Product Image

St. John's Wort Flower & Leaf 300 mg

Eclectic Institute
4.5
★ ★ ★ ★ ★
(164 ratings)
St. John's Wort 300 mg
Product Image
Score66

Clearly identified freeze-dried flower and leaf offer a whole-herb option. Lack of concentration and active-marker standards limits dose confidence.

How scoring works
Quantity:90 Capsule(s) • (90 servings)
Goals:
Mood Support

Score 66

Clearly identified freeze-dried flower and leaf offer a whole-herb option. Lack of concentration and active-marker standards limits dose confidence.

How scoring works
$18.35($0.20 per serving)
iHerb
$ 18.35
Amazon
$ 22.99
Report prices

Analysis

The capsule contains freeze-dried St. John’s wort flower and leaf rather than a concentrated extract. Naming the aerial plant material is helpful, and the formula avoids unrelated ingredients.

No hypericin or hyperforin content is provided, so batch potency and clinical comparability remain uncertain. A 300 mg whole-herb amount should not be assumed equivalent to 300 mg of a standardized extract.

The 90-serving supply is convenient for established users. People choosing it should value minimally processed herb material more than consistent active-marker delivery.

Who is it for
  • Adults who prefer freeze-dried whole-herb material
  • Users who have cleared St. John’s wort medication interactions
Best for
  • A minimally processed St. John’s wort option
  • Longer supply of a simple single-herb capsule

Pros

  • Identifies flower and leaf material
  • Freeze-dried preparation
  • Single-herb formula
  • Ninety servings

Cons

  • Not a concentrated extract
  • No hypericin or hyperforin standardization
  • Whole-herb amount is not directly comparable with clinical extracts

Warnings

  • Do not combine St. John’s wort with SSRI, SNRI, MAOI, or other serotonergic medicines because serotonin toxicity can occur.
  • St. John’s wort can reduce the effectiveness of oral contraceptives, warfarin, transplant medicines, some HIV medicines, and several seizure medicines.
  • The herb can increase sensitivity to sunlight, so extra sun protection may be needed.
  • People with bipolar disorder should avoid unsupervised use because St. John’s wort can trigger agitation or mania.

Nutrient quality

64 Moderate impact

Freeze-dried plant material and absent active-marker standardization weaken form quality. Duplicate ingredient entries also make the true amount uncertain, although the focused herb still fits mood support.

Ingredient transparency

64 Moderate impact

Duplicate St. John's wort entries make the true active amount ambiguous, with no proprietary blend obscuring the main doses.

Customer satisfaction

67 High impact

The supplied aggregate rating is favorable and supported by a useful review volume. Detailed feedback is unavailable, so repeated complaints and fit with the intended use cannot be judged.

Value for money

69 High impact

The formula provides moderate practical value for its quality and serving profile. Few low-value additions dilute the core formula.

Report analysis

Goals

Mood Support
Mood Support
Impact
High effect
B+ Goal FitC+ Strength of SupportD- CoverageA Formula Quality

St. John's Wort Flower & Leaf 300 mg provides 300 mg per serving and uses a St. John's wort extract with incomplete active-marker detail, giving it direct but dose-dependent alignment with mood support.

Customer feedback averages 4.54 from 165 reviews, while the published label carries medication-interaction cautions and a product-specific independent certification was not confirmed.

Study evidence
St. John's Wort Supportive 97 studies

Ingredients

IngredientAmount per serving
St. John's Wort, Freeze-Dried
300 mg
Adults 18–50 Vegan Kosher Dairy Free Women Vegetarian
Report overview
St. John's Wort (St. John's Wort, Freeze-Dried) · 300 mg OverallScore32
F Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyB- Value

Eclectic Institute Saint John's Wort Flower and Leaf provides 300 mg per serving and uses freeze-dried flower-and-leaf material rather than a standardized extract, producing a partial dosage fit under the collection rubric. Customer feedback averages 4.54 from 165 reviews, while the available label warning remains general rather than drug-class specific.

View ingredientView products
Loading alternative details
84 Performance

Feeling Positive St. John's Wort 300 mg

Sundown
Marker standardization supports consistent extract quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Performance

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; its extract quality and goal fit provide a clearer option when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Performance

Perika St. John's Wort

Nature's Way
The named extract supports consistent quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort Extract

Swanson Superior Herbs
Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort 300 mg

NOW
Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
89 Budget

St. John's Wort 300 mg

California Gold Nutrition EuroHerbs
A hypericin-standardized extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the lower serving cost improves economy when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
87 Value

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the quality-to-cost balance is favorable when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

St. John's Wort 300 mg

Nature's Bounty
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Value

St. John's Wort

Paradise
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression: a randomized double-blind trial in a Brazilian sample.
    Moreno RA; Teng CT; Almeida KM; Tavares Junior H · Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2006
    Randomized trial72 participantsMood Support forSt. John's Wort
  2. The impact of missing data on clinical trials: a re-analysis of a placebo controlled trial of Hypericum perforatum (St Johns wort) and sertraline in major depressive disorder.
    Grobler AC; Matthews G; Molenberghs G · Psychopharmacology · 2014
    Randomized trial340 participantsMood Support forSt. John's Wort
  3. Documentary Analysis of Hypericum perforatum (St. John's Wort) and Its Effect on Depressive Disorders.
    Otero MC; Ceric F; Miranda-Rojas S; Carreño C; Escares R; Escobar MJ; Saracini C; Atala C; Ramírez-Barrantes R; Gordillo-Fuenzalida F · Pharmaceuticals (Basel, Switzerland) · 2025
    Narrative reviewMood Support forSt. John's Wort
  4. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  5. St John's wort for depression--an overview and meta-analysis of randomised clinical trials.
    Linde K; Ramirez G; Mulrow CD; Pauls A; Weidenhammer W; Melchart D · BMJ (Clinical research ed.) · 1996
    Meta-analysis1,757 participants23 studies pooledMood Support forSt. John's Wort
  6. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  7. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  8. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort
  9. [Meta-analysis of effectiveness and tolerability of treatment of mild to moderate depression with St. John's Wort].
    Röder C; Schaefer M; Leucht S · Fortschritte der Neurologie-Psychiatrie · 2004
    Meta-analysis30 studies pooledMood Support forSt. John's Wort
  10. A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults.
    Cui YH; Zheng Y · Neuropsychiatric disease and treatment · 2016
    Meta-analysis3,126 participants27 studies pooledMood Support forSt. John's Wort
  11. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort