Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Caffeine administration at night during extended wakefulness effectively mitigates performance impairment but not subjective assessments of fatigue and sleepiness.
Paech GM; Banks S; Pajcin M; Grant C; Johnson K; Kamimori GH; Vedova CB · Pharmacology, biochemistry, and behavior · 2017
Randomized trial24 participantsflagEnergy forscienceCaffeine
- Differential cognitive effects of energy drink ingredients: caffeine, taurine, and glucose.
Giles GE; Mahoney CR; Brunyé TT; Gardony AL; Taylor HA; Kanarek RB · Pharmacology, biochemistry, and behavior · 2013
Randomized trial48 participantsflagEnergy forscienceCaffeine
- Effect of Caffeine on Golf Performance and Fatigue during a Competitive Tournament.
Mumford PW; Tribby AC; Poole CN; Dalbo VJ; Scanlan AT; Moon JR; Roberts MD; Young KC · Medicine and science in sports and exercise · 2016
Randomized trial12 participantsflagEnergy forscienceCaffeine
- No effects of caffeine on cycling to exhaustion and perceptual responses in non-caffeine-restricted subjects.
Weippert M; Behrens M; Schlegel M; Schröder T; Tillmann M; Rühe N; Römer R; Mau-Möller A; Bruhn S · Journal of the International Society of Sports Nutrition · 2025
Randomized trial56 participantsflagEnergy forscienceCaffeine
- A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features.
Juliano LM; Griffiths RR · Psychopharmacology · 2005
Systematic review66 studies pooledflagEnergy forscienceCaffeine
- Oral taurine improves critical power and severe-intensity exercise tolerance.
Waldron M; Patterson SD; Jeffries O · Amino acids · 2020
Randomized trial12 participantsflagFitness forscienceTaurine
- Effects of different doses of taurine supplementation on repeated-sprint performance after exhaustive exercise in a high temperature and humidity environment.
Cheng X; Lin Y; Li Z · Frontiers in nutrition · 2026
Randomized trial16 participantsflagFitness forscienceTaurine
- Acute taurine supplementation enhances thermoregulation and endurance cycling performance in the heat.
Page LK; Jeffries O; Waldron M · European journal of sport science · 2019
Randomized trial11 participantsflagFitness forscienceTaurine
- Acute Effects of Taurine Supplementation on Maximal Fat Oxidation and FATmax in Recreational Endurance Runners: A Randomized, Placebo-Controlled, Crossover, and Triple-Blinded Study.
Ghazzagh A; Naderi A; Agha-Alinejad H; Livani A; Sarlak M; Aghamohammadi S; Saunders B · International journal of sport nutrition and exercise metabolism · 2024
Randomized trial11 participantsflagFitness forscienceTaurine
- Does caffeine ingestion before a short-term sprint interval training promote body fat loss?
Ferreira GA; Felippe LC; Bertuzzi R; Bishop DJ; Ramos IS; De-Oliveira FR; Lima-Silva AE · Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2020
Randomized trial20 participantsflagWeight Loss forscienceCaffeine
- Caffeine treatment prevented from weight regain after calorie shifting diet induced weight loss.
Davoodi SH; Hajimiresmaiel SJ; Ajami M; Mohseni-Bandpei A; Ayatollahi SA; Dowlatshahi K; Javedan G; Pazoki-Toroudi H · Iranian journal of pharmaceutical research : IJPR · 2014
Non-randomized trial60 participantsflagWeight Loss forscienceCaffeine
- Eight Weeks of Sprint Interval Training With Adding Caffeine Ingestion Leads to Greater Improvements in Health-Related Physiological Parameters in Obese Male Adults.
Zhiang J; Song Q · Physiological research · 2026
Randomized trial30 participantsflagWeight Loss forscienceCaffeine
- Interventions associated with brown adipose tissue activation and the impact on energy expenditure and weight loss: A systematic review.
Perez LC; Perez LT; Nene Y; Umpierrez GE; Davis GM; Pasquel FJ · Frontiers in endocrinology · 2022
Systematic review47 studies pooledflagWeight Loss forscienceCaffeine
- Acute effects of caffeine on attention: a comparison of non-consumers and withdrawn consumers.
Smith AP; Christopher G; Sutherland D · Journal of psychopharmacology (Oxford, England) · 2013
Randomized trial70 participantsflagMental Focus forscienceCaffeine
- Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.
Wingelaar-Jagt YQ; Bottenheft C; Riedel WJ; Ramaekers JG · Journal of psychopharmacology (Oxford, England) · 2023
Randomized trial32 participantsflagMental Focus forscienceCaffeine
- Using coffee to compensate for poor sleep: Impact on vigilance and implications for workplace performance.
Anderson JR; Hagerdorn PL; Gunstad J; Spitznagel MB · Applied ergonomics · 2018
Randomized trial69 participantsflagMental Focus forscienceCaffeine
- Caffeine and attentional control: improved and impaired performance in healthy older adults and Parkinson's disease according to task demands.
Sharma K; Fallon SJ; Davis T; Ankrett S; Munro G; Christopher G; Coulthard E · Psychopharmacology · 2022
Randomized trial68 participantsflagMental Focus forscienceCaffeine
- Caffeinated Coffee and Tea Consumption, Genetic Variation and Cognitive Function in the UK Biobank.
Cornelis MC; Weintraub S; Morris MC · The Journal of nutrition · 2020
Cross-sectional study445,786 participantsflagMental Focus forscienceCaffeine
- Effects of choline alfoscerate on cognitive function and quality of life in type 2 diabetes: A double-blind, randomized, placebo-controlled trial.
Sohn M; Park YH; Lim S · Diabetes, obesity & metabolism · 2025
Randomized trial36 participantsflagCognitive Support forscienceCholine
- Association of dietary choline intake with incidence of dementia, Alzheimer disease, and mild cognitive impairment: a large population-based prospective cohort study.
Niu YY; Yan HY; Zhong JF; Diao ZQ; Li J; Li CP; Chen LH; Huang WQ; Xu M; Xu ZT; Liang XF; Li ZH; Liu D · The American journal of clinical nutrition · 2025
Cohort study125,594 participantsflagCognitive Support forscienceCholine
- Association of trimethylamine oxide and its precursors with cognitive impairment: a systematic review and meta-analysis.
Long C; Li Z; Feng H; Jiang Y; Pu Y; Tao J; Yue R · Frontiers in aging neuroscience · 2024
Meta-analysis82,246 participants9 studies pooledflagCognitive Support forscienceCholine
- Randomized, double-blind, placebo-controlled clinical trial of choline supplementation in school-aged children with fetal alcohol spectrum disorders.
Nguyen TT; Risbud RD; Mattson SN; Chambers CD; Thomas JD · The American journal of clinical nutrition · 2017
Randomized trial55 participantsflagCognitive Support forscienceCholine
- Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.
De Jesus Moreno Moreno M · Clinical therapeutics · 2003
Randomized trial261 participantsflagCognitive Support forscienceCholine
- Choline intake during pregnancy and child cognition at age 7 years.
Boeke CE; Gillman MW; Hughes MD; Rifas-Shiman SL; Villamor E; Oken E · American journal of epidemiology · 2013
Cohort study895 participantsflagCognitive Support forscienceCholine
- Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.
Warton FL; Molteno CD; Warton CMR; Wintermark P; Lindinger NM; Dodge NC; Zöllei L; van der Kouwe AJW; Carter RC; Jacobson JL; Jacobson SW; Meintjes EM · Alcoholism, clinical and experimental research · 2022
Randomized trial52 participantsflagCognitive Support forscienceCholine
- Choline and contribution to normal liver function of the foetus and exclusively breastfed infants: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
EFSA Panel on Nutrition, Novel Foods and Food allergens (NDA); Turck D; Bohn T; Castenmiller J; De Henauw S; Hirsch-Ernst KI; Knutsen HK; Maciuk A; Mangelsdorf I; McArdle HJ; Naska A; Pentieva K; Thies F; Tsabouri S; Vinceti M; Bresson JL; Fiolet T; Siani A · EFSA journal. European Food Safety Authority · 2024
Guideline / consensusflagDetoxification forscienceCholine
- Adiposity May Moderate the Link Between Choline Intake and Non-alcoholic Fatty Liver Disease.
Mazidi M; Katsiki N; Mikhailidis DP; Banach M · Journal of the American College of Nutrition · 2020
Cross-sectional study20,643 participantsflagDetoxification forscienceCholine
- Choline and Choline-Related Metabolites in Pediatric Short Bowel Syndrome.
Hilberath J; Shunova A; Heister L; Poets CF; Bernhard W · Nutrients · 2026
Observational study80 participantsflagDetoxification forscienceCholine
- Choline Supplementation in Cystic Fibrosis-The Metabolic and Clinical Impact.
Bernhard W; Lange R; Graepler-Mainka U; Engel C; Machann J; Hund V; Shunova A; Hector A; Riethmüller J · Nutrients · 2019
Single-arm trial10 participantsflagDetoxification forscienceCholine
- 1H MR Spectroscopy at 3T for Hepatic Choline Quantification in Healthy Young Women: A Translational Imaging Study with Dietary Correlation.
Hawesa H; Alghamdi R; Allam H; Alfaifi B; Alrabiah N; Alghumaiz M; Shanawani M; Alshegri H; Hassan MG · Current medical imaging · 2026
Cohort study88 participantsflagDetoxification forscienceCholine
- Dietary amino acid taurine ameliorates liver injury in chronic hepatitis patients.
Hu YH; Lin CL; Huang YW; Liu PE; Hwang DF · Amino acids · 2008
Non-randomized trial24 participantsflagDetoxification forscienceTaurine
- Taurine status and response to intravenous taurine supplementation in adults with short-bowel syndrome undergoing long-term parenteral nutrition: a pilot study.
Schneider SM; Joly F; Gehrardt MF; Badran AM; Myara A; Thuillier F; Coudray-Lucas C; Cynober L; Trivin F; Messing B · The British journal of nutrition · 2006
Single-arm trial32 participantsflagDetoxification forscienceTaurine
- Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine.
Haskell CF; Kennedy DO; Wesnes KA; Scholey AB · Psychopharmacology · 2005
Randomized trial48 participantsflagEnergy forscienceCaffeine
- Caffeine-containing energy drink improves physical performance of elite rugby players during a simulated match.
Del Coso J; Ramírez JA; Muñoz G; Portillo J; Gonzalez-Millán C; Muñoz V; Barbero-Álvarez JC; Muñoz-Guerra J · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016
Randomized trial26 participantsflagEnergy forscienceCaffeine
- Does Single or Combined Caffeine and Taurine Supplementation Improve Athletic and Cognitive Performance without Affecting Fatigue Level in Elite Boxers? A Double-Blind, Placebo-Controlled Study.
Ozan M; Buzdagli Y; Eyipinar CD; Baygutalp NK; Yüce N; Oget F; Kan E; Baygutalp F · Nutrients · 2022
Randomized trial20 participantsflagEnergy forscienceCaffeine
- Trait Energy and Fatigue Modify the Effects of Caffeine on Mood, Cognitive and Fine-Motor Task Performance: A Post-Hoc Study.
Fuller DT; Smith ML; Boolani A · Nutrients · 2021
Randomized trialflagEnergy forscienceCaffeine
- Effect of caffeine ingestion on cycling performance: a systematic review and meta-analysis.
Wu J; Xu K; Yin M; Ding X; Wang T; Zhang Q; Wu X; Xiao N · Frontiers in nutrition · 2026
Meta-analysis226 participants20 studies pooledflagFitness forscienceCaffeine
- Effects of Caffeine Intake on Endurance Running Performance and Time to Exhaustion: A Systematic Review and Meta-Analysis.
Wang Z; Qiu B; Gao J; Del Coso J · Nutrients · 2023
Meta-analysis254 participants21 studies pooledflagFitness forscienceCaffeine
- Acute Effects of Caffeine Supplementation on Movement Velocity in Resistance Exercise: A Systematic Review and Meta-analysis.
Raya-González J; Rendo-Urteaga T; Domínguez R; Castillo D; Rodríguez-Fernández A; Grgic J · Sports medicine (Auckland, N.Z.) · 2021
Meta-analysis12 studies pooledflagFitness forscienceCaffeine
- Sex Differences in the Ergogenic Response of Acute Caffeine Intake on Muscular Strength, Power and Endurance Performance in Resistance-Trained Individuals: A Randomized Controlled Trial.
Montalvo-Alonso JJ; Ferragut C; Del Val-Manzano M; Valadés D; Roberts J; Pérez-López A · Nutrients · 2024
Randomized trial76 participantsflagFitness forscienceCaffeine
- Can I Have My Coffee and Drink It? A Systematic Review and Meta-analysis to Determine Whether Habitual Caffeine Consumption Affects the Ergogenic Effect of Caffeine.
Carvalho A; Marticorena FM; Grecco BH; Barreto G; Saunders B · Sports medicine (Auckland, N.Z.) · 2022
Meta-analysis60 studies pooledflagFitness forscienceCaffeine
- Taurine supplementation enhances anaerobic power in elite speed skaters: A double-blind, randomized, placebo-controlled, crossover study.
Buzdağlı Y; Eyipınar CD; Öget F; Şıktar E; Forbes SC; Tekin A · Biology of sport · 2023
Randomized trial30 participantsflagFitness forscienceTaurine
- The effect of acute taurine ingestion on 3-km running performance in trained middle-distance runners.
Balshaw TG; Bampouras TM; Barry TJ; Sparks SA · Amino acids · 2013
Randomized trial8 participantsflagFitness forscienceTaurine
- Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation.
Wesensten NJ; Killgore WD; Balkin TJ · Journal of sleep research · 2006
Randomized trial48 participantsflagMental Focus forscienceCaffeine
- Effects of caffeine on mood and performance: a study of realistic consumption.
Brice CF; Smith AP · Psychopharmacology · 2003
Clinical trial24 participantsflagMental Focus forscienceCaffeine
- Effects of caffeine or diphenhydramine on visual vigilance.
Fine BJ; Kobrick JL; Lieberman HR; Marlowe B; Riley RH; Tharion WJ · Psychopharmacology · 1995
Randomized trial24 participantsflagMental Focus forscienceCaffeine
- Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder.
Wozniak JR; Fink BA; Fuglestad AJ; Eckerle JK; Boys CJ; Sandness KE; Radke JP; Miller NC; Lindgren C; Brearley AM; Zeisel SH; Georgieff MK · Journal of neurodevelopmental disorders · 2021
Randomized trial31 participantsflagMental Focus forscienceCholine
- The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort.
Poly C; Massaro JM; Seshadri S; Wolf PA; Cho E; Krall E; Jacques PF; Au R · The American journal of clinical nutrition · 2012
Cohort study1,391 participantsflagMental Focus forscienceCholine
- Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies.
Obeid R; Derbyshire E; Schön C · Advances in nutrition (Bethesda, Md.) · 2022
Meta-analysis30 studies pooledflagMental Focus forscienceCholine
- Effect of Choline Supplementation on Neurological, Cognitive, and Behavioral Outcomes in Offspring Arising from Alcohol Exposure During Development: A Quantitative Systematic Review of Clinical and Preclinical Studies.
Akison LK; Kuo J; Reid N; Boyd RN; Moritz KM · Alcoholism, clinical and experimental research · 2019
Systematic reviewflagMental Focus forscienceCholine
- Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk.
Ross RG; Hunter SK; McCarthy L; Beuler J; Hutchison AK; Wagner BD; Leonard S; Stevens KE; Freedman R · The American journal of psychiatry · 2013
Randomized trialflagMental Focus forscienceCholine
- A Randomized Study to Examine the Ability of a Caffeine-Based Energy Drink to Impact Energy Expenditure, Fat Oxidation, and Cognitive Performance.
Krieger J; Schrautemeier A; Hagele A; Gaige C; Mennemeyer O; Tolbert S; Iannotti J; Kerksick C; Noonan C; Mumford P · Nutrients · 2025
Randomized trial60 participantsflagMetabolism Boost forscienceCaffeine
- Oolong tea increases metabolic rate and fat oxidation in men.
Rumpler W; Seale J; Clevidence B; Judd J; Wiley E; Yamamoto S; Komatsu T; Sawaki T; Ishikura Y; Hosoda K · The Journal of nutrition · 2001
Randomized trial12 participantsflagMetabolism Boost forscienceCaffeine
- Effect of caffeine intake on fat oxidation rate during exercise: is there a dose-response effect?
Gutiérrez-Hellín J; Aguilar-Navarro M; Ruiz-Moreno C; Muñoz A; Varillas-Delgado D; Amaro-Gahete FJ; Del Coso J · European journal of nutrition · 2023
Randomized trial18 participantsflagMetabolism Boost forscienceCaffeine
- Comparison of changes in energy expenditure and body temperatures after caffeine consumption.
