Product Image

5-HTP with Vitamin B6 & Vitamin C

Lake Avenue Nutrition
4.7
★ ★ ★ ★ ★
(5705 ratings)
5-HTP 100 mg
Vitamin B6 15 mg
Product Image
Score83
A focused, affordable 100 mg 5-HTP capsule with clear dosing, though limited source detail and serious serotonin-related interactions require care.
How scoring works
Quantity:60 Capsule(s) • (60 servings)
Goals:
Mood Support
Sleep Support
Stress Relief
Weight Loss

Score 83

A focused, affordable 100 mg 5-HTP capsule with clear dosing, though limited source detail and serious serotonin-related interactions require care.
How scoring works
$8.64($0.14 per serving)
iHerb
$ 8.64
Report prices

Analysis

The 100 mg 5-HTP amount offers a moderate starting level for serotonin-related mood, sleep, or appetite support. Vitamin C and B6 provide straightforward companion nutrients without an overly complex blend.

Griffonia simplicifolia is identified as the source, but its 5-HTP standardization is not stated. The finished active amount is clear, though the raw-material quality cannot be judged as confidently.

A single capsule and strong value make routine use convenient. Medication and supplement compatibility remains the deciding safety issue because 5-HTP can substantially add to other serotonin-raising agents.

Who is it for
  • Adults seeking a moderate 5-HTP amount
  • Value-focused users wanting simple mood or sleep support
Best for
  • Entry-level 5-HTP supplementation
  • Serotonin-related mood and sleep support

Pros

  • Clearly discloses 100 mg of 5-HTP
  • Simple one-capsule serving
  • Strong serving value

Cons

  • Griffonia standardization is not stated
  • Uses conventional pyridoxine hydrochloride
  • Formula is limited to one main functional pathway

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, tramadol, or other serotonin-raising agents because dangerous serotonin excess may occur
  • 5-HTP may cause nausea or digestive discomfort
  • 5-HTP may cause drowsiness, so assess tolerance before driving or operating machinery

Nutrient quality

81 Highest impact

5-HTP is identified as Griffonia seed extract, while the supporting vitamins use conventional forms. The 5-HTP amount is meaningful and the supporting vitamin amounts are substantial.

Ingredient transparency

82 Highest impact

All three active ingredients have explicit amounts. Inactive capsule ingredients are not disclosed.

Customer satisfaction

72 High impact

The supplied average and volume indicate strong aggregate satisfaction. No detailed experience reports are available to identify repeated complaints or confirm perceived benefits.

Value for money

94 Highest impact

The focused formula and meaningful 5-HTP amount support the accessible cost. A useful dose is provided at a favorable serving cost.

Report analysis

Goals

Mood Support
Mood Support
Impact
Highest effect
A- Goal FitA Strength of SupportC+ CoverageA+ Formula Quality
Vitamin B6 · 15 mg5-HTP · 100 mg

5-HTP directly supplies a serotonin precursor at a commonly used amount, while vitamin B6 supports its conversion pathway. Vitamin C adds little direct mood value but does not undermine the focused design.

The active doses are clear and the combination is more coherent than 5-HTP alone. Griffonia standardization is not stated; combining 5-HTP with SSRIs, SNRIs, MAOIs, or other serotonin-raising agents can increase serotonin-toxicity risk.

Study evidence
5-HTP Supportive 9 studies
Vitamin B6 Supportive 19 studies
Sleep Support
Sleep Support
Impact
High effect
C- Goal FitA- Strength of SupportC+ CoverageB+ Formula Quality

A meaningful amount of 5-HTP may support serotonin and downstream melatonin production, while vitamin B6 helps that conversion pathway. Sleep-specific evidence is less direct and less consistent than for melatonin.

The active amounts are disclosed, though the Griffonia extract lacks a stated standardization level. 5-HTP can dangerously increase serotonin when combined with selective serotonin reuptake inhibitors, monoamine oxidase inhibitors, or other serotonergic medicines.

Study evidence
5-HTP Supportive 1 study
Vitamin B6 Disputed 7 studies
Stress Relief
Stress Relief
Impact
High effect
C Goal FitB- Strength of SupportC- CoverageB Formula Quality
Vitamin B6 · 15 mgVitamin C · 200 mg

5-HTP may support serotonin production and promote calm or emotional balance in selected users. Evidence is more established for mood-related use than for reducing everyday perceived stress.

The 100 mg amount is practical and fully disclosed, while vitamin B6 supports conversion pathways. Avoid combining 5-HTP with SSRIs, MAO inhibitors, or other serotonin-raising medicines because excess serotonin can be dangerous.

Study evidence
5-HTP Supportive 18 studies
Vitamin B6 Supportive 10 studies
Vitamin C Supportive 11 studies
Weight Loss
Weight Loss
Impact
High effect
C- Goal FitB+ Strength of SupportD CoverageB Formula Quality

5-HTP may help some people manage appetite or carbohydrate cravings through serotonin production. The effect is situational, and the formula does not support thermogenesis, fiber-based fullness, or lean-mass retention.

The 5-HTP amount is clearly disclosed and matches a commonly used supplemental serving, while vitamins B6 and C play supporting roles. Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, or other serotonergic medicines because excessive serotonin can cause a serious reaction.

Study evidence
5-HTP Supportive 5 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid)
 200 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 15 mg
L-5-Hydroxytryptophan (Griffonia simplicifolia Seed Extract)
 100 mg
Gluten Free Adults 18–50 Dairy Free No Allergies
Report overview
5-HTP (Griffonia simplicifolia Seed Extract) · 100 mg OverallScore75
B- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyA- Value

Griffonia simplicifolia seed extract supplies the preferred 5-HTP amount, but the standardization percentage is not stated. A vegetable capsule and added vitamins support practical daily use without offering controlled release. Good cost efficiency is a strength, while the provided information lacks a specific serotonergic-drug warning.

View ingredientView products
Vitamin B6 (Pyridoxine Hydrochloride) · 15 mg OverallScore74
D+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB- Value

Pyridoxine hydrochloride is used without a listed riboflavin cofactor. The 15 mg dose lies within the preferred range for metabolic and neurological support. The one capsule serving is practical, while the serving cost is moderate for a pyridoxine hydrochloride product.

View ingredientView products
Loading alternative details
80 Performance

5-HTP 5-Hydroxytryptophan 100 mg

Natural Factors Stress-Relax
<p>Time-release delivery may spread the same 5-HTP amount and improve stomach comfort for some users. It avoids added B6, but extract standardization is absent and serotonin-raising medicine interactions remain.</p>
81 Performance

5-HTP Plus+ 200 mg

NatureWise
<p>A higher 5-HTP amount paired with active pyridoxal 5-phosphate improves the B6 form compared with the original pyridoxine. The stronger dose is not automatically more suitable and needs careful screening for serotonergic medicines.</p>
84 Performance

5-HTP 50 mg

NOW
<p>A starting-level 5-HTP serving offers a more cautious dose than the original while avoiding added B6. It retains a named Griffonia seed source, but serotonin-related medicine interactions still apply.</p>
83 Budget

5-HTP Enhanced with Vitamins B6 and C

Doctor's Best
<p>A lower-cost formula provides the same amounts of 5-HTP, vitamin B6, and vitamin C with similarly clear disclosure. The practical improvement is mainly the longer supply, while the same serotonergic medicine interaction concern applies.</p>
85 Budget

5-HTP 100 mg

NOW
<p>A cheaper focused capsule keeps the same 5-HTP amount while removing added vitamin B6 and vitamin C. It may suit users who do not need those vitamins, but Griffonia standardization is absent and serotonin-related interactions remain.</p>
83 Budget

5-HTP 100 mg Extra Strength

Swanson
<p>A lower-cost single-active capsule matches the original 5-HTP amount and avoids extra B6 exposure. The botanical source is identified without a standardization percentage, and serotonergic medicines still require caution.</p>
85 Value

5-HTP 100 mg

Doctor's Best
<p>A focused capsule supplies the same 5-HTP amount at lower routine cost without extra B6 or vitamin C. It delivers strong value for the core active, though Griffonia standardization is absent.</p>
79 Value

5-HTP 50 mg

Jarrow Formulas
<p>A lower-cost 50 mg serving may suit cautious starting use and avoids unnecessary vitamin B6. It is less potent than the original, while the same serotonin-related interaction warning applies.</p>
82 Value

5-HTP 50 mg

Swanson Premium Brand
<p>A low-cost starting-level 5-HTP capsule offers simple, clearly identified support without added vitamins. The amount is half the original and still should not be combined with serotonin-raising medicines without clinician guidance.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
    Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
    Randomized trial48 participantsWeight Loss for5-HTP
  2. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
    Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
    Randomized trial25 participantsWeight Loss for5-HTP
  3. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
    Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
    Clinical trial19 participantsWeight Loss for5-HTP
  4. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  5. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  6. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  7. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  8. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  9. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  10. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  11. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  12. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support Stress Relief forVitamin B6
  13. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  14. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B6
  15. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6
  16. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  17. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  18. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  19. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  20. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6
  21. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  22. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  23. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  24. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  25. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  26. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forVitamin B6
  27. RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
    Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
    Randomized trial128 participantsStress Relief forVitamin B6
  28. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  29. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
    Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
    Cross-sectional study447 participantsStress Relief forVitamin B6
  30. Vitamin C supplementation alleviates hypercortisolemia caused by chronic stress.
    Beglaryan N; Hakobyan G; Nazaretyan E · Stress and health : journal of the International Society for the Investigation of Stress · 2024
    Randomized trial69 participantsStress Relief forVitamin C
  31. Effect of Vitamin C on adrenal suppression by etomidate induction in patients undergoing cardiac surgery: A randomized controlled trial.
    Das D; Sen C; Goswami A · Annals of cardiac anaesthesia · 2017
    Randomized trial78 participantsStress Relief forVitamin C
  32. The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a systematic review.
    McCabe D; Lisy K; Lockwood C; Colbeck M · JBI database of systematic reviews and implementation reports · 2018
    Systematic review14 studies pooledStress Relief forVitamin C
  33. Exercise-induced oxidative stress before and after vitamin C supplementation.
    Alessio HM; Goldfarb AH; Cao G · International journal of sport nutrition · 1997
    Clinical trialStress Relief forVitamin C
  34. Effects of Oral Vitamin C Supplementation on Anxiety in Students: A Double-Blind, Randomized, Placebo-Controlled Trial.
    de Oliveira IJ; de Souza VV; Motta V; Da-Silva SL · Pakistan journal of biological sciences : PJBS · 2015
    Randomized trial42 participantsStress Relief forVitamin C
  35. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
    Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
    Narrative reviewWeight Loss for5-HTP
  36. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
    Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
    Randomized trial20 participantsWeight Loss for5-HTP