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Nugenix Ultimate

Nugenix
4.2
★ ★ ★ ★ ★
(5312 ratings)
Stinging Nettle 300 mg
Boron 10 mg
Fenugreek 700 mg
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Score70
A fully dosed-looking testosterone blend with many disclosed actives and strong chelated boron. Missing botanical standardization, medicine interactions, and high cost keep it from being an easy choice.
How scoring works
Quantity:120 Tablet(s) • (30 servings)
Goals:
Testosterone Support
Anti-Inflammatory Support
General Health

Score 70

A fully dosed-looking testosterone blend with many disclosed actives and strong chelated boron. Missing botanical standardization, medicine interactions, and high cost keep it from being an easy choice.
How scoring works
$67.99($2.26 per serving)
Amazon
$ 71.99
iHerb
$ 67.99
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Analysis

D-aspartic acid leads the serving, supported by substantial fenugreek, epimedium, nettle root, maca, tongkat ali, mucuna, and boron. The breadth is notable, but most botanical extracts do not quantify their active-marker yields.

Testosterone support is the strongest fit, while general and anti-inflammatory goals receive less direct coverage. Several ingredients overlap around libido or hormone pathways, and their combined value is harder to predict than their individual amounts suggest.

The label avoids a proprietary blend and makes the major doses visible. Four tablets and a very high serving cost weaken value, particularly when users must also screen the formula for dopamine, blood-glucose, blood-pressure, and clotting interactions.

Who is it for
  • Adult men specifically seeking a broad testosterone-support blend
  • Experienced users able to screen multiple botanical interactions
  • People who value full dose disclosure over a simple formula
Best for
  • Testosterone-oriented supplementation
  • Multi-pathway male-vitality support
  • Users wanting D-aspartic acid with botanicals

Pros

  • Discloses every major active amount
  • Uses a well-absorbed boron form
  • Includes substantial nettle root and fenugreek

Cons

  • Most botanical active markers are not quantified
  • Serving cost is very high
  • Four-tablet formula creates substantial interaction complexity

Warnings

  • Mucuna supplies L-Dopa and can interact with levodopa, antipsychotics, and other dopamine-active medicines.
  • Fenugreek may lower blood glucose and increase bleeding risk with related medicines.
  • Epimedium and tongkat ali may affect blood pressure or hormone-related treatment, so combined use needs careful review.

Nutrient quality

76 High impact

Several key ingredients reach meaningful amounts and fit the testosterone-focused purpose. High boron, mixed evidence, incomplete botanical standardization, and a complex stimulant-like stack reduce balance and safety confidence.

Ingredient transparency

74 High impact

Every named active has an individual amount and no proprietary blend hides the formula. Missing extract ratios, marker percentages, directions, and non-active tablet ingredients reduce potency assessment.

Customer satisfaction

67 High impact

The aggregate rating provides useful satisfaction context, with confidence shaped by the response count. No review text is supplied, so repeated complaints and purpose-specific experiences cannot be verified.

Value for money

60 Moderate impact

Broad ingredient coverage and several substantial doses provide some practical value. The high ongoing cost, mixed evidence, and incomplete standardization make the formula weakly competitive.

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Goals

Testosterone Support
Impact
High effect
B Goal FitB+ Strength of SupportA- CoverageB- Formula Quality
Boron · 10 mg

D-aspartic acid, fenugreek, nettle root, tongkat ali, and boron create broad testosterone-focused coverage, with several actives at meaningful amounts. Boron and fenugreek have relevant human evidence, while findings for D-aspartic acid and several other botanicals are less consistent.

The label discloses every amount but often omits extract ratios or active-marker percentages, which weakens confidence in botanical potency. Mucuna supplies an L-Dopa-bearing extract and fenugreek may lower blood sugar, so users taking dopamine-active or glucose-lowering medicines need product-specific medical guidance.

Study evidence
Boron Disputed 3 studies
Fenugreek Supportive 12 studies
Anti-Inflammatory Support
Impact
Moderate effect
D- Goal FitC Strength of SupportD+ CoverageC- Formula Quality

Nettle root offers some context-specific inflammatory relevance, but the formula is designed mainly for testosterone and performance support. Several botanicals are substantial, yet most do not directly target the selected goal.

The broad blend emphasizes endocrine and sexual-health pathways rather than a balanced anti-inflammatory strategy. Mucuna supplies L-Dopa and may interact with dopaminergic or antipsychotic medicines, while fenugreek may lower blood sugar.

Study evidence
Stinging Nettle Supportive 5 studies
General Health
Impact
Moderate effect
F Goal FitC Strength of SupportC- CoverageD+ Formula Quality
Boron · 10 mg

The formula combines a meaningful boron amount with several botanicals and amino-acid-related compounds aimed at male hormonal and performance support. That narrow purpose is less aligned with foundational daily health than a vitamin, mineral, or essential-fat formula.

Boron uses an absorbable organic form, but the high amount is better suited to a defined use than casual maintenance. Mucuna supplies an L-Dopa source that may interact with levodopa, dopamine-blocking medicines, or some psychiatric treatments, while the large botanical mix makes benefits and tolerability harder to predict.

Study evidence
Boron Supportive 6 studies

Ingredients

IngredientAmount per serving
D-Aspartic Acid
3000 mg
Fenugreek Seed Extract (Saponins)
700 mg
Epimedium Aerial Part Extract (Icariins)
625 mg
Stinging Nettle root extract
300 mg
Maca Root Extract
200 mg
Eurycoma longifolia root extract
150 mg
Mucuna pruriens seed extract (L-Dopa)
125 mg
Boron (Bororganic Glycine)
10 mg
Men 18–50
Report overview
Stinging Nettle · 300 mg OverallScore78
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Nettle root is appropriately chosen for a testosterone-focused formula. The 300 mg extract dose is useful, though no active-marker standardization or concentration ratio is given. The very high cost is the main drawback.

A- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

Bororganic glycine is a well-absorbed form, but the label does not identify a validated trademark or purity certification. The 10 mg dose sits at the upper end of the higher clinical range and may be better suited to limited, goal-specific use than routine maintenance. Its high serving cost makes it poor value when judged only as a boron source.

F Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyF Value

The fenugreek amount is substantial, but the label does not identify a branded extract or quantify its saponin yield. Standard tablets add no absorption support. The high serving cost is difficult to justify for fenugreek-focused use despite the broad testosterone-support formula.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The effect of hydro alcoholic Nettle (Urtica dioica) extracts on insulin sensitivity and some inflammatory indicators in patients with type 2 diabetes: a randomized double-blind control trial.
    Namazi N; Esfanjani AT; Heshmati J; Bahrami A · Pakistan journal of biological sciences : PJBS · 2012
    Randomized trial50 participantsAnti-Inflammatory Support forStinging Nettle
  2. Urtica Dioica Root Extract on Clinical and Biochemical Parameters in Patients with Benign Prostatic Hyperplasia, Randomized Controlled Trial.
    Akbar Karami A; Sheikhsoleimani M; Reza Memarzadeh M; Haddadi E; Bakhshpour M; Mohammadi N; Mehdi Mirhashemi S · Pakistan journal of biological sciences : PJBS · 2021
    Randomized trial60 participantsAnti-Inflammatory Support forStinging Nettle
  3. Safety, Tolerability, and Efficacy of Hox Alpha, a Dry Extract from Stinging Nettle Leaves versus OTC NSAIDs in Osteoarthritis: A Retrospective, Propensity-Matched 12-Week Analysis from the German Pain e-Registry (SIPHARO Study).
    Überall MA; Küster MA; Müller-Schwefe PCG; Müller-Schwefe GHH · Journal of pain research · 2026
    Cohort study2,146 participantsAnti-Inflammatory Support forStinging Nettle
  4. [Recommendations of the DGRh Committee on Complementary Medicine and Nutrition on the application of selected phytotherapeutic drugs and herbal medicines in rheumatology].
    Keyßer G; Seifert O; Frohne I; Michalsen A; Pfeil A; Reuß-Borst M; Sander O · Zeitschrift fur Rheumatologie · 2025
    Guideline / consensusAnti-Inflammatory Support forStinging Nettle
  5. Randomized controlled trial of nettle sting for treatment of base-of-thumb pain
    C Randall, H Randall, F Dobbs, C Hutton, H Sanders · Journal of the Royal Society of Medicine · 2000
    Randomized trial27 participantsAnti-Inflammatory Support forStinging Nettle
  6. Effects of boron supplementation on the severity and duration of pain in primary dysmenorrhea.
    Nikkhah S; Dolatian M; Naghii MR; Zaeri F; Taheri SM · Complementary therapies in clinical practice · 2015
    Randomized trial113 participantsGeneral Health forBoron
  7. Efficacy and safety of tavaborole topical solution, 5%, a novel boron-based antifungal agent, for the treatment of toenail onychomycosis: Results from 2 randomized phase-III studies.
    Elewski BE; Aly R; Baldwin SL; González Soto RF; Rich P; Weisfeld M; Wiltz H; Zane LT; Pollak R · Journal of the American Academy of Dermatology · 2015
    Randomized trialGeneral Health forBoron
  8. The efficacy and safety of tavaborole, a novel, boron-based pharmaceutical agent: phase 2 studies conducted for the topical treatment of toenail onychomycosis.
    Toledo-Bahena ME; Bucko A; Ocampo-Candiani J; Herz-Ruelas ME; Jones TM; Jarratt MT; Pollak RA; Zane LT · Journal of drugs in dermatology : JDD · 2015
    Clinical trial336 participantsGeneral Health forBoron
  9. Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA).
    Henriksson R; Capala J; Michanek A; Lindahl SA; Salford LG; Franzén L; Blomquist E; Westlin JE; Bergenheim AT; Swedish Brain Tumour Study Group · Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2009
    Single-arm trial30 participantsGeneral Health forBoron
  10. Effects of Calcium Fructoborate on Levels of C-Reactive Protein, Total Cholesterol, Low-Density Lipoprotein, Triglycerides, IL-1β, IL-6, and MCP-1: a Double-blind, Placebo-controlled Clinical Study
    Otilia-Constantina Rogoveanu, George Dan Mogosanu, Cornelia Bejenaru, Ludovic Everard Bejenaru, Octavian Croitoru, Johny Neamtu, Zbigniew Pietrzkowski, Tania Reyes-Izquierdo, Andrei Bita, Iulia Daria Scorei, Romulus Ion Scorei · Biological Trace Element Research · 2015
    Randomized trial78 participantsGeneral Health forBoron
  11. Biochemical and physiologic consequences of boron deprivation in humans.
    Nielsen FH · Environmental health perspectives · 1995
    Single-arm trial12 participantsTestosterone Support forBoron
  12. Plasma boron and the effects of boron supplementation in males.
    Green NR; Ferrando AA · Environmental health perspectives · 1995
    Randomized trial19 participantsTestosterone Support forBoron
  13. Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines
    Mohammad Reza Naghii, Mahmoud Mofid, Ali Reza Asgari, Mehdi Hedayati, Maryam-Saddat Daneshpour · Journal of Trace Elements in Medicine and Biology · 2011
    Non-randomized trial8 participantsTestosterone Support forBoron
  14. Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a double-blind randomised clinical study.
    Rao A; Steels E; Inder WJ; Abraham S; Vitetta L · The aging male : the official journal of the International Society for the Study of the Aging Male · 2017
    Randomized trial120 participantsTestosterone Support forFenugreek
  15. Effect of a plant extract of fenugreek (Trigonella foenum-graecum) on testosterone in blood plasma and saliva in a double blind randomized controlled intervention study.
    Lee-Ødegård S; Gundersen TE; Drevon CA · PloS one · 2024
    Randomized trial95 participantsTestosterone Support forFenugreek
  16. Examining the Effects of Herbs on Testosterone Concentrations in Men: A Systematic Review.
    Smith SJ; Lopresti AL; Teo SYM; Fairchild TJ · Advances in nutrition (Bethesda, Md.) · 2021
    Systematic review32 studies pooledTestosterone Support forFenugreek
  17. Efficacy of a novel extract of fenugreek seeds in alleviating vasomotor symptoms and depression in perimenopausal women: A randomized, double-blinded, placebo-controlled study.
    Khanna A; John F; Das S; Thomas J; Rao J; Maliakel B; Im K · Journal of food biochemistry · 2021
    Randomized trial48 participantsTestosterone Support forFenugreek
  18. Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training: A randomized controlled pilot study.
    Wankhede S; Mohan V; Thakurdesai P · Journal of sport and health science · 2024
    Randomized trial60 participantsTestosterone Support forFenugreek