5-HTP Enhanced with Vitamins B6 and C
Doctor's Best
5-HTP Enhanced with Vitamins B6 and C
4.8
★ ★ ★ ★ ★
(5265 ratings)
5-HTP 100 mg
Vitamin B6 15 mg
Score 80.0
Doctor's Best 5-HTP Enhanced provides a well-dosed combination of 5-HTP and Vitamin B6 for mood, sleep, and stress support, but its product name is misleading regarding Vitamin C content.
Quantity: 120 Veggie Cap(s)Servings size: 1 Veggie Capsule(s) (120 servings)
Selected goals:
Other goals:
Stress Relief
Mood Support
Sleep Support
Energy
Brain Health
leaderboard Score 80.0
Doctor's Best 5-HTP Enhanced provides a well-dosed combination of 5-HTP and Vitamin B6 for mood, sleep, and stress support, but its product name is misleading regarding Vitamin C content.
insights Analysis
This product offers a combination of 100mg 5-HTP from Griffonia simplicifolia seed extract and 15mg Vitamin B6 in the form of Pyridoxine Hydrochloride. The 5-HTP dosage is a common and effective amount for mood and sleep support. The inclusion of Vitamin B6 is crucial as it acts as a cofactor in the conversion of 5-HTP to serotonin, enhancing its efficacy. However, the product name explicitly mentions "Vitamin C," which is not listed in the provided ingredients, suggesting a potential discrepancy or omission that could be misleading to consumers, impacting trust.
- Contains 100mg of 5-HTP, a widely studied and effective dose for mood and sleep support.
- Includes Vitamin B6 (15mg) which is a crucial cofactor for the conversion of 5-HTP to serotonin, enhancing its bioavailability and effectiveness.
- Doctor's Best is a reputable brand with a high volume of positive reviews for their products, indicating general consumer satisfaction and trust.
- The product name explicitly states "Enhanced with Vitamins B6 and C," but Vitamin C is not listed in the ingredients, which is misleading and lacks transparency.
- Uses Pyridoxine Hydrochloride (HCl) for Vitamin B6, which is a common form, but Pyridoxal-5-Phosphate (P-5-P) is often considered more bioavailable and the preferred active form by many nutritionists.
- While effective, the combination might not be ideal for individuals seeking a pure 5-HTP product or those sensitive to B6 in the HCl form.
$14.62($0.12 per serving)
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bolt Effectiveness for goals
Vitamin B6 acts as a necessary coenzyme for the conversion of 5-HTP into serotonin. Without adequate B6, the metabolism of 5-HTP may be inefficient. This interaction is key for 5-HTP's intended effects on neurotransmitter levels.
Because Vitamin B6 is required for the body to convert 5-HTP into serotonin, some suggest taking them together could optimize 5-HTP's action. This co-factor relationship is important for the intended biochemical pathway. However, the precise optimal dosing and balance are complex and still subjects of ongoing research.
Some research suggests 5-HTP may help support mood by increasing serotonin levels in the brain. Serotonin is a neurotransmitter involved in mood regulation. However, more extensive research is needed to confirm its efficacy for specific mood conditions.
Vitamin B6 is a crucial coenzyme involved in over 100 enzymatic reactions, including protein, fat, and carbohydrate metabolism. It plays vital roles in red blood cell formation, neurotransmitter synthesis, and maintaining normal homocysteine levels. It also supports immune function and brain health.
5-HTP is a precursor to serotonin, which can then be converted into melatonin, a hormone that regulates sleep-wake cycles. Preliminary studies indicate it might assist with sleep, but further robust research is needed to establish its full impact.
schedule Dosage, timing & forms
The recommended dietary allowance (RDA) for Vitamin B6 in adult men and women (19-50 years) is generally 1.3 mg per day. Needs can vary by age, pregnancy, or lactation status.
Typical starting dosages for 5-HTP often range from 50 to 100 mg per day. It is usually advised to begin with a lower dose and gradually increase if needed. Individual needs and responses can vary.
Vitamin B6 is a crucial cofactor for the enzyme that converts 5-HTP into serotonin. Some supplement protocols include Vitamin B6 to support this conversion. However, high doses of B6 could potentially affect peripheral 5-HTP conversion, which may be undesired.
5-HTP is often taken before bedtime due to its potential role in sleep, or divided into smaller doses throughout the day with meals to help minimize potential stomach upset. Optimal timing can vary based on individual goals and tolerance.
Some approaches suggest taking a moderate dose of P-5-P (the active form of B6) alongside 5-HTP to facilitate its conversion. The specific timing or ratio can be complex, and some sources recommend taking them at separate times or with specific forms of B6. Professional guidance is often sought for personalized strategies.
health_and_safety Safety & interactions
Combining 5-HTP with antidepressant medications, such as SSRIs, SNRIs, or MAOIs, is generally not recommended without strict medical supervision. This combination can lead to excessively high serotonin levels, potentially causing a serious and life-threatening condition known as serotonin syndrome. Always consult a healthcare professional before combining 5-HTP with any prescription medication.
Serotonin syndrome is a potentially serious condition caused by excessive serotonin levels in the brain. It can occur if 5-HTP is combined with other substances that increase serotonin, such as antidepressants or other serotonergic drugs. Symptoms can range from mild (agitation, rapid heart rate, tremors) to severe (fever, seizures, unconsciousness), requiring immediate medical attention.
Yes, because Vitamin B6 facilitates the conversion of 5-HTP to serotonin, taking them together could potentially lead to higher serotonin levels than 5-HTP alone, especially at higher doses. This may increase the risk of serotonin-related side effects such as nausea, gastrointestinal upset, or, in rare cases, serotonin syndrome when combined with other serotonergic substances.
Vitamin B6 is a crucial cofactor for the enzyme that converts 5-HTP into serotonin in the body. Taking both supplements might enhance the conversion of 5-HTP, potentially leading to increased serotonin levels. This interaction is often considered in the formulation of 5-HTP supplements.
Yes, Vitamin B6 can interact with several medications. For instance, it may reduce the effectiveness of certain anti-seizure medications like phenytoin and phenobarbital, and can also interfere with levodopa used for Parkinson's disease. Additionally, some drugs, like isoniazid, can deplete Vitamin B6 levels. It is advisable to consult a healthcare professional if you are on medication.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin C | 200 mg |
Vitamin B6 | 15 mg |
5-HTP | 100 mg |
Categories
5-HTP 85.0
With 100mg of 5-HTP per serving, derived from Griffonia simplicifolia, this product offers a standard and clinically relevant dose that is well-regarded for supporting mood and sleep without being excessively high for typical use.
Vitamin B6 75.0
The product provides 15mg of Pyridoxine Hydrochloride, which is an effective co-factor dose for 5-HTP conversion and general B6 benefits. However, it's not the more bioavailable P-5-P form, which would generally be preferred by nutritionists for optimal absorption and utilization.
Goals
Mood Support 90.0
5-HTP is highly effective for mood support by increasing serotonin levels in the brain, which is often associated with feelings of well-being and happiness. The synergistic action with Vitamin B6 enhances this primary benefit.
Sleep Support 88.0
Serotonin, derived from 5-HTP, is a precursor to melatonin, the hormone that regulates sleep-wake cycles. Therefore, adequate 5-HTP can aid in natural melatonin production, promoting better sleep quality and duration.
Stress Relief 85.0
By promoting balanced serotonin levels, 5-HTP can help regulate mood and reduce feelings of anxiety and stress. Improved sleep quality, a common benefit, also significantly aids in stress management.
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