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L-Methylfolate 15 mg

Metabolic Maintenance
4.8
★ ★ ★ ★ ★
(65 ratings)
Glycine 250 mg
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Score69
An extremely high methylfolate product belongs in a supervised regimen, while its small glycine addition offers little benefit.
How scoring works
Quantity:60 Capsule(s) • (60 servings)
Goals:

Score 69

An extremely high methylfolate product belongs in a supervised regimen, while its small glycine addition offers little benefit.
How scoring works
$57.00($0.95 per serving)
Pure Formulas
$ 57.00
iHerb
$ 57.00
iHerb
$ 57.00
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Analysis

The capsule supplies L-methylfolate equivalent to 25 mg DFE. Such an extremely high active-folate amount requires a defined clinical rationale.

Glycine is present at 250 mg, far below a useful standalone amount. Its source quality is not described, and it adds little to the formula's value.

Sixty one-capsule servings support a set regimen but do not reduce the need for monitoring. B12 status, mood changes, and medication context should determine whether it fits.

Who is it for
  • Adults with a clinician-directed methylfolate plan
  • Users who specifically need the listed specialty amount
  • People not using it for glycine
Best for
  • Supervised high-dose methylfolate
  • Defined sixty-serving regimens
  • One-capsule use

Pros

  • Provides active L-methylfolate
  • Clearly states folate and glycine amounts
  • One capsule per serving
  • Sixty servings

Cons

  • Only 250 mg glycine
  • Extremely high folate dose
  • No glycine purity designation
  • Poor value for glycine

Warnings

  • High-dose folate can mask blood signs of vitamin B12 deficiency while neurologic harm continues, so B12 status must be considered before long-term use.
  • People with bipolar disorder should use this dose only under clinical supervision because mood activation can occur.
  • A prescriber should review concurrent antifolate medicines such as methotrexate.

Nutrient quality

70 High impact

Very high-dose methylfolate with glycine in capsules gives the formula reasonable ingredient quality. The disclosed amounts are meaningful and the ingredient selection stays focused.

Ingredient transparency

83 Highest impact

Important active details are incomplete or internally inconsistent. Serving guidance and the complete inactive-ingredient list are not fully supplied.

Customer satisfaction

61 Moderate impact

The aggregate rating is strong but the review volume limits confidence. No review excerpts are supplied to assess repeated complaints or purpose-specific experiences.

Value for money

56 Moderate impact

Premium positioning or disclosure limits weaken the value case. The useful active content appears limited relative to the serving cost.

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Ingredients

IngredientAmount per serving
Folate
25 mg DFE
Glycine
250 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
Glycine · 250 mg OverallScore57
C+ Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyB- Value

The clearly stated glycine amount is far below a targeted dose and mainly supports a high-dose methylfolate product. Standard capsule delivery is convenient, but the glycine source has no premium purity marker. The high cost offers weak glycine value and is justified only by the primary methylfolate use.

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85 Performance

Glycine Powder

Metabolic Maintenance
<p>Glycine Powder provides a stronger or more purposeful glycine profile than the original for focused glycine use. The single-ingredient powder is easy to assess and practical to scale toward a multi-gram intake. The disclosed serving is useful, though no premium purity grade or source certification is provided.</p>
84 Performance

Glycine 1000 mg

Life Extension
<p>Glycine 1000 mg provides a stronger or more purposeful glycine profile than the original for focused glycine use. A clearly measured gram-level serving gives the focused capsule useful support for glycine-related pathways. Several capsules may be needed for higher multi-gram use, while source grade and inactive ingredients are not supplied.</p>
78 Performance

Glycine

Pure Encapsulations
<p>Glycine provides a stronger or more purposeful glycine profile than the original for focused glycine use. The focused formula supplies a useful intermediate glycine amount with clear active disclosure. A multi-capsule serving, very limited review volume, and no stated source grade keep the value only moderate.</p>
83 Budget

Pharmaceutical Grade AjiPure Glycine 500 mg

Swanson Ultra
<p>A lower serving cost makes Pharmaceutical Grade AjiPure Glycine 500 mg a more economical choice than the original. A branded pharmaceutical-grade source gives the simple capsule unusually clear raw-material quality. The serving remains modest for multi-gram glycine use, and the inactive-ingredient list is not supplied.</p>
80 Budget

Glycine 500 mg

Solgar
<p>A lower serving cost makes Glycine 500 mg a more economical choice than the original. The simple capsule clearly discloses glycine but provides an entry-level amount that may require several capsules for multi-gram use. Practical pricing and extensive feedback help, while source grade and inactive ingredients remain unclear.</p>
80 Budget

Glycine 500 mg

Country Life
<p>A lower serving cost makes Glycine 500 mg a more economical choice than the original. The disclosed glycine amount is modest, while vitamin B6 adds a relevant cofactor without solving the low glycine dose. Accessible value and broad feedback are positives, but source grade and inactive ingredients remain unclear.</p>
82 Value

Advanced Magnesium Complex

AOR Advanced Orthomolecular Research Advanced
<p>Advanced Magnesium Complex offers a more useful balance of glycine relevance and recurring cost than the original. Several absorbable magnesium forms and a substantial glycine yield make this a well-designed foundational mineral formula. The label does not separate how much elemental magnesium comes from each form, and several carriers overlap in purpose.</p>
79 Value

Melatonin 2 mg

Metabolic Maintenance
<p>Melatonin 2 mg offers a more useful balance of glycine relevance and recurring cost than the original. A practical melatonin amount gives the simple capsule strong alignment with sleep timing and onset. Glycine is relevant but far below a focused standalone amount, and no release profile is supplied.</p>
83 Value

DGL Ultra

Nature's Way
<p>DGL Ultra offers a more useful balance of glycine relevance and recurring cost than the original. Standardized DGL in a simple capsule supports the product’s digestive purpose, while glycine is only a minor addition. Serving value is reasonable for the DGL formula but very weak for anyone primarily seeking glycine.</p>
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