Methylfolate 1333 mcg DFE (800 mcg (6S)-5-Methyltetrahydrofolate) Orange Flavor
Country Life
Methylfolate 1333 mcg DFE (800 mcg (6S)-5-Methyltetrahydrofolate) Orange Flavor
4.8
★ ★ ★ ★ ★
(807 ratings)
Folate 1333 mcg
Score 90.0
A high-quality, high-dose active methylfolate (Quatrefolic) product in a pleasant flavor, ideal for optimal absorption and those with MTHFR concerns, justifying its premium price.
Quantity: 60 Tablet(s)Servings size: 1 Chewable Tablet(s) (60 servings)
Selected goals:
Other goals:
General Health
Brain Health
Mood Support
Heart Health
leaderboard Score 90.0
A high-quality, high-dose active methylfolate (Quatrefolic) product in a pleasant flavor, ideal for optimal absorption and those with MTHFR concerns, justifying its premium price.
insights Analysis
Country Life Methylfolate features 1333mcg DFE (800mcg actual) of (6S)-5-Methyltetrahydrofolate-Glucosamine Salt, known as Quatrefolic, which is a highly regarded and bioavailable form of active folate. Its 'Orange Flavor' suggests a chewable or sublingual format, enhancing user experience for those who prefer alternatives to pills. This product is particularly valuable for individuals who have difficulty converting synthetic folic acid due to MTHFR gene mutations, offering direct utilization for various bodily functions. The review count is solid, indicating positive user reception for a specialized product.
- Uses highly bioavailable and active methylfolate (Quatrefolic), ensuring direct utilization by the body.
- Provides a high and effective dosage (1333mcg DFE / 800mcg actual) for comprehensive support.
- Particularly beneficial for individuals with MTHFR mutations who struggle to convert synthetic folic acid.
- Offered in a pleasant orange flavor, likely in a chewable or sublingual format, enhancing user compliance.
- Higher price per serving compared to synthetic folic acid alternatives.
- Specific flavor might not appeal to all users.
- Chewable or sublingual form may not be preferred by all individuals who prefer swallowing pills.
$17.39($0.28 per serving)
 iHerb | $ 17.39 | |
 Amazon | $ 17.39 |
bolt Effectiveness for goals
Yes, adequate folate intake, especially before and during early pregnancy, is highly effective in preventing neural tube defects (NTDs) like spina bifida and anencephaly. This is why many prenatal supplements contain folic acid, the synthetic form of folate. Health organizations recommend women of childbearing age consume sufficient folate daily.
Folate is essential for cell growth and division, DNA synthesis and repair, and red blood cell formation. It plays a crucial role in various metabolic processes, including the metabolism of homocysteine. Many people take folate to support overall health and prevent deficiency.
Folate supplements are very effective in treating and resolving a folate deficiency. Deficiency can lead to megaloblastic anemia, fatigue, and other symptoms. Supplementation typically restores folate levels and alleviates associated symptoms.
Folic acid, the synthetic form found in supplements and fortified foods, is often considered more bioavailable than natural folate from foods. This is because folic acid is more stable and readily absorbed by the body. Once absorbed, both forms are converted to the active form of folate within the body to exert their effects.
Folate is crucial for the formation of red blood cells, which transport oxygen throughout the body, and it's involved in energy metabolism. A deficiency in folate can lead to megaloblastic anemia, causing symptoms like fatigue and low energy. Therefore, ensuring adequate folate intake can support healthy energy levels, especially if a deficiency is present.
schedule Dosage, timing & forms
For most adult men and women, the RDA is 400 micrograms (mcg) of dietary folate equivalents (DFEs) daily. Pregnant individuals are advised to consume 600 mcg DFE daily, and lactating individuals 500 mcg DFE. These recommendations help ensure adequate intake for essential bodily functions.
The two primary forms are folic acid, which is the synthetic form commonly used in fortified foods and supplements, and L-methylfolate (also known as 5-MTHF), which is the active, natural form of folate. Other forms like folinic acid are also available but less common. The choice of form may depend on individual needs or preferences.
Folic acid must be converted by the body into L-methylfolate to become biologically active. L-methylfolate, being the already active form, does not require this conversion. This difference can be significant for individuals with certain genetic variations that affect the conversion process.
Yes, there is an established Tolerable Upper Intake Level (UL) of 1,000 mcg (1 mg) per day for *synthetic folic acid* from supplements and fortified foods for adults. This UL is set because high intakes of folic acid can mask the symptoms of vitamin B12 deficiency. There is no UL established for folate from food sources or for L-methylfolate.
Supplemental dosages vary based on individual needs and health goals, but common doses often range from 400 mcg to 1,000 mcg (1 mg) daily. For specific needs, such as during pregnancy planning, healthcare providers may recommend higher doses of folic acid, often 800 mcg or more. Always consult a healthcare professional for personalized dosage advice.
health_and_safety Safety & interactions
Yes, high doses of Folate, especially folic acid, can mask a Vitamin B12 deficiency. Folate can correct the megaloblastic anemia associated with B12 deficiency, but it does not prevent the irreversible neurological damage that can progress if the underlying B12 deficiency remains untreated. This is a critical safety concern.
Yes, Folate can interact with certain medications. These include some anti-seizure drugs, methotrexate (used for cancer and autoimmune diseases), and drugs that reduce stomach acid, which may affect Folate absorption or effectiveness. It is advisable to consult a healthcare professional about potential interactions.
Folate is considered safe and is crucially important during pregnancy for fetal development, particularly to prevent neural tube defects. Supplementation with synthetic folic acid is widely recommended before and during early pregnancy. It is also safe and beneficial during breastfeeding.
While Folate is water-soluble, exceptionally high intakes, particularly from synthetic folic acid, may lead to certain side effects. These can include abdominal cramps, diarrhea, or sleep problems. The tolerable upper intake level is established for synthetic folic acid.
Folate supplements are generally well-tolerated at recommended doses. Mild, rare side effects might include nausea, bloating, or sleep disturbances. Consuming extremely high doses over time could potentially lead to other effects.
Ingredients
| Ingredient | Amount per serving |
|---|---|
| Folate ((6S)-5-Methyltetrahydrofolate-Glucosamine Salt) | 1333 mcg |
Categories
Folate 95.0
This product utilizes (6S)-5-Methyltetrahydrofolate Glucosamine Salt (Quatrefolic), which is widely recognized as one of the most superior and bioavailable forms of active folate. This form bypasses metabolic limitations, ensuring optimal absorption and utilization for nearly all individuals, placing it at the top tier for folate supplementation.
Goals
Brain Health 95.0
Methylfolate is crucial for the synthesis of essential neurotransmitters (including serotonin, dopamine, and norepinephrine) and for maintaining neurological health. Its direct bioavailability makes it exceptionally effective for supporting cognitive function, memory, and overall brain health, especially for those with impaired folate metabolism.
Mood Support 95.0
Adequate methylfolate levels are strongly linked to healthy mood regulation, as it directly supports the production of key neurotransmitters involved in emotional well-being. This active form at a significant dose is highly effective in assisting with mood balance, particularly when conventional folate forms are insufficient.
General Health 90.0
As the active form of folate, methylfolate is directly utilized for critical functions such as DNA synthesis, cell division, and repair, providing robust and efficient support for overall health and vitality for virtually all individuals without conversion limitations.
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