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NAD+ Cell Regenerator

Life Extension
4.7
★ ★ ★ ★ ★
(4163 ratings)
Niacin 300 mg
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Score81
A clearly disclosed, substantial nicotinamide riboside supplement for focused NAD support. Strong ingredient quality is offset by high cost and indirect goal alignment.
How scoring works
Quantity:30 Capsule(s) • (30 servings)
Goals:
Heart Health
Cardiovascular Support
Skin Health

Score 81

A clearly disclosed, substantial nicotinamide riboside supplement for focused NAD support. Strong ingredient quality is offset by high cost and indirect goal alignment.
How scoring works

Also available as

1 option
100.00mg • 30 Capsule(s) servings B3 100 mg • 30 Capsule(s) • 30 servings $18.00 ($0.60 per serving)
$40.50($1.35 per serving)
iHerb
$ 40.50
Pure Formulas
$ 45.00
Vitacost
$ 44.39
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Analysis

The formula supplies a substantial amount of a clearly named nicotinamide riboside ingredient. That provides much better specificity than generic labels that list only vitamin B3.

Nicotinamide riboside is designed around NAD metabolism and does not act like flushing nicotinic acid. Its fit for the listed heart and skin goals is therefore indirect rather than targeted.

The single-active capsule is easy to evaluate and avoids unnecessary extras. Regular use is comparatively costly, so the product best suits people who specifically value this form rather than basic niacin coverage.

Who is it for
  • Adults specifically seeking nicotinamide riboside
  • Users focused on NAD metabolism
  • People comfortable paying for a branded single active
Best for
  • Focused NAD support
  • Higher-dose nicotinamide riboside
  • Simple one-capsule routines

Pros

  • Substantial NIAGEN amount
  • Excellent active identification
  • Single ingredient is easy to assess

Cons

  • High serving cost
  • Indirect fit for listed heart and skin goals
  • Unnecessary for basic B3 intake

Warnings

  • Nicotinamide riboside may cause mild digestive discomfort in sensitive users.
  • Avoid stacking it with several other high-dose vitamin B3 products without reviewing total intake.
  • It should not be treated as interchangeable with nicotinic acid for lipid-focused use.

Nutrient quality

88 Highest impact

Branded nicotinamide riboside provides strong source identity and a relevant NAD precursor. The amount sits in a meaningful range for NAD support.

.

Ingredient transparency

84 Highest impact

All meaningful active amounts are clearly disclosed. The supplied data does not include a complete inactive ingredient list.

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Customer satisfaction

71 High impact

The aggregate satisfaction measure is strong and supported by adequate volume. Missing feedback themes leave recurring complaints and purpose fit uncertain.

.

Value for money

79 High impact

The price is reasonable for the formula quality and dose. Each serving provides only moderate cost efficiency.

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Report analysis

Goals

Heart Health
Heart Health
Impact
Moderate effect
F Goal FitB+ Strength of SupportD- CoverageA Formula Quality

Nicotinamide riboside supports cellular NAD production, but it is not the lipid-modifying form of niacin used clinically for cholesterol management. Its connection to cardiovascular outcomes is therefore indirect and not well established.

The branded 300 mg amount is clearly disclosed and suitable for its intended NAD pathway. The label is focused and transparent, but a good NR dose does not compensate for the weak match to heart-specific evidence.

Study evidence
Niacin Supportive 105 studies
Cardiovascular Support
Cardiovascular Support
Impact
Moderate effect
F Goal FitC- Strength of SupportF CoverageA Formula Quality
Niacin · 300 mg

Nicotinamide riboside supports cellular energy, but its link to the selected cardiovascular goal is indirect. The branded ingredient and disclosed amount are strengths, while human evidence for improving core cardiovascular markers remains limited.

The single-ingredient formula is clear and avoids padding. It does not directly support lipids, vascular tone, arterial calcium handling, or rhythm, so it is better suited to general cellular-energy goals.

Study evidence
Niacin Supportive 136 studies
Skin Health
Skin Health
Impact
Moderate effect
F Goal FitC+ Strength of SupportF CoverageB+ Formula Quality

Nicotinamide riboside supports cellular NAD production, but that mechanism is only indirectly related to visible skin health. Evidence for oral nicotinamide riboside improving hydration, wrinkles, barrier function, or UV resilience is limited.

The branded ingredient and exact amount are clearly disclosed, and the single-active design avoids padding. It lacks the more established skin roles of niacinamide as well as structural, hydration, and antioxidant skin actives.

Study evidence
Niacin Supportive 61 studies

Ingredients

IngredientAmount per serving
NIAGEN Nicotinamide Riboside
300 mg
Gluten Free Adults 18–50
Report overview
Niacin · 300 mg OverallScore86
A Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyC Value

Patented nicotinamide riboside is strongly aligned with NAD and cellular-energy goals. Its dose sits within the preferred range, although no stabilization or enteric protection is stated. The branded ingredient has good source credibility, while the serving cost falls in a middle value tier for this class.

View ingredientView products
Loading alternative details
72 Performance

NiaCel 400

Thorne
<p>A meaningful nicotinamide-riboside amount with clearly identified betaine creates a compact cellular-energy formula. Compared with the original, it gives cellular-energy support a clearer ingredient identity or a more practical dose-and-cost balance; however, the serving is costly and direct support for weight, heart, cardiovascular, or skin goals remains limited.</p>
77 Performance

Tru Niagen Unflavored

ChromaDex
<p>Specific nicotinamide riboside chloride provides a clearly identified NAD precursor in a simple active powder. Compared with the original, it gives cellular-energy support a clearer ingredient identity or a more practical dose-and-cost balance; however, the carbohydrate base and premium positioning do not establish better heart or skin outcomes from the supplied data.</p>
82 Performance

No Flush Niacin (Inositol Hexanicotinate) 800 mg

Life Extension
<p>Clearly named inositol hexanicotinate provides substantial flush-free niacin exposure with economical serving value. Compared with the original, it gives cellular-energy support a clearer ingredient identity or a more practical dose-and-cost balance; however, its cardiovascular effects may be less direct and reliable than those of nicotinic acid.</p>
79 Budget

NAD+ Cell Regenerator 100 mg

Life Extension
<p>Branded nicotinamide riboside provides credible identity and a clear low-dose NAD-support purpose. Serving cost is lower than the original, but the amount is below the stronger option in the supplied set and direct heart or skin benefits are not established by the input.</p>
86 Budget

Niacinamide B-3 100 mg

Source Naturals
<p>A clearly identified moderate niacinamide tablet offers simple non-flushing vitamin B3 support with excellent serving economics. Serving cost is lower than the original, but it does not provide nicotinic acid’s lipid-focused effects and complete excipient details are missing.</p>
81 Budget

B-Complex with Folic Acid plus Vitamin C

Nature's Bounty
<p>A broad B-complex with vitamin C provides practical daily B-vitamin coverage at very low serving cost. Serving cost is lower than the original, but several forms are conventional, thiamine entries are duplicated, and it is not a dedicated niacin or performance formula.</p>
80 Value

Super Vitamin B-Complex

Spring Valley
<p>Broad measured B-vitamin coverage offers accessible everyday value and a simple alternative to opaque blends. Its lower serving cost and clearer active design support practical value compared with the original, although chemical forms are not identified, thiamine is unnecessarily high, and it is not a one-for-one performance formula.</p>
80 Value

B-Complex plus Vitamin C

21st Century
<p>Vitamin C and several core B vitamins provide inexpensive general energy-metabolism support. Its lower serving cost and clearer active design support practical value compared with the original, although the formula omits folate, vitamin B12, and biotin and is not a dedicated niacin or pre-workout product.</p>
85 Value

Niacin 100 mg

Source Naturals
<p>A moderate niacinamide tablet provides clearly identified vitamin B3 without typical nicotinic-acid flushing. Its lower serving cost and clearer active design support practical value compared with the original, although the form is intended for nutritional or skin support rather than lipid-focused effects.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Role of Niacin in Current Clinical Practice: A Systematic Review.
    Garg A; Sharma A; Krishnamoorthy P; Garg J; Virmani D; Sharma T; Stefanini G; Kostis JB; Mukherjee D; Sikorskaya E · The American journal of medicine · 2017
    Meta-analysis35,206 participants13 studies pooledHeart Health forNiacin
  2. Effect of Nicotinamide in Skin Cancer and Actinic Keratoses Chemoprophylaxis, and Adverse Effects Related to Nicotinamide: A Systematic Review and Meta-Analysis.
    Mainville L; Smilga AS; Fortin PR · Journal of cutaneous medicine and surgery · 2022
    Meta-analysis3,039 participants29 studies pooledSkin Health forNiacin
  3. Relationship of lipoproteins to cardiovascular events: the AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes).
    Guyton JR; Slee AE; Anderson T; Fleg JL; Goldberg RB; Kashyap ML; Marcovina SM; Nash SD; O'Brien KD; Weintraub WS; Xu P; Zhao XQ; Boden WE · Journal of the American College of Cardiology · 2013
    Randomized trial3,414 participantsHeart Health forNiacin
  4. Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients.
    Allen NC; Martin AJ; Snaidr VA; Eggins R; Chong AH; Fernandéz-Peñas P; Gin D; Sidhu S; Paddon VL; Banney LA; Lim A; Upjohn E; Schaider H; Ganhewa AD; Nguyen J; McKenzie CA; Prakash S; McLean C; Lochhead A; Ibbetson J; Dettrick A; Landgren A; Allnutt KJ; Allison C; Davenport RB; Mumford BP; Wong B; Stagg B; Tedman A; Gribbin H; Edwards HA; De Rosa N; Stewart T; Doolan BJ; Kok Y; Simpson K; Low ZM; Kovitwanichkanont T; Scolyer RA; Dhillon HM; Vardy JL; Chadban SJ; Bowen DG; Chen AC; Damian DL · The New England journal of medicine · 2023
    Randomized trial158 participantsSkin Health forNiacin
  5. A Foodborne Outbreak Traced to Niacin Overenrichment.
    Hudson PJ; Vogt RL · Journal of food protection · 2023
    Case-control study21 participantsSkin Health forNiacin
  6. Exploring the Cardiovascular Impacts of Oral Nicotinamide: A Comprehensive Narrative Review.
    Shoukfeh R; Tisack AM; Lim HW; Mohammad TF · Journal of drugs in dermatology : JDD · 2025
    Narrative reviewHeart Health forNiacin
  7. Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease.
    Duggal JK; Singh M; Attri N; Singh PP; Ahmed N; Pahwa S; Molnar J; Singh S; Khosla S; Arora R · Journal of cardiovascular pharmacology and therapeutics · 2010
    Meta-analysis5,137 participants7 studies pooledHeart Health forNiacin
  8. The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial.
    Chiu PC; Chan CC; Lin HM; Chiu HC · Journal of cosmetic dermatology · 2008
    Randomized trial52 participantsSkin Health forNiacin
  9. Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: A randomized trial. Arterial Disease Multiple Intervention Trial.
    Elam MB; Hunninghake DB; Davis KB; Garg R; Johnson C; Egan D; Kostis JB; Sheps DS; Brinton EA · JAMA · 2000
    Randomized trial468 participantsHeart Health forNiacin
  10. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.
    Hakozaki T; Minwalla L; Zhuang J; Chhoa M; Matsubara A; Miyamoto K; Greatens A; Hillebrand GG; Bissett DL; Boissy RE · The British journal of dermatology · 2002
    Randomized trial138 participantsSkin Health forNiacin
  11. Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis.
    D'Andrea E; Hey SP; Ramirez CL; Kesselheim AS · JAMA network open · 2020
    Meta-analysis35,760 participants17 studies pooledHeart Health forNiacin
  12. Niacinamide: A B vitamin that improves aging facial skin appearance.
    Bissett DL; Oblong JE; Berge CA · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2005
    Randomized trial50 participantsSkin Health forNiacin
  13. The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration.
    Villines TC; Stanek EJ; Devine PJ; Turco M; Miller M; Weissman NJ; Griffen L; Taylor AJ · Journal of the American College of Cardiology · 2010
    Randomized trial315 participantsHeart Health forNiacin
  14. Nicotinamide for Skin Cancer Chemoprevention.
    Breglio KF; Knox KM; Hwang J; Weiss R; Maas K; Zhang S; Yao L; Madden C; Xu Y; Hartman RI; Wheless L · JAMA dermatology · 2025
    Cohort study33,822 participantsSkin Health forNiacin
  15. The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome.
    Thoenes M; Oguchi A; Nagamia S; Vaccari CS; Hammoud R; Umpierrez GE; Khan BV · International journal of clinical practice · 2008
    Randomized trial50 participantsHeart Health forNiacin
  16. Niacin intake and risk of skin cancer in US women and men.
    Park SM; Li T; Wu S; Li WQ; Weinstock M; Qureshi AA; Cho E · International journal of cancer · 2017
    Cohort study114,116 participantsSkin Health forNiacin
  17. Differential effect of two nicotinic acid preparations on low-density lipoprotein subclass distribution in patients classified as low-density lipoprotein pattern A, B, or I.
    Superko HR; McGovern ME; Raul E; Garrett B · The American journal of cardiology · 2004
    Randomized trial180 participantsHeart Health forNiacin
  18. Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide.
    Kawada A; Konishi N; Oiso N; Kawara S; Date A · The Journal of dermatology · 2008
    Randomized trial30 participantsSkin Health forNiacin
  19. Extended-release niacin therapy and risk of ischemic stroke in patients with cardiovascular disease: the Atherothrombosis Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcome (AIM-HIGH) trial.
    Teo KK; Goldstein LB; Chaitman BR; Grant S; Weintraub WS; Anderson DC; Sila CA; Cruz-Flores S; Padley RJ; Kostuk WJ; Boden WE; AIM-HIGH Investigators · Stroke · 2013
    Randomized trial3,414 participantsHeart Health forNiacin
  20. Chemoprevention of keratinocyte carcinomas and actinic keratoses in adults who were immunocompetent: a systematic review.
    Susanto A; Morgan E; Lindsay D; Collins LG · Clinical and experimental dermatology · 2026
    Systematic review7,355 participants11 studies pooledSkin Health forNiacin
  21. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.
    Lavigne PM; Karas RH · Journal of the American College of Cardiology · 2013
    Meta-analysis9,959 participants11 studies pooledCardiovascular Support forNiacin
  22. Effects of niacin on apo A1 and B levels: a systematic review and meta-analysis of randomised controlled trials.
    Saboori S; Yousefi Rad E; Tammam J; Thondre PS; Coe S · The British journal of nutrition · 2024
    Meta-analysis12 studies pooledCardiovascular Support forNiacin
  23. Effect of lipid-lowering therapies on lipoprotein(a) levels: a comprehensive meta-analysis of randomized controlled trials.
    Xie S; Galimberti F; Olmastroni E; Carugo S; Catapano AL; Casula M; META-LIPID Group · Atherosclerosis · 2025
    Meta-analysis145,314 participants147 studies pooledCardiovascular Support forNiacin
  24. Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Study Group.
    Guyton JR; Blazing MA; Hagar J; Kashyap ML; Knopp RH; McKenney JM; Nash DT; Nash SD · Archives of internal medicine · 2000
    Randomized trial173 participantsCardiovascular Support forNiacin
  25. Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia.
    Knopp RH; Alagona P; Davidson M; Goldberg AC; Kafonek SD; Kashyap M; Sprecher D; Superko HR; Jenkins S; Marcovina S · Metabolism: clinical and experimental · 1998
    Randomized trial223 participantsCardiovascular Support forNiacin
  26. Effect of niacin on endothelial function: a systematic review and meta-analysis of randomized controlled trials.
    Sahebkar A · Vascular medicine (London, England) · 2014
    Meta-analysis441 participants7 studies pooledHeart Health forNiacin
  27. A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention.
    Chen AC; Martin AJ; Choy B; Fernández-Peñas P; Dalziell RA; McKenzie CA; Scolyer RA; Dhillon HM; Vardy JL; Kricker A; St George G; Chinniah N; Halliday GM; Damian DL · The New England journal of medicine · 2015
    Randomized trial386 participantsSkin Health forNiacin