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Glycine 1000 mg

Life Extension
4.8
★ ★ ★ ★ ★
(15892 ratings)
Glycine 1000 mg
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Score84
A practical 1 g glycine capsule offers clear, economical support, though multi-gram use and purity verification remain limitations.
How scoring works
Quantity:100 Capsule(s) • (100 servings)
Goals:
Detoxification
Anti-Inflammatory Support

Score 84

A practical 1 g glycine capsule offers clear, economical support, though multi-gram use and purity verification remain limitations.
How scoring works
$12.00($0.12 per serving)
Pure Formulas
$ 12.00
iHerb
$ 12.00
Amazon
$ 12.00
Vitacost
$ 12.00
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Analysis

The capsule supplies 1 g of glycine without unrelated actives. That amount offers a useful starting point for amino-acid support and is more practical than 500 mg capsule products.

Glycine supports glycination and provides a building block for glutathione, while its anti-inflammatory role is more indirect. Several capsules may still be needed for common multi-gram goals, and source or purity details are missing.

One hundred servings and a simple label support regular use. The formula fits users wanting a moderate capsule amount rather than the flexibility of bulk powder.

Who is it for
  • Adults seeking a moderate glycine capsule
  • Users interested in glutathione and glycination support
  • People who prefer capsules to powder
Best for
  • Daily glycine maintenance
  • Detoxification-pathway support
  • Simple capsule routines

Pros

  • Provides 1,000 mg glycine
  • Single-ingredient formula
  • One hundred servings
  • More practical than 500 mg capsules

Cons

  • Below common multi-gram use
  • Purity grade is not stated
  • No independent verification is supplied
  • Narrow pathway coverage

Warnings

  • Several capsules used to reach multi-gram intake may cause nausea or loose stool in sensitive users.
  • Do not exceed label directions when scaling the dose.
  • People with significant kidney or liver disease should review concentrated amino-acid use with their clinician.

Nutrient quality

87 Highest impact

Free-form glycine in a capsule gives the formula reasonable ingredient quality. Dose uncertainty or limited delivery detail prevents a confident quality assessment.

Ingredient transparency

82 Highest impact

Important active details are incomplete or internally inconsistent. Serving guidance and the complete inactive-ingredient list are not fully supplied.

Customer satisfaction

73 High impact

The aggregate rating is strong and supported by useful review volume. No review excerpts are supplied to assess repeated complaints or purpose-specific experiences.

Value for money

94 Highest impact

Formula quality and active content support strong category value. The effective serving and focused ingredient list compare favorably with similar options.

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Goals

Detoxification
Detoxification
Impact
High effect
B Goal FitB- Strength of SupportC+ CoverageA+ Formula Quality
Glycine · 1000 mg

Glycine directly supports glycination and also supplies a building block for glutathione. The serving is useful, although some applications use larger multi-gram amounts.

The simple capsule clearly states the active amount and avoids unrelated additions. Source, purity grade, and independent verification are not provided.

Study evidence
Glycine Supportive 5 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
D+ Goal FitB- Strength of SupportD- CoverageA+ Formula Quality
Glycine · 1000 mg

Glycine may support glutathione production and help regulate inflammatory signaling, but its effect is indirect. The 1,000 mg amount provides a modest contribution compared with doses commonly used for broader glycine support.

A single-ingredient design is transparent and free from padding. Narrow pathway coverage and limited direct human anti-inflammatory evidence keep it from matching targeted omega-3 or botanical formulas.

Study evidence
Glycine Supportive 7 studies

Ingredients

IngredientAmount per serving
Glycine
1000 mg
Adults 18–50
Report overview
Glycine · 1000 mg OverallScore67
F Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyA- Value

The free-form capsule provides a clearly measured maintenance dose with convenient use and no disclosed additives. Its amount is below the multi-gram level commonly used for sleep, so several capsules would be needed for that goal. The low cost per gram makes it good value among capsule options despite the missing premium purity designation.

View ingredientView products
Loading alternative details
85 Performance

Glycine Powder

Metabolic Maintenance
<p>Glycine Powder provides a stronger or more purposeful glycine profile than the original for focused glycine use. The single-ingredient powder is easy to assess and practical to scale toward a multi-gram intake. The disclosed serving is useful, though no premium purity grade or source certification is provided.</p>
78 Performance

Glycine

Pure Encapsulations
<p>Glycine provides a stronger or more purposeful glycine profile than the original for focused glycine use. The focused formula supplies a useful intermediate glycine amount with clear active disclosure. A multi-capsule serving, very limited review volume, and no stated source grade keep the value only moderate.</p>
82 Performance

Advanced Magnesium Complex

AOR Advanced Orthomolecular Research Advanced
<p>Advanced Magnesium Complex provides a stronger or more purposeful glycine profile than the original for focused glycine use. Several absorbable magnesium forms and a substantial glycine yield make this a well-designed foundational mineral formula. The label does not separate how much elemental magnesium comes from each form, and several carriers overlap in purpose.</p>
83 Budget

Pharmaceutical Grade AjiPure Glycine 500 mg

Swanson Ultra
<p>A lower serving cost makes Pharmaceutical Grade AjiPure Glycine 500 mg a more economical choice than the original. A branded pharmaceutical-grade source gives the simple capsule unusually clear raw-material quality. The serving remains modest for multi-gram glycine use, and the inactive-ingredient list is not supplied.</p>
80 Budget

Glycine 500 mg

Solgar
<p>A lower serving cost makes Glycine 500 mg a more economical choice than the original. The simple capsule clearly discloses glycine but provides an entry-level amount that may require several capsules for multi-gram use. Practical pricing and extensive feedback help, while source grade and inactive ingredients remain unclear.</p>
80 Budget

Glycine 500 mg

Country Life
<p>A lower serving cost makes Glycine 500 mg a more economical choice than the original. The disclosed glycine amount is modest, while vitamin B6 adds a relevant cofactor without solving the low glycine dose. Accessible value and broad feedback are positives, but source grade and inactive ingredients remain unclear.</p>
79 Value

Melatonin 2 mg

Metabolic Maintenance
<p>Melatonin 2 mg offers a more useful balance of glycine relevance and recurring cost than the original. A practical melatonin amount gives the simple capsule strong alignment with sleep timing and onset. Glycine is relevant but far below a focused standalone amount, and no release profile is supplied.</p>
83 Value

DGL Ultra

Nature's Way
<p>DGL Ultra offers a more useful balance of glycine relevance and recurring cost than the original. Standardized DGL in a simple capsule supports the product’s digestive purpose, while glycine is only a minor addition. Serving value is reasonable for the DGL formula but very weak for anyone primarily seeking glycine.</p>
81 Value

DGL Deglycyrrhizinated Licorice Root Extract

Swanson Superior Herbs
<p>DGL Deglycyrrhizinated Licorice Root Extract offers a more useful balance of glycine relevance and recurring cost than the original. The DGL-centered formula provides a clearly disclosed licorice amount and uses glycine only as a small companion. It may suit its digestive purpose, but it is poorly aligned with anyone seeking meaningful standalone glycine.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.
    Tan HC; Hsu JW; Tai ES; Chacko S; Kovalik JP; Jahoor F · Frontiers in endocrinology · 2024
    Cohort study42 participantsDetoxification forGlycine
  2. Contribution towards a Metabolite Profile of the Detoxification of Benzoic Acid through Glycine Conjugation: An Intervention Study.
    Irwin C; van Reenen M; Mason S; Mienie LJ; Westerhuis JA; Reinecke CJ · PloS one · 2017
    Non-randomized trial21 participantsDetoxification forGlycine
  3. Glycine conjugation of para-aminobenzoic acid (PABA): a quantitative test of liver function.
    Furuya KN; Durie PR; Roberts EA; Soldin SJ; Verjee Z; Yung-Jato L; Giesbrecht E; Ellis L · Clinical biochemistry · 1996
    Methods validation study74 participantsDetoxification forGlycine
  4. Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes.
    Cruz M; Maldonado-Bernal C; Mondragón-Gonzalez R; Sanchez-Barrera R; Wacher NH; Carvajal-Sandoval G; Kumate J · Journal of endocrinological investigation · 2009
    Randomized trial74 participantsAnti-Inflammatory Support forGlycine
  5. Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: a pilot randomized trial.
    Vargas MH; Del-Razo-Rodríguez R; López-García A; Lezana-Fernández JL; Chávez J; Furuya MEY; Marín-Santana JC · BMC pulmonary medicine · 2018
    Randomized trial13 participantsAnti-Inflammatory Support forGlycine
  6. Clinical, inflammatory and microbiological outcomes of full-mouth scaling with adjunctive glycine powder air-polishing: A randomized trial.
    Zhang W; Wang W; Chu C; Jing J; Yao NA; Sun Q; Li S · Journal of clinical periodontology · 2021
    Randomized trial41 participantsAnti-Inflammatory Support forGlycine
  7. Subgingival air polishing (glycine powder) versus minocycline hydrochloride: efficacy in residual periodontal pockets following endoscope-assisted scaling and root planing.
    Guo X; Bai H; Lu X; Guo J; Qi Y; Huo X; Li S · Clinical oral investigations · 2026
    Randomized trial80 participantsAnti-Inflammatory Support forGlycine
  8. Long-term Implant Maintenance: A Systematic Review of Home and Professional Care Strategies in Supportive Implant Therapy.
    Araújo TG; Moreira CS; Neme RA; Luan H; Bertolini M · Brazilian dental journal · 2024
    Systematic review13 studies pooledAnti-Inflammatory Support forGlycine
  9. Analysis of the factors influencing the occurrence of peri-implantitis in patients with implant-supported restoration and study on the maintenance effect of subgingival sandblasting.
    Pan T; Meng W; Zhang M; Xie Y; Chen Z; Zhou M; Yin L; Xie H · BMC oral health · 2026
    Randomized trial198 participantsAnti-Inflammatory Support forGlycine
  10. Metabolic impact of dietary glycine supplementation in individuals with severe obesity.
    Tan HC; Hsu JW; Tai ES; Chacko S; Wu V; Yen PM; Kovalik JP; Jahoor F · Scientific reports · 2025
    Single-arm trial19 participantsDetoxification forGlycine
  11. The treatment of isovaleric acidemia with glycine supplement
    M Naglak, R Salvo, K Madsen, P Dembure, L Elsas · Pediatric research · 1988
    Non-randomized trial2 participantsDetoxification forGlycine