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Perika St. John's Wort

Nature's Way
4.4
★ ★ ★ ★ ★
(845 ratings)
St. John's Wort 300 mg
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Score85
A defined extract and simple dosing improve potency clarity, but incomplete marker detail and extensive drug interactions remain important limits.
How scoring works
Quantity:60 Tablet(s) • (60 servings)
Goals:
Mood Support

Score 85

A defined extract and simple dosing improve potency clarity, but incomplete marker detail and extensive drug interactions remain important limits.
How scoring works
$10.69($0.17 per serving)
iHerb
$ 10.69
Amazon
$ 0.00
Vitacost
$ 13.59
Pure Formulas
$ 11.70
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Analysis

The 300 mg serving uses a defined WS 5570 St. John’s wort extract linked to hyperforin. That is easier to assess than a raw-herb weight alone.

The supplied data does not state a precise hyperforin percentage or yield, so exact potency comparison remains limited. A full medication review is essential because the herb strongly changes drug metabolism.

Adults with mild mood concerns who take no interacting medicines are the clearest audience. The one tablet format is convenient, but suitability depends more on medication compatibility than ease of use.

Who is it for
  • Adults seeking focused St. John’s wort support
  • People who take no interacting medicines
  • Users who prefer a tablet
Best for
  • Focused mood-support supplementation
  • Defined St. John’s wort extract intake
  • one tablet daily use

Pros

  • Uses a hyperforin extract
  • Clearly states a 300 mg serving
  • one tablet format

Cons

  • Marker percentage is not fully disclosed
  • Extensive medication interactions restrict use
  • No supporting nutrients are included

Warnings

  • St. John’s wort can sharply reduce the effectiveness of oral contraceptives, warfarin, transplant medicines, HIV medicines, and many other drugs by speeding their clearance.
  • Combining St. John’s wort with SSRIs, SNRIs, MAO inhibitors, triptans, tramadol, or dextromethorphan can cause dangerous serotonin excess.
  • St. John’s wort can increase sensitivity to sunlight, so strong sun or UV exposure may require extra skin and eye protection.

Nutrient quality

90 Highest impact

The named WS extract provides unusually specific form quality. The daily amount is useful but may require multiple servings to match common researched use.

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Ingredient transparency

84 Highest impact

The active amount and named extract are clearly disclosed without a hidden blend. Complete intake directions and inactive ingredients are not supplied.

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Customer satisfaction

67 High impact

The supplied average rating is generally favorable. A very large rating base makes the average dependable, but no detailed experience evidence was supplied.

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Value for money

95 Highest impact

Serving economics are highly favorable. Formula quality supports the asking price well.

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Goals

Mood Support
Mood Support
Impact
Highest effect
A Goal FitB Strength of SupportD CoverageA Formula Quality

Perika St. John's Wort provides 300 mg per serving and uses a clearly standardized St. John's wort extract, giving it direct but dose-dependent alignment with mood support.

Customer feedback averages 4.39 from 845 reviews, while the published label carries medication-interaction cautions and a product-specific independent certification was not confirmed.

Study evidence
St. John's Wort Supportive 97 studies

Ingredients

IngredientAmount per serving
St. John's Wort extract WS 5570 (Hyperforin)
 300 mg
Gluten Free Adults 18–50 Vegan Dairy Free Women Vegetarian
Report overview
St. John's Wort (Hyperforin) · 300 mg OverallScore80
A+ Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyB- Value

Nature's Way Perika Saint John's Wort provides 300 mg per serving and uses the specialized WS 5570 extract, producing a partial dosage fit under the collection rubric. Customer feedback averages 4.39 from 845 reviews, while the published label includes a specific interaction warning.

View ingredientView products
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88 Performance

Full Spectrum St. John's Wort Extract 600 mg

Planetary Herbals
A standardized, substantial Saint John’s wort blend offers focused mood support with stronger potency clarity than nonstandardized options; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
84 Performance

Feeling Positive St. John's Wort 300 mg

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Marker standardization supports consistent extract quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Performance

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort Extract

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Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort 300 mg

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Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
89 Budget

St. John's Wort 300 mg

California Gold Nutrition EuroHerbs
A hypericin-standardized extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the lower serving cost improves economy when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
87 Value

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

St. John's Wort 300 mg

Nature's Bounty
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Value

St. John's Wort

Paradise
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  2. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  3. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  4. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort
  5. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort