ATP Cofactors
Optimox
ATP Cofactors
4.8
★ ★ ★ ★ ★
(513 ratings)
Niacin 500 mg
Riboflavin 100 mg
Score 88.0
A high-dose, 'no-flush' Niacin and Riboflavin combination, ideal for energy, metabolism, and cardiovascular support without the typical Niacin side effects.
Quantity: 90 Tablet(s)Servings size: 1 Tablet(s) (90 servings)
Selected goals:
Other goals:
Heart Health
Skin Health
Energy
Metabolism Boost
General Health
leaderboard Score 88.0
A high-dose, 'no-flush' Niacin and Riboflavin combination, ideal for energy, metabolism, and cardiovascular support without the typical Niacin side effects.
insights Analysis
Optimox ATP Cofactors is a targeted supplement delivering 500mg of Niacin in the Inositol Hexanicotinate form and 100mg of Riboflavin. The choice of Inositol Hexanicotinate is a key advantage, as it significantly reduces the unpleasant flushing sensation often associated with other forms of Niacin, making it a more tolerable option for consumers. Both Niacin and Riboflavin are essential B vitamins crucial for numerous metabolic processes, especially energy production (ATP), and play roles in heart health, skin health, and vision. The dosages provided are quite high, suggesting a focus on therapeutic or higher-level support rather than just basic dietary supplementation. While effective for its specific blend, it does not offer a comprehensive B-complex, meaning individuals seeking a full spectrum of B vitamins would need additional supplements.
- Utilizes Inositol Hexanicotinate form of Niacin, significantly reducing the 'niacin flush' side effect, which is highly valued by consumers.
- Provides high dosages of both Niacin (500mg) and Riboflavin (100mg), beneficial for individuals needing therapeutic levels or targeting specific deficiencies.
- The combination of these two essential B vitamins directly supports various metabolic processes and energy production.
- The high dosages of Niacin and Riboflavin may be excessive for individuals without specific deficiencies or therapeutic needs, potentially leading to unnecessary intake.
- Lacks other B vitamins found in a comprehensive B-complex, meaning a user might need additional supplements to cover a broader range of B vitamin needs.
- High doses of Niacin, even in the no-flush form, can still cause gastrointestinal upset or liver enzyme elevation in sensitive individuals, though less common than with nicotinic acid.
- Riboflavin can cause bright yellow urine, which is harmless but can be startling for new users.
$34.99($0.38 per serving)
 Pure Formulas | $ 34.99 | |
 iHerb | $ 34.99 |
bolt Effectiveness for goals
Niacin (specifically nicotinic acid) can be effective in helping to manage cholesterol by lowering LDL ("bad") cholesterol and triglycerides, and raising HDL ("good") cholesterol. This effect typically requires higher doses, often under medical supervision. The flush response is a common side effect at these doses.
Niacin's primary effectiveness claims include supporting cardiovascular health, particularly by influencing cholesterol levels at higher doses. It is also essential for metabolism, helping convert food into energy, and plays a role in DNA repair. Furthermore, Niacin is effective in preventing and treating pellagra, its deficiency disease.
Riboflavin is effective in supporting cellular energy production and metabolism. It also plays a role in maintaining healthy vision and skin. Some evidence suggests its effectiveness in potentially reducing migraine frequency in certain individuals.
Some studies suggest that high-dose Riboflavin supplementation may help reduce the frequency and duration of migraine headaches in some individuals. This is thought to be due to its role in mitochondrial energy metabolism. Consistent supplementation for several months may be needed to observe potential benefits.
Riboflavin is a crucial component of coenzymes FAD and FMN, which play central roles in various metabolic pathways that produce energy. These coenzymes are essential for the electron transport chain, a key process in cellular energy generation. Adequate Riboflavin intake supports normal energy metabolism.
schedule Dosage, timing & forms
To help reduce the 'niacin flush,' which is common with immediate-release nicotinic acid, it is often recommended to take it with a meal or a small snack. Starting with a low dose and gradually increasing it can also help the body adapt. Alternatively, choosing flush-free forms like niacinamide or inositol hexanicotinate can prevent this sensation.
Niacin supplements are commonly available as nicotinic acid (which can cause a 'flush'), niacinamide (also known as nicotinamide, typically flush-free), and inositol hexanicotinate (also generally flush-free). Each form has distinct characteristics regarding absorption and potential side effects. The choice of form often depends on individual tolerance and specific health goals.
Taking niacin, especially the nicotinic acid form, with food is often recommended to help reduce gastrointestinal upset and the intensity of the 'niacin flush.' Riboflavin absorption may also be slightly enhanced when taken with food. Therefore, taking both supplements with a meal is generally a good practice.
The Recommended Dietary Allowance (RDA) for adult men is 1.3 mg/day and for adult women is 1.1 mg/day. Supplemental doses can vary widely, often ranging from 1.7 mg to over 100 mg, depending on individual needs or specific health conditions. Higher doses should be taken under the guidance of a healthcare professional.
Yes, extended-release (ER) forms of niacin are available. These formulations are designed to release niacin slowly over several hours, which can help reduce the severity of the niacin flush compared to immediate-release nicotinic acid. However, ER forms may have different side effect profiles and should generally be used under medical guidance.
health_and_safety Safety & interactions
The niacin flush is a common, harmless reaction characterized by redness, warmth, tingling, and itching of the skin, often occurring after taking niacin due to blood vessel dilation. To minimize it, taking niacin with food, starting with a low dose and gradually increasing, or using sustained-release forms may help, though sustained-release niacin has its own considerations. It typically subsides with continued use.
Yes, niacin can interact with certain medications, including statins, blood pressure medications, and blood thinners. Concurrent use with statins may increase the risk of muscle-related side effects, while interactions with blood pressure medications can lead to excessive drops in blood pressure. It is important to discuss all medications with a healthcare provider before starting niacin.
Yes, particularly at high doses, niacin can cause elevations in liver enzymes and, in rare cases, lead to liver damage. This risk is higher with sustained-release forms of niacin compared to immediate-release. Regular monitoring of liver function tests is recommended for individuals taking high-dose niacin.
Individuals with liver disease, active stomach ulcers, gout, or uncontrolled diabetes should exercise caution or avoid niacin supplementation, especially at high doses. Pregnant or breastfeeding women should also consult a healthcare professional. High doses of niacin can exacerbate these conditions.
Niacin, especially in higher doses, can potentially increase blood sugar levels, making it more challenging to manage diabetes. Individuals with diabetes who are considering niacin supplementation should do so under medical supervision. Blood glucose levels may need closer monitoring and medication adjustments.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Riboflavin | 100 mg |
Niacin | 500 mg |
Categories
Niacin 95.0
The product uses Inositol Hexanicotinate, a superior form for user comfort due to its 'no-flush' properties, while still delivering a high dose of Niacin.
Riboflavin 90.0
Provides a substantial dose of Riboflavin (100mg), which is effective for supporting functions where higher intake of B2 is beneficial, such as energy metabolism and eye health.
Goals
Energy 90.0
Niacin and Riboflavin are fundamental coenzymes in the body's primary energy production pathways (ATP synthesis), making them highly effective for supporting energy levels.
Metabolism Boost 90.0
As integral components of numerous metabolic enzymes, Niacin and Riboflavin are directly involved in the metabolism of carbohydrates, fats, and proteins, thereby supporting overall metabolic function.
Heart Health 85.0
Niacin (B3) is well-established for supporting cardiovascular health, particularly in managing lipid profiles, though the Inositol Hexanicotinate form has a less pronounced effect on cholesterol than nicotinic acid. Riboflavin also indirectly contributes by aiding homocysteine metabolism.
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