Product Image

ACF Advanced Immune Response

Buried Treasure Liquid Nutrients
4.6
★ ★ ★ ★ ★
(216 ratings)
European Elder 750 mg
Zinc 15 mg
Ginger
Vitamin C 1000 mg
Rutin 50 mg
Flavonoid (mixture) 300 mg
Product Image
Score66
A liquid immune blend with strong core amounts of vitamin C, zinc, elderberry, and echinacea. The many poorly characterized herbs and important interaction risks make it a selective rather than broadly suitable choice.
How scoring works
Quantity:16 Liquid(s) • (16 servings)
Goals:
Anti-Inflammatory Support
General Health
Skin Health

Score 66

A liquid immune blend with strong core amounts of vitamin C, zinc, elderberry, and echinacea. The many poorly characterized herbs and important interaction risks make it a selective rather than broadly suitable choice.
How scoring works
$26.77($1.67 per serving)
Pure Formulas
$ 26.77
Amazon
$ 32.87
Walmart
$ 31.11
Daily Vita
$ 28.81
iHerb
$ 28.81
Report prices

Analysis

Vitamin C, zinc, elderberry, and echinacea provide a recognizable immune-support base. The liquid form is convenient for people who avoid capsules, and most active weights are stated rather than hidden in one proprietary blend.

White willow, citrus bioflavonoids, goldenseal, ginger, myrrh, osha, usnea, rutin, and thyme create a very busy serving. Most botanical sources are not standardized, so their active yield and consistency remain uncertain.

The formula is best treated as a targeted botanical product rather than a simple daily nutrient supplement. Salicin from white willow and medication effects from goldenseal require more screening than the front-of-label nutrient profile may suggest.

Who is it for
  • Adults who prefer a liquid immune formula
  • People specifically seeking elderberry and echinacea together
  • Users who can screen the botanical blend against their medicines
Best for
  • Short-term liquid supplementation
  • Broad botanical immune support
  • Avoiding multiple capsules

Pros

  • Supplies 1,000 mg vitamin C
  • Provides 15 mg zinc gluconate
  • Includes substantial elderberry and echinacea extracts
  • Discloses individual botanical weights

Cons

  • Most extracts lack standardization details
  • Contains several low-priority botanical additions
  • Rutin and ginger amounts are modest
  • Purified silver lacks a clear nutritional purpose

Warnings

  • White willow salicin may increase bleeding risk and is unsuitable for people with aspirin sensitivity
  • Goldenseal can affect the metabolism of multiple prescription medicines
  • Vitamin C at 1,000 mg may cause diarrhea or stomach upset
  • Avoid goldenseal during pregnancy unless specifically directed by a qualified clinician

Nutrient quality

63 Moderate impact

Vitamin C, zinc, elderberry, and echinacea form a substantial short-term immune core. Plain nutrient forms and many lightly characterized botanicals reduce quality and focus.

Ingredient transparency

79 High impact

Every listed active has an individual amount and no blend hides the quantities. Many botanicals lack extract ratios or active-marker details, and the inactive liquid base is not disclosed here.

Customer satisfaction

74 High impact

The strong average rating has a substantial review base and supports broad satisfaction. No review excerpts describe taste, tolerance, or repeated complaints, leaving those practical experiences unknown.

Value for money

42 Lower impact

Useful elderberry and core nutrient amounts provide some serving value. A short supply, ordinary forms, and numerous weakly characterized additions make the purchase less efficient than a focused immune formula.

Report analysis

Goals

Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
B+ Goal FitC+ Strength of SupportB+ CoverageC- Formula Quality
Vitamin C · 1000 mg

Vitamin C, white willow, ginger, rutin, and bioflavonoids span antioxidant, COX, LOX, and vascular inflammatory pathways. The blend is broad, but several botanical extracts lack standardization and much of the formula serves short-term immune support.

White willow may be unsafe for aspirin-sensitive users and can increase bleeding risk with anticoagulant or antiplatelet medicines. Goldenseal can also alter the handling of many medicines, while added silver has no clear nutritional anti-inflammatory role.

Study evidence
Ginger Supportive 30 studies
Rutin Supportive 6 studies
Vitamin C Supportive 50 studies
General Health
General Health
Impact
High effect
C Goal FitB- Strength of SupportB+ CoverageD- Formula Quality
Zinc · 15 mgVitamin C · 1000 mg

Vitamin C and zinc provide established foundational support at meaningful amounts. The large botanical mixture is geared toward short-term immune use, so it is less well matched to simple daily wellness.

