St. John's Wort 300 mg
NOW
St. John's Wort 300 mg
4.5
★ ★ ★ ★ ★
(3444 ratings)
St. John's Wort 300 mg
Score 90.0
A top-tier standardized St. John's Wort extract from a reputable brand, offering consistent effects and exceptional value for comprehensive mood and stress support.
Quantity: 250 Capsule(s)Servings size: 1 Veg Capsule(s) (250 servings)
Selected goals:
Other goals:
Mood Support
Stress Relief
Sleep Support
leaderboard Score 90.0
A top-tier standardized St. John's Wort extract from a reputable brand, offering consistent effects and exceptional value for comprehensive mood and stress support.
insights Analysis
NOW Foods is a highly respected name in the supplement industry, known for its quality and transparency. Their St. John's Wort product provides a 300mg extract meticulously standardized to Hypericin, ensuring consistent and reliable potency. This standardization is critical for achieving predictable therapeutic effects for mood support, stress relief, and indirectly, improved sleep. The significant quantity of 250 servings, coupled with a very competitive price per serving, makes this product an outstanding value, offering a dependable and cost-effective solution for long-term use.
- Precisely standardized to Hypericin, guaranteeing consistent potency and reliable therapeutic effects.
- Excellent value due to a very low price per serving and a generous quantity, making it highly cost-effective.
- Comes from NOW Foods, a highly reputable brand known for quality and rigorous testing.
- May require taking multiple capsules daily to reach higher therapeutic doses (e.g., 900mg) often cited in some studies.
- St. John's Wort can interact significantly with numerous medications, including antidepressants (SSRIs, MAOIs), oral contraceptives, blood thinners, and immunosuppressants, potentially leading to serious side effects like serotonin syndrome.
- It can cause increased sensitivity to sunlight (photosensitivity), making skin more prone to sunburn or rash, especially in fair-skinned individuals.
$14.84($0.05 per serving)
 Amazon | $ 14.84 | |
 Vitacost | $ 19.19 | |
 Daily Vita | $ 19.70 | |
 Pure Formulas | $ 20.23 | |
 iHerb | $ 20.81 |
bolt Effectiveness for goals
Some research suggests St. John's Wort may be effective for mild to moderate depression. Its use for severe depression is not well-supported by evidence. Consultation with a healthcare professional is advisable before considering use.
For mild to moderate depression, some studies suggest St. John's Wort can be similarly effective to certain conventional antidepressants. However, it may have a different side effect profile and significant drug interactions. This comparison does not extend to all types or severities of depression.
Scientific research indicates that St. John's Wort extracts can be effective for treating mild to moderate depression, often showing comparable efficacy to some standard antidepressants. However, results can vary depending on the extract used and the specific study design. Research on its effectiveness for other conditions is less conclusive.
For mild to moderate depression, some studies suggest St. John's Wort may be as effective as certain prescription antidepressants. However, results can vary, and it is not generally recommended as a substitute for standard care for severe depression.
Clinical studies indicate that St. John's Wort can be effective for relieving symptoms of mild depression. Its efficacy in this context has been compared to that of some conventional antidepressants. However, individual responses may vary.
schedule Dosage, timing & forms
Common dosages of St. John's Wort extract often range from 300 mg to 900 mg per day. These dosages typically provide standardized amounts of active compounds like hypericin or hyperforin. It's important to check the product label for specific recommendations.
The effects of St. John's Wort are generally not immediate and may take several weeks to become noticeable. Individuals typically report feeling benefits after two to four weeks of consistent daily use. It's important to continue taking it as directed for the recommended duration.
The effects of St. John's Wort are typically not immediate and may take several weeks to become noticeable. Individuals often report initial changes within 2 to 4 weeks, with more pronounced benefits potentially appearing after 4 to 6 weeks of consistent use. This gradual onset is common for many herbal supplements.
Common dosages for St. John's Wort extracts, often standardized to hypericin or hyperforin, typically range from 300 mg to 900 mg per day. These doses are usually divided into two or three administrations throughout the day. The specific dosage can vary based on the extract's standardization and the product's concentration.
St. John's Wort is typically taken two to three times per day. Dividing the daily dose helps maintain consistent levels of its active compounds in the body. Always follow the specific instructions provided on the supplement's label or by a qualified healthcare professional.
health_and_safety Safety & interactions
No, St. John's Wort should not be taken with antidepressant medications, especially selective serotonin reuptake inhibitors (SSRIs). Combining them can lead to a serious condition called serotonin syndrome, which involves symptoms like confusion, rapid heart rate, and high fever. Always consult a healthcare professional before combining St. John's Wort with any prescription drugs.
Yes, St. John's Wort can interact significantly with many antidepressant medications. This interaction may lead to a serious condition called serotonin syndrome, which involves symptoms like confusion, rapid heart rate, and high blood pressure. It is crucial to consult a healthcare professional before combining St. John's Wort with any antidepressant.
St. John's Wort can interact significantly with many medications, reducing their effectiveness or increasing side effects. Common side effects may include photosensitivity, upset stomach, fatigue, and restlessness. It is important to discuss its use with a healthcare provider.
Yes, St. John's Wort significantly interacts with medications used for HIV/AIDS (e.g., protease inhibitors, NNRTIs) and immunosuppressants used after organ transplantation (e.g., cyclosporine). It can dramatically reduce the levels and effectiveness of these critical drugs. Such combinations are generally contraindicated and should be strictly avoided.
Yes, St. John's Wort is known to reduce the effectiveness of hormonal contraceptives, including birth control pills. This interaction can potentially lead to unintended pregnancy. It is recommended to use an alternative or additional method of contraception while taking St. John's Wort.
Ingredients
| Ingredient | Amount per serving |
|---|---|
St. John's Wort extract | 300 mg |
Categories
St. John's Wort 90.0
A top contender in the St. John's Wort category, excelling in both quality (standardized extract) and value, making it a highly recommended choice for consistent benefits.
Goals
Mood Support 90.0
Standardization to Hypericin provides reliable and consistent support for mood regulation, aligning with expert recommendations.
Stress Relief 90.0
Consistent active compound levels ensure predictable and effective stress reduction, promoting a calmer state.
Sleep Support 90.0
Its strong and consistent effects on mood and stress significantly contribute to improved sleep quality and healthier sleep patterns.
Recommended Alternatives
98 Value 
St. John's Wort Extract 300 mg
Lake Avenue Nutrition
4.6
★★★★★
(4042 ratings)
Delivers excellent efficacy through standardization at an exceptionally low price, offering unmatched value for a quality standardized product.
95 Value 
St. John's Wort Extract 300 mg
Lake Avenue Nutrition
4.6
★★★★★
(4042 ratings)
A larger quantity of the same high-value standardized extract, providing even greater long-term cost-effectiveness for consistent use.
88 Value 
St. John's Wort 300 mg
California Gold Nutrition EuroHerbs
4.5
★★★★★
(5243 ratings)
A good quality standardized extract from a reliable brand at a very competitive price, representing excellent overall value for consistent efficacy.
90 Performance 
Perika St. John's Wort
Nature's Way
4.4
★★★★★
(834 ratings)
A clinically studied extract (WS 5570) standardized to Hyperforin, offering strong scientific validation and a potentially broader mechanism of action.
92 Performance 
Mood Support
NOW
4.5
★★★★★
(8436 ratings)
A comprehensive multi-ingredient blend for broader mood support, combining standardized St. John's Wort with other synergistic compounds like 5-HTP and GABA.
88 Performance 
St. John's Wort Extended Release
NaturesPlus Herbal Actives
4.6
★★★★★
(394 ratings)
Features an extended-release formulation for prolonged and steady delivery of active compounds, which can be beneficial for consistent daily mood management.
98 Budget
St. John's Wort Extract 300 mg
Lake Avenue Nutrition
4.6
★★★★★
(4042 ratings)
Offers a standardized extract at an even lower price point, providing the absolute best value per serving available.
85 Budget 
St. John's Wort Extract
Swanson Superior Herbs
4.7
★★★★★
(344 ratings)
Provides a standardized extract at a slightly lower price per serving, offering good value for money.
50 Budget 
St. John's Wort 375 mg
Swanson Premium Brand
4.7
★★★★★
(2868 ratings)
While considerably cheaper, it is an unstandardized whole herb product and therefore lacks the consistent efficacy of an extract.
98 Value
St. John's Wort Extract 300 mg
Lake Avenue Nutrition
4.6
★★★★★
(4042 ratings)
Delivers excellent efficacy through standardization at an exceptionally low price, offering unmatched value for a quality standardized product.
95 Value
St. John's Wort Extract 300 mg
Lake Avenue Nutrition
4.6
★★★★★
(4042 ratings)
A larger quantity of the same high-value standardized extract, providing even greater long-term cost-effectiveness for consistent use.
88 Value
St. John's Wort 300 mg
California Gold Nutrition EuroHerbs
4.5
★★★★★
(5243 ratings)
A good quality standardized extract from a reliable brand at a very competitive price, representing excellent overall value for consistent efficacy.
90 Performance
Perika St. John's Wort
Nature's Way
4.4
★★★★★
(834 ratings)
A clinically studied extract (WS 5570) standardized to Hyperforin, offering strong scientific validation and a potentially broader mechanism of action.
92 Performance
Mood Support
NOW
4.5
★★★★★
(8436 ratings)
A comprehensive multi-ingredient blend for broader mood support, combining standardized St. John's Wort with other synergistic compounds like 5-HTP and GABA.
88 Performance
St. John's Wort Extended Release
NaturesPlus Herbal Actives
4.6
★★★★★
(394 ratings)
Features an extended-release formulation for prolonged and steady delivery of active compounds, which can be beneficial for consistent daily mood management.