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Beyond Wellness

KAL
4.8
★ ★ ★ ★ ★
(151 ratings)
Vitamin C 1000 mg
Astragalus 100 mg
European Elder 100 mg
Maitake Mushroom 125 mg
Shiitake Mushroom 125 mg
Product Image
Score72
A broad immune blend anchored by buffered vitamin C and zinc, with useful botanical variety but uneven extract quality, modest secondary doses, and interaction considerations.
How scoring works
Quantity:90 Tablet(s) • (30 servings)
Goals:
Immunity
Anti-Inflammatory Support
General Health
Skin Health

Score 72

A broad immune blend anchored by buffered vitamin C and zinc, with useful botanical variety but uneven extract quality, modest secondary doses, and interaction considerations.
How scoring works
$14.49($0.48 per serving)
Walmart
$ 16.89
iHerb
$ 14.49
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Analysis

Buffered vitamin C and zinc provide the strongest foundational support in this immune-focused formula. Echinacea, andrographis, olive leaf, elderberry, astragalus, mushrooms, garlic, and hesperidin add several botanical pathways.

Every active amount is listed, and some extracts identify relevant constituent classes. Species, plant-part, extraction, or standardization details are still missing for several botanicals, making their depth harder to judge.

The breadth suits someone wanting a short, purpose-built immune blend rather than a simple daily vitamin. Modest mushroom, elderberry, and astragalus amounts limit their individual contribution, and the many botanicals increase the need to screen for allergies and medication conflicts.

Who is it for
  • Adults seeking a multi-ingredient immune formula
  • People who prefer buffered vitamin C
  • Users who have screened the botanicals for personal fit
Best for
  • Focused immune support
  • Antioxidant nutrition
  • Short-term multi-botanical use

Pros

  • Substantial buffered vitamin C
  • Useful zinc form and amount
  • Broad immune-oriented ingredient coverage

Cons

  • Several botanicals lack full standardization
  • Mushroom and astragalus amounts are modest
  • Complexity makes individual effects harder to identify

Warnings

  • Garlic may increase bleeding tendency with anticoagulant or antiplatelet medicines
  • Avoid the formula if allergic to any listed plant or mushroom ingredient
  • Astragalus may conflict with immune-suppressing medicines
  • The large vitamin C amount may cause digestive upset in sensitive users

Nutrient quality

80 Highest impact

Potassium ascorbate and zinc picolinate are favorable, while some mushrooms lack source and extraction detail. Vitamin C, zinc, andrographis, and several extracts are useful, while the mushrooms remain modest.

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Ingredient transparency

74 High impact

Ingredient weights are listed, but several active-marker percentages remain undisclosed. The supplied data does not include a complete inactive ingredient list.

.

Customer satisfaction

66 High impact

The aggregate satisfaction measure is strong enough to support a favorable first impression. Missing feedback themes leave repeat complaints and purpose fit uncertain despite adequate volume.

.

Value for money

66 High impact

The moderate price is reasonably matched to broad immune coverage and good core forms. Each serving offers fair value despite modest secondary ingredients.

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Report analysis

Goals

Immunity
Immunity
Impact
Highest effect
A Goal FitB+ Strength of SupportA- CoverageB+ Formula Quality
Vitamin C · 1000 mgZinc · 11 mgMaitake Mushroom · 125 mgEuropean Elder · 100 mg

A full buffered vitamin C dose joins zinc, echinacea, andrographis, elderberry, mushrooms, astragalus, olive leaf, and garlic in a purpose-built immune formula. The ingredients span antioxidant, botanical, and immune-cell pathways with clear individual amounts.

Zinc is slightly below the preferred threshold, and several botanicals lack species, plant-part, extraction, or active-marker details. The breadth is useful, but the modest mushroom, elderberry, and astragalus amounts limit the depth of some pathways.

Study evidence
Astragalus Supportive 16 studies
European Elder Mixed 5 studies
Maitake Mushroom Mixed 4 studies
Vitamin C Supportive 53 studies
Zinc Supportive 73 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
C Goal FitC+ Strength of SupportC+ CoverageC+ Formula Quality
Vitamin C · 1000 mg

Buffered vitamin C, andrographis, olive leaf, elderberry, garlic, mushrooms, and zinc provide broad antioxidant and immune-modulating support. The formula lacks fish oil, curcumin, boswellia, or another strong direct inflammatory-pathway anchor.

Several extracts identify active classes, including andrographolides, oleuropein, and anthocyanins. The focused immune blend is coherent, though its anti-inflammatory evidence is less direct than dedicated botanical formulas.

Study evidence
Vitamin C Supportive 50 studies
Zinc Supportive 64 studies
General Health
General Health
Impact
High effect
C Goal FitB- Strength of SupportC- CoverageC Formula Quality
Zinc · 11 mgVitamin C · 1000 mg

Vitamin C and zinc provide credible foundational antioxidant and immune support. Echinacea, andrographis, elderberry, olive leaf, mushrooms, astragalus, and garlic create a situational immune formula rather than comprehensive daily general-health coverage.

The vitamin C and zinc forms and amounts are clear, while several botanical extracts name active constituents but not every standardization level. Garlic may increase bleeding tendency with anticoagulant or antiplatelet medicines, and the multi-botanical formula may be unsuitable for people with allergies to its plant or mushroom ingredients.

Study evidence
European Elder Supportive 2 studies
Vitamin C Supportive 56 studies
Zinc Supportive 60 studies
Skin Health
Skin Health
Impact
Moderate effect
D Goal FitB- Strength of SupportD CoverageD+ Formula Quality
Zinc · 11 mgVitamin C · 1000 mg

Vitamin C and zinc provide collagen-cofactor and normal skin-repair support within an immune-focused botanical formula. Evidence is strongest for vitamin C and zinc, while the immune botanicals are not established for skin hydration or structure.

The 1,000 mg vitamin C amount is substantial and the 11 mg zinc amount supports daily nutrition. Buffered potassium ascorbate and zinc picolinate are useful forms with clear amounts, while botanical skin relevance is limited.

Study evidence
Vitamin C Supportive 53 studies
Zinc Supportive 66 studies

Ingredients

IngredientAmount per serving
Total Carbohydrates
1 Gram(s)
Vitamin C (Potassium Ascorbate)
 1000 mg
Zinc (Zinc Picolinate)
 11 mg
Echinacea
200 mg
Andrographis extract (Andrographolides)
 200 mg
Hesperidin Concentrate (citrus)
 200 mg
Olive leaf extract (Oleuropein)
 150 mg
organic Maitake
125 mg
organic Shiitake
125 mg
Elderberry extract (Anthocyanins)
 100 mg
Astragalus root extract (Polysaccharides)
 100 mg
Garlic bulb extract
100 mg
Adults 18–50 Women
Report overview
Vitamin C (Potassium Ascorbate) · 1000 mg OverallScore69
B+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyF Value

Buffered potassium ascorbate provides a stomach-friendly vitamin C form at a practical daily dose. The broad botanical blend makes the formula less focused than a dedicated vitamin C supplement, while source details for the associated mineral remain limited. Cost efficiency is weak for the amount of vitamin C delivered.

View ingredientView products
Astragalus (Polysaccharides) · 100 mg OverallScore52
D Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyF Value

Root and polysaccharide labeling help identify the intended botanical material, but neither the species nor marker concentration is supplied. The exact 100 mg amount offers modest blend-level support but remains below the preferred standalone extract dose. Its cost per standard extract amount is high.

View ingredientView products
European Elder (Anthocyanins) · 100 mg OverallScore51
D- Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyD+ Value

The common elderberry name and unstandardized extract leave the species, plant part, and potency less certain. The 100 mg extract amount is below the collection median. The serving cost provides moderate value relative to the disclosed extract weight.

View ingredientView products
Loading alternative details
79 Performance

Nordic Immune Daily Defense

Nordic Naturals
<p>Vitamin C, vitamin D3, zinc glycinate, and a substantial black elderberry amount provide clearer core immune-nutrient dosing than the original’s many modest additions. Elderberry standardization is missing and unbuffered vitamin C may be less comfortable for sensitive users.</p>
79 Performance

M/R/S Mushroom Formula

Pure Encapsulations
<p>Clearly identified maitake, reishi, and shiitake fruiting-body extracts provide stronger mushroom disclosure and more focused amounts than the original. Extraction methods and beta-glucan yield remain unknown, and the formula omits vitamin C, zinc, elderberry, and astragalus.</p>
79 Performance

Reishi Shiitake Maitake Mushroom Extract

Solgar
<p>A focused three-mushroom blend adds reishi marker details and avoids the original’s crowded botanical formula. Maitake and shiitake remain modest and mushroom parts are unclear, while vitamin C, zinc, elderberry, and astragalus are absent.</p>
80 Budget

Reacta C with Black Elderberry

Solaray
<p>Buffered vitamin C and a marked black elderberry extract provide a focused immune combination at lower serving cost. The simpler formula loses the original’s zinc, astragalus, mushrooms, and several botanical extracts, while the support-base ingredients remain hidden.</p>
72 Budget

Immune Action

NaturesPlus
<p>Astragalus, shiitake, echinacea, schisandra, and ligustrum retain a broad botanical immune focus at better value. Most amounts are modest and poorly standardized, and the formula omits the original’s vitamin C and zinc.</p>
73 Budget

DefensePlus

NutriBiotic
<p>Vitamin C, zinc, astragalus, reishi, maitake, shiitake, echinacea, and ginger preserve broad immune coverage at lower serving cost. Most botanical amounts are light and unstandardized, but the formula remains closer to the original than a plain vitamin C product.</p>
76 Value

Immune Essentials Comprehensive Formula

Swanson
<p>Larch arabinogalactan, colostrum, beta-glucan, elderberry, maitake, and shiitake create broad immune coverage at favorable value. Mushroom amounts are light and poorly characterized, and bovine colostrum makes it unsuitable for people with a milk allergy.</p>
78 Value

Olive Leaf & Oregano Immune Wellness

Bio Nutrition
<p>Meaningful olive leaf, oregano, elderberry, maitake, zinc, and vitamins provide concentrated immune coverage at a reasonable serving cost. Most botanical extracts lack active-marker details, but the formula offers more depth than the original in several shared ingredients.</p>
72 Value

Wellness Fizz Natural Berry Flavor

Source Naturals
<p>Vitamin C, zinc, elderberry, echinacea, vitamin E, and selenium provide a convenient immune blend with fair value. Several herbs are lightly dosed and the supply is short, but the core nutrients are clearly disclosed.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of Vitamin C Supplements on Respiratory Tract Infections: A Systematic Review and Meta-Analysis.
    Keya TA; Leela A; Fernandez K; Habib N; Rashid M · Current reviews in clinical and experimental pharmacology · 2022
    Meta-analysis10 studies pooledImmunity forVitamin C
  2. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  3. The effect of macronutrient and micronutrient supplements on COVID-19: an umbrella review.
    SeyedAlinaghi S; Shahidi R; Mojdeganlou H; Akhtaran FK; Maroufi SF; Maroufi SP; Mirzapour P; Karimi A; Khodaei S; Pour MM; Mehraeen E; Dadras O · Journal of health, population, and nutrition · 2024
    Systematic review28 studies pooledImmunity forVitamin C
  4. Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review.
    Wieland LS; Piechotta V; Feinberg T; Ludeman E; Hutton B; Kanji S; Seely D; Garritty C · BMC complementary medicine and therapies · 2021
    Systematic review5 studies pooledImmunity forEuropean Elder
  5. Select Dietary Supplement Ingredients for Preserving and Protecting the Immune System in Healthy Individuals: A Systematic Review.
    Crawford C; Brown LL; Costello RB; Deuster PA · Nutrients · 2022
    Systematic review39 studies pooledImmunity forEuropean Elder
  6. Oral Astragalus (Huang qi) for preventing frequent episodes of acute respiratory tract infection in children.
    Su G; Chen X; Liu Z; Yang L; Zhang L; Stålsby Lundborg C; Wen Z; Guo X; Qin X; Liang J; Liu X · The Cochrane database of systematic reviews · 2017
    Systematic reviewImmunity forAstragalus
  7. Astragalus in the prevention of upper respiratory tract infection in children with nephrotic syndrome: evidence-based clinical practice.
    Zou C; Su G; Wu Y; Lu F; Mao W; Liu X · Evidence-based complementary and alternative medicine : eCAM · 2013
    Systematic reviewImmunity forAstragalus
  8. Astragalus mongholicus (Fisch.) Bge Improves Peripheral Treg Cell Immunity Imbalance in the Children With Viral Myocarditis by Reducing the Levels of miR-146b and miR-155.
    Zhang Z; Dai X; Qi J; Ao Y; Yang C; Li Y · Frontiers in pediatrics · 2020
    Randomized trial68 participantsImmunity forAstragalus
  9. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  10. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  11. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  12. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  13. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  14. Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent.
    Bao B; Prasad AS; Beck FW; Fitzgerald JT; Snell D; Bao GW; Singh T; Cardozo LJ · The American journal of clinical nutrition · 2010
    Randomized trial40 participantsAnti-Inflammatory Support forZinc
  15. Zinc Supplementation in Individuals with Prediabetes and type 2 Diabetes: a GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
    Nazari M; Nikbaf-Shandiz M; Pashayee-Khamene F; Bagheri R; Goudarzi K; Hosseinnia NV; Dolatshahi S; Omran HS; Amirani N; Ashtary-Larky D; Asbaghi O; Ghanavati M · Biological trace element research · 2024
    Meta-analysis23 studies pooledAnti-Inflammatory Support forZinc
  16. The Effects of Zinc Supplementation on C-Reactive Protein and Inflammatory Cytokines: A Meta-Analysis and Systematical Review.
    Ceylan MN; Akdas S; Yazihan N · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022
    Meta-analysis73 studies pooledAnti-Inflammatory Support forZinc
  17. The Effects of Zinc Sulfate Supplementation on Serum Copeptin, C-Reactive Protein and Metabolic Markers in Zinc-Deficient Diabetic Patients on Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Hosseini R; Montazerifar F; Shahraki E; Karajibani M; Mokhtari AM; Dashipour AR; Ferns GA; Jalali M · Biological trace element research · 2021
    Randomized trial46 participantsAnti-Inflammatory Support forZinc
  18. Zinc supplementation and cardiovascular disease risk factors: A GRADE-assessed systematic review and dose-response meta-analysis.
    Nazari M; Ashtary-Larky D; Nikbaf-Shandiz M; Goudarzi K; Bagheri R; Dolatshahi S; Omran HS; Amirani N; Ghanavati M; Asbaghi O · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023
    Meta-analysis75 studies pooledAnti-Inflammatory Support forZinc
  19. Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial.
    Tiralongo E; Wee SS; Lea RA · Nutrients · 2016
    Randomized trial312 participantsGeneral Health Immunity forEuropean Elder
  20. COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?
    Silveira D; Prieto-Garcia JM; Boylan F; Estrada O; Fonseca-Bazzo YM; Jamal CM; Magalhães PO; Pereira EO; Tomczyk M; Heinrich M · Frontiers in pharmacology · 2023
    Narrative reviewGeneral Health forEuropean Elder
  21. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  22. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  23. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  24. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  25. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  26. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  27. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsGeneral Health forZinc
  28. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  29. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  30. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  31. Astragalus polysaccharides combined with radiochemotherapy for cervical cancer: a systematic review and meta-analysis of randomized controlled studies.
    Sun T; Zhao R; Zhang Y; Li D; Shan X; Tang X; Zheng Y · Frontiers in pharmacology · 2025
    Meta-analysis776 participants9 studies pooledImmunity forAstragalus
  32. [Effect of intravenous drip infusion of cyclophosphamide with high-dose Astragalus injection in treating lupus nephritis].
    Su L; Mao JC; Gu JH · Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine · 2008
    Randomized trial43 participantsImmunity forAstragalus
  33. [Clinical study on effect of Astragalus in efficacy enhancing and toxicity reducing of chemotherapy in patients of malignant tumor].
    Duan P; Wang ZM · Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine · 2003
    Randomized trial120 participantsImmunity forAstragalus
  34. [Modulatory effect of Astragalus membranaceus on Th1/Th2 cytokine in patients with herpes simplex keratitis].
    Mao SP; Cheng KL; Zhou YF · Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine · 2004
    Randomized trial168 participantsImmunity forAstragalus
  35. Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials
    Jessie Hawkins, Christy Baker, Lindsey Cherry, Erich Dunne · Complementary Therapies in Medicine · 2019
    Meta-analysis180 participants4 studies pooledImmunity forEuropean Elder
  36. Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections
    Z Zakay-Rones, E Thom, T Wollan, J Wadstein · Journal of International Medical Research · 2004
    Randomized trial60 participantsImmunity forEuropean Elder
  37. Maitake mushroom supplementation modulates upper respiratory symptoms and immune responses in healthy adults: a randomized, double-blind, placebo-controlled trial.
    Masuda Y; Nakayama Y; Shimizu R; Jogi EM; Kato MC; Yamasaki K; Aoki R; Hashimoto M; Ohno M; Ohata S; Kato S; Konishi M · Food & function · 2026
    Randomized trialImmunity forMaitake Mushroom
  38. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects.
    Deng G; Lin H; Seidman A; Fornier M; D'Andrea G; Wesa K; Yeung S; Cunningham-Rundles S; Vickers AJ; Cassileth B · Journal of cancer research and clinical oncology · 2009
    Single-arm trial34 participantsImmunity forMaitake Mushroom
  39. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study.
    Wesa KM; Cunningham-Rundles S; Klimek VM; Vertosick E; Coleton MI; Yeung KS; Lin H; Nimer S; Cassileth BR · Cancer immunology, immunotherapy : CII · 2015
    Single-arm trial21 participantsImmunity forMaitake Mushroom
  40. Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients.
    Kodama N; Komuta K; Nanba H · Journal of medicinal food · 2004
    Single-arm trial10 participantsImmunity forMaitake Mushroom
  41. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  42. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  43. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  44. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  45. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  46. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  47. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  48. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  49. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc
  50. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  51. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  52. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  53. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  54. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  55. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  56. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  57. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  58. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc
  59. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forZinc