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St. John's Wort Extract 300 mg

Lake Avenue Nutrition
4.6
★ ★ ★ ★ ★
(4423 ratings)
St. John's Wort 300 mg
Product Image
Score84

Clear standardization, one capsule, and an excellent long supply support a top rating. The herb remains unsuitable with many common medicines.

How scoring works
Quantity:240 Capsule(s) • (240 servings)
Goals:
Mood Support
Stress Relief

Score 84

Clear standardization, one capsule, and an excellent long supply support a top rating. The herb remains unsuitable with many common medicines.

How scoring works
$14.16($0.05 per serving)
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$ 14.16
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$ 19.06
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Analysis

Each capsule supplies 300 mg of St. John’s wort aerial-parts extract standardized to 0.3% hypericin. The form and amount are precise enough for consistent comparison.

The single-active design aligns directly with mood support and may be situationally useful for stress-related emotional balance. It does not cover other stress pathways such as sleep, relaxation, or nutrient status.

A very large 240-serving bottle and low serving cost support long-term convenience. Extensive drug interactions and photosensitivity still matter more than the favorable formulation score.

Who is it for
  • Adults seeking a standardized St. John’s wort capsule
  • Established users who have completed medication and mood-history screening
Best for
  • Long-term value among standardized extracts
  • Consistent 0.3% hypericin delivery

Pros

  • Standardized to 0.3% hypericin
  • Identifies aerial parts
  • One capsule per serving
  • Large 240-serving supply
  • Excellent qualitative value

Cons

  • Hyperforin is not disclosed
  • Single pathway does not provide broad stress support
  • Large bottle is a long commitment

Warnings

  • Do not combine St. John’s wort with SSRI, SNRI, MAOI, or other serotonergic medicines because serotonin toxicity can occur.
  • St. John’s wort can reduce the effectiveness of oral contraceptives, warfarin, transplant medicines, some HIV medicines, and several seizure medicines.
  • The herb can increase sensitivity to sunlight, so extra sun protection may be needed.
  • People with bipolar disorder should avoid unsupervised use because St. John’s wort can trigger agitation or mania.

Nutrient quality

86 Highest impact

A hypericin-standardized aerial-parts extract provides strong form quality and direct mood relevance. The moderate amount is not excessive, though it may represent only a partial daily dose.

Ingredient transparency

80 Highest impact

The shown active amounts are generally clear, with no proprietary blend obscuring the main doses. Daily directions and a complete inactive-ingredient list are not supplied.

Customer satisfaction

72 High impact

The supplied aggregate rating is favorable and supported by a very large review volume. Detailed feedback is unavailable, so repeated complaints and fit with the intended use cannot be judged.

Value for money

97 Highest impact

The formula provides strong practical value for its quality and serving profile. Few low-value additions dilute the core formula.

Report analysis

Goals

Mood Support
Impact
High effect
A Goal FitB Strength of SupportD CoverageA Formula Quality

St. John's Wort Extract 300 mg provides 300 mg per serving and uses a clearly standardized St. John's wort extract, giving it direct but dose-dependent alignment with mood support.

Customer feedback averages 4.59 from 4400 reviews, while the published label carries medication-interaction cautions and a product-specific independent certification was not confirmed.

Study evidence
St. John's Wort Supportive 97 studies
Stress Relief
Impact
Moderate effect
D+ Goal FitC+ Strength of SupportD CoverageA Formula Quality

Lake Avenue Nutrition St. John's Wort Extract 300 mg supplies 300 mg of St. John's wort in a 0.3% hypericin-standardized aerial-parts extract, offering a focused but situational route to stress-related emotional balance.

Supplied feedback averages 4.59 across 4,400 reviews, while published safety information makes medication-interaction and photosensitivity review important before use.

Study evidence
St. John's Wort Mixed 6 studies

Ingredients

IngredientAmount per serving
St. John's Wort aerial parts extract (Hypericin)
300 mg
Gluten Free Adults 18–50 Dairy Free Women
Report overview
A+ Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyA+ Value

Lake Avenue Nutrition Saint John's Wort Extract provides 300 mg per serving and uses a 0.3% hypericin standardized aerial-parts extract, producing a partial dosage fit under the collection rubric. Customer feedback averages 4.59 from 4400 reviews, while the published label includes a specific interaction warning.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression: a randomized double-blind trial in a Brazilian sample.
    Moreno RA; Teng CT; Almeida KM; Tavares Junior H · Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2006
    Randomized trial72 participantsMood Support forSt. John's Wort
  2. The impact of missing data on clinical trials: a re-analysis of a placebo controlled trial of Hypericum perforatum (St Johns wort) and sertraline in major depressive disorder.
    Grobler AC; Matthews G; Molenberghs G · Psychopharmacology · 2014
    Randomized trial340 participantsMood Support forSt. John's Wort
  3. Documentary Analysis of Hypericum perforatum (St. John's Wort) and Its Effect on Depressive Disorders.
    Otero MC; Ceric F; Miranda-Rojas S; Carreño C; Escares R; Escobar MJ; Saracini C; Atala C; Ramírez-Barrantes R; Gordillo-Fuenzalida F · Pharmaceuticals (Basel, Switzerland) · 2025
    Narrative reviewMood Support forSt. John's Wort
  4. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  5. St John's wort for depression--an overview and meta-analysis of randomised clinical trials.
    Linde K; Ramirez G; Mulrow CD; Pauls A; Weidenhammer W; Melchart D · BMJ (Clinical research ed.) · 1996
    Meta-analysis1,757 participants23 studies pooledMood Support forSt. John's Wort
  6. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  7. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  8. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort
  9. [Meta-analysis of effectiveness and tolerability of treatment of mild to moderate depression with St. John's Wort].
    Röder C; Schaefer M; Leucht S · Fortschritte der Neurologie-Psychiatrie · 2004
    Meta-analysis30 studies pooledMood Support forSt. John's Wort
  10. A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults.
    Cui YH; Zheng Y · Neuropsychiatric disease and treatment · 2016
    Meta-analysis3,126 participants27 studies pooledMood Support forSt. John's Wort
  11. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort
  12. Comparison of St John's wort and imipramine for treating depression: randomised controlled trial.
    Woelk H · BMJ (Clinical research ed.) · 2000
    Randomized trial324 participantsStress Relief forSt. John's Wort
  13. Differential therapy of mild to moderate depressive episodes (ICD-10 F 32.0; F 32.1) with St. John's wort.
    Friede M; Henneicke von Zepelin HH; Freudenstein J · Pharmacopsychiatry · 2002
    Randomized trial240 participantsStress Relief forSt. John's Wort
  14. Kava and St. John's Wort: current evidence for use in mood and anxiety disorders.
    Sarris J; Kavanagh DJ · Journal of alternative and complementary medicine (New York, N.Y.) · 2009
    Systematic reviewStress Relief forSt. John's Wort
  15. Do early changes in the HAM-D-17 anxiety/somatization factor items affect the treatment outcome among depressed outpatients? Comparison of two controlled trials of St John's wort (Hypericum perforatum) versus a SSRI.
    Bitran S; Farabaugh AH; Ameral VE; LaRocca RA; Clain AJ; Fava M; Mischoulon D · International clinical psychopharmacology · 2012
    Other475 participantsStress Relief forSt. John's Wort
  16. Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review.
    Lakhan SE; Vieira KF · Nutrition journal · 2011
    Systematic review2,619 participants24 studies pooledStress Relief forSt. John's Wort