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St. John's Wort Extract

21st Century
4.5
★ ★ ★ ★ ★
(1081 ratings)
St. John's Wort 300 mg
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Score79

A focused, affordable extract is easy to use. Unstandardized potency and major medication interactions are the key trade-offs.

How scoring works
Quantity:60 Capsule(s) • (60 servings)
Goals:
Mood Support

Score 79

A focused, affordable extract is easy to use. Unstandardized potency and major medication interactions are the key trade-offs.

How scoring works
$5.93($0.09 per serving)
iHerb
$ 5.93
Amazon
$ 0.00
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Analysis

One capsule provides 300 mg of Hypericum perforatum extract with no unrelated actives. The serving is easy to use and sits within a commonly used extract amount.

The label does not state hypericin, hyperforin, or an extraction ratio. That omission limits comparison with the better-defined products used for mood support.

Low serving cost and a focused formula are practical strengths. Medication interactions are extensive enough that suitability should be checked before use rather than inferred from the simple label.

Who is it for
  • Adults seeking a basic single-herb mood supplement
  • Users who have checked St. John’s wort against all current medicines
Best for
  • Low-cost St. John’s wort use
  • A simple one-capsule formula

Pros

  • Single active ingredient
  • Clearly states species and extract weight
  • One capsule per serving
  • Favorable serving value

Cons

  • No hypericin standardization
  • No hyperforin or extract-ratio detail
  • Potency is harder to compare with standardized extracts

Warnings

  • Do not combine St. John’s wort with SSRI, SNRI, MAOI, or other serotonergic medicines because serotonin toxicity can occur.
  • St. John’s wort can reduce the effectiveness of oral contraceptives, warfarin, transplant medicines, some HIV medicines, and several seizure medicines.
  • The herb can increase sensitivity to sunlight, so extra sun protection may be needed.
  • People with bipolar disorder should avoid unsupervised use because St. John’s wort can trigger agitation or mania.

Nutrient quality

77 High impact

The focused extract fits mood support, but missing active-marker standardization limits potency confidence. The moderate amount is plausible without appearing excessive, though it may provide only a partial daily dose.

Ingredient transparency

77 High impact

The shown active amounts are generally clear, with no proprietary blend obscuring the main doses. Daily directions and a complete inactive-ingredient list are not supplied.

Customer satisfaction

71 High impact

The supplied aggregate rating is favorable and supported by a very large review volume. Detailed feedback is unavailable, so repeated complaints and fit with the intended use cannot be judged.

Value for money

93 Highest impact

The formula provides strong practical value for its quality and serving profile. Few low-value additions dilute the core formula.

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Goals

Mood Support
Impact
High effect
B+ Goal FitC+ Strength of SupportD- CoverageA Formula Quality

St. John's Wort Extract provides 300 mg per serving and uses a St. John's wort extract with incomplete active-marker detail, giving it direct but dose-dependent alignment with mood support.

Customer feedback averages 4.50 from 1081 reviews, while the published label carries medication-interaction cautions and a product-specific independent certification was not confirmed.

Study evidence
St. John's Wort Supportive 97 studies

Ingredients

IngredientAmount per serving
St. John's Wort extract (Hypericum perforatum)
300 mg
Gluten Free Adults 18–50 Vegetarian
Report overview
B- Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyA+ Value

21st Century Saint John's Wort Extract provides 300 mg per serving and uses an extract without a stated hypericin percentage, producing a partial dosage fit under the collection rubric. Customer feedback averages 4.50 from 1081 reviews, while the available label warning remains general rather than drug-class specific.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression: a randomized double-blind trial in a Brazilian sample.
    Moreno RA; Teng CT; Almeida KM; Tavares Junior H · Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2006
    Randomized trial72 participantsMood Support forSt. John's Wort
  2. The impact of missing data on clinical trials: a re-analysis of a placebo controlled trial of Hypericum perforatum (St Johns wort) and sertraline in major depressive disorder.
    Grobler AC; Matthews G; Molenberghs G · Psychopharmacology · 2014
    Randomized trial340 participantsMood Support forSt. John's Wort
  3. Documentary Analysis of Hypericum perforatum (St. John's Wort) and Its Effect on Depressive Disorders.
    Otero MC; Ceric F; Miranda-Rojas S; Carreño C; Escares R; Escobar MJ; Saracini C; Atala C; Ramírez-Barrantes R; Gordillo-Fuenzalida F · Pharmaceuticals (Basel, Switzerland) · 2025
    Narrative reviewMood Support forSt. John's Wort
  4. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  5. St John's wort for depression--an overview and meta-analysis of randomised clinical trials.
    Linde K; Ramirez G; Mulrow CD; Pauls A; Weidenhammer W; Melchart D · BMJ (Clinical research ed.) · 1996
    Meta-analysis1,757 participants23 studies pooledMood Support forSt. John's Wort
  6. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  7. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  8. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort
  9. [Meta-analysis of effectiveness and tolerability of treatment of mild to moderate depression with St. John's Wort].
    Röder C; Schaefer M; Leucht S · Fortschritte der Neurologie-Psychiatrie · 2004
    Meta-analysis30 studies pooledMood Support forSt. John's Wort
  10. A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults.
    Cui YH; Zheng Y · Neuropsychiatric disease and treatment · 2016
    Meta-analysis3,126 participants27 studies pooledMood Support forSt. John's Wort
  11. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort