5-HTP 200 mg
NutraBio
5-HTP 200 mg
4.7
★ ★ ★ ★ ★
(375 ratings)
Vitamin B6 50 mg
5-HTP 200 mg
Score 75.0
NutraBio's 5-HTP offers a potent 200mg dose of 5-HTP with 50mg of Vitamin B6, suitable for higher needs but potentially associated with more side effects and a higher price per serving.
Quantity: 90 Capsule(s)Servings size: 1 Vegetable Capsule(s) (90 servings)
Selected goals:
Other goals:
Energy
Brain Health
Mood Support
General Health
Stress Relief
leaderboard Score 75.0
NutraBio's 5-HTP offers a potent 200mg dose of 5-HTP with 50mg of Vitamin B6, suitable for higher needs but potentially associated with more side effects and a higher price per serving.
insights Analysis
NutraBio's 5-HTP product provides a high dose of 200mg of 5-HTP per serving, combined with 50mg of Vitamin B6 (Pyridoxine Hydrochloride). This higher 5-HTP dosage can be very effective for individuals with significant mood or sleep challenges, but it also increases the potential for gastrointestinal side effects like nausea. The 50mg B6 dose is also quite high, and while generally safe, long-term intake of Pyridoxine HCl at this level could theoretically pose a slight risk of neuropathy for sensitive individuals, although evidence varies. The product has a relatively low review count compared to other brands, which might suggest a smaller user base or newer market presence.
- Delivers a potent 200mg dose of 5-HTP, which can be highly effective for individuals with more pronounced mood imbalances or severe sleep disturbances.
- Includes a generous 50mg of Vitamin B6, which is well above the co-factor requirement for 5-HTP conversion, potentially ensuring optimal serotonin synthesis.
- NutraBio is known for its transparent labeling and high-quality standards in the supplement industry, which instills confidence in product purity.
- The 200mg 5-HTP dose can lead to increased gastrointestinal side effects such as nausea or stomach upset, particularly for new users or those with sensitive digestive systems.
- The 50mg dose of Pyridoxine Hydrochloride (B6) is higher than typically needed for 5-HTP conversion and, while generally safe, some individuals might prefer a lower dose or the P-5-P form due to theoretical long-term neuropathy concerns at higher doses of the HCl form.
- At 24 cents per serving, it is considerably more expensive than many other 5-HTP supplements on the market, potentially limiting its value proposition for average users.
$20.86($0.23 per serving)
 iHerb | $ 20.86 |
bolt Effectiveness for goals
Vitamin B6 acts as a necessary coenzyme for the conversion of 5-HTP into serotonin. Without adequate B6, the metabolism of 5-HTP may be inefficient. This interaction is key for 5-HTP's intended effects on neurotransmitter levels.
Because Vitamin B6 is required for the body to convert 5-HTP into serotonin, some suggest taking them together could optimize 5-HTP's action. This co-factor relationship is important for the intended biochemical pathway. However, the precise optimal dosing and balance are complex and still subjects of ongoing research.
Some research suggests 5-HTP may help support mood by increasing serotonin levels in the brain. Serotonin is a neurotransmitter involved in mood regulation. However, more extensive research is needed to confirm its efficacy for specific mood conditions.
Vitamin B6 is a crucial coenzyme involved in over 100 enzymatic reactions, including protein, fat, and carbohydrate metabolism. It plays vital roles in red blood cell formation, neurotransmitter synthesis, and maintaining normal homocysteine levels. It also supports immune function and brain health.
5-HTP is a precursor to serotonin, which can then be converted into melatonin, a hormone that regulates sleep-wake cycles. Preliminary studies indicate it might assist with sleep, but further robust research is needed to establish its full impact.
schedule Dosage, timing & forms
The recommended dietary allowance (RDA) for Vitamin B6 in adult men and women (19-50 years) is generally 1.3 mg per day. Needs can vary by age, pregnancy, or lactation status.
Typical starting dosages for 5-HTP often range from 50 to 100 mg per day. It is usually advised to begin with a lower dose and gradually increase if needed. Individual needs and responses can vary.
Vitamin B6 is a crucial cofactor for the enzyme that converts 5-HTP into serotonin. Some supplement protocols include Vitamin B6 to support this conversion. However, high doses of B6 could potentially affect peripheral 5-HTP conversion, which may be undesired.
5-HTP is often taken before bedtime due to its potential role in sleep, or divided into smaller doses throughout the day with meals to help minimize potential stomach upset. Optimal timing can vary based on individual goals and tolerance.
Some approaches suggest taking a moderate dose of P-5-P (the active form of B6) alongside 5-HTP to facilitate its conversion. The specific timing or ratio can be complex, and some sources recommend taking them at separate times or with specific forms of B6. Professional guidance is often sought for personalized strategies.
health_and_safety Safety & interactions
Combining 5-HTP with antidepressant medications, such as SSRIs, SNRIs, or MAOIs, is generally not recommended without strict medical supervision. This combination can lead to excessively high serotonin levels, potentially causing a serious and life-threatening condition known as serotonin syndrome. Always consult a healthcare professional before combining 5-HTP with any prescription medication.
Serotonin syndrome is a potentially serious condition caused by excessive serotonin levels in the brain. It can occur if 5-HTP is combined with other substances that increase serotonin, such as antidepressants or other serotonergic drugs. Symptoms can range from mild (agitation, rapid heart rate, tremors) to severe (fever, seizures, unconsciousness), requiring immediate medical attention.
Yes, because Vitamin B6 facilitates the conversion of 5-HTP to serotonin, taking them together could potentially lead to higher serotonin levels than 5-HTP alone, especially at higher doses. This may increase the risk of serotonin-related side effects such as nausea, gastrointestinal upset, or, in rare cases, serotonin syndrome when combined with other serotonergic substances.
Vitamin B6 is a crucial cofactor for the enzyme that converts 5-HTP into serotonin in the body. Taking both supplements might enhance the conversion of 5-HTP, potentially leading to increased serotonin levels. This interaction is often considered in the formulation of 5-HTP supplements.
Yes, Vitamin B6 can interact with several medications. For instance, it may reduce the effectiveness of certain anti-seizure medications like phenytoin and phenobarbital, and can also interfere with levodopa used for Parkinson's disease. Additionally, some drugs, like isoniazid, can deplete Vitamin B6 levels. It is advisable to consult a healthcare professional if you are on medication.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin B6 | 50 mg |
5-HTP | 200 mg |
Categories
5-HTP 80.0
The 200mg dose of 5-HTP is among the higher concentrations available, which can deliver strong effects. However, this higher dose makes it less suitable as a starting point for all users due to increased potential for side effects, leading to a slightly lower score compared to a well-balanced 100mg option.
Vitamin B6 65.0
While it provides a substantial 50mg of Pyridoxine Hydrochloride, ensuring ample cofactor for 5-HTP conversion, this form and dose may be considered high by some nutritionists for daily, long-term use due to concerns about potential sensory neuropathy in very sensitive individuals.
Goals
Mood Support 92.0
With 200mg of 5-HTP, this product offers a robust dose for enhancing serotonin levels, making it potentially very effective for alleviating symptoms of low mood and promoting a greater sense of well-being.
Stress Relief 90.0
The potent increase in serotonin due to the 200mg 5-HTP dosage can effectively modulate stress responses, promoting calmness and emotional resilience. Improved sleep is also a key factor in stress reduction.
Sleep Support 90.0
A higher 5-HTP dose can lead to more robust melatonin production, which is essential for regulating sleep cycles, potentially resulting in more profound and restorative sleep for individuals struggling with insomnia.
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