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5-Methyl Folate 1000 mcg

Protocol For Life Balance
4.9
★ ★ ★ ★ ★
(234 ratings)
Folate 1667 mcg
Product Image
Score85
High-quality Quatrefolic offers efficient active folate support at a strong value. Confirm the apparent duplicate label entries and account for the lack of B12.
How scoring works
Quantity:90 Tablet(s) • (90 servings)
Goals:
General Health
Hair Health

Score 85

High-quality Quatrefolic offers efficient active folate support at a strong value. Confirm the apparent duplicate label entries and account for the lack of B12.
How scoring works
$24.00($0.26 per serving)
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$ 24.00
Pure Formulas
$ 24.00
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Analysis

Quatrefolic (6S)-5-MTHF is a clearly identified active folate form that avoids the conversion required by folic acid. The disclosed amount is high and better suited to a targeted need than casual nutritional insurance.

A single tablet provides convenient dosing and good value for an active form. Two entries both list 1,667 mcg, so the physical label should be checked to confirm whether they describe one source and one total rather than separate amounts.

No vitamin B12 accompanies the high folate exposure. The product fits users who have a defined reason for active methylfolate and who monitor B12 status and dose tolerance.

Who is it for
  • Adults seeking active 6S-5-MTHF
  • Users with a defined higher-folate plan
  • People who separately maintain adequate vitamin B12
Best for
  • Targeted methylfolate intake
  • Users avoiding synthetic folic acid
  • One-tablet active folate dosing

Pros

  • Uses Quatrefolic 6S-5-MTHF
  • Provides a clearly named active isomer
  • Offers strong value for an active folate
  • Requires one tablet

Cons

  • The amount is high for routine unsupervised use
  • No vitamin B12 is included
  • Duplicate-looking label entries create total-dose ambiguity

Warnings

  • Confirm the physical label total because two entries may describe the same folate amount
  • High folate without adequate B12 can mask blood signs of B12 deficiency
  • Methylfolate may cause headache, agitation, or sleep changes in sensitive users, particularly when starting at a high amount

Nutrient quality

90 Highest impact

The focused single-nutrient formula contains no active padding. The high amount without vitamin B12 warrants added caution about masking deficiency.

Ingredient transparency

84 Highest impact

No proprietary blend hides the folate dose. The supplied data omit a complete inactive-ingredient list.

Customer satisfaction

70 High impact

The aggregate satisfaction metric is strong. No complaint text is supplied, so repeated negative themes cannot be assessed.

Value for money

92 Highest impact

No extras inflate the formula. The serving delivers a substantial active folate amount at good relative value.

Report analysis

Goals

General Health
Impact
Highest effect
A- Goal FitB+ Strength of SupportC- CoverageA- Formula Quality
Folate · 1667 mcg

Active methylfolate provides a body-ready form of an essential vitamin involved in cell growth and one-carbon metabolism. The clearly identified Quatrefolic form is a meaningful quality strength.

The amount is high for routine unsupervised use, and the formula does not include vitamin B12 to support balanced long-term use. High folate intake can mask signs of vitamin B12 deficiency, so people at risk of deficiency should seek clinical guidance.

Study evidence
Folate Supportive 80 studies
Hair Health
Impact
Moderate effect
C Goal FitB- Strength of SupportD- CoverageB- Formula Quality

Active methylfolate supports follicle cell division and may help when folate status is low. Quatrefolic identifies a body-ready form with clear active-isomer quality.

The formula remains narrow and does not supply structural proteins, minerals, or other common hair nutrients. The high folate amount lacks vitamin B12 and may mask signs of vitamin B12 deficiency.

Study evidence
Folate Mixed 15 studies

Ingredients

IngredientAmount per serving
Folate (Glucosamine Salt, Quatrefolic (6S)-5-MTHF)
1667 mcg
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
A+ Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyA+ Value

Quatrefolic (6S)-5-MTHF provides a body-ready form with clear active-isomer quality. The stated folate amount falls in a high-dose band that warrants added attention to safety. Without B12, the high folate amount may mask deficiency signs, although the active folate form is delivered at a highly efficient serving cost.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  2. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  3. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  4. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  5. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  6. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  7. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate
  8. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  9. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  10. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate