.

Nutrient quality

86 Highest impact

A protected tablet and substantial bromelain amount support systemic enzyme delivery. Missing activity units and meal timing still limit precise potency assessment.

Ingredient transparency

80 Highest impact

Listed active ingredients have specific amounts and no proprietary blend hides their doses. Bromelain activity, meal timing, full source details, or non-active ingredients remain incompletely disclosed.

Customer satisfaction

72 High impact

The aggregate rating is favorable and is supported by a large review sample. No review comments are supplied, so recurring complaints and fit with the intended use cannot be checked.

Value for money

87 Highest impact

The effective serving offers strong value relative to formula quality. A focused or coherent ingredient list supports efficient spending.

Report analysis

Goals

Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
C+ Goal FitB+ Strength of SupportC- CoverageA Formula Quality

A full bromelain amount with enteric coating is well suited to focused systemic enzyme use. Evidence is most relevant to acute swelling and tissue recovery rather than broad chronic inflammatory control.

Pineapple is named, but enzyme activity units, plant part, and between-meal timing are not disclosed. Bromelain may increase bleeding tendency in people using anticoagulant or antiplatelet medicines.

Study evidence
Bromelain Supportive 12 studies
Digestive Health
Digestive Health
Impact
High effect
B Goal FitB Strength of SupportD CoverageA- Formula Quality
Bromelain · 500 mg

Bromelain provides focused enzyme support for protein digestion and may reduce post-meal heaviness or bloating. The full ingredient weight is disclosed, but the missing activity units prevent a reliable judgment of enzyme potency.

Enteric coating protects the tablet from stomach acid, although absent meal-timing directions make its digestive use less clear. Bromelain may increase bleeding risk with anticoagulant or antiplatelet medicines, which is the main product-specific caution.

Study evidence
Bromelain Supportive 2 studies
Joint Health
Joint Health
Impact
High effect
B- Goal FitB Strength of SupportD- CoverageA Formula Quality

Bromelain may help inflammatory joint discomfort through systemic proteolytic enzyme activity. The 500 mg amount and enteric coating support targeted use beyond digestion.

Enzyme activity units are not disclosed, so potency cannot be compared reliably across products or trials. Bromelain may increase bleeding risk with anticoagulant or antiplatelet medicines and around surgery.

Study evidence
Bromelain Mixed 5 studies

Ingredients

IngredientAmount per serving
Calcium (Calcium Carbonate)
 75 mg
Bromelain (Pineapple)
 500 mg
Adults 18–50
Report overview
Bromelain (Pineapple) · 500 mg OverallScore56
D Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyB+ Value

The full bromelain dose and enteric coating align well with systemic enzyme use. Pineapple is named, but the stem and enzyme activity are not disclosed, leaving source precision and potency uncertain. Its standardized cost offers good value for a protected high-dose tablet.

View ingredientView products
Loading alternative details
86 Performance

Bromelain 2400 GDU/g - 500 mg

NOW
Ingredient quality is stronger because the formula provides 500 mg of pineapple bromelain with 2400 GDU/g activity. The focused formula is easy to compare, although it provides no complementary enzymes or botanicals.
83 Performance

High Potency Bromelain 3000 GDU 500 mg

Doctor's Best
Ingredient quality is stronger because the formula provides 500 mg of bromelain with higher activity stated in the product name. The supplied ingredient record does not repeat the activity units, and the single-ingredient design adds no complementary enzymes.
82 Performance

Bromelain 2400 GDU/g 500 mg

Protocol For Life Balance
Ingredient quality is stronger because the formula provides 500 mg of pineapple bromelain with 2400 GDU/g activity. The focused formula is easy to compare, although it provides no complementary enzymes or botanicals.
81 Budget

Bromelain 500 mg

AN Amazing Nutrition Amazing Formulas
The lower-cost serving provides 500 mg of pineapple bromelain in a focused formula. Activity units are not disclosed, so the low cost comes with less potency information.
77 Budget

Bromelain 500 mg

Herbal Secrets
The lower-cost serving provides 500 mg of pineapple bromelain in a very simple formula. Activity units are not disclosed, so its potency evidence is limited.
79 Budget

Bromelain 500 mg

Source Naturals
The lower-cost serving provides 500 mg of bromelain with a small amount of calcium. The bromelain source and activity units are not disclosed.
81 Value

Bromelain 500 mg

The Vitamin Shoppe
The value balance improves because the lower-cost serving provides 500 mg of pineapple bromelain in a focused formula. Activity units are not disclosed, so enzyme strength cannot be compared precisely.
82 Value

Bromelain 500 mg

Natural Factors
The value balance improves because the lower-cost serving provides 500 mg of pineapple-extract bromelain in a simple formula. Activity units are not disclosed, which makes enzyme potency harder to compare.
79 Value

Bromelain 500 mg

Nutricost
The value balance improves because the lower-cost serving provides 500 mg of pineapple bromelain without unrelated active ingredients. Activity units are not disclosed, which limits confidence in potency.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of Oral Administration of Bromelain on Postoperative Discomfort After Third Molar Surgery.
    Ghensi P; Cucchi A; Creminelli L; Tomasi C; Zavan B; Maiorana C · The Journal of craniofacial surgery · 2018
    Randomized trial84 participantsAnti-Inflammatory Support forBromelain
  2. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis.
    Kasemsuk T; Saengpetch N; Sibmooh N; Unchern S · Clinical rheumatology · 2017
    Randomized trial40 participantsJoint Health forBromelain
  3. The role of enzyme supplementation in digestive disorders.
    Roxas M · Alternative medicine review : a journal of clinical therapeutic · 2009
    Narrative reviewDigestive Health forBromelain
  4. Is bromelain an effective drug for the control of pain and inflammation associated with impacted third molar surgery? Systematic review and meta-analysis.
    de A C Almeida R; de Sousa Lima FCM; do E Vasconcelos BC · International journal of oral and maxillofacial surgery · 2019
    Meta-analysis252 participants5 studies pooledAnti-Inflammatory Support forBromelain
  5. Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies.
    Brien S; Lewith G; Walker A; Hicks SM; Middleton D · Evidence-based complementary and alternative medicine : eCAM · 2024
    Narrative reviewAnti-Inflammatory Support Joint Health forBromelain
  6. Therapeutic efficacy of bromelain in impacted third molar surgery: a randomized controlled clinical study.
    Ordesi P; Pisoni L; Nannei P; Macchi M; Borloni R; Siervo S · Quintessence international (Berlin, Germany : 1985) · 2016
    Randomized trial80 participantsAnti-Inflammatory Support forBromelain
  7. Efficacy of proteolytic enzyme bromelain on health outcomes after third molar surgery. Systematic review and meta-analysis of randomized clinical trials.
    Mendes ML; do Nascimento-Júnior EM; Reinheimer DM; Martins-Filho PR · Medicina oral, patologia oral y cirugia bucal · 2019
    Meta-analysis6 studies pooledAnti-Inflammatory Support forBromelain
  8. Bromelain supplementation and inflammatory markers: A systematic review of clinical trials.
    Pereira IC; Sátiro Vieira EE; de Oliveira Torres LR; Carneiro da Silva FC; de Castro E Sousa JM; Torres-Leal FL · Clinical nutrition ESPEN · 2023
    Systematic review7 studies pooledAnti-Inflammatory Support forBromelain
  9. Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain.
    Müller S; März R; Schmolz M; Drewelow B; Eschmann K; Meiser P · Phytotherapy research : PTR · 2013
    Randomized trial12 participantsAnti-Inflammatory Support forBromelain
  10. Prospective double-blind clinical trial evaluating the effectiveness of Bromelain in the third molar extraction postoperative period.
    de la Barrera-Núñez MC; Yáñez-Vico RM; Batista-Cruzado A; Heurtebise-Saavedra JM; Castillo-de Oyagüe R; Torres-Lagares D · Medicina oral, patologia oral y cirugia bucal · 2014
    Randomized trial34 participantsAnti-Inflammatory Support forBromelain
  11. Therapeutic uses of pineapple-extracted bromelain in surgical care - A review.
    Muhammad ZA; Ahmad T · JPMA. The Journal of the Pakistan Medical Association · 2019
    Narrative reviewAnti-Inflammatory Support forBromelain
  12. An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study.
    Colletti A; Procchio C; Pisano M; Martelli A; Pellizzato M; Cravotto G · Nutrients · 2024
    Randomized trial42 participantsAnti-Inflammatory Support forBromelain
  13. Effects of bromelain supplementation on disease activity and quality of life in patients with ulcerative colitis: a randomized, triple-blind, placebo-controlled study.
    Delgarm P; Mokhtare M; Ebrahimi Daryani N; Abolghasemi J; Rahideh ST · Scientific reports · 2025
    Randomized trial70 participantsDigestive Health forBromelain
  14. Oral enzyme combination therapy reduces systemic inflammation, urinary CTXII and pain in knee osteoarthritis: a proof-of-mechanism, randomised, crossover, double-blind, placebo-controlled trial.
    Henrotin Y; Pap T; Lieten S; Badot V; Dubuc JE; Urbin-Choffray D; von Eynatten M; Johansen OE; Rau S; Brabants K · RMD open · 2025
    Randomized trial45 participantsJoint Health forBromelain
  15. Efficacy, tolerability, and safety of an oral enzyme combination vs diclofenac in osteoarthritis of the knee: results of an individual patient-level pooled reanalysis of data from six randomized controlled trials
    Ueberall MA, Mueller-Schwefe GH, Wigand R, Essner U · Journal of Pain Research · 2016
    Meta-analysis697 participants6 studies pooledJoint Health forBromelain
  16. The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults: a randomized, double-blind, placebo-controlled trial
    Bolten WW, Glade MJ, Raum S, Ritz BW · Arthritis · 2015
    Randomized trial150 participantsJoint Health forBromelain