Product Image

Twice Daily Multi Energy Multi-Vita-Min

Solaray
4.8
★ ★ ★ ★ ★
(26 ratings)
PABA 25 mg
Vitamin E 200 IU
Vitamin A 15000 IU
Boron 1 mg
Product Image
Score65
Best suited to skin health, with the clearest benefits coming from the disclosed active ingredients. The multivitamin lacks collagen, ceramides, or hyaluronic acid and devotes much of its label to unrelated high-dose B vitamins.
How scoring works
Quantity:120 Capsule(s) • (60 servings)
Goals:
Skin Health
Vision Support
Anti-Inflammatory Support
Cardiovascular Support

Score 65

Best suited to skin health, with the clearest benefits coming from the disclosed active ingredients. The multivitamin lacks collagen, ceramides, or hyaluronic acid and devotes much of its label to unrelated high-dose B vitamins.
How scoring works
$31.79($0.52 per serving)
Vitacost
$ 31.79
iHerb
$ 31.79
Report prices

Analysis

Vitamins A, C, and E plus zinc and selenium provide broad antioxidant and skin-maintenance support. The multivitamin lacks collagen, ceramides, or hyaluronic acid and devotes much of its label to unrelated high-dose B vitamins. Skin-relevant amounts are substantial, but the vitamin A split between beta-carotene and preformed retinyl palmitate is unclear.

Vitamin E, B vitamins, magnesium, and antioxidant nutrients provide broad but nonspecific cardiovascular support. The product remains a multivitamin and lacks a strong dose of omega-3 fats, CoQ10, K2, or a nitric-oxide active. Natural vitamin E reaches a substantial amount, while magnesium is modest and several B vitamins use conventional forms.

The 25 mg amount reaches the standard high-potency multinutrient range. PABA is named directly, and immediate release suits this nutritional amount. Cost efficiency is weak for the PABA amount delivered.

Who is it for
  • People seeking skin health support
  • People seeking vision support support
  • People seeking anti-inflammatory support support
Best for
  • Skin Health
  • Vision Support
  • Anti-Inflammatory Support

Pros

  • Vitamins A, C, and E plus zinc and selenium provide broad antioxidant and skin-maintenance support.
  • People who are pregnant or planning pregnancy should avoid excess preformed vitamin A unless a clinician has reviewed the total intake.
  • Antioxidant vitamins, zinc, selenium, and copper provide several nutrients relevant to retinal and lens maintenance.
  • People who already use preformed vitamin A should account for that uncertainty before adding another source.
  • Vitamin E, vitamin C, selenium, zinc, and vitamin D provide several antioxidant and immune-support routes.

Cons

  • The multivitamin lacks collagen, ceramides, or hyaluronic acid and devotes much of its label to unrelated high-dose B vitamins.
  • Skin-relevant amounts are substantial, but the vitamin A split between beta-carotene and preformed retinyl palmitate is unclear.
  • Missing lutein, zeaxanthin, and DHA keep it from being a complete vision-focused formula.
  • The zinc and copper pairing is sensible, but the high vitamin A amount lacks a clear beta-carotene-to-retinyl ratio.
  • The broad nutrient base may help systemic balance, but it lacks a strongly targeted botanical or fatty-acid active.

Warnings

  • People who are pregnant or planning pregnancy should avoid excess preformed vitamin A unless a clinician has reviewed the total intake.
  • The 50 mg vitamin B6 amount deserves care with long-term stacking because excess supplemental B6 can contribute to nerve symptoms.

Nutrient quality

67 High impact

Several mineral chelates, natural vitamin E, and selenomethionine are favorable choices. Basic vitamin forms and potentially aggressive totals reduce balance and safety.

Ingredient transparency

70 High impact

Many active amounts are disclosed, and no named proprietary blend is shown. Repeated entries for several nutrients make the true totals difficult to verify.

Customer satisfaction

60 Moderate impact

The supplied average rating is strong, but the review base is small. No review text is available to assess recurring complaints or consistency with the intended use.

Value for money

59 Moderate impact

Broad coverage and several good forms provide some value. Higher cost, dose ambiguity, and an aggressive nutrient pattern limit competitiveness for routine use.

Report analysis

Goals

Skin Health
Skin Health
Impact
High effect
B- Goal FitB Strength of SupportB- CoverageD+ Formula Quality
Zinc · 15 mgVitamin C · 300 mgCopper · 1 mgSelenium · 100 mcgVitamin E · 200 IU

Vitamins A, C, and E plus zinc and selenium provide broad antioxidant and skin-maintenance support. The multivitamin lacks collagen, ceramides, or hyaluronic acid and devotes much of its label to unrelated high-dose B vitamins.

Skin-relevant amounts are substantial, but the vitamin A split between beta-carotene and preformed retinyl palmitate is unclear. People who are pregnant or planning pregnancy should avoid excess preformed vitamin A unless a clinician has reviewed the total intake.

Study evidence
Selenium Supportive 22 studies
Vitamin A Supportive 106 studies
Vitamin C Supportive 53 studies
Vitamin E Supportive 38 studies
Zinc Supportive 66 studies
Vision Support
Macular and Blue Light Defense
Vision Support
Impact
High effect
C Goal FitB Strength of SupportC+ CoverageC+ Formula Quality
Zinc · 15 mgVitamin E · 200 IUVitamin C · 300 mgCopper · 1 mgVitamin A · 15000 IU

Antioxidant vitamins, zinc, selenium, and copper provide several nutrients relevant to retinal and lens maintenance. Missing lutein, zeaxanthin, and DHA keep it from being a complete vision-focused formula.

The zinc and copper pairing is sensible, but the high vitamin A amount lacks a clear beta-carotene-to-retinyl ratio. People who already use preformed vitamin A should account for that uncertainty before adding another source.

Study evidence
Copper Supportive 7 studies
Selenium Supportive 15 studies
Vitamin A Supportive 65 studies
Vitamin C Disputed 24 studies
Vitamin E Disputed 35 studies
Zinc Supportive 39 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
C+ Goal FitC+ Strength of SupportC+ CoverageD+ Formula Quality
Vitamin D · 400 IUVitamin E · 200 IUVitamin C · 300 mg

Vitamin E, vitamin C, selenium, zinc, and vitamin D provide several antioxidant and immune-support routes. The broad nutrient base may help systemic balance, but it lacks a strongly targeted botanical or fatty-acid active.

Many nutrients are clearly quantified, yet the crowded formula mixes stronger and weaker mineral forms. The 50 mg vitamin B6 amount and 18 mg iron make routine long-term use less broadly suitable without an individual need.

Study evidence
Selenium Supportive 34 studies
Vitamin C Supportive 50 studies
Vitamin D Supportive 101 studies
Vitamin E Supportive 20 studies
Zinc Supportive 64 studies
Cardiovascular Support
Arterial Integrity and Protection
Cardiovascular Support
Impact
Moderate effect
C- Goal FitC- Strength of SupportC CoverageD+ Formula Quality
Potassium · 20 mgMagnesium · 100 mgVitamin D · 400 IUSelenium · 100 mcgVitamin B12 · 50 mcgVitamin B6 · 50 mgVitamin E · 200 IUFolate · 400 mcgNiacin · 50 mgVitamin C · 300 mg

Vitamin E, B vitamins, magnesium, and antioxidant nutrients provide broad but nonspecific cardiovascular support. The product remains a multivitamin and lacks a strong dose of omega-3 fats, CoQ10, K2, or a nitric-oxide active.

Natural vitamin E reaches a substantial amount, while magnesium is modest and several B vitamins use conventional forms. The 50 mg vitamin B6 amount deserves care with long-term stacking because excess supplemental B6 can contribute to nerve symptoms.

Study evidence
Magnesium Supportive 123 studies
Vitamin B6 Supportive 35 studies
Vitamin E Mixed 79 studies

Ingredients

IngredientAmount per serving
Vitamin A (Beta-Carotene, Retinyl Palmitate)
 15000 IU
Vitamin C (Acerola Cherry, Ascorbic Acid, Rose Hip)
 300 mg
Vitamin D (Cholecalciferol, Fish)
 400 IU
Vitamin E (D-Alpha-Tocopheryl Succinate)
 200 IU
Thiamine (Thiamine Mononitrate, Vitamin B1)
 50 mg
Riboflavin (Vitamin B2)
 50 mg
Niacin (Niacinamide, Vitamin B3)
 50 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 50 mg
Folate (Folic Acid)
 400 mcg
Vitamin B12 (Cyanocobalamin)
 50 mcg
Biotin
300 mcg
Pantothenic Acid (Calcium Pantothenate)
 50 mg
Calcium (Calcium Amino Acid Chelate, Calcium Carbonate)
 200 mg
Iron (Iron Fumarate)
 18 mg
Iodine (Kelp, Potassium Iodide)
 225 mcg
Magnesium (Magnesium Amino Acid Chelate, Magnesium Oxide)
 100 mg
Zinc (Zinc Amino Acid Chelate)
 15 mg
Selenium (Selenomethionine)
 100 mcg
Copper (Copper Gluconate)
 1 mg
Manganese (Manganese Gluconate)
 6 mg
Chromium (Chromium Polynicotinate)
 200 mcg
Sodium
5 mg
Potassium (Potassium Chloride)
 20 mg
PABA
25 mg
Choline Bitartrate
25 mg
Inositol
25 mg
Boron (Boron Aspartate, Boron Citrate, Boron Glycinate, Boron Lysinate)
 1 mg
Adults 18–50
Report overview
PABA · 25 mg OverallScore82
A Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value

The 25 mg amount reaches the standard high-potency multinutrient range. PABA is named directly, and immediate release suits this nutritional amount. Cost efficiency is weak for the PABA amount delivered.

View ingredientView products
Vitamin E (D-Alpha-Tocopheryl Succinate) · 200 IU OverallScore72
D Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB- Value

d-alpha-tocopheryl succinate provides a clearly identified natural form, but no mixed tocopherols or tocotrienols are included. The 200 IU amount sits within the therapeutic range for general antioxidant support. Serving-level cost efficiency is reasonable for the disclosed natural form.

View ingredientView products
Vitamin A (Beta-Carotene, Retinyl Palmitate) · 15000 IU OverallScore60
C- Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyB+ Value

A mixed beta-carotene and retinyl palmitate source offers a more balanced form profile than retinyl alone, but its ratio is unclear. The high total dose raises uncertainty because the preformed share is not quantified. Value is good, while the dry capsule should be taken with dietary fat for absorption.

View ingredientView products
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68 Performance

Twice Daily Multi

Designs for Health
Mixed tocopherols, methylcobalamin, folate, chelated chromium, zinc, manganese, and molybdenum create a more polished multivitamin core. It omits iron, magnesium, choline, and inositol, but avoids the original aggressive iron and vitamin A profile.
59 Performance

CoEnzymated Complete Clinical+Multi 4 Daily

Emerald
Active B-vitamin forms, chelated minerals, mixed tocopherols and tocotrienols, vitamin K forms, alpha-lipoic acid, and boron provide broader form quality. A raw-food blend remains proprietary, but the core nutrients are more deliberately specified than the original duplicates.
65 Performance

Gynovite Plus

Optimox
Broad vitamins and minerals include folate, vitamin B12, iron, magnesium, zinc, chromium, inositol, PABA, and boron with useful overlap. Digestive additions complicate the formula, but the active nutrient presentation is less ambiguous than the original.
59 Budget

Daily Total One

Country Life
A lower serving cost preserves broad vitamins, minerals, chromium, boron, choline, and inositol while adding several active B-vitamin forms. Some duplicate source entries remain, but the formula avoids the original high iron and aggressive vitamin A emphasis.
66 Budget

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Irwin Naturals
A lower serving cost provides broad vitamins, chelated or citrate minerals, chromium, selenium, and methylcobalamin in a compact formula. Magnesium and the green blend are small, but the overall nutrient balance is easier to use than the original high-iron design.
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Energy +

Noor Vitamins
A lower serving cost keeps a broad vitamin and mineral base with chromium, selenium, manganese, and boron. Several forms are basic and the formula omits iron, choline, and inositol, but it avoids the original ambiguous duplicate entries.
58 Value

Premium Adult Multi-Vitamin Mineral

Tropical Oasis
A lower serving cost covers vitamins A, C, D, E, B vitamins, biotin, pantothenic acid, and iron in a simpler formula. It gives up several minerals and metabolic cofactors, but the active list is easier to understand.
60 Value

CoEnzymated Complete Premium+Multi 2 Daily

Emerald Laboratories
Active folate and B-vitamin forms, chelated minerals, mixed tocopherols and tocotrienols, alpha-lipoic acid, and boron support a stronger quality-to-cost balance. It costs more per serving than the original, yet avoids high iron and offers more purposeful nutrient forms.
71 Value

Norwegian Cod Liver Oil 1000 mg Fresh Orange Flavor

AN Amazing Nutrition Amazing Omega
A very low serving cost supplies vitamins A, D, and E in a simple oil-based formula. It is far narrower than a multivitamin and cannot replace B vitamins, minerals, choline, or inositol.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of tocotrienol on aging skin: A systematic review.
    Ghazali NI; Mohd Rais RZ; Makpol S; Chin KY; Yap WN; Goon JA · Frontiers in pharmacology · 2022
    Systematic reviewSkin Health forVitamin E
  2. A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh.
    Verret WJ; Chen Y; Ahmed A; Islam T; Parvez F; Kibriya MG; Graziano JH; Ahsan H · Journal of occupational and environmental medicine · 2006
    Randomized trial121 participantsSkin Health forVitamin E Skin Health forSelenium
  3. Patch Testing With Tocopherol and Tocopherol Acetate: The North American Contact Dermatitis Group Experience, 2001 to 2016.
    Warshaw EM; Ruggiero JL; DeKoven JG; Silverberg JI; Maibach HI; Taylor JS; Atwater AR; Zug KA; Sasseville D; Fowler JF; Fransway AF; Pratt MD; Belsito DV; DeLeo VA; Reeder MJ · Dermatitis : contact, atopic, occupational, drug · 2022
    Observational study38,699 participantsSkin Health forVitamin E
  4. Efficacy and Tolerability of Topical 0.1% Stabilized Bioactive Retinol for Photoaging: A Vehicle-Controlled Integrated Analysis.
    Farris P; Berson D; Bhatia N; Goldberg D; Lain E; Mariwalla K; Zeichner J; Miller D; McGuire T; Kizoulis M · Journal of drugs in dermatology : JDD · 2024
    Meta-analysis471 participants6 studies pooledSkin Health forVitamin A
  5. Biomarkers of Tretinoin Precursors and Tretinoin Efficacy in Patients With Moderate to Severe Facial Photodamage: A Randomized Clinical Trial.
    Chien AL; Kim DJ; Cheng N; Shin J; Leung SG; Nelson AM; Zang J; Suh H; Rainer B; Wallis L; Okoye GA; Loss M; Kang S · JAMA dermatology · 2022
    Randomized trial24 participantsSkin Health forVitamin A
  6. Photodecomposition of vitamin A and photobiological implications for the skin.
    Fu PP; Xia Q; Yin JJ; Cherng SH; Yan J; Mei N; Chen T; Boudreau MD; Howard PC; Wamer WG · Photochemistry and photobiology · 2007
    Narrative reviewSkin Health forVitamin A
  7. Supplementation with vitamin E alone is associated with reduced myocardial infarction: a meta-analysis.
    Loffredo L; Perri L; Di Castelnuovo A; Iacoviello L; De Gaetano G; Violi F · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2016
    Meta-analysis16 studies pooledCardiovascular Support forVitamin E
  8. Interventional study with vitamin E in cardiovascular disease and meta-analysis.
    Violi F; Nocella C; Loffredo L; Carnevale R; Pignatelli P · Free radical biology & medicine · 2022
    Meta-analysisCardiovascular Support forVitamin E
  9. The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial.
    Ward NC; Wu JH; Clarke MW; Puddey IB; Burke V; Croft KD; Hodgson JM · Journal of hypertension · 2007
    Randomized trial58 participantsCardiovascular Support forVitamin E
  10. Selenium and the course of mild Graves' orbitopathy.
    Marcocci C; Kahaly GJ; Krassas GE; Bartalena L; Prummel M; Stahl M; Altea MA; Nardi M; Pitz S; Boboridis K; Sivelli P; von Arx G; Mourits MP; Baldeschi L; Bencivelli W; Wiersinga W; European Group on Graves' Orbitopathy · The New England journal of medicine · 2011
    Randomized trial159 participantsAnti-Inflammatory Support forSelenium
  11. Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial.
    Asemi Z; Jamilian M; Mesdaghinia E; Esmaillzadeh A · Nutrition (Burbank, Los Angeles County, Calif.) · 2016
    Randomized trial70 participantsAnti-Inflammatory Support forSelenium
  12. Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease.
    Farrokhian A; Bahmani F; Taghizadeh M; Mirhashemi SM; Aarabi MH; Raygan F; Aghadavod E; Asemi Z · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2017
    Randomized trial60 participantsAnti-Inflammatory Support forSelenium
  13. The effects of selenium supplementation on cardiovascular risk factors in patients with metabolic diseases ‒ A systematic review and meta-analysis of randomized controlled trials.
    Qiu W; Huang N; Zhang K; Qiu H; Guo Z; Han F; Sun X; Hou N; Kan C · Nutricion hospitalaria · 2026
    Meta-analysis656 participants11 studies pooledAnti-Inflammatory Support forSelenium
  14. Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Kamali A; Amirani E; Asemi Z · Biological trace element research · 2020
    Randomized trial33 participantsAnti-Inflammatory Support forSelenium
  15. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  16. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  17. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  18. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  19. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  20. Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study.
    Zhou A; Hyppönen E · International journal of epidemiology · 2023
    Observational study294,970 participantsAnti-Inflammatory Support forVitamin D
  21. Vitamin D in Children With Inflammatory Bowel Disease: A Randomized Controlled Clinical Trial.
    El Amrousy D; El Ashry H; Hodeib H; Hassan S · Journal of clinical gastroenterology · 2021
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  22. Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers.
    Gao YQ; Gao YH; Xing JH · World journal of diabetes · 2025
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  23. Associations of C-reactive Protein with 25-hydroxyvitamin D in 24 Specific Diseases: A Cross-sectional Study from NHANES.
    Yang F; Sun M; Sun C; Li J; Yang X; Bi C; Wang M; Pu L; Wang J; Wang C; Xie M; Yao Y; Jin L · Scientific reports · 2020
    Cross-sectional study9,809 participantsAnti-Inflammatory Support forVitamin D
  24. Combined effects of vitamin D deficiency and systemic inflammation on all-cause mortality and cause-specific mortality in older adults.
    Zhang C; Cui J; Li S; Shen J; Luo X; Yao Y; Shi H · BMC geriatrics · 2024
    Cohort study3,072 participantsAnti-Inflammatory Support forVitamin D
  25. Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial.
    Mahjabeen W; Khan DA; Mirza SA; Pervez MA · Phytotherapy research : PTR · 2021
    Randomized trial110 participantsAnti-Inflammatory Support forVitamin E
  26. Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials.
    Saboori S; Shab-Bidar S; Speakman JR; Yousefi Rad E; Djafarian K · European journal of clinical nutrition · 2016
    Meta-analysis495 participants12 studies pooledAnti-Inflammatory Support forVitamin E
  27. Efficacy of Nutritional Interventions on Inflammatory Markers in Haemodialysis Patients: A Systematic Review and Limited Meta-Analysis.
    Khor BH; Narayanan SS; Sahathevan S; Gafor AHA; Daud ZAM; Khosla P; Sabatino A; Fiaccadori E; Chinna K; Karupaiah T · Nutrients · 2018
    Meta-analysis46 studies pooledAnti-Inflammatory Support forVitamin E
  28. Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
    Chee NM; Sinnanaidu RP; Chan WK · Journal of gastroenterology and hepatology · 2024
    Meta-analysis8 studies pooledAnti-Inflammatory Support forVitamin E
  29. Delta-tocotrienol supplementation improves biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial.
    Pervez MA; Khan DA; Slehria AUR; Ijaz A · Complementary therapies in medicine · 2021
    Randomized trial71 participantsAnti-Inflammatory Support forVitamin E
  30. Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent.
    Bao B; Prasad AS; Beck FW; Fitzgerald JT; Snell D; Bao GW; Singh T; Cardozo LJ · The American journal of clinical nutrition · 2010
    Randomized trial40 participantsAnti-Inflammatory Support forZinc
  31. Zinc Supplementation in Individuals with Prediabetes and type 2 Diabetes: a GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
    Nazari M; Nikbaf-Shandiz M; Pashayee-Khamene F; Bagheri R; Goudarzi K; Hosseinnia NV; Dolatshahi S; Omran HS; Amirani N; Ashtary-Larky D; Asbaghi O; Ghanavati M · Biological trace element research · 2024
    Meta-analysis23 studies pooledAnti-Inflammatory Support forZinc
  32. The Effects of Zinc Supplementation on C-Reactive Protein and Inflammatory Cytokines: A Meta-Analysis and Systematical Review.
    Ceylan MN; Akdas S; Yazihan N · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022
    Meta-analysis73 studies pooledAnti-Inflammatory Support forZinc
  33. The Effects of Zinc Sulfate Supplementation on Serum Copeptin, C-Reactive Protein and Metabolic Markers in Zinc-Deficient Diabetic Patients on Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Hosseini R; Montazerifar F; Shahraki E; Karajibani M; Mokhtari AM; Dashipour AR; Ferns GA; Jalali M · Biological trace element research · 2021
    Randomized trial46 participantsAnti-Inflammatory Support forZinc
  34. Zinc supplementation and cardiovascular disease risk factors: A GRADE-assessed systematic review and dose-response meta-analysis.
    Nazari M; Ashtary-Larky D; Nikbaf-Shandiz M; Goudarzi K; Bagheri R; Dolatshahi S; Omran HS; Amirani N; Ghanavati M; Asbaghi O · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023
    Meta-analysis75 studies pooledAnti-Inflammatory Support forZinc
  35. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  36. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  37. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support forMagnesium
  38. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support forMagnesium
  39. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  40. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  41. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  42. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  43. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support forVitamin B6
  44. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  45. Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.
    Chen B; Li Y; Li Z; Hu X; Zhen H; Chen H; Nie C; Hou Y; Zhu S; Xiao L; Li T · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2025
    Randomized trial90 participantsCardiovascular Support forVitamin E
  46. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.
    Lonn E; Bosch J; Yusuf S; Sheridan P; Pogue J; Arnold JM; Ross C; Arnold A; Sleight P; Probstfield J; Dagenais GR; HOPE and HOPE-TOO Trial Investigators · JAMA · 2005
    Randomized trial9,541 participantsCardiovascular Support forVitamin E
  47. Independent and combined associations of dietary antioxidant exposure with all-cause and cause-specific mortality in the general population.
    Liu Z; He Z; Xing Y · Journal of nutritional science · 2026
    Cohort study34,955 participantsCardiovascular Support forVitamin E
  48. Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study.
    Chin SF; Ibahim J; Makpol S; Abdul Hamid NA; Abdul Latiff A; Zakaria Z; Mazlan M; Mohd Yusof YA; Abdul Karim A; Wan Ngah WZ · Nutrition & metabolism · 2011
    Randomized trial62 participantsCardiovascular Support forVitamin E
  49. Comparative clinical trial of bifonazole solution versus selenium sulphide shampoo in the treatment of pityriasis versicolor.
    Chu AC · Dermatologica · 1985
    Randomized trial38 participantsSkin Health forSelenium
  50. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial.
    Duffield-Lillico AJ; Slate EH; Reid ME; Turnbull BW; Wilkins PA; Combs GF; Park HK; Gross EG; Graham GF; Stratton MS; Marshall JR; Clark LC; Nutritional Prevention of Cancer Study Group · Journal of the National Cancer Institute · 2003
    Randomized trial1,312 participantsSkin Health forSelenium
  51. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forSelenium Skin Health forVitamin E Skin Health forZinc
  52. The Whitening, Moisturizing, Anti-aging Activities, and Skincare Evaluation of Selenium-Enriched Mung Bean Fermentation Broth.
    Wei K; Guo C; Zhu J; Wei Y; Wu M; Huang X; Zhang M; Li J; Wang X; Wang Y; Wei X · Frontiers in nutrition · 2022
    Clinical trial31 participantsSkin Health forSelenium
  53. Tensile properties and contours of aging facial skin. A controlled double-blind comparative study of the effects of retinol, melibiose-lactose and their association.
    Piérard-Franchimont C; Castelli D; Cromphaut IV; Bertin C; Ries G; Cauwenbergh G; Piérard GE · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2016
    Randomized trial120 participantsSkin Health forVitamin A
  54. Antiaging action of retinol: from molecular to clinical.
    Bellemère G; Stamatas GN; Bruère V; Bertin C; Issachar N; Oddos T · Skin pharmacology and physiology · 2009
    Randomized trial48 participantsSkin Health forVitamin A
  55. An Updated Review of Topical Tretinoin in Dermatology: From Acne and Photoaging to Skin Cancer.
    Balado-Simó P; Morgado-Carrasco D; Gómez-Armayones S; López-Ferrer A; Barco D; Ferrándiz-Pulido C; Podlipnik S · Journal of clinical medicine · 2025
    Narrative reviewSkin Health forVitamin A
  56. Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial.
    Chang H; Tao K; Yang Y; Wang Y; Ge M; Wang X; Tang S; Yu H · Journal of cosmetic dermatology · 2025
    Randomized trialSkin Health forVitamin A
  57. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  58. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  59. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  60. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  61. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  62. Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.
    Javanbakht MH; Keshavarz SA; Djalali M; Siassi F; Eshraghian MR; Firooz A; Seirafi H; Ehsani AH; Chamari M; Mirshafiey A · The Journal of dermatological treatment · 2011
    Randomized trial45 participantsSkin Health forVitamin E
  63. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
    Liu X; Yang G; Luo M; Lan Q; Shi X; Deng H; Wang N; Xu X; Zhang C · PloS one · 2022
    Meta-analysis20 studies pooledSkin Health forVitamin E
  64. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
    Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H · The American journal of clinical nutrition · 2000
    Randomized trialSkin Health forVitamin E
  65. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  66. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  67. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  68. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc
  69. What did we learn in 35 years of research on nutrition and supplements for age-related macular degeneration: a systematic review.
    Pameijer EM; Heus P; Damen JAA; Spijker R; Hooft L; Ringens PJ; Imhof SM; van Leeuwen R · Acta ophthalmologica · 2023
    Systematic review27 studies pooledVision Support forCopper
  70. Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2.
    Agrón E; Mares J; Clemons TE; Swaroop A; Chew EY; Keenan TDL; AREDS and AREDS2 Research Groups · Ophthalmology · 2021
    Cohort study8,242 participantsVision Support forCopper
  71. Association between late age-related macular degeneration and dietary intake of copper, iron, zinc and selenium: a 2005-2008 NHANES cross-sectional observational study.
    Lu Y; Li C; Liu Y; Wu T; Lu P · BMC ophthalmology · 2025
    Observational study4,996 participantsVision Support forCopper
  72. Associations between dietary nutrient intake and the risk of multiple age-related ocular diseases: evidence from longitudinal analysis.
    Yang Y; Zou H · The journal of nutrition, health & aging · 2026
    Cohort study103,192 participantsVision Support forCopper
  73. Dietary habits and dietary nutrient intake in patients with age-related macular degeneration: A case-control study.
    Šalková Kráľová J; Kolář P; Kapounová Z; Veselý P; Derflerová Brázdová Z · Central European journal of public health · 2023
    Case-control study151 participantsVision Support forCopper
  74. Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction: A vehicle-controlled, randomized clinical trial.
    Watson SL; Jones LW; Stapleton F; Hinds M; Ng A; Tan J; Alster Y; Bosworth C; Rafaeli O; DePuy V; CELESTIAL STUDY Group · The ocular surface · 2026
    Randomized trial245 participantsVision Support forSelenium
  75. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledVision Support forSelenium
  76. Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction over six months of treatment: A Phase 2, vehicle-controlled, randomized extension trial.
    Downie LE; Craig JP; Stapleton F; Tan J; Jones LW; Ng A; Hinds M; Bosworth C; Alster Y · The ocular surface · 2025
    Randomized trial245 participantsVision Support forSelenium
  77. AZR-MD-001 0.5% selenium sulfide ophthalmic ointment for the treatment of contact lens discomfort: A vehicle-controlled, randomized, clinical trial.
    Stapleton F; Hinds M; Tan J; Jones L; Chalmers R; Bosworth C; Alster Y · The ocular surface · 2025
    Randomized trial67 participantsVision Support forSelenium
  78. The effect of a biweekly novel selenium sulfide-containing topical treatment in symptomatic contact lens wearers: An exploratory study.
    Stapleton F; Jia T; DePuy V; Bosworth C; Gleeson M; Tan J · The ocular surface · 2025
    Randomized trial14 participantsVision Support forSelenium
  79. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa.
    Berson EL; Rosner B; Sandberg MA; Hayes KC; Nicholson BW; Weigel-DiFranco C; Willett W · Archives of ophthalmology (Chicago, Ill. : 1960) · 1993
    Randomized trial601 participantsVision Support forVitamin A
  80. Efficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese Phase II clinical trial.
    Toshida H; Funaki T; Ono K; Tabuchi N; Watanabe S; Seki T; Otake H; Kato T; Ebihara N; Murakami A · Drug design, development and therapy · 2018
    Randomized trial66 participantsVision Support forVitamin A
  81. Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age.
    Imdad A; Mayo-Wilson E; Haykal MR; Regan A; Sidhu J; Smith A; Bhutta ZA · The Cochrane database of systematic reviews · 2022
    Meta-analysis1,223,856 participants47 studies pooledVision Support forVitamin A
  82. Vitamin A supplementation improves retinal function in infants at risk of retinopathy of prematurity.
    Mactier H; McCulloch DL; Hamilton R; Galloway P; Bradnam MS; Young D; Lavy T; Farrell L; Weaver LT · The Journal of pediatrics · 2012
    Randomized trial89 participantsVision Support forVitamin A
  83. Effect of short-term, high-dose retinol on dark adaptation in aging and early age-related maculopathy.
    Owsley C; McGwin G; Jackson GR; Heimburger DC; Piyathilake CJ; Klein R; White MF; Kallies K · Investigative ophthalmology & visual science · 2006
    Randomized trial104 participantsVision Support forVitamin A
  84. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsVision Support forVitamin C
  85. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyVision Support forVitamin C
  86. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewVision Support forVitamin C
  87. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin C Vision Support forVitamin E
  88. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsVision Support forVitamin C
  89. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration.
    Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2018
    Meta-analysis55,614 participants4 studies pooledVision Support forVitamin E
  90. Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study.
    Christen WG; Liu S; Glynn RJ; Gaziano JM; Buring JE · Archives of ophthalmology (Chicago, Ill. : 1960) · 2008
    Cohort study35,551 participantsVision Support forVitamin E
  91. Long-term nutrient intake and 5-year change in nuclear lens opacities.
    Jacques PF; Taylor A; Moeller S; Hankinson SE; Rogers G; Tung W; Ludovico J; Willett WC; Chylack LT · Archives of ophthalmology (Chicago, Ill. : 1960) · 2005
    Cohort study408 participantsVision Support forVitamin E
  92. Dietary intake of antioxidants and risk of age-related macular degeneration.
    van Leeuwen R; Boekhoorn S; Vingerling JR; Witteman JC; Klaver CC; Hofman A; de Jong PT · JAMA · 2005
    Cohort study4,765 participantsVision Support forVitamin E
  93. Antioxidant vitamin and mineral supplements for age-related macular degeneration.
    Evans JR · The Cochrane database of systematic reviews · 2002
    Systematic review170 participants7 studies pooledVision Support forZinc
  94. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration.
    Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2023
    Meta-analysis3,790 participants5 studies pooledVision Support forZinc
  95. Oral zinc in macular degeneration.
    Newsome DA; Swartz M; Leone NC; Elston RC; Miller E · Archives of ophthalmology (Chicago, Ill. : 1960) · 1988
    Randomized trial151 participantsVision Support forZinc
  96. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.
    Age-Related Eye Disease Study Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2001
    Randomized trial3,640 participantsVision Support forZinc
  97. Effect of vitamin A and zinc supplementation on the nutriture of children in Northeast Thailand.
    Udomkesmalee E; Dhanamitta S; Sirisinha S; Charoenkiatkul S; Tuntipopipat S; Banjong O; Rojroongwasinkul N; Kramer TR; Smith JC · The American journal of clinical nutrition · 1992
    Randomized trial133 participantsVision Support forZinc