Product Image

Glycine

Pure Encapsulations
4.7
★ ★ ★ ★ ★
(32 ratings)
Glycine 1500 mg
Product Image
Score78
A useful 1.5 g capsule serving offers focused glycine support, though three capsules and missing purity verification limit convenience.
How scoring works
Quantity:180 Capsule(s) • (60 servings)
Goals:
Detoxification
Anti-Inflammatory Support

Score 78

A useful 1.5 g capsule serving offers focused glycine support, though three capsules and missing purity verification limit convenience.
How scoring works
$35.00($0.58 per serving)
Pure Formulas
$ 35.00
Report prices

Analysis

Three capsules deliver 1.5 g of glycine as the only listed active. The amount is more substantial than most capsule products and supports a focused amino-acid routine.

Glycine directly participates in glycination and glutathione synthesis, while anti-inflammatory support is indirect. The serving remains below common multi-gram use and no branded purity standard is supplied.

Sixty servings make the bottle practical for moderate daily use. Powder is still easier to adjust and usually more convenient when a larger amount is desired.

Who is it for
  • Adults seeking a moderate capsule-based glycine amount
  • Users interested in glycination and glutathione support
  • People who avoid powder
Best for
  • Intermediate-dose glycine
  • Detoxification-pathway support
  • Capsule-only routines

Pros

  • Provides 1,500 mg glycine
  • Single-ingredient design
  • Clearly states the active amount
  • Sixty servings

Cons

  • Requires three capsules
  • Still below common multi-gram use
  • No branded purity source
  • Less flexible than powder

Warnings

  • Three capsules or larger multi-gram amounts may cause nausea or loose stool in sensitive users.
  • Do not add extra servings beyond label directions when increasing the dose.
  • People with significant kidney or liver disease should review concentrated amino-acid use with their clinician.

Nutrient quality

90 Highest impact

Free-form glycine in a multi-capsule serving gives the formula reasonable ingredient quality. The amounts are useful, though dose depth or delivery detail leaves room for improvement.

Ingredient transparency

82 Highest impact

Important active details are incomplete or internally inconsistent. Serving guidance and the complete inactive-ingredient list are not fully supplied.

Customer satisfaction

57 Moderate impact

The aggregate rating is strong but the review volume limits confidence. No review excerpts are supplied to assess repeated complaints or purpose-specific experiences.

Value for money

80 Highest impact

Formula quality provides fair value for the category. Serving value is reasonable, with trade-offs in delivery or disclosure.

Report analysis

Goals

Impact
High effect
B- Goal FitC+ Strength of SupportD CoverageA+ Formula Quality
Glycine · 1500 mg

Glycine directly supplies a substrate used in Phase II conjugation and glutathione synthesis. The single-ingredient design offers focused support for that pathway without making broad cleanse claims.

The 1.5 g amount is useful but below more intensive multi-gram intake, and no branded purity standard is stated. Full disclosure and the absence of unrelated ingredients make the formula simple and easy to judge.

Study evidence
Glycine Supportive 5 studies
Anti-Inflammatory Support
Impact
Moderate effect
F Goal FitC Strength of SupportF CoverageA+ Formula Quality
Glycine · 1500 mg

Glycine may support glutathione production and immune balance, but its anti-inflammatory role is indirect. Human evidence for broad inflammatory outcomes is limited compared with omega-3 fats, curcumin, or boswellia.

The serving is meaningful as supplemental glycine but below common gram-level amounts used for broader metabolic effects. The product is better suited to general glycine support than to a dedicated anti-inflammatory plan.

Study evidence
Glycine Supportive 7 studies

Ingredients

IngredientAmount per serving
Calories
5 Calorie(s)
Glycine
1500 mg
Gluten Free Adults 18–50
Report overview
Glycine · 1500 mg OverallScore70
C+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyC Value

The standalone capsule provides a useful intermediate glycine dose but does not reach the common sleep-focused target. Its exact amount is clear, though no branded purity standard is stated. The cost per gram falls in a moderate value range, and the multi-capsule serving is less convenient than powder.

Loading alternative details
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.
    Tan HC; Hsu JW; Tai ES; Chacko S; Kovalik JP; Jahoor F · Frontiers in endocrinology · 2024
    Cohort study42 participantsDetoxification forGlycine
  2. Contribution towards a Metabolite Profile of the Detoxification of Benzoic Acid through Glycine Conjugation: An Intervention Study.
    Irwin C; van Reenen M; Mason S; Mienie LJ; Westerhuis JA; Reinecke CJ · PloS one · 2017
    Non-randomized trial21 participantsDetoxification forGlycine
  3. Glycine conjugation of para-aminobenzoic acid (PABA): a quantitative test of liver function.
    Furuya KN; Durie PR; Roberts EA; Soldin SJ; Verjee Z; Yung-Jato L; Giesbrecht E; Ellis L · Clinical biochemistry · 1996
    Methods validation study74 participantsDetoxification forGlycine
  4. Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes.
    Cruz M; Maldonado-Bernal C; Mondragón-Gonzalez R; Sanchez-Barrera R; Wacher NH; Carvajal-Sandoval G; Kumate J · Journal of endocrinological investigation · 2009
    Randomized trial74 participantsAnti-Inflammatory Support forGlycine
  5. Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: a pilot randomized trial.
    Vargas MH; Del-Razo-Rodríguez R; López-García A; Lezana-Fernández JL; Chávez J; Furuya MEY; Marín-Santana JC · BMC pulmonary medicine · 2018
    Randomized trial13 participantsAnti-Inflammatory Support forGlycine
  6. Clinical, inflammatory and microbiological outcomes of full-mouth scaling with adjunctive glycine powder air-polishing: A randomized trial.
    Zhang W; Wang W; Chu C; Jing J; Yao NA; Sun Q; Li S · Journal of clinical periodontology · 2021
    Randomized trial41 participantsAnti-Inflammatory Support forGlycine
  7. Subgingival air polishing (glycine powder) versus minocycline hydrochloride: efficacy in residual periodontal pockets following endoscope-assisted scaling and root planing.
    Guo X; Bai H; Lu X; Guo J; Qi Y; Huo X; Li S · Clinical oral investigations · 2026
    Randomized trial80 participantsAnti-Inflammatory Support forGlycine
  8. Long-term Implant Maintenance: A Systematic Review of Home and Professional Care Strategies in Supportive Implant Therapy.
    Araújo TG; Moreira CS; Neme RA; Luan H; Bertolini M · Brazilian dental journal · 2024
    Systematic review13 studies pooledAnti-Inflammatory Support forGlycine
  9. Analysis of the factors influencing the occurrence of peri-implantitis in patients with implant-supported restoration and study on the maintenance effect of subgingival sandblasting.
    Pan T; Meng W; Zhang M; Xie Y; Chen Z; Zhou M; Yin L; Xie H · BMC oral health · 2026
    Randomized trial198 participantsAnti-Inflammatory Support forGlycine
  10. Metabolic impact of dietary glycine supplementation in individuals with severe obesity.
    Tan HC; Hsu JW; Tai ES; Chacko S; Wu V; Yen PM; Kovalik JP; Jahoor F · Scientific reports · 2025
    Single-arm trial19 participantsDetoxification forGlycine
  11. The treatment of isovaleric acidemia with glycine supplement
    M Naglak, R Salvo, K Madsen, P Dembure, L Elsas · Pediatric research · 1988
    Non-randomized trial2 participantsDetoxification forGlycine