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CoEnzymated Complete Clinical+Multi 4 Daily

Emerald
4.9
★ ★ ★ ★ ★
(30 ratings)
Vitamin E 10 mg
Vanadium 200 mcg
Vitamin A 4000 IU
Boron 1 mg
Rutin 25 mg
Product Image
Score59
Active B vitamins, vitamin D3, natural vitamin E, chelated minerals, and broad antioxidant support create a high-quality multivitamin base. Vitamin B6 is very high, the four-tablet serving is demanding, and a proprietary whole-food blend weakens full transparency.
How scoring works
Quantity:120 Tablet(s) • (30 servings)
Goals:
Vision Support
Skin Health

Score 59

Active B vitamins, vitamin D3, natural vitamin E, chelated minerals, and broad antioxidant support create a high-quality multivitamin base. Vitamin B6 is very high, the four-tablet serving is demanding, and a proprietary whole-food blend weakens full transparency.
How scoring works
$49.46($1.64 per serving)
Pure Formulas
$ 49.46
iHerb
$ 49.46
Walmart
$ 49.46
Vitacost
$ 49.46
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Analysis

Active B vitamins, vitamin D3, natural vitamin E, chelated minerals, and broad antioxidant support create a high-quality multivitamin base. Vitamin B6 is very high, the four-tablet serving is demanding, and a proprietary whole-food blend weakens full transparency.

Natural d-alpha-tocopherol is paired with mixed tocopherols and tocotrienols, although the individual mixed isomers are not quantified. The 30 IU amount is more suitable for maintenance than higher-dose support.

Rutin, Vitamin E, and Vitamin A provide a useful but incomplete connection to vision support. Some relevant amounts are useful, while others are better suited to general antioxidant support.

Who is it for
  • Adults focused on vision support
  • Adults focused on skin health
Best for
  • Vitamin E supplementation
  • Vanadium supplementation
  • Vitamin A supplementation

Pros

  • Provides a disclosed 1000.00IU of vitamin d3
  • Provides a disclosed 50.00mg of vitamin b6
  • Provides a disclosed 100.00mg of magnesium

Cons

  • Vitamin B6 is very high for long-term use
  • The four-tablet serving reduces convenience
  • The whole-food blend hides individual doses

Warnings

  • The listed vitamin B6 forms total a very high amount; sustained use may contribute to tingling or numbness in susceptible users.
  • Vitamin K1 and K2 can oppose warfarin and related medicines, so intake should remain consistent and medically coordinated.
  • Iodine should be counted by people managing thyroid disease or using thyroid medicine.

Nutrient quality

70 High impact

Methylated B vitamins and TRAACS mineral chelates provide strong absorption quality. Broad vitamin coverage is meaningful, but several eye and skin actives are small while vitamin B6 and pantothenic acid are aggressive.

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Ingredient transparency

55 Moderate impact

Most named actives have amounts, but the proprietary whole-food blend hides its contents. Complete non-active ingredient details are not included in the supplied label data.

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Customer satisfaction

63 Moderate impact

The supplied average rating provides limited high-level context. Detailed firsthand feedback is unavailable, so recurring complaints and purpose fit cannot be assessed.

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Value for money

47 Lower impact

Premium forms support quality, but the high serving cost and hidden blend limit value. Light doses of several specialty actives weaken effective serving value.

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Goals

Vision Support
Macular and Blue Light DefenseRetinal Health and Eye Moisture +1
Vision Support
Impact
Moderate effect
B- Goal FitC+ Strength of SupportC- CoverageD Formula Quality
Zinc · 15 mgVitamin E · 30 IUVitamin C · 400 mgCopper · 1 mgVitamin A · 1000 IU

Rutin, Vitamin E, and Vitamin A provide a useful but incomplete connection to vision support. Some relevant amounts are useful, while others are better suited to general antioxidant support.

Coverage reaches macular pigment and light filtering and ocular antioxidant defense. Missing form, standardization, ratio, or lipid-delivery details limit confidence in ocular uptake.

Study evidence
Rutin Not classified 1 study
Vitamin A Supportive 65 studies
Vitamin E Disputed 35 studies
Skin Health
Skin Health
Impact
Moderate effect
C Goal FitB- Strength of SupportC CoverageD- Formula Quality
Zinc · 15 mgVitamin C · 400 mgCopper · 1 mgSelenium · 100 mcgLycopene · 1 mgVitamin E · 30 IU

Vitamin C, mixed vitamin E compounds, zinc, copper, grape seed, and carotenoids support antioxidant defense and collagen synthesis. Small lycopene and CoQ10 amounts add little meaningful skin depth.

Chelated minerals and active vitamin forms improve quality, while the broad multivitamin design remains nonspecific. A proprietary whole-food blend further limits ingredient-level assessment.

Study evidence
Copper Supportive 16 studies
Lycopene Supportive 20 studies
Vitamin C Supportive 53 studies
Vitamin E Supportive 38 studies
Zinc Supportive 66 studies

Ingredients

IngredientAmount per serving
Beta-Carotene
4000 IU
Vitamin A (Vitamin A Palmitate)
 1000 IU
Mixed full-spectrum Tocopherols & Tocotrienols
10 mg
Vitamin C (Citrus Bioflavonoids, Pureway-C, Vegetable Fatty Acids)
 400 mg
Vitamin D3 (Cholecalciferol)
 1000 IU
Vitamin E (D-Alpha-Tocopherol)
 30 IU
Vitamin K1
45 mcg
Vitamin K2 (Menaquinone-4, Menaquinone-7)
 5 mcg
Vitamin B1 (Thiamine Mononitrate)
 50 mg
Vitamin B2 (R-5-P)
 50 mg
Vitamin B3 (Niacin)
 10 mg
Vitamin B3 (Niacinamide)
 40 mg
Vitamin B6 (P-5-P, Pyridoxine Hydrochloride)
 50 mg
(6S)-5-Methyltetrahydrofolate
400 mcg
Vitamin B12 (Methylcobalamin)
 200 mcg
Vitamin B5 (D-Calcium Pantothenate)
 150 mg
Biotin
300 mcg
Calcium (TRAACS Calcium Bisglycinate Chelate)
 200 mg
Magnesium (TRAACS Magnesium Bisglycinate Chelate)
 100 mg
Zinc (TRAACS Zinc Bisglycinate Chelate)
 15 mg
Selenium (Selenium Glycinate)
 100 mcg
Iodine (Atlantic Kelp)
 75 mcg
Copper (TRAACS Copper Bisglycinate Chelate)
 1 mg
Manganese (TRAACS Manganese Bisglycinate Chelate)
 1.5 mg
Chromium (TRAACS Chromium Nicotinate Glycinate Chelate)
 200 mcg
Molybdenum (TRAACS Molybdenum Glycinate Chelate)
 25 mcg
Potassium (Potassium Glycinate Complex)
 50 mg
Alpha Lipoic Acid
50 mg
Inositol
50 mg
Rutin
25 mg
Boron (Boroganic Glycine)
 1 mg
Lutein
3 mg
Lycopene
1 mg
Vanadium (TRAACS Vanadium Nicotinate Glycinate Chelate)
 200 mcg
European Grapeseed extract (OPC's)
 50 mg
CoQ10
25 mg
Raw Whole Food Proprietary Blend
340 mg
Gluten Free Adults 18–50 Vegetarian
Report overview
Vitamin E · 10 mg OverallScore74
B+ Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyB- Value

Natural d-alpha-tocopherol is paired with mixed tocopherols and tocotrienols, although the individual mixed isomers are not quantified. The 30 IU amount is more suitable for maintenance than higher-dose support. The premium complex adds formulation value despite a comparatively high serving cost.

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Vanadium (TRAACS Vanadium Nicotinate Glycinate Chelate) · 200 mcg OverallScore72
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The TRAACS chelate and 200 mcg amount provide excellent form quality and a well-targeted supplemental dose. Elemental disclosure is clear, but no manufacturing or independent testing signal is included. The broad multivitamin formula comes with poor vanadium serving value.

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Vitamin A · 4000 IU OverallScore69
C Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

A beta-carotene-heavy blend limits reliance on preformed vitamin A. The dry format lacks a lipid carrier, so absorption depends on food. The 5,000 IU serving falls within the preferred efficacy and safety range, and the vitamin a delivered per serving offers weak cost efficiency.

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Loading alternative details
74 Performance

VitaSpectrum Capsule Formula

Klaire Labs
<p>Active vitamins, methylfolate, methylcobalamin, chelated minerals, boron, vanadium, and natural vitamin E create a stronger high-quality multivitamin base. Several amounts are aggressive and duplicate entries make exposure harder to interpret, while the likely capsule count and serving cost remain high.</p>
68 Performance

Twice Daily Multi

Designs for Health
<p>Chelated trace minerals, methylcobalamin, mixed carotenoids, natural vitamin E, boron, and vanadium closely match the original’s premium positioning with better transparency. High pyridoxine, repeated nutrient entries, and modest vitamin D reduce balance.</p>
70 Performance

Nutrient 950 with Vitamin K

Pure Encapsulations
<p>Active B vitamins, methylfolate, methylcobalamin, citrate and glycinate minerals, multiple vitamin K forms, boron, and vanadium provide broad high-quality coverage. Several vitamin amounts are aggressive, the carotenoid blend is opaque, and vitamin K may not suit users of warfarin-type medicines.</p>
58 Budget

Premium Adult Multi-Vitamin Mineral

Tropical Oasis
<p>A broad liquid vitamin panel covers basic daily needs at a much lower serving cost. Natural vitamin E and methylcobalamin are useful, but vitamin D2, conventional forms, token specialty ingredients, and a hidden herbal blend make it less refined.</p>
59 Budget

Energy +

Noor Vitamins
<p>Broad vitamins, minerals, vitamin A, vitamin E, boron, and several trace nutrients provide substantial overlap at a lower cost. Synthetic vitamin E, oxide minerals, token carotenoids, and an undisclosed herbal blend weaken quality and transparency.</p>
70 Budget

Poly-Vi-Sol

Enfamil
<p>A focused pediatric vitamin panel supplies vitamin A and vitamin E with very favorable serving economics. The chemical forms and inactive ingredients are not identified, and it lacks the minerals and antioxidant breadth of the original, so it only fits infant or child use.</p>
60 Value

CoEnzymated Complete Premium+Multi 2 Daily

Emerald Laboratories
<p>Active B vitamins, chelated minerals, natural vitamin E, vitamin A, boron, vanadium, and rutin closely preserve the original formula concept. The serving economics are better for this version, although a proprietary whole-food blend and several lightly dosed specialty ingredients still reduce transparency and depth.</p>
65 Value

Twice Daily Multi Energy Multi-Vita-Min

Solaray
<p>Natural vitamin E, selenium, several chelated minerals, vitamin A, and boron deliver broad coverage with stronger serving value. Ambiguous duplicates and aggressive amounts of vitamin A, vitamin B6, and iron make it less suitable for routine unsupervised use.</p>
71 Value

Nutrient 950 without Copper and Iron

Pure Encapsulations
<p>Active B vitamins, methylfolate, methylcobalamin, strong mineral forms, boron, vanadium, and natural vitamin E provide a high-quality alternative with better value. It intentionally omits copper and iron, while several vitamin amounts are aggressive and the carotenoid blend is not fully disclosed.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration.
    Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2018
    Meta-analysis55,614 participants4 studies pooledVision Support forVitamin E
  2. Age-related cataract in men in the selenium and vitamin e cancer prevention trial eye endpoints study: a randomized clinical trial.
    Christen WG; Glynn RJ; Gaziano JM; Darke AK; Crowley JJ; Goodman PJ; Lippman SM; Lad TE; Bearden JD; Goodman GE; Minasian LM; Thompson IM; Blanke CD; Klein EA · JAMA ophthalmology · 2015
    Randomized trial11,267 participantsVision Support forVitamin E
  3. Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study.
    Christen WG; Liu S; Glynn RJ; Gaziano JM; Buring JE · Archives of ophthalmology (Chicago, Ill. : 1960) · 2008
    Cohort study35,551 participantsVision Support forVitamin E
  4. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa.
    Berson EL; Rosner B; Sandberg MA; Hayes KC; Nicholson BW; Weigel-DiFranco C; Willett W · Archives of ophthalmology (Chicago, Ill. : 1960) · 1993
    Randomized trial601 participantsVision Support forVitamin A Vision Support forVitamin E
  5. Efficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese Phase II clinical trial.
    Toshida H; Funaki T; Ono K; Tabuchi N; Watanabe S; Seki T; Otake H; Kato T; Ebihara N; Murakami A · Drug design, development and therapy · 2018
    Randomized trial66 participantsVision Support forVitamin A
  6. Vitamin A and fish oils for retinitis pigmentosa.
    Rayapudi S; Schwartz SG; Wang X; Chavis P · The Cochrane database of systematic reviews · 2014
    Systematic review866 participants3 studies pooledVision Support forVitamin A
  7. Vitamin A supplementation improves retinal function in infants at risk of retinopathy of prematurity.
    Mactier H; McCulloch DL; Hamilton R; Galloway P; Bradnam MS; Young D; Lavy T; Farrell L; Weaver LT · The Journal of pediatrics · 2012
    Randomized trial89 participantsVision Support forVitamin A
  8. Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2.
    Agrón E; Mares J; Clemons TE; Swaroop A; Chew EY; Keenan TDL; AREDS and AREDS2 Research Groups · Ophthalmology · 2021
    Cohort study8,242 participantsVision Support forVitamin A
  9. Noninferiority of Copper Dressings Than Negative Pressure Wound Therapy in Healing Diabetic Wounds: A Randomized Clinical Trial.
    Melamed E; Dabbah J; Israel T; Kan I; Pinzur MS; Roth T; Borkow G · Advances in wound care · 2026
    Randomized trialSkin Health forCopper
  10. Improvement of facial skin characteristics using copper oxide containing pillowcases: a double-blind, placebo-controlled, parallel, randomized study.
    Borkow G; Gabbay J; Lyakhovitsky A; Huszar M · International journal of cosmetic science · 2010
    Randomized trial57 participantsSkin Health forCopper
  11. Radially Electrospun Fibrous Membrane Incorporated with Copper Peroxide Nanodots Capable of Self-Catalyzed Chemodynamic Therapy for Angiogenesis and Healing Acceleration of Diabetic Wounds.
    Huang Y; Qi L; Liu Z; Jiang Y; Wang J; Liu L; Li Y; Zhang L; Feng G · ACS applied materials & interfaces · 2023
    Animal experimentSkin Health forCopper
  12. Engineering copper nanoparticle/polysaccharide-immobilized cotton gauze for accelerated healing of Staphylococcus aureus-infected dermal wounds.
    Sahoo M; Banerjee T; Virkar S; Das S; Biswas S; Mitra D · Journal of materials chemistry. B · 2026
    Animal experimentSkin Health forCopper
  13. Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings.
    Melamed E; Rovitsky A; Roth T; Assa L; Borkow G · Medicina (Kaunas, Lithuania) · 2021
    Single-arm trialSkin Health forCopper
  14. Systemic and skin-targeting beneficial effects of lycopene-enriched ice cream: A pilot study.
    Chernyshova MP; Pristenskiy DV; Lozbiakova MV; Chalyk NE; Bandaletova TY; Petyaev IM · Journal of dairy science · 2019
    Randomized trialSkin Health forLycopene
  15. Topical lycopene emulgel significantly improves biophysical parameters of human skin.
    Sohail M; Muhammad Faran Ashraf Baig M; Akhtar N; Chen Y; Xie B; Li B · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2022
    Clinical trialSkin Health forLycopene
  16. Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema.
    Aust O; Stahl W; Sies H; Tronnier H; Heinrich U · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2005
    Randomized trialSkin Health forLycopene
  17. Association of Vitamin A Intake With Cutaneous Squamous Cell Carcinoma Risk in the United States.
    Kim J; Park MK; Li WQ; Qureshi AA; Cho E · JAMA dermatology · 2024
    Cohort study123,570 participantsSkin Health forLycopene
  18. β-Carotene and other carotenoids in protection from sunlight.
    Stahl W; Sies H · The American journal of clinical nutrition · 2013
    Narrative reviewSkin Health forLycopene
  19. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  20. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  21. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  22. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  23. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  24. Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.
    Javanbakht MH; Keshavarz SA; Djalali M; Siassi F; Eshraghian MR; Firooz A; Seirafi H; Ehsani AH; Chamari M; Mirshafiey A · The Journal of dermatological treatment · 2011
    Randomized trial45 participantsSkin Health forVitamin E
  25. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
    Liu X; Yang G; Luo M; Lan Q; Shi X; Deng H; Wang N; Xu X; Zhang C · PloS one · 2022
    Meta-analysis20 studies pooledSkin Health forVitamin E
  26. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forVitamin E Skin Health forZinc
  27. Effects of tocotrienol on aging skin: A systematic review.
    Ghazali NI; Mohd Rais RZ; Makpol S; Chin KY; Yap WN; Goon JA · Frontiers in pharmacology · 2022
    Systematic reviewSkin Health forVitamin E
  28. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
    Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H · The American journal of clinical nutrition · 2000
    Randomized trialSkin Health forVitamin E
  29. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  30. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  31. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  32. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc
  33. A randomized, double-masked study on the treatment of retinal vein occlusion with troxerutin
    Glacet-Bernard A, Coscas G, Chabanel A, Zourdani A, Lelong F, Samama MM · American Journal of Ophthalmology · 1994
    Randomized trial53 participantsVision Support forRutin
  34. Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age.
    Imdad A; Mayo-Wilson E; Haykal MR; Regan A; Sidhu J; Smith A; Bhutta ZA · The Cochrane database of systematic reviews · 2022
    Meta-analysis1,223,856 participants47 studies pooledVision Support forVitamin A
  35. Effect of short-term, high-dose retinol on dark adaptation in aging and early age-related maculopathy.
    Owsley C; McGwin G; Jackson GR; Heimburger DC; Piyathilake CJ; Klein R; White MF; Kallies K · Investigative ophthalmology & visual science · 2006
    Randomized trial104 participantsVision Support forVitamin A
  36. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin E
  37. Long-term nutrient intake and 5-year change in nuclear lens opacities.
    Jacques PF; Taylor A; Moeller S; Hankinson SE; Rogers G; Tung W; Ludovico J; Willett WC; Chylack LT · Archives of ophthalmology (Chicago, Ill. : 1960) · 2005
    Cohort study408 participantsVision Support forVitamin E
  38. Dietary intake of antioxidants and risk of age-related macular degeneration.
    van Leeuwen R; Boekhoorn S; Vingerling JR; Witteman JC; Klaver CC; Hofman A; de Jong PT · JAMA · 2005
    Cohort study4,765 participantsVision Support forVitamin E