Koot P; Deurenberg P · Annals of nutrition & metabolism · 1995
Randomized trial12 participantsflagMetabolism Boost forscienceCaffeine
- Caffeine Increases Work Done above Critical Power, but Not Anaerobic Work.
Silveira R; Andrade-Souza VA; Arcoverde L; Tomazini F; Sansonio A; Bishop DJ; Bertuzzi R; Lima-Silva AE · Medicine and science in sports and exercise · 2018
Randomized trial9 participantsflagMetabolism Boost forscienceCaffeine
- Taurine supplementation as a therapeutic strategy for cellular senescence and chronic inflammation in long COVID: a systematic review and meta-analysis.
Wang K; Ma CH; Khoramjoo M; Kung JY; Oudit GY · BMC infectious diseases · 2026
Meta-analysis1,030 participants27 studies pooledflagMetabolism Boost forscienceTaurine
- Effect of Long-Term Taurine Supplementation on the Lipid and Glycaemic Profile in Adults with Overweight or Obesity: A Systematic Review and Meta-Analysis.
Sun Q; Wang J; Wang H; Yu H; Wan K; Ma F; Wang R · Nutrients · 2025
Meta-analysis9 studies pooledflagMetabolism Boost forscienceTaurine
- The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials.
Guan L; Miao P · European journal of pharmacology · 2021
Meta-analysis12 studies pooledflagMetabolism Boost forscienceTaurine
- Beneficial effects of taurine on serum lipids in overweight or obese non-diabetic subjects.
Zhang M; Bi LF; Fang JH; Su XL; Da GL; Kuwamori T; Kagamimori S · Amino acids · 2005
Randomized trial30 participantsflagMetabolism Boost forscienceTaurine
- Use of skeletal muscle fiber composition to assess relationship between amino acid metabolism and insulin sensitivity.
Magnusson TE; Blackwood SJ; Tischer D; Strmeň T; Pontén M; Edman S; Horwath O; Apró W; Moberg M; Chorell E; Katz A · European journal of endocrinology · 2025
Cross-sectional study36 participantsflagMetabolism Boost forscienceTaurine
- Effects of caffeine on alertness.
Zwyghuizen-Doorenbos A; Roehrs TA; Lipschutz L; Timms V; Roth T · Psychopharmacology · 1990
Randomized trial24 participantsflagProductivity Boost forscienceCaffeine
- Effects of Different Sources of Low-Dose Caffeine on Mood/Arousal and Cognitive Performance.
Irwin C; McCartney D; Grant G; Delang N; Bartrim K; Cox GR; Desbrow B · Perceptual and motor skills · 2023
Randomized trial22 participantsflagProductivity Boost forscienceCaffeine
- Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land.
Lieberman HR; Tharion WJ; Shukitt-Hale B; Speckman KL; Tulley R · Psychopharmacology · 2003
Randomized trial68 participantsflagProductivity Boost forscienceCaffeine
- A review of caffeine's effects on cognitive, physical and occupational performance.
McLellan TM; Caldwell JA; Lieberman HR · Neuroscience and biobehavioral reviews · 2017
Narrative reviewflagProductivity Boost forscienceCaffeine
- Acute caffeine supplementation as a nutrition-based strategy to mitigate sleep-loss-related cognitive and operational performance impairments in military personnel: a systematic review and meta-analysis.
Wang R; Wang W; Meng L; Hao G; Gu G · Frontiers in nutrition · 2026
Meta-analysis7 studies pooledflagProductivity Boost forscienceCaffeine
- Changes in caffeine intake and long-term weight change in men and women.
Lopez-Garcia E; van Dam RM; Rajpathak S; Willett WC; Manson JE; Hu FB · The American journal of clinical nutrition · 2006
Cohort study58,157 participantsflagWeight Loss forscienceCaffeine
- The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials.
Tabrizi R; Saneei P; Lankarani KB; Akbari M; Kolahdooz F; Esmaillzadeh A; Nadi-Ravandi S; Mazoochi M; Asemi Z · Critical reviews in food science and nutrition · 2020
Meta-analysis606 participants13 studies pooledflagWeight Loss forscienceCaffeine