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Methyl Folate 800 mcg

KAL
4.9
★ ★ ★ ★ ★
(2858 ratings)
Folate 800 mcg
Product Image
Score87
High-quality active folate is paired with convenient dosing and good value. Verify the apparent duplicate entries and account for the absence of B12.
How scoring works
Quantity:90 Tablet(s) • (90 servings)
Goals:
General Health
Hair Health

Score 87

High-quality active folate is paired with convenient dosing and good value. Verify the apparent duplicate entries and account for the absence of B12.
How scoring works
$16.29($0.18 per serving)
Amazon
$ 16.29
iHerb
$ 16.29
Walmart
$ 16.29
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Analysis

The formula uses (6S)-5-MTHF glucosamine salt, a body-ready folate form that avoids the conversion needed by folic acid. An 800 mcg active amount is substantial and fits targeted supplementation.

Two label entries each show 800 mcg and may represent one ingredient described twice rather than a combined dose. The physical label should be checked before use so the actual total is clear.

One tablet and a long supply offer good convenience and value. The missing B12 makes it better suited to users who monitor B12 adequacy rather than taking high-dose folate indefinitely without review.

Who is it for
  • Adults seeking active 6S-5-MTHF
  • Users with a defined 800 mcg folate target
  • People who separately maintain vitamin B12
Best for
  • Targeted methylfolate use
  • Avoiding synthetic folic acid
  • One-tablet dosing

Pros

  • Uses active 6S-5-MTHF
  • Provides a meaningful amount
  • Requires one tablet
  • Offers good serving value

Cons

  • Two entries create dose ambiguity
  • No vitamin B12 is included
  • The amount is above basic daily coverage

Warnings

  • Verify the physical label total before use because the two folate entries may be duplicates
  • High folate without adequate B12 can mask blood signs of B12 deficiency
  • Methylfolate may cause headache, restlessness, or sleep changes in sensitive users

Nutrient quality

91 Highest impact

The focused single-nutrient formula contains no active padding. The high amount without vitamin B12 warrants added caution.

Ingredient transparency

86 Highest impact

No proprietary blend hides the folate dose. The supplied data omit a complete inactive-ingredient list.

Customer satisfaction

73 High impact

The aggregate satisfaction metric is strong. No complaint text is supplied, so repeated negative themes cannot be assessed.

Value for money

97 Highest impact

No extras inflate the formula. An active form and low relative cost provide excellent value.

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Goals

General Health
General Health
Impact
High effect
A- Goal FitB+ Strength of SupportC- CoverageA- Formula Quality
Folate · 800 mcg

The supplement uses methylfolate, an active folate form that supports normal methylation and cell division without requiring conversion from folic acid. The listed amount is meaningful for targeted folate support.

Two label entries appear to describe the same methylfolate ingredient and amount, creating uncertainty about whether they are aliases or separate contributions. The single-nutrient design also leaves vitamin B12 and other complementary nutritional needs uncovered.

Study evidence
Folate Supportive 80 studies
Hair Health
Hair Health
Impact
High effect
C+ Goal FitB Strength of SupportD- CoverageB- Formula Quality

Methylfolate may support follicle cell division and blood formation when low folate contributes to thinning. It offers little direct support for hair structure or growth when folate status is already adequate.

The active 5-MTHF form and substantial amount are strengths, but the ingredient appears listed twice at the same dose. That duplication creates label uncertainty about whether the serving supplies one amount or the sum of both entries.

Study evidence
Folate Mixed 15 studies

Ingredients

IngredientAmount per serving
Folate ((6S)-5-Methyltetrahydrofolate, Glucosamine Salt, 5-MTHF)
 800 mcg
Adults 18–50
Report overview
Folate ((6S)-5-Methyltetrahydrofolate, Glucosamine Salt, 5-MTHF) · 800 mcg OverallScore92
A+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyA+ Value

the explicitly identified active 6S methylfolate gives the formula excellent biological readiness at a useful 800 mcg serving. The active amount is clear, although the label does not provide a separate DFE source breakdown. Low serving cost makes the active folate especially economical.

View ingredientView products
Loading alternative details
86 Performance

Methyl B-12 Methyl Folate Lonzenge Natural Cherry Flavor

Solaray
<p>Methylcobalamin and branded methylfolate provide a high-quality active-form pairing at targeted amounts, providing broader B-vitamin cofactor coverage than methylfolate alone. The vitamin B12 concentration may exceed basic maintenance needs.</p>
86 Performance

B-6 B-12 Folic Acid Drop Ins Natural Mixed Berry Flavor

KAL
<p>Active vitamin B6, methylfolate, and methylcobalamin provide strong form quality in a flexible liquid, providing broader B-vitamin cofactor coverage than methylfolate alone. The concentrated vitamin B12 amount is more suited to targeted use than basic maintenance.</p>
82 Performance

BioActive Vitamin B

Terry Naturally
<p>Active forms of vitamin B6, vitamin B12, and folate create a compact and well-targeted B-vitamin formula, providing broader B-vitamin cofactor coverage than methylfolate alone. The vitamin B6 amount may be more than many users need for long-term daily use.</p>
84 Budget

Folic Acid 800 mcg

Spring Valley
<p>A substantial folic acid amount provides simple targeted support at the lowest listed serving cost, making it a more economical alternative to the substantial methylfolate-only tablet. Synthetic folic acid requires conversion and the missing vitamin B12 can allow an unrecognized B12 deficiency to remain hidden.</p>
80 Budget

Folic Acid 400 mcg

Carlson
<p>A simple folic acid tablet provides useful daily coverage at very low serving cost, making it a more economical alternative to the substantial methylfolate-only tablet. The label does not clearly separate source folic acid from dietary folate equivalents, and vitamin B12 is absent.</p>
88 Budget

MegaFolinic 800 mcg

Source Naturals
<p>Calcium folinate supplies a metabolically active folate form at a substantial amount with excellent serving value, making it a more economical alternative to the substantial methylfolate-only tablet. The single-nutrient formula omits vitamin B12, so prolonged high folate use can mask an unrecognized B12 deficiency.</p>
88 Value

Methylfolate 1333 mcg DFE (800 mcg (6S)-5-Methyltetrahydrofolate) Orange Flavor

Country Life
<p>Explicitly identified 6S methylfolate provides a biologically ready form with clear dietary-equivalent context, offering a competitive form-to-cost trade-off for targeted folate support. The substantial amount is not paired with vitamin B12, so prolonged use could mask an unrecognized B12 deficiency.</p>
85 Value

5-Methyl Folate 1000 mcg

Protocol For Life Balance
<p>Quatrefolic provides a body-ready methylfolate form at a high targeted amount with clear isomer detail, offering a competitive form-to-cost trade-off for targeted folate support. The high folate exposure lacks vitamin B12 and could mask an unrecognized B12 deficiency.</p>
77 Value

Vitamin B12 & Folic Acid Natural Raspberry Flavor

Bluebonnet EarthSweet Chewables
<p>Vitamin B12 and folate are supplied together at meaningful amounts in a convenient chewable, offering a competitive form-to-cost trade-off for targeted folate support. Cyanocobalamin, synthetic folic acid, and the carbohydrate base reduce form quality compared with active-form tablets.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  2. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  3. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  4. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  5. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  6. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  7. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate
  8. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  9. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  10. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate