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Quiet Sleep Melatonin 3 mg

Life Extension
4.6
★ ★ ★ ★ ★
(914 ratings)
Melatonin 3 mg
Vitamin B12 100 mcg
Product Image
Score71
Direct sleep-onset support from melatonin, with a busy nutrient blend that adds less value than the label suggests.
How scoring works
Quantity:60 Capsule(s) • (60 servings)
Goals:
General Health
Sleep Support
Stress Relief
Brain Health

Score 71

Direct sleep-onset support from melatonin, with a busy nutrient blend that adds less value than the label suggests.
How scoring works

Also available as

1 option
5.00mg • 60 Capsule(s) servings Melatonin 5 mg • 60 Capsule(s) • 60 servings $12.83 ($0.21 per serving)
$9.75($0.16 per serving)
iHerb
$ 9.75
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Analysis

The 3 mg melatonin serving is the clear functional center and may help users who have trouble falling asleep or managing sleep timing. Immediate release is better aligned with sleep onset than with staying asleep through the night.

Vitamin C, active B6, methylcobalamin, magnesium, chromium, and inositol broaden the label, but most do not strengthen the main sleep mechanism. Magnesium oxide is poorly absorbed, and the inositol amount is too small for strong standalone relaxation support.

The lower of the two available melatonin strengths is the more measured option, although many people may still prefer less. It suits occasional nighttime use better than broad daily nutrition or focused immune, brain, or hair support.

Who is it for
  • Adults seeking help with sleep onset
  • Users who prefer a moderate melatonin serving
  • People who want a capsule rather than a gummy
Best for
  • Occasional sleep-timing support
  • Falling asleep
  • Nighttime use when a full sleep window is available

Pros

  • Clearly disclosed melatonin amount
  • Uses active P-5-P vitamin B6
  • Uses methylcobalamin
  • Simple once-nightly capsule format

Cons

  • Immediate release does not target sleep maintenance
  • Magnesium oxide has weak absorption
  • Inositol is modestly dosed
  • The broad vitamin blend is not sleep-specific

Warnings

  • The 3 mg melatonin amount may cause vivid dreams or next-morning drowsiness, so it should be used only when a full sleep period is possible.
  • Niacin at 73.5 mg NE may cause stomach upset or other tolerance issues in sensitive users even though niacinamide is less likely to flush.

Nutrient quality

67 High impact

Methylcobalamin and active vitamin B6 are favorable, while magnesium oxide is poorly absorbed. Melatonin is meaningful, but several supporting nutrients add limited sleep value.

Ingredient transparency

73 High impact

Most totals are disclosed, but repeated vitamin C and calcium amounts obscure how forms are divided. Daily directions and inactive ingredients are not supplied.

Customer satisfaction

69 High impact

The aggregate rating is strong and backed by high volume. No detailed experience reports are supplied, so recurring complaints and purpose fit remain uncertain.

Value for money

76 High impact

The serving cost is low for a multi-ingredient sleep product. Basic mineral quality and unnecessary supporting nutrients reduce formula efficiency.

Report analysis

Goals

General Health
General Health
Impact
High effect
B+ Goal FitB- Strength of SupportB CoverageB- Formula Quality
Vitamin B12 · 100 mcgMagnesium · 120 mgVitamin C · 220 mg

The formula combines a well-aligned melatonin amount with several vitamins and minerals that support energy and general physiology. Sleep timing remains its main strength, while vitamin C, active B6, and methylcobalamin add broader nutritional relevance.

Magnesium oxide is poorly absorbed and the amounts of several supporting nutrients are modest. Niacin at 73.5 mg NE may cause unwanted effects in sensitive users even though the niacinamide form is less likely to cause flushing.

Study evidence
Magnesium Supportive 114 studies
Melatonin Supportive 69 studies
Vitamin B12 Adverse 66 studies
Vitamin C Supportive 56 studies
Sleep Support
Sleep Support
Impact
High effect
A- Goal FitB- Strength of SupportB- CoverageD Formula Quality
Magnesium · 120 mgMelatonin · 3 mg

Melatonin directly supports circadian signaling and sleep onset, and the 3 mg amount is clearly disclosed. Magnesium and inositol add modest relaxation support, although magnesium oxide is poorly absorbed.

The large vitamin blend is not necessary for nighttime use, and higher B-vitamin amounts may feel activating for some users. Immediate-release melatonin favors falling asleep rather than maintaining sleep through the night.

Study evidence
Magnesium Supportive 23 studies
Melatonin Supportive 181 studies
Stress Relief
Stress Relief
Impact
High effect
B- Goal FitB- Strength of SupportC+ CoverageC Formula Quality
Magnesium · 120 mgVitamin B12 · 100 mcgVitamin B6 · 10 mgVitamin C · 220 mg

Melatonin mainly supports stress-related difficulty falling asleep rather than daytime resilience. Inositol, active vitamin B forms, and magnesium add broader nervous-system support.

The melatonin amount is well aligned with nighttime use, but magnesium oxide is poorly absorbed and inositol is modestly dosed. Melatonin can cause next-morning drowsiness, so use should be limited to times when full sleep is possible.

Study evidence
Magnesium Supportive 13 studies
Melatonin Supportive 21 studies
Brain Health
Brain Health
Impact
High effect
C Goal FitB- Strength of SupportC+ CoverageC Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 10 mgMagnesium · 120 mg

Melatonin supports sleep-related cognitive recovery, while active B6 and methylcobalamin contribute to neurotransmitter and methylation functions. Vitamin C, magnesium, chromium, and inositol add broader nutritional support.

Magnesium oxide is poorly absorbed, and 100 mg inositol is too small for a strong neurological effect. The crowded nutrient profile is less focused than the 3 mg melatonin centerpiece and may not improve cognition beyond correcting deficiencies.

Study evidence
Magnesium Supportive 86 studies
Melatonin Supportive 29 studies
Vitamin B12 Supportive 74 studies
Immunity
Immunity
Impact
Moderate effect
C- Goal FitC- Strength of SupportD+ CoverageD Formula Quality
Magnesium · 120 mgVitamin C · 220 mg

Melatonin, vitamin C, and several B vitamins offer indirect sleep-related resilience plus modest antioxidant support. The vitamin C amount is below the preferred immune target, and magnesium oxide provides weak systemic mineral delivery.

The formula is designed more for sleep than for immune readiness, with repeated nutrient forms and several unrelated additions. The melatonin amount may cause next-morning drowsiness in sensitive users, and the formula does not deliver a strong direct immune dose.

Study evidence
Magnesium Supportive 8 studies
Melatonin Supportive 10 studies
Vitamin C Supportive 53 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid, Niacinamide Ascorbate)
 220 mg
Niacin (Niacinamide Ascorbate)
 73.5 mg NE
Vitamin B6 (Pyridoxal 5-Phosphate)
 10 mg
Vitamin B12 (Methylcobalamin)
 100 mcg
Calcium (Calcium Carbonate, Calcium Citrate)
 48 mg
Magnesium (Magnesium Oxide)
 120 mg
Chromium (ChromeMate Chromium Polynicotinate)
 50 mcg
Melatonin
3 mg
Inositol
100 mg
Gluten Free Adults 18–50
Report overview
Melatonin · 3 mg OverallScore64
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyC Value

The 3 mg dose is physiologically aligned and clearly supplied in one capsule. Standard immediate-release delivery favors sleep initiation rather than all-night maintenance. The broader nutrient blend carries a moderate cost, while independent purity verification is absent.

View ingredientView products
Vitamin B12 (Methylcobalamin) · 100 mcg OverallScore54
A- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

Methylcobalamin provides a bioactive B12 form with clear label disclosure. The 100 mcg dose is better suited to basic maintenance than higher needs. Cost efficiency is weak, although the bioactive form adds some formulation value.

View ingredientView products
Loading alternative details
90 Performance

Melatonin Lozenges 3 mg

Life Extension
<p>A focused melatonin lozenge keeps a practical sleep-onset amount without the original’s high niacin, magnesium oxide, and metabolic extras. The simpler design is easier to assess, although no sustained-release feature supports sleep maintenance.</p>
89 Performance

Melatonin 3 mg Fast Dissolve Strawberry Natural Flavor

Natrol
<p>Fast-dissolve delivery and a practical melatonin amount are well aligned with sleep initiation. The formula is more focused than the original and avoids unnecessary nutrient complexity, but it does not provide overnight release.</p>
86 Performance

Liquid Melatonin

NOW
<p>Liquid delivery may support prompt use while retaining a conservative, clearly disclosed melatonin amount. The single-active design avoids the original’s poorly absorbed magnesium and high niacin, though full delivery and duration details remain limited.</p>
91 Budget

Fast-Dissolve Melatonin 3 mg Artificial Strawberry Flavor

Spring Valley
<p>A focused melatonin formula provides the same practical sleep-onset amount at a much lower serving cost. Removing high niacin, magnesium oxide, chromium, and unrelated nutrient additions makes the formula easier to assess.</p>
88 Budget

Melatonin Lozenge 2.5 mg

Nature's Way
<p>A practical lozenge amount supports sleep initiation at substantially lower serving cost. The simple formula avoids the original’s high niacin and poorly absorbed magnesium oxide, though it does not offer sustained release.</p>
89 Budget

Melatonin 1.0 mg Orange Flavor

Source Naturals Sleep Science
<p>A lower melatonin amount and dissolving format offer a more conservative approach to sleep onset at much lower serving cost. The streamlined formula avoids the original’s unrelated metabolic nutrients but does not support overnight release.</p>
89 Value

Quick Dissolve Melatonin 3 mg

Nature's Bounty
<p>A simple quick-dissolve melatonin serving provides strong sleep-onset value without unrelated vitamins, minerals, or metabolic ingredients. The lower cost and focused formula are advantages, while the lack of sustained release limits overnight coverage.</p>
88 Value

Melatonin 1.0 mg Peppermint Flavor

Source Naturals Sleep Science
<p>Low-dose dissolving melatonin offers a conservative sleep-signaling approach with excellent serving value. It avoids the original’s high niacin and magnesium oxide, but users needing stronger or overnight support may find it too limited.</p>
87 Value

Melatonin 1 mg Fast Dissolve Strawberry Natural Flavor

Natrol
<p>A low melatonin amount and fast-dissolve delivery provide a focused, cost-efficient option for sleep initiation. The conservative dose may reduce unnecessary exposure, although next-day drowsiness remains possible and no sustained release is provided.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Meta-analysis: melatonin for the treatment of primary sleep disorders.
    Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
    Meta-analysis1,683 participants19 studies pooledSleep Support forMelatonin
  2. Exogenous melatonin as a treatment for secondary sleep disorders: A systematic review and meta-analysis.
    Li T; Jiang S; Han M; Yang Z; Lv J; Deng C; Reiter RJ; Yang Y · Frontiers in neuroendocrinology · 2019
    Meta-analysis205 participants7 studies pooledSleep Support forMelatonin
  3. Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.
    Sletten TL; Magee M; Murray JM; Gordon CJ; Lovato N; Kennaway DJ; Gwini SM; Bartlett DJ; Lockley SW; Lack LC; Grunstein RR; Rajaratnam SMW; Delayed Sleep on Melatonin (DelSoM) Study Group · PLoS medicine · 2019
    Randomized trial116 participantsSleep Support forMelatonin
  4. Melatonin treatment for age-related insomnia.
    Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
    Randomized trial30 participantsSleep Support forMelatonin
  5. Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysis.
    Salanitro M; Wrigley T; Ghabra H; de Haan E; Hill CM; Solmi M; Cortese S · Neuroscience and biobehavioral reviews · 2022
    Meta-analysis1,998 participants34 studies pooledSleep Support forMelatonin
  6. Effects of Melatonin Treatment on Perioperative Sleep Quality: A Systematic Review and Meta-Analysis with Trial Sequential Analysis of Randomized Controlled Trials.
    Gao Y; Chen X; Zhou Q; Song J; Zhang X; Sun Y; Yu M; Li Y · Nature and science of sleep · 2022
    Meta-analysis725 participants10 studies pooledSleep Support forMelatonin
  7. Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.
    Tsukinaga A; Mihara T; Takeshima T; Tomita M; Goto T · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Meta-analysis516 participants8 studies pooledSleep Support forMelatonin
  8. Unintended consequences: college students' melatonin usage, sleep disturbance, and depressive symptoms.
    Peltz JS; Rogge R · Sleep and biological rhythms · 2025
    Cohort study331 participantsSleep Support forMelatonin
  9. Antenatal magnesium sulfate and neuroprotection.
    Doyle LW · Current opinion in pediatrics · 2012
    Meta-analysis6,145 participants5 studies pooledBrain Health forMagnesium
  10. No. 376-Magnesium Sulphate for Fetal Neuroprotection.
    Magee LA; De Silva DA; Sawchuck D; Synnes A; von Dadelszen P · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2020
    Guideline / consensus4,446 participantsBrain Health forMagnesium
  11. Magnesium Sulfate Before Preterm Birth for Neuroprotection: An Updated Cochrane Systematic Review.
    Shepherd ES; Goldsmith S; Doyle LW; Middleton P; Marret S; Rouse DJ; Pryde P; Wolf HT; Crowther CA · Obstetrics and gynecology · 2024
    Systematic review5,917 participants6 studies pooledBrain Health forMagnesium
  12. Magnesium sulphate for fetal neuroprotection at imminent risk for preterm delivery: a systematic review with meta-analysis and trial sequential analysis.
    Wolf HT; Huusom LD; Henriksen TB; Hegaard HK; Brok J; Pinborg A · BJOG : an international journal of obstetrics and gynaecology · 2020
    Meta-analysis5,917 participants6 studies pooledBrain Health forMagnesium
  13. Magnesium sulfate and fetal neuroprotection: overview of clinical evidence.
    Chollat C; Marret S · Neural regeneration research · 2020
    Narrative reviewBrain Health forMagnesium
  14. Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
    Terao I; Kodama W · Journal of Alzheimer's disease : JAD · 2024
    Meta-analysis4,599 participants10 studies pooledBrain Health forMelatonin
  15. Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
    Mdluli NT; Banda KJ; Chang YC · Age and ageing · 2025
    Meta-analysis516 participants10 studies pooledBrain Health forMelatonin
  16. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
    Wade AG; Farmer M; Harari G; Fund N; Laudon M; Nir T; Frydman-Marom A; Zisapel N · Clinical interventions in aging · 2015
    Randomized trial80 participantsBrain Health forMelatonin
  17. Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule.
    Garofoli F; Asteggiano C; Minniti ML; Accorsi P; Albertini R; Angelini M; Aversa S; Ballante E; Cabini RF; Caporali C; Cociglio S; Franco V; Longo S; Malerba L; Materia V; Mazzocchi L; Naboni C; Palmisani M; Pullega C; Pisoni C; Preda L; Riboli A; Risso FM; Rognone E; Savini G; Simoncelli AM; Villani P; Tzialla C; Pinelli L; Fazzi E; Chiapparini L; Borgatti R; Ghirardello S; Pichiecchio A; Orcesi S · Journal of pineal research · 2026
    Randomized trial54 participantsBrain Health forMelatonin
  18. Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Abouelmagd ME; Aldemerdash MA; Khatatbeh AA; Osman ASA; Abbas A; Allam S; AlEdani EM; Aldemerdash A; Monteith TS · Current pain and headache reports · 2026
    Meta-analysis788 participants9 studies pooledBrain Health forMelatonin
  19. Relationship between vitamin B12 levels and motor development: A systematic review.
    Dos Santos MERA; da Silva KG; da Silva Souza AP; da Silva ABJ; da Silva RF; da Silva EHA; de Souza SL; Barros WMA · Clinical nutrition ESPEN · 2024
    Systematic review1,559 participants8 studies pooledBrain Health forVitamin B12
  20. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
    Zhou L; Bai X; Huang J; Tan Y; Yang Q · Nutricion hospitalaria · 2023
    Randomized trial115 participantsBrain Health forVitamin B12
  21. Structural and Functional Brain Changes Associated with Vitamin B12 Deficiency using Magnetic Resonance Imaging: A Systematic Review and Meta-analysis.
    Alghamdi A · Current medical imaging · 2023
    Meta-analysis12 studies pooledBrain Health forVitamin B12
  22. Maternal vitamin B12, vitamin D, and folic acid status during pregnancy and child neurodevelopment: a systematic review.
    Franco L; de Andrade CVF; Margini LV; Sousa N · Frontiers in neuroscience · 2026
    Systematic review22 studies pooledBrain Health forVitamin B12
  23. Higher vitamin B12 from mid- to late life is related to slower rates of cognitive decline.
    Marino FR; Rogers G; Miller JW; Selhub J; Mez J; Crane PK; Mukherjee S; Saykin AJ; Hohman TJ; Trittschuh EH; Au R; Jacques PF; Hwang PH · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Cohort study1,994 participantsBrain Health forVitamin B12
  24. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  25. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  26. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  27. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  28. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  29. Melatonin for preventing and treating jet lag.
    Herxheimer A; Petrie KJ · The Cochrane database of systematic reviews · 2001
    Systematic review10 studies pooledGeneral Health forMelatonin
  30. Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life.
    Schroder CM; Malow BA; Maras A; Melmed RD; Findling RL; Breddy J; Nir T; Shahmoon S; Zisapel N; Gringras P · Journal of autism and developmental disorders · 2019
    Randomized trial125 participantsGeneral Health forMelatonin
  31. Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials.
    Fatemeh G; Sajjad M; Niloufar R; Neda S; Leila S; Khadijeh M · Journal of neurology · 2022
    Meta-analysis23 studies pooledGeneral Health forMelatonin
  32. Efficacy of melatonin for chronic insomnia: Systematic reviews and meta-analyses.
    Choi K; Lee YJ; Park S; Je NK; Suh HS · Sleep medicine reviews · 2022
    Meta-analysis24 studies pooledGeneral Health forMelatonin
  33. Effectiveness of melatonin for the treatment of nocturia: a randomized controlled trial.
    Leerasiri P; Pariyaeksut P; Hengrasmee P; Asumpinwong C · International urogynecology journal · 2023
    Randomized trial60 participantsGeneral Health forMelatonin
  34. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  35. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  36. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  37. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  38. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  39. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  40. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  41. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  42. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  43. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  44. Hypomagnesemia Is a Risk Factor for Infections after Kidney Transplantation: A Retrospective Cohort Analysis.
    Odler B; Deak AT; Pregartner G; Riedl R; Bozic J; Trummer C; Prenner A; Söllinger L; Krall M; Höflechner L; Hebesberger C; Boxler MS; Berghold A; Schemmer P; Pilz S; Rosenkranz AR · Nutrients · 2021
    Cohort study376 participantsImmunity forMagnesium
  45. Higher Intake of Dietary Magnesium Is Inversely Associated With COVID-19 Severity and Symptoms in Hospitalized Patients: A Cross-Sectional Study.
    Nouri-Majd S; Ebrahimzadeh A; Mousavi SM; Zargarzadeh N; Eslami M; Santos HO; Taghizadeh M; Milajerdi A · Frontiers in nutrition · 2022
    Cross-sectional study250 participantsImmunity forMagnesium
  46. Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D.
    Chaigne-Delalande B; Li FY; O'Connor GM; Lukacs MJ; Jiang P; Zheng L; Shatzer A; Biancalana M; Pittaluga S; Matthews HF; Jancel TJ; Bleesing JJ; Marsh RA; Kuijpers TW; Nichols KE; Lucas CL; Nagpal S; Mehmet H; Su HC; Cohen JI; Uzel G; Lenardo MJ · Science (New York, N.Y.) · 2013
    Single-arm trialImmunity forMagnesium
  47. Effect of magnesium on granulocyte function and on the exercise induced inflammatory response.
    Mooren FC; Golf SW; Völker K · Magnesium research · 2003
    Randomized trialImmunity forMagnesium
  48. Maternal and neonatal outcomes following magnesium sulfate in the setting of chorioamnionitis: a meta-analysis.
    Pergialiotis V; Sapantzoglou I; Rodolaki K; Varthaliti A; Theodora M; Antsaklis P; Thomakos N; Stavros S; Daskalakis G; Papapanagiotou A · Archives of gynecology and obstetrics · 2024
    Meta-analysis6,559 participants8 studies pooledImmunity forMagnesium
  49. Exogenous melatonin boosts vaccine-induced immunity in individuals with high pre-existing influenza immunity.
    Oda K; Danko J; Villasante E; Bergmann-Leitner E; Lee R; Wijayalath W · Frontiers in immunology · 2025
    Randomized trialImmunity forMelatonin
  50. Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis.
    Chojnacki C; Wisniewska-Jarosinska M; Walecka-Kapica E; Klupinska G; Jaworek J; Chojnacki J · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · 2012
    Randomized trial60 participantsImmunity forMelatonin
  51. Pineal-opioid system interactions in the control of immunoinflammatory responses.
    Lissoni P; Barni S; Tancini G; Fossati V; Frigerio F · Annals of the New York Academy of Sciences · 1995
    Clinical trial130 participantsImmunity forMelatonin
  52. Influenza vaccine response is predicted by chronotype and differentially associated with pre- and post-vaccination sleep.
    Harrison EM; Lee RU; Porter CK; Isidean SD; Easterling AP; White L; Boulifard DA; DeTizio K; Liang Z; Sedegah M; Danko J; Glickman GL · Brain, behavior, & immunity - health · 2026
    Randomized trialImmunity forMelatonin
  53. Mechanisms and clinical evidence to support melatonin's use in severe COVID-19 patients to lower mortality.
    Tan DX; Reiter RJ · Life sciences · 2022
    Narrative review19 participantsImmunity forMelatonin
  54. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  55. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  56. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  57. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  58. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  59. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  60. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  61. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  62. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  63. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  64. The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
    Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
    Meta-analysis409 participants8 studies pooledSleep Support forMelatonin
  65. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
    Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
    Randomized trial791 participantsSleep Support forMelatonin
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    Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
    Meta-analysis284 participants8 studies pooledSleep Support forMelatonin
  67. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  68. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  69. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  70. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  71. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
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  72. The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial.
    Rahafard S; Akbari Jokar Z; Hosseini SA; Alaee E · Annals of medicine and surgery (2012) · 2024
    Randomized trial202 participantsStress Relief forMelatonin
  73. Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial.
    Javaherforooshzadeh F; Amirpour I; Janatmakan F; Soltanzadeh M · Anesthesiology and pain medicine · 2022
    Randomized trial90 participantsStress Relief forMelatonin
  74. Melatonin for pre- and postoperative anxiety in adults.
    Hansen MV; Halladin NL; Rosenberg J; Gögenur I; Møller AM · The Cochrane database of systematic reviews · 2015
    Meta-analysis774 participants12 studies pooledStress Relief forMelatonin
  75. Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.
    Demirhan Kayacik A; İlcioglu K · Archives of women's mental health · 2024
    Meta-analysis441 participants5 studies pooledStress Relief forMelatonin
  76. Premedication effect of melatonin on propofol induction dose for anesthesia, anxiety, orientation and sedation after abdominal surgery: a double-blinded randomized trial.
    Norouzi A; Fateh S; Modir H; Kamali A; Akrami L · Medical gas research · 2020
    Randomized trial88 participantsStress Relief forMelatonin