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St. John's Wort

Oregon's Wild Harvest
4.6
★ ★ ★ ★ ★
(39 ratings)
St. John's Wort 1000 mg
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Score70

Substantial fresh-herb weight and liquid flexibility are useful. Active potency is uncertain because the extract and marker details are missing.

How scoring works
Quantity:2 Liquid(s) • (59 servings)
Goals:
Mood Support

Score 70

Substantial fresh-herb weight and liquid flexibility are useful. Active potency is uncertain because the extract and marker details are missing.

How scoring works
$28.76($0.48 per serving)
Vitacost
$ 28.76
iHerb
$ 28.76
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Analysis

A liquid serving is listed as the equivalent of 1,000 mg of fresh organic St. John’s wort. Flexible delivery may suit people who cannot swallow capsules.

The label does not identify the plant part, concentration ratio, hypericin, or hyperforin. Fresh-herb weight alone cannot establish the active potency of the liquid.

The single-herb approach is focused, but the serving value is only moderate for such uncertain standardization. Medication and sun-sensitivity risks remain the same as with capsule forms.

Who is it for
  • Adults who need a liquid St. John’s wort format
  • Users who prefer organic fresh-herb preparations
Best for
  • Flexible liquid dosing
  • People unable to swallow capsules

Pros

  • Fresh organic herb source
  • Substantial listed herb-equivalent amount
  • Liquid format permits adjustment
  • Single-herb formula

Cons

  • Plant part is not stated
  • No extraction ratio
  • No hypericin or hyperforin standardization
  • Serving value is only moderate

Warnings

  • Do not combine St. John’s wort with SSRI, SNRI, MAOI, or other serotonergic medicines because serotonin toxicity can occur.
  • St. John’s wort can reduce the effectiveness of oral contraceptives, warfarin, transplant medicines, some HIV medicines, and several seizure medicines.
  • The herb can increase sensitivity to sunlight, so extra sun protection may be needed.
  • People with bipolar disorder should avoid unsupervised use because St. John’s wort can trigger agitation or mania.

Nutrient quality

77 High impact

The substantial fresh-herb amount fits mood support, but absent extract and active-marker details limit bioavailability confidence. The focused formula avoids filler and shows no clear dosing excess.

Ingredient transparency

75 High impact

The shown active amounts are generally clear, with no proprietary blend obscuring the main doses. Daily directions and a complete inactive-ingredient list are not supplied.

Customer satisfaction

62 Moderate impact

The supplied aggregate rating is favorable and supported by a limited review volume. Detailed feedback is unavailable, so repeated complaints and fit with the intended use cannot be judged.

Value for money

64 Moderate impact

The formula provides moderate practical value for its quality and serving profile. Few low-value additions dilute the core formula.

Report analysis

Goals

Mood Support
Mood Support
Impact
High effect
B+ Goal FitC Strength of SupportC- CoverageA Formula Quality

Saint John’s wort is directly relevant to mood support and the fresh-herb amount is substantial. Missing extract and active-marker standardization makes its clinical comparability uncertain.

The single-herb formula is focused but covers only one mood pathway. Saint John’s wort can reduce the effects of oral contraceptives and anticoagulants, and combining it with serotonergic antidepressants can cause a serious interaction.

Study evidence
St. John's Wort Supportive 97 studies

Ingredients

IngredientAmount per serving
fresh organic St. John's Wort
1000 mg
Gluten Free Adults 18–50 Dairy Free Women Organic
Report overview
St. John's Wort · 1000 mg OverallScore33
F Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyB- Value

Fresh organic Saint John’s wort is listed without an extract, plant part, or active-marker standardization. The daily amount falls within the broad clinically relevant range. The cost for an equivalent clinical daily amount is moderately above the target. Saint John’s wort can reduce the effect of oral contraceptives and anticoagulants, and combining it with serotonergic antidepressants may cause a serious interaction.

View ingredientView products
Loading alternative details
84 Performance

Feeling Positive St. John's Wort 300 mg

Sundown
Marker standardization supports consistent extract quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Performance

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; its extract quality and goal fit provide a clearer option when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Performance

Perika St. John's Wort

Nature's Way
The named extract supports consistent quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort Extract

Swanson Superior Herbs
Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort 300 mg

NOW
Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
89 Budget

St. John's Wort 300 mg

California Gold Nutrition EuroHerbs
A hypericin-standardized extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the lower serving cost improves economy when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
87 Value

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the quality-to-cost balance is favorable when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

St. John's Wort 300 mg

Nature's Bounty
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Value

St. John's Wort

Paradise
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression: a randomized double-blind trial in a Brazilian sample.
    Moreno RA; Teng CT; Almeida KM; Tavares Junior H · Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2006
    Randomized trial72 participantsMood Support forSt. John's Wort
  2. The impact of missing data on clinical trials: a re-analysis of a placebo controlled trial of Hypericum perforatum (St Johns wort) and sertraline in major depressive disorder.
    Grobler AC; Matthews G; Molenberghs G · Psychopharmacology · 2014
    Randomized trial340 participantsMood Support forSt. John's Wort
  3. Documentary Analysis of Hypericum perforatum (St. John's Wort) and Its Effect on Depressive Disorders.
    Otero MC; Ceric F; Miranda-Rojas S; Carreño C; Escares R; Escobar MJ; Saracini C; Atala C; Ramírez-Barrantes R; Gordillo-Fuenzalida F · Pharmaceuticals (Basel, Switzerland) · 2025
    Narrative reviewMood Support forSt. John's Wort
  4. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  5. St John's wort for depression--an overview and meta-analysis of randomised clinical trials.
    Linde K; Ramirez G; Mulrow CD; Pauls A; Weidenhammer W; Melchart D · BMJ (Clinical research ed.) · 1996
    Meta-analysis1,757 participants23 studies pooledMood Support forSt. John's Wort
  6. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  7. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  8. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort
  9. [Meta-analysis of effectiveness and tolerability of treatment of mild to moderate depression with St. John's Wort].
    Röder C; Schaefer M; Leucht S · Fortschritte der Neurologie-Psychiatrie · 2004
    Meta-analysis30 studies pooledMood Support forSt. John's Wort
  10. A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults.
    Cui YH; Zheng Y · Neuropsychiatric disease and treatment · 2016
    Meta-analysis3,126 participants27 studies pooledMood Support forSt. John's Wort
  11. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort