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CoQ10 100 mg plus BioPerine

Lake Avenue Nutrition
4.8
★ ★ ★ ★ ★
(7041 ratings)
Coenzyme Q-10 100 mg
Product Image
Score83
The maintenance-level amount and softgel delivery create a practical base formula. The carrier oil is not identified, and piperine makes the formula less suitable for some medicine users.
How scoring works
Quantity:365 Softgel(s) • (365 servings)
Goals:
Heart Health
Energy
Anti-Aging
Anti-Inflammatory Support
Metabolism Boost
Cardiovascular Support

Score 83

The maintenance-level amount and softgel delivery create a practical base formula. The carrier oil is not identified, and piperine makes the formula less suitable for some medicine users.
How scoring works

Also available as

1 option
150 servings Coenzyme Q-10 100 mg • 150 Softgel(s) • 150 servings $16.12 ($0.10 per serving)
$37.00($0.10 per serving)
iHerb
$ 37.00
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Analysis

The serving provides 100 mg of ubiquinone in a softgel. The maintenance-level amount and softgel delivery create a practical base formula.

CoQ10 supports cellular energy production and may fit heart, energy, or healthy-aging routines. Five milligrams of black pepper extract may improve uptake while adding medication-interaction potential.

A 365-serving bottle offers a full year of use and excellent recurring value. The carrier oil is not identified, and piperine makes the formula less suitable for some medicine users.

Who is it for
  • Long-term CoQ10 users
  • Adults who tolerate black pepper extract
Best for
  • Year-long maintenance use
  • Strong bulk value

Pros

  • Provides 365 servings
  • Softgel delivery
  • Includes black pepper extract

Cons

  • Carrier oil is not named
  • Ubiquinone is less readily used than ubiquinol
  • Piperine can alter medicine exposure

Warnings

  • CoQ10 may reduce warfarin’s anticoagulant effect, so warfarin users should ask their prescriber about monitoring.
  • Black pepper extract may alter exposure to medicines handled by CYP3A4 or P-glycoprotein.

Nutrient quality

85 Highest impact

Ubiquinone is clearly identified, and softgel delivery may help absorption of the fat-soluble active. The CoQ10 amount is meaningful for general maintenance.

.

Ingredient transparency

82 Highest impact

Every supplied active ingredient has a specific amount. No proprietary blend hides a meaningful active dose.

.

Customer satisfaction

69 High impact

The supplied aggregate rating is strong, although no specific comments are included. The large rating count makes the aggregate result relatively stable.

.

Value for money

92 Highest impact

Formula quality provides strong support for the product positioning. Dose-adjusted serving value appears strong, and the formula avoids obvious low-value padding.

.
Report analysis

Goals

Heart Health
Heart Health
Impact
Highest effect
A- Goal FitA- Strength of SupportC CoverageA Formula Quality
Coenzyme Q-10 · 100 mg

CoQ10 directly supports mitochondrial energy production in heart muscle and provides antioxidant activity. The 100 mg ubiquinone amount is practical, while 5 mg black pepper extract may improve uptake.

The focused formula does not address lipids, vascular tone, or homocysteine through separate actives. CoQ10 may reduce warfarin anticoagulation, while piperine can alter exposure to medicines handled by CYP3A4 or P-glycoprotein.

Study evidence
Coenzyme Q-10 Supportive 114 studies
Energy
Energy
Impact
Highest effect
A Goal FitB+ Strength of SupportC CoverageA Formula Quality
Coenzyme Q-10 · 100 mg

CoQ10 directly supports mitochondrial ATP production and offers a focused non-stimulant approach to cellular energy. The amount is suitable for general maintenance, while black pepper extract may improve uptake.

Ubiquinone is an established form, but no lipid carrier is disclosed. Black pepper extract can alter exposure to medicines handled by CYP3A4 or P-glycoprotein, so users of narrow-therapeutic-index drugs need interaction-specific guidance.

Study evidence
Coenzyme Q-10 Supportive 32 studies
Anti-Aging
Anti-Aging
Impact
Highest effect
A- Goal FitB+ Strength of SupportC+ CoverageA Formula Quality
Coenzyme Q-10 · 100 mg

The 100 mg CoQ10 amount supports mitochondrial energy and antioxidant protection, while black pepper extract may increase absorption. The two-active design remains focused on improving exposure to a relevant cellular nutrient.

Ubiquinone is less readily absorbed than ubiquinol, so the enhancer does not fully close the form-quality gap. Black pepper extract can alter medicines handled by CYP3A4 or P-glycoprotein, including some anticoagulants, immunosuppressants, and calcium-channel blockers.

Study evidence
Coenzyme Q-10 Supportive 6 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
B Goal FitB+ Strength of SupportC+ CoverageA+ Formula Quality
Coenzyme Q-10 · 100 mg

The 100 mg CoQ10 serving provides meaningful mitochondrial antioxidant support and may help moderate systemic inflammatory markers. Black pepper extract offers a logical absorption aid for the less readily absorbed ubiquinone form.

The formula remains narrower than combinations that pair CoQ10 with a direct botanical or omega-3 pathway. Black pepper extract can alter medicines handled by CYP3A4 or P-glycoprotein, creating a relevant interaction concern.

Study evidence
Coenzyme Q-10 Supportive 46 studies
Metabolism Boost
Metabolism Boost
Impact
High effect
B Goal FitB+ Strength of SupportC- CoverageA Formula Quality
Coenzyme Q-10 · 100 mg

CoQ10 directly supports mitochondrial energy production, while black pepper extract may improve uptake. The 100 mg amount is suitable for daily mitochondrial support.

Ubiquinone is less readily absorbed than ubiquinol, but BioPerine partly addresses that limitation. Black pepper extract can alter the handling of medicines that depend on CYP3A4 or P-glycoprotein, so users of those medicines should seek individualized guidance.

Study evidence
Coenzyme Q-10 Disputed 11 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
B Goal FitB+ Strength of SupportD+ CoverageA Formula Quality
Coenzyme Q-10 · 100 mg

CoQ10 supports energy production in heart muscle and provides antioxidant protection. The disclosed maintenance amount gives the formula meaningful cardiovascular relevance through a focused pathway.

Black pepper extract may improve absorption from the dry ubiquinone capsule. It can also alter exposure to medicines handled by CYP3A4 or P-glycoprotein, so users of narrow-safety-margin medicines should seek a pharmacist's review.

Study evidence
Coenzyme Q-10 Supportive 89 studies

Ingredients

IngredientAmount per serving
Coenzyme Q-10 (Ubiquinone)
 100 mg
Black Pepper fruit extract
5 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
Coenzyme Q-10 (Ubiquinone) · 100 mg OverallScore79
C Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyA+ Value

The ubiquinone dose is suitable for general maintenance, though it is typically less readily absorbed than ubiquinol. Black pepper extract may improve uptake, and the low cost per effective amount provides strong value. Black pepper extract can also alter the handling of medicines that depend on CYP3A4 or P-glycoprotein, creating an interaction concern for those users.

View ingredientView products
Loading alternative details
87 Performance

QH-absorb 100 mg

Jarrow Formulas
A 100 mg ubiquinol softgel uses the reduced CoQ10 form and offers a stronger absorption case than conventional dry ubiquinone formulas. Higher-dose originals provide more total CoQ10, while warfarin users should monitor clotting control when CoQ10 use changes.
87 Performance

Extra Strength Ubiquinol 200 mg

NOW
A substantial 200 mg ubiquinol amount in a softgel combines the reduced form with lipid-based delivery. It may replace lower-dose or conventional ubiquinone products more effectively, although very high-dose originals still supply more total CoQ10.
87 Performance

Mega CoQ10 Ubiquinol 100 mg

Qunol
A 100 mg ubiquinol softgel offers a readily used CoQ10 form at a practical maintenance amount. The dose is lower than several originals, but the reduced form and focused delivery can improve formulation quality for routine use.
84 Budget

CoQ10 100 mg

Best Naturals
A clearly stated 100 mg ubiquinone amount provides a much lower-cost maintenance option than the original. The dry capsule lacks a lipid carrier or absorption enhancer, and CoQ10 may reduce warfarin response when use changes.
83 Budget

CoQ10 100 mg plus BioPerine

Lake Avenue Nutrition
A 100 mg ubiquinone softgel with black pepper extract offers focused CoQ10 support at a lower serving cost than the original. The amount may be lower than stronger originals, and black pepper can change exposure to medicines handled by CYP3A4 or P-glycoprotein.
85 Budget

High Absorption CoQ10 with BioPerine 100 mg

Doctor's Best
Clearly identified 100 mg ubiquinone with piperine provides exceptional serving value compared with the original. The dry capsule has no lipid carrier, and piperine may alter exposure to medicines processed through common metabolic pathways.
87 Value

CoQ10 200 mg

California Gold Nutrition
A substantial 200 mg ubiquinone amount in a softgel provides strong dose-based value compared with the original. Ubiquinol originals use the reduced form, but this option balances meaningful potency, lipid-based delivery, and favorable serving economics.
83 Value

CoQ10 100 mg

Healthy Origins
A 100 mg ubiquinone softgel provides a practical maintenance amount with very favorable serving value. Higher-dose or ubiquinol originals offer form or potency advantages, but the lipid-based delivery makes this a balanced routine option.
86 Value

Ubiquinol 100 mg

NOW
A 100 mg ubiquinol softgel combines the reduced CoQ10 form with a large supply and strong ongoing value. Higher-dose originals provide more CoQ10 per serving, but this option is well aligned with general maintenance and users prioritizing form quality.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies.
    Mehrabani S; Askari G; Miraghajani M; Tavakoly R; Arab A · Complementary therapies in medicine · 2019
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  2. Ubiquinol-10 Intake Is Effective in Relieving Mild Fatigue in Healthy Individuals.
    Mizuno K; Sasaki AT; Watanabe K; Watanabe Y · Nutrients · 2021
    Clinical trial62 participantsEnergy forCoenzyme Q-10
  3. Coenzyme Q10 supplementation increases blood concentrations but shows limited and inconsistent effects on exercise performance: a systematic review and meta-analysis.
    Deng H; Song T; Yin M; Xu K; Zhong Y; Mohd NB; Naharudin MNB; Yusof A; Fan X · The British journal of nutrition · 2026
    Meta-analysis24 studies pooledEnergy forCoenzyme Q-10
  4. A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer.
    Lesser GJ; Case D; Stark N; Williford S; Giguere J; Garino LA; Naughton MJ; Vitolins MZ; Lively MO; Shaw EG; Wake Forest University Community Clinical Oncology Program Research Base · The journal of supportive oncology · 2013
    Randomized trial236 participantsEnergy forCoenzyme Q-10
  5. Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials.
    Lei L; Liu Y · BMC cardiovascular disorders · 2018
    Meta-analysis2,149 participants14 studies pooledHeart Health forCoenzyme Q-10
  6. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.
    Liu Z; Tian Z; Zhao D; Liang Y; Dai S; Liu M; Hou S; Dong X; Zhaxinima; Yang Y · The Journal of clinical endocrinology and metabolism · 2022
    Meta-analysis2,794 participants50 studies pooledHeart Health Cardiovascular Support forCoenzyme Q-10
  7. Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders: A Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Zhao D; Liang Y; Dai S; Hou S; Liu Z; Liu M; Dong X; Zhan Y; Tian Z; Yang Y · Advances in nutrition (Bethesda, Md.) · 2022
    Meta-analysis1,831 participants26 studies pooledHeart Health forCoenzyme Q-10
  8. Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial.
    Sabbatinelli J; Orlando P; Galeazzi R; Silvestri S; Cirilli I; Marcheggiani F; Dludla PV; Giuliani A; Bonfigli AR; Mazzanti L; Olivieri F; Antonicelli R; Tiano L · Nutrients · 2021
    Randomized trial51 participantsHeart Health forCoenzyme Q-10
  9. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension.
    Ho MJ; Li EC; Wright JM · The Cochrane database of systematic reviews · 2016
    Meta-analysis50 participants3 studies pooledHeart Health forCoenzyme Q-10
  10. Coenzyme Q10: an independent predictor of mortality in chronic heart failure.
    Molyneux SL; Florkowski CM; George PM; Pilbrow AP; Frampton CM; Lever M; Richards AM · Journal of the American College of Cardiology · 2008
    Cohort study236 participantsHeart Health forCoenzyme Q-10
  11. Coenzyme Q10 Supplementation in Aging and Disease.
    Hernández-Camacho JD; Bernier M; López-Lluch G; Navas P · Frontiers in physiology · 2022
    Narrative reviewAnti-Aging forCoenzyme Q-10
  12. Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview.
    Mantle D; Hargreaves I · Antioxidants (Basel, Switzerland) · 2020
    Narrative reviewAnti-Aging forCoenzyme Q-10
  13. Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals.
    Pabis K; Wang W; Selvarajoo K; Budovskaya YV; Sorrentino V; Gruber J; Kennedy BK · Aging cell · 2026
    Cross-sectional study4,260 participantsAnti-Aging forCoenzyme Q-10
  14. Coenzyme Q10 supplementation raises plasma levels without improving mitochondrial function in older adults.
    Schmücker M; Tranberg C; Borch J; Kaae MK; Damgaard M; Flensted-Jensen M; Blom I; Morosetti M; Barbarossa S; Orlando P; Tiano L; Dela F; Helge JW; Larsen S · GeroScience · 2026
    Randomized trial40 participantsAnti-Aging forCoenzyme Q-10
  15. Coenzyme Q10, a cutaneous antioxidant and energizer.
    Hoppe U; Bergemann J; Diembeck W; Ennen J; Gohla S; Harris I; Jacob J; Kielholz J; Mei W; Pollet D; Schachtschabel D; Sauermann G; Schreiner V; Stäb F; Steckel F · BioFactors (Oxford, England) · 1999
    Clinical trialAnti-Aging forCoenzyme Q-10
  16. The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients.
    Taghizadeh S; Izadi A; Shirazi S; Parizad M; Pourghassem Gargari B · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2021
    Randomized trial43 participantsAnti-Inflammatory Support forCoenzyme Q-10
  17. The effects of coenzyme Q10 supplementation on metabolic profiles and parameters of mental health in women with polycystic ovary syndrome.
    Karamali M; Gholizadeh M · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2022
    Randomized trial55 participantsAnti-Inflammatory Support forCoenzyme Q-10
  18. Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials.
    Hou S; Tian Z; Zhao D; Liang Y; Dai S; Ji Q; Fan Z; Liu Z; Liu M; Yang Y · Molecular nutrition & food research · 2023
    Meta-analysis1,517 participants31 studies pooledAnti-Inflammatory Support forCoenzyme Q-10
  19. Can coenzyme Q10 supplementation effectively reduce human tumor necrosis factor-α and interleukin-6 levels in chronic inflammatory diseases? A systematic review and meta-analysis of randomized controlled trials.
    Farsi F; Heshmati J; Keshtkar A; Irandoost P; Alamdari NM; Akbari A; Janani L; Morshedzadeh N; Vafa M · Pharmacological research · 2020
    Meta-analysis509 participants9 studies pooledAnti-Inflammatory Support forCoenzyme Q-10
  20. Promising efficacy of coenzyme Q10 supplementation as adjunctive therapy in juvenile idiopathic arthritis: a randomized-controlled pilot study.
    Elsherif N; Shousha G; Sabri NA; Shawki MA · Immunopharmacology and immunotoxicology · 2026
    Randomized trial58 participantsAnti-Inflammatory Support forCoenzyme Q-10
  21. Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial.
    Vrentzos E; Ikonomidis I; Pavlidis G; Katogiannis K; Korakas E; Kountouri A; Pliouta L; Michalopoulou E; Pelekanou E; Boumpas D; Lambadiari V · Cardiovascular diabetology · 2024
    Randomized trial60 participantsCardiovascular Support forCoenzyme Q-10
  22. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial.
    Mortensen SA; Rosenfeldt F; Kumar A; Dolliner P; Filipiak KJ; Pella D; Alehagen U; Steurer G; Littarru GP; Q-SYMBIO Study Investigators · JACC. Heart failure · 2015
    Randomized trial420 participantsCardiovascular Support forCoenzyme Q-10
  23. [Coenzyme Q-10 in the treatment of patients with chronic heart failure and reduced left ventricular ejection fraction: systematic review and meta-analysis].
    Mareev VY; Mareev YV; Begrambekova YL · Kardiologiia · 2022
    Meta-analysis1,139 participants6 studies pooledCardiovascular Support forCoenzyme Q-10
  24. Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial.
    Mortensen AL; Rosenfeldt F; Filipiak KJ · Cardiology journal · 2020
    Randomized trialCardiovascular Support forCoenzyme Q-10
  25. Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
    Qu H; Guo M; Chai H; Wang WT; Gao ZY; Shi DZ · Journal of the American Heart Association · 2019
    Meta-analysis575 participants12 studies pooledEnergy forCoenzyme Q-10
  26. Coenzyme Q10 Supplementation in Athletes: A Systematic Review.
    Fernandes MSS; Fidelis DEDS; Aidar FJ; Badicu G; Greco G; Cataldi S; Santos GCJ; de Souza RF; Ardigò LP · Nutrients · 2026
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  27. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Tsai IC; Hsu CW; Chang CH; Tseng PT; Chang KV · Frontiers in pharmacology · 2024
    Meta-analysis1,126 participants13 studies pooledEnergy forCoenzyme Q-10
  28. Antifatigue effects of coenzyme Q10 during physical fatigue.
    Mizuno K; Tanaka M; Nozaki S; Mizuma H; Ataka S; Tahara T; Sugino T; Shirai T; Kajimoto Y; Kuratsune H; Kajimoto O; Watanabe Y · Nutrition (Burbank, Los Angeles County, Calif.) · 2008
    Randomized trial17 participantsEnergy forCoenzyme Q-10
  29. Effects of Coenzyme Q10 on Lipid, Glycemic, and Inflammatory Markers in Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Zhang Z; Liu Z; Geng Y; Huang Y; Hu R; Li F; Song Y; Zhang M · Journal of diabetes research · 2026
    Meta-analysis3,422 participants64 studies pooledHeart Health Metabolism Boost forCoenzyme Q-10
  30. Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals.
    Zhang P; Yang C; Guo H; Wang J; Lin S; Li H; Yang Y; Ling W · Journal of clinical lipidology · 2019
    Randomized trial101 participantsHeart Health forCoenzyme Q-10
  31. Coenzyme Q10 supplementation improves adipokine profile in dyslipidemic individuals: a randomized controlled trial.
    Zhang P; Chen K; He T; Guo H; Chen X · Nutrition & metabolism · 2022
    Randomized trial101 participantsMetabolism Boost forCoenzyme Q-10
  32. Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis.
    Hu X; Wang W; Su X; Peng H; Tan Z; Li Y; Huang Y · PeerJ · 2023
    Meta-analysis2,362 participants41 studies pooledMetabolism Boost forCoenzyme Q-10
  33. Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise.
    Diaz-Castro J; Mira-Rufino PJ; Moreno-Fernandez J; Chirosa I; Chirosa JL; Guisado R; Ochoa JJ · Food & function · 2021
    Randomized trial100 participantsMetabolism Boost forCoenzyme Q-10
  34. The effect of coenzyme Q10 intake on metabolic profiles in women candidates for in-vitro fertilization: a randomised trial.
    Ahmadi Asouri S; Asemi R; Aghadavod E; Jamilian M · Annals of medicine and surgery (2012) · 2024
    Randomized trial40 participantsMetabolism Boost forCoenzyme Q-10