Most active amounts are disclosed, but the crowded formula includes several ingredients with limited general-health evidence. White willow supplies salicin and may raise bleeding risk with anticoagulants or cause reactions in people sensitive to aspirin.

Study evidence
Vitamin C Supportive 56 studies
Zinc Supportive 60 studies
Skin Health
Skin Health
Impact
High effect
B Goal FitB Strength of SupportC+ CoverageF Formula Quality
Zinc · 15 mgVitamin C · 1000 mg

Vitamin C and zinc provide meaningful collagen-cofactor, antioxidant, and normal repair support. Those actives are clearly disclosed at useful amounts.

The large immune-botanical mixture is not targeted to skin and the liquid lacks stabilization details. White willow salicin may raise bleeding or sensitivity concerns for people using anticoagulants or reacting to aspirin.

Study evidence
Vitamin C Supportive 53 studies
Zinc Supportive 66 studies
Immunity
Immunity
Impact
Moderate effect
C Goal FitC+ Strength of SupportC+ CoverageD+ Formula Quality
Vitamin C · 1000 mgZinc · 15 mgEuropean Elder · 750 mg

Vitamin C and zinc provide a credible nutritional base, while the many botanicals focus the formula on short-term immune support. Several plant extracts are meaningfully disclosed, but they do not create a balanced daily wellness product.

White willow supplies salicin and may be unsuitable for people with aspirin sensitivity or those taking anticoagulant or antiplatelet medicines. Goldenseal, numerous unstandardized botanicals, and added silver also make routine long-term use difficult to justify.

Study evidence
Vitamin C Supportive 53 studies
Zinc Supportive 73 studies
Hair Health
Healthy Hair Growth CycleScalp Health and Protection
Hair Health
Impact
Moderate effect
C- Goal FitB Strength of SupportC CoverageF Formula Quality
Zinc · 15 mgVitamin C · 1000 mg

Zinc and vitamin C may help hair when low intake contributes to follicle stress. Both are supplied at substantial, clearly stated amounts.

The remaining ingredients form an immune-response blend rather than a hair strategy. White willow salicin may be unsuitable for aspirin-sensitive users or people taking anticoagulants.

Study evidence
Vitamin C Mixed 5 studies
Zinc Supportive 22 studies
Vision Support
Vision Support
Impact
Moderate effect
D Goal FitB+ Strength of SupportF CoverageF Formula Quality
Zinc · 15 mgVitamin C · 1000 mg

Vitamin C and zinc offer relevant antioxidant support, but the formula is primarily an intensive immune botanical mixture. It lacks macular carotenoids, vitamin E, copper, and omega-3 fats, while most herbs have little established ocular value.

Core nutrient doses are clear, though the crowded botanical list does not improve eye-health confidence. White willow supplies salicin, which may increase bleeding risk for people using anticoagulants, antiplatelet drugs, or aspirin.

Study evidence
Vitamin C Disputed 24 studies
Zinc Supportive 39 studies

Ingredients

IngredientAmount per serving
Calories
17 Calorie(s)
Total Fat
0 Gram(s)
Cholesterol
0 mg
Sodium
10 mg
Total Carbohydrates
4 Gram(s)
Vitamin C (Ascorbic Acid)
 1000 mg
Zinc (Zinc Gluconate)
 15 mg
Elderberry extract
750 mg
Echinacea purpurea extract
600 mg
White Willow bark extract (Salicin)
 400 mg
Citrus Bioflavonoids Complex (Hesperidin)
 300 mg
Goldenseal extract
200 mg
Ginger root extract
100 mg
Myrrh
100 mg
Osha
100 mg
Usnea Lichen
100 mg
Rutin
50 mg
Thyme
50 mg
purified Silver
30 mcg
Gluten Free Adults 18–50 Dairy Free Vegetarian
Report overview
European Elder · 750 mg OverallScore74
D- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

The elderberry extract provides some concentration, but no ratio or active-marker standardization is disclosed. The disclosed 750 mg serving reaches a high-potency elderberry level. The cost efficiency per active elderberry weight is good.

View ingredientView products
Zinc (Zinc Gluconate) · 15 mg OverallScore73
B+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value
Gluconate provides a useful, generally well-tolerated zinc form at a maintenance-focused dose. The liquid format is easy to take and dissolves readily, although it is not a preferred capsule or lozenge format. Cost efficiency is weak for the zinc delivered, so the broader botanical formula must provide the main value.
View ingredientView products
Ginger · 100 mg OverallScore47
D Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyF Value

Ginger root extract is disclosed, but its active markers and raw-herb equivalent are not. The modest amount makes it a supporting ingredient in the broader liquid. An extremely high serving cost makes ginger-specific value poor.

View ingredientView products
Loading alternative details
81 Performance

Ultimate Ascorbate C 1000 mg

Source Naturals
<p>Buffered mineral ascorbates, zinc, manganese, rutin, and citrus bioflavonoids improve form quality and retain several original collections. The formula omits elderberry and ginger, while the concentrated vitamin C amount may cause digestive discomfort in sensitive users.</p>
82 Performance

Ester-C Plus 1000 mg Vitamin C

Solgar
<p>Buffered calcium ascorbate supplies substantial vitamin C with compatible citrus bioflavonoids and good expected stomach comfort. It lacks zinc, elderberry, and ginger, but avoids the original white willow, silver, and unstandardized botanical stack.</p>
87 Performance

Ester-C with Citrus Bioflavonoids

American Health
<p>Buffered vitamin C and a substantial citrus bioflavonoid amount create a simple, well-dosed antioxidant formula. It gives up the original zinc and botanical breadth, but its focused disclosure makes quality and suitability easier to judge.</p>
76 Budget

Multivitamin plus 24 HR Immune Support

Sundown
<p>Vitamin C, vitamin D, zinc, and elderberry retain the main immune ingredients at a much lower serving cost. The small botanical amounts provide less breadth, but the formula avoids white willow, silver, and the original long list of unstandardized herbs.</p>
80 Budget

Supreme C Complex

Swanson Premium Brand
<p>Vitamin C, citrus bioflavonoids, and rutin preserve important antioxidant ingredients at a very low serving cost. It omits zinc, elderberry, and ginger, but offers a simpler and easier-to-assess formula.</p>
80 Budget

AlphaSorb-C 500

NOW
<p>Buffered calcium ascorbate provides a practical vitamin C amount with favorable expected stomach comfort at a very low serving cost. The focused option lacks the original zinc and botanicals, while avoiding white willow and added silver.</p>
79 Value

Buffered Vitamin C 500 mg

Bluebonnet
<p>Buffered calcium ascorbate with citrus bioflavonoids supplies a practical immune-support base at a much lower serving cost. It lacks zinc and elderberry, but clearer dosing and fewer interaction concerns improve value.</p>
86 Value

C

Swanson
<p>Fully buffered calcium ascorbate provides focused vitamin C support with good expected stomach comfort at a very low serving cost. It does not match the original zinc, elderberry, ginger, or rutin coverage, but removes low-value botanical complexity.</p>
77 Value

Super C Complex

NaturesPlus
<p>Vitamin C, citrus bioflavonoids, rutin, hesperidin, and rose hips preserve broad antioxidant coverage at a lower serving cost. Unbuffered ascorbic acid may be less comfortable, but the disclosed formula offers better value than the original crowded botanical liquid.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  2. Effect of Vitamin C Supplements on Respiratory Tract Infections: A Systematic Review and Meta-Analysis.
    Keya TA; Leela A; Fernandez K; Habib N; Rashid M · Current reviews in clinical and experimental pharmacology · 2022
    Meta-analysis10 studies pooledImmunity forVitamin C
  3. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  4. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  5. Intestinal and systemic immune responses to an oral cholera toxoid B subunit whole-cell vaccine administered during zinc supplementation.
    Karlsen TH; Sommerfelt H; Klomstad S; Andersen PK; Strand TA; Ulvik RJ; Ahrén C; Grewal HM · Infection and immunity · 2003
    Randomized trial30 participantsImmunity forZinc
  6. The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis.
    Mazidi M; Gao HK; Rezaie P; Ferns GA · Food & nutrition research · 2022
    Meta-analysis9 studies pooledAnti-Inflammatory Support forGinger
  7. Ginger supplementation and metabolic health: an umbrella review of meta-analyses of randomized trials.
    Musazadeh V; Morvaridi M; Hosseini-Roknabadi SM; Mahmoudinezhad M; Jafari A; Shidfar F · Diabetology & metabolic syndrome · 2026
    Meta-analysis43,570 participants36 studies pooledAnti-Inflammatory Support forGinger
  8. Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial.
    Mozaffari-Khosravi H; Naderi Z; Dehghan A; Nadjarzadeh A; Fallah Huseini H · Journal of nutrition in gerontology and geriatrics · 2017
    Randomized trial120 participantsAnti-Inflammatory Support forGinger
  9. Effects of Ginger Supplementation on Markers of Inflammation and Functional Capacity in Individuals with Mild to Moderate Joint Pain.
    Broeckel J; Estes L; Leonard M; Dickerson BL; Gonzalez DE; Purpura M; Jäger R; Sowinski RJ; Rasmussen CJ; Kreider RB · Nutrients · 2025
    Randomized trial30 participantsAnti-Inflammatory Support forGinger
  10. The effect of ginger supplementation on some immunity and inflammation intermediate genes expression in patients with active Rheumatoid Arthritis.
    Aryaeian N; Shahram F; Mahmoudi M; Tavakoli H; Yousefi B; Arablou T; Jafari Karegar S · Gene · 2019
    Randomized trial70 participantsAnti-Inflammatory Support forGinger
  11. The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, brain-derived neurotrophic factor (BDNF), some serum inflammatory, and oxidative stress factors in patients with type 2 diabetes mellitus: A double-blind, placebo-controlled trial.
    Bazyar H; Moradi L; Zaman F; Zare Javid A · Phytotherapy research : PTR · 2023
    Randomized trial50 participantsAnti-Inflammatory Support forRutin
  12. Rutin ameliorates inflammation and improves metabolic function: A comprehensive analysis of scientific literature.
    Muvhulawa N; Dludla PV; Ziqubu K; Mthembu SXH; Mthiyane F; Nkambule BB; Mazibuko-Mbeje SE · Pharmacological research · 2022
    Systematic reviewAnti-Inflammatory Support forRutin
  13. Rutin-loaded chitosan microspheres: Characterization and evaluation of the anti-inflammatory activity.
    Cosco D; Failla P; Costa N; Pullano S; Fiorillo A; Mollace V; Fresta M; Paolino D · Carbohydrate polymers · 2018
    OtherAnti-Inflammatory Support forRutin
  14. Oral enzyme combination therapy reduces systemic inflammation, urinary CTXII and pain in knee osteoarthritis: a proof-of-mechanism, randomised, crossover, double-blind, placebo-controlled trial.
    Henrotin Y; Pap T; Lieten S; Badot V; Dubuc JE; Urbin-Choffray D; von Eynatten M; Johansen OE; Rau S; Brabants K · RMD open · 2025
    Randomized trial45 participantsAnti-Inflammatory Support forRutin
  15. The Impact of the Combination of Proteolytic Enzyme and Rutin on the Post-operative Management of Inflammation: A Randomized, Controlled, Double-Blind, Comparative Clinical Trial
    Rathi PC, Rathi CL, Risbud SP, Ganu GP · Cureus · 2024
    Randomized trial65 participantsAnti-Inflammatory Support forRutin
  16. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  17. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  18. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  19. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  20. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  21. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  22. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  23. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  24. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  25. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  26. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  27. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsGeneral Health forZinc
  28. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  29. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  30. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  31. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  32. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  33. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  34. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  35. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
    Case reportHair Health forVitamin C
  36. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  37. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  38. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  39. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  40. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  41. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  42. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  43. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  44. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  45. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  46. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  47. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc
  48. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  49. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  50. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  51. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  52. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  53. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  54. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  55. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  56. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc
  57. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forZinc
  58. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsVision Support forVitamin C
  59. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyVision Support forVitamin C
  60. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewVision Support forVitamin C
  61. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin C
  62. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsVision Support forVitamin C
  63. Antioxidant vitamin and mineral supplements for age-related macular degeneration.
    Evans JR · The Cochrane database of systematic reviews · 2002
    Systematic review170 participants7 studies pooledVision Support forZinc
  64. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration.
    Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2023
    Meta-analysis3,790 participants5 studies pooledVision Support forZinc
  65. Oral zinc in macular degeneration.
    Newsome DA; Swartz M; Leone NC; Elston RC; Miller E · Archives of ophthalmology (Chicago, Ill. : 1960) · 1988
    Randomized trial151 participantsVision Support forZinc
  66. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.
    Age-Related Eye Disease Study Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2001
    Randomized trial3,640 participantsVision Support forZinc
  67. Effect of vitamin A and zinc supplementation on the nutriture of children in Northeast Thailand.
    Udomkesmalee E; Dhanamitta S; Sirisinha S; Charoenkiatkul S; Tuntipopipat S; Banjong O; Rojroongwasinkul N; Kramer TR; Smith JC · The American journal of clinical nutrition · 1992
    Randomized trial133 participantsVision Support forZinc