Product Image

Betaine Anhydrous

NutraBio
4.8
★ ★ ★ ★ ★
(109 ratings)
Betaine Anhydrous 1000 mg
Product Image
Score83
Transparent trimethylglycine and strong value make this useful for methylation, but it is not a digestive-acid supplement or full performance dose.
How scoring works
Quantity:90 Capsule(s) • (45 servings)
Goals:
Detoxification
Weight Gain

Score 83

Transparent trimethylglycine and strong value make this useful for methylation, but it is not a digestive-acid supplement or full performance dose.
How scoring works
$14.99($0.33 per serving)
iHerb
$ 14.99
Report prices

Analysis

One gram of trimethylglycine provides a fully disclosed methyl donor that can support SAMe production and a Phase II methylation pathway. The simple formula is easy to evaluate and avoids confusing anhydrous betaine with betaine hydrochloride.

The amount is useful for general methylation support but below a typical full performance serving. It may complement resistance training, yet it does not provide protein, calories, creatine, or recovery nutrients for weight gain.

Two capsules per serving and favorable value make routine use practical. It suits users focused on methylation or modest performance support, not people seeking stomach-acid or broad digestive help.

Who is it for
  • Adults seeking methylation support
  • Training-focused users adding trimethylglycine
Best for
  • A focused methyl-donor formula
  • General betaine anhydrous use

Pros

  • Trimethylglycine form is explicit
  • Fully disclosed active amount
  • Simple and economical formula

Cons

  • Below a typical full performance dose
  • Not betaine hydrochloride
  • Does not supply calories or protein

Warnings

  • Betaine anhydrous can cause nausea, stomach upset, or diarrhea in some users.
  • Trimethylglycine may raise LDL cholesterol in some people at higher intakes; monitor if cholesterol is a concern.
  • People with trimethylaminuria may notice stronger body odor from betaine use.

Nutrient quality

84 Highest impact

Betaine anhydrous is clearly identified as trimethylglycine. The amount is meaningful for general methylation but below a common full performance serving.

Ingredient transparency

84 Highest impact

The betaine amount is clearly disclosed. Excipients and daily directions are absent from the supplied data, which leaves some label details uncertain.

Customer satisfaction

69 High impact

The aggregate satisfaction average is exceptionally strong, though no detailed feedback is supplied. The moderate volume provides a reasonably useful aggregate satisfaction signal.

Value for money

93 Highest impact

A clear form and useful general dose support strong formula value. The serving cost is low for the disclosed trimethylglycine amount.

Report analysis

Goals

Detoxification
Impact
High effect
B Goal FitB+ Strength of SupportD- CoverageA+ Formula Quality
Betaine Anhydrous · 1000 mg

Betaine anhydrous directly donates methyl groups and can support SAMe production for Phase II methylation. The single-active formula is well aligned with one important pathway but does not cover antioxidant or intestinal clearance.

The 1 g amount is fully disclosed and meaningful for general methylation support. A clearly identified trimethylglycine form and no unrelated ingredients make the product focused and easy to evaluate.

Study evidence
Betaine Anhydrous Mixed 4 studies
Weight Gain
Impact
High effect
C+ Goal FitC+ Strength of SupportF CoverageA+ Formula Quality

Betaine anhydrous may support power and training volume, which can indirectly help lean-mass gain when paired with resistance training and adequate nutrition. The single ingredient does not supply protein, meaningful calories, creatine, or recovery support.

The anhydrous trimethylglycine form and exact amount are fully disclosed. The serving is below the usual full performance amount, so it is better suited to general betaine intake than a targeted hypertrophy-support protocol.

Study evidence
Betaine Anhydrous Disputed 13 studies

Ingredients

IngredientAmount per serving
Betaine Anhydrous (Trimethylglycine)
1000 mg
Gluten Free Adults 18–50 Kosher Vegetarian
Report overview
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The single-ingredient formula clearly identifies betaine anhydrous as trimethylglycine, removing uncertainty about the form. Its 1,000 mg serving comfortably supports a general wellness or methylation use case, and the amount is fully disclosed. Low serving cost and a simple capsule format provide strong value for users who do not need a full performance dose.

Loading alternative details
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Betaine consumption as a new clinical approach to treatment and prophylaxis of folate-related pathologies.
    Yeroshkina K; Rossokha Z; Fishchuk L; Gorovenko N · Nutrition reviews · 2023
    Narrative reviewDetoxification forBetaine Anhydrous
  2. Effects of betaine supplementation on cardiovascular markers: A systematic review and Meta-analysis.
    Ashtary-Larky D; Bagheri R; Ghanavati M; Asbaghi O; Tinsley GM; Mombaini D; Kooti W; Kashkooli S; Wong A · Critical reviews in food science and nutrition · 2022
    Meta-analysisDetoxification forBetaine Anhydrous
  3. Decoding Betaine: A Critical Analysis of Therapeutic Potential Compared with Marketing Hype-A Narrative Review.
    Nikrandt G; Chmurzynska A · The Journal of nutrition · 2024
    Narrative reviewDetoxification forBetaine Anhydrous
  4. Therapy of NAFLD: antioxidants and cytoprotective agents.
    Chang CY; Argo CK; Al-Osaimi AM; Caldwell SH · Journal of clinical gastroenterology · 2006
    Narrative reviewDetoxification forBetaine Anhydrous
  5. Effects of betaine on body composition, performance, and homocysteine thiolactone.
    Cholewa JM; Wyszczelska-Rokiel M; Glowacki R; Jakubowski H; Matthews T; Wood R; Craig SA; Paolone V · Journal of the International Society of Sports Nutrition · 2013
    Randomized trial23 participantsWeight Gain forBetaine Anhydrous
  6. Maternal Betaine and Methylation Potential during Pregnancy Are Associated with Child Growth at Birth and Early Childhood: Results of the Chilean Maternal & Infant Cohort Study-II.
    Trujillo-González I; Barisione G; Bottiglieri T; Reyes M; Garmendia ML; Mujica-Coopman MF · The Journal of nutrition · 2026
    Cohort study150 participantsWeight Gain forBetaine Anhydrous
  7. Serum betaine is inversely associated with low lean mass mainly in men in a Chinese middle-aged and elderly community-dwelling population.
    Huang BX; Zhu YY; Tan XY; Lan QY; Li CL; Chen YM; Zhu HL · The British journal of nutrition · 2017
    Cohort study1,996 participantsWeight Gain forBetaine Anhydrous
  8. Dietary betaine intake is associated with skeletal muscle mass change over 3 years in middle-aged adults: the Guangzhou Nutrition and Health Study.
    Long JA; Zhong RH; Chen S; Wang F; Luo Y; Lu XT; Yishake D; Chen YM; Fang AP; Zhu HL · The British journal of nutrition · 2021
    Cohort study1,242 participantsWeight Gain forBetaine Anhydrous
  9. Effects of Betaine Supplementation on Markers of Metabolic Flexibility, Body Composition, and Anaerobic Performance in Active College-Age Females.
    Waldman HS; Bryant AR; McAllister MJ · Journal of dietary supplements · 2023
    Randomized trial23 participantsWeight Gain forBetaine Anhydrous