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Methylfolate 1333 mcg DFE (800 mcg (6S)-5-Methyltetrahydrofolate) Orange Flavor

Country Life
4.8
★ ★ ★ ★ ★
(887 ratings)
Folate 1333 mcg
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Score88
A clearly labeled active methylfolate tablet provides a substantial amount with good value. The missing B12 safeguard is the main reason to use it deliberately.
How scoring works
Quantity:60 Tablet(s) • (60 servings)
Goals:
General Health
Hair Health

Score 88

A clearly labeled active methylfolate tablet provides a substantial amount with good value. The missing B12 safeguard is the main reason to use it deliberately.
How scoring works
$17.39($0.28 per serving)
iHerb
$ 17.39
Amazon
$ 17.39
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Analysis

The tablet supplies 1,333 mcg DFE from 800 mcg of (6S)-5-MTHF glucosamine salt. That active form is directly usable and clearly identifies the preferred isomer.

Orange flavor and a one-tablet serving may improve adherence for users who dislike plain pills. The amount is above basic daily coverage and is better matched to a defined need.

No vitamin B12 is included, which is the main limitation for long-term high-folate use. It fits users seeking active methylfolate who can separately maintain B12 adequacy and monitor tolerance.

Who is it for
  • Adults seeking 6S-5-MTHF
  • Users avoiding synthetic folic acid
  • People with a defined higher-folate target
Best for
  • Active methylfolate support
  • One-tablet dosing
  • Users who want DFE and source-amount disclosure

Pros

  • Uses the active 6S isomer
  • Clearly states both DFE and source amount
  • Requires one tablet
  • Offers strong value

Cons

  • No vitamin B12 is included
  • The amount exceeds basic daily needs
  • Flavored tablets may include excipients not shown in the supplied data

Warnings

  • High folate without adequate B12 can mask blood signs of B12 deficiency
  • Methylfolate may cause headache, agitation, or sleep changes in sensitive users
  • Review use with a prescriber when taking methotrexate or another folate-antagonist medicine

Nutrient quality

91 Highest impact

The focused single-nutrient formula contains no active padding. The high folate exposure without vitamin B12 deserves added caution.

Ingredient transparency

91 Highest impact

The dietary equivalent and active source amount are clearly presented. The supplied data omit a complete inactive-ingredient list.

Customer satisfaction

72 High impact

The aggregate satisfaction metric is strong. No complaint text is supplied, so repeated negative themes cannot be assessed.

Value for money

94 Highest impact

No extras inflate the formula. The serving provides substantial active folate at good relative value.

Report analysis

Goals

General Health
General Health
Impact
Highest effect
B+ Goal FitA Strength of SupportC CoverageA Formula Quality
Folate · 1333 mcg

Active methylfolate directly supports a fundamental pathway involved in DNA synthesis and methylation. The clearly disclosed form is biologically relevant, but a single-nutrient product cannot cover general wellness broadly.

The amount is substantial and suits a defined folate need better than casual supplementation. High folate intake without vitamin B12 can hide blood changes from B12 deficiency while nerve injury continues, so B12 status matters for ongoing use.

Study evidence
Folate Supportive 80 studies
Hair Health
Hair Health
Impact
High effect
C- Goal FitA Strength of SupportD CoverageB Formula Quality

Methylfolate supports rapid cell division and red-blood-cell pathways that can matter to growing follicles. Its value for hair is mainly situational, such as when folate status is inadequate.

The active folate form and amount are clearly disclosed, but the single nutrient does not build keratin or address other common causes of shedding. It also lacks vitamin B12, iron, zinc, vitamin D, collagen, and amino acids for broader support.

Study evidence
Folate Mixed 15 studies

Ingredients

IngredientAmount per serving
Folate ((6S)-5-Methyltetrahydrofolate-Glucosamine Salt)
 1333 mcg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Sugar Free Halal Vegetarian
Report overview
Folate ((6S)-5-Methyltetrahydrofolate-Glucosamine Salt) · 1333 mcg OverallScore88
A+ Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyA+ Value

The explicitly identified active isomer offers strong biological availability and purity confidence. The dose is above the usual daily range but remains within the stated upper scoring band, with clear DFE and source-amount disclosure. No vitamin B12 is included, so the high folate exposure could mask anemia from a B12 deficiency while neurological harm continues, although the serving cost is highly efficient.

View ingredientView products
Loading alternative details
86 Performance

Methyl B-12 Methyl Folate Lonzenge Natural Cherry Flavor

Solaray
<p>Methylcobalamin and branded methylfolate provide a high-quality active-form pairing at targeted amounts, providing broader B-vitamin cofactor coverage than active methylfolate alone. The vitamin B12 concentration may exceed basic maintenance needs.</p>
86 Performance

B-6 B-12 Folic Acid Drop Ins Natural Mixed Berry Flavor

KAL
<p>Active vitamin B6, methylfolate, and methylcobalamin provide strong form quality in a flexible liquid, providing broader B-vitamin cofactor coverage than active methylfolate alone. The concentrated vitamin B12 amount is more suited to targeted use than basic maintenance.</p>
82 Performance

BioActive Vitamin B

Terry Naturally
<p>Active forms of vitamin B6, vitamin B12, and folate create a compact and well-targeted B-vitamin formula, providing broader B-vitamin cofactor coverage than active methylfolate alone. The vitamin B6 amount may be more than many users need for long-term daily use.</p>
84 Budget

Folic Acid 800 mcg

Spring Valley
<p>A substantial folic acid amount provides simple targeted support at the lowest listed serving cost, making it a more economical alternative to the substantial active methylfolate-only lozenge. Synthetic folic acid requires conversion and the missing vitamin B12 can allow an unrecognized B12 deficiency to remain hidden.</p>
80 Budget

Folic Acid 400 mcg

Carlson
<p>A simple folic acid tablet provides useful daily coverage at very low serving cost, making it a more economical alternative to the substantial active methylfolate-only lozenge. The label does not clearly separate source folic acid from dietary folate equivalents, and vitamin B12 is absent.</p>
88 Budget

MegaFolinic 800 mcg

Source Naturals
<p>Calcium folinate supplies a metabolically active folate form at a substantial amount with excellent serving value, making it a more economical alternative to the substantial active methylfolate-only lozenge. The single-nutrient formula omits vitamin B12, so prolonged high folate use can mask an unrecognized B12 deficiency.</p>
87 Value

Methyl Folate 800 mcg

KAL
<p>Active 6S methylfolate provides biologically ready folate at a substantial amount and favorable serving value, offering a competitive active-folate and serving-cost trade-off compared with the single-nutrient lozenge. The high folate exposure is not paired with vitamin B12, which can leave an unrecognized B12 deficiency hidden.</p>
85 Value

5-Methyl Folate 1000 mcg

Protocol For Life Balance
<p>Quatrefolic provides a body-ready methylfolate form at a high targeted amount with clear isomer detail, offering a competitive active-folate and serving-cost trade-off compared with the single-nutrient lozenge. The high folate exposure lacks vitamin B12 and could mask an unrecognized B12 deficiency.</p>
77 Value

Vitamin B12 & Folic Acid Natural Raspberry Flavor

Bluebonnet EarthSweet Chewables
<p>Vitamin B12 and folate are supplied together at meaningful amounts in a convenient chewable, offering a competitive active-folate and serving-cost trade-off compared with the single-nutrient lozenge. Cyanocobalamin, synthetic folic acid, and the carbohydrate base reduce form quality compared with active-form tablets.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  2. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  3. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  4. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  5. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  6. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  7. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate
  8. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  9. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  10. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate