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Collagen

youtheory men
4.7
★ ★ ★ ★ ★
(9755 ratings)
Collagen 5000 mg
Biotin 900 mcg
Protein (unspecified) 5 Gram(s)
Product Image
Score75
Best suited to men seeking value-focused collagen who have no liver-related concerns; fo-Ti adds avoidable liver-safety uncertainty, while the six-tablet serving creates a substantial pill burden.
How scoring works
Quantity:290 Tablet(s) • (48 servings)
Goals:
Skin Health
Joint Health
Nail Health
Anti-Aging
Bone Health
Hair Health
General Health

Score 75

Best suited to men seeking value-focused collagen who have no liver-related concerns; fo-Ti adds avoidable liver-safety uncertainty, while the six-tablet serving creates a substantial pill burden.
How scoring works

Also available as

1 option
160 servings Protein 5 Gram(s), Collagen 5000 mg +1 more • 160 Tablet(s) • 26 servings $12.79 ($0.49 per serving)
$19.96($0.41 per serving)
Vitacost
$ 19.96
Vitacost
$ 21.93
iHerb
$ 19.96
Amazon
$ 19.96
Walmart
$ 21.85
Report prices

Analysis

A 5 g hydrolyzed collagen serving with vitamin C and biotin provides useful structural support for skin, joints, and nails. The disclosed amounts make the main contribution reasonably easy to judge.

Fo-Ti adds avoidable liver-safety uncertainty, while the six-tablet serving creates a substantial pill burden. Practical value depends on whether the main active and format match the user’s priority.

The product is best suited to men seeking value-focused collagen who have no liver-related concerns. Benefits for appearance, structure, or wellness should be viewed as nutritional support rather than a guaranteed visible change.

Who is it for
  • Men seeking value-focused collagen who have no liver-related concerns
  • Adults whose diet leaves a gap addressed by the core ingredients
  • Users comfortable with the listed format and serving size
Best for
  • Meaningful hydrolyzed collagen amount
  • Vitamin C supports normal collagen formation
  • Users who accept that requires roughly six tablets per serving

Pros

  • Meaningful hydrolyzed collagen amount
  • Vitamin C supports normal collagen formation
  • Strong value for the active amount
  • Broad relevance to skin, joints, and nails

Cons

  • Requires roughly six tablets per serving
  • Fo-Ti does not improve the core collagen rationale
  • Collagen source and types are not disclosed
  • Biotin adds limited value without inadequate intake

Warnings

  • Fo-Ti has been linked to liver injury and is unsuitable for people with liver disease or those using medicines that can affect the liver.
  • The 900 mcg biotin amount may distort thyroid, hormone, or cardiac troponin blood tests; disclose use before testing.
  • The collagen source is not stated, so users with animal-protein allergies or dietary restrictions should verify the package.

Nutrient quality

73 High impact

Hydrolyzed collagen and buffered vitamin C are useful forms, and the collagen amount is meaningful, while biotin and vitamin C provide secondary support. Fo-ti extract has been linked to liver injury, making routine use a concern, while most ingredients have a clear role, but fo-ti does not improve the core collagen formula.

Ingredient transparency

77 High impact

Specific amounts are listed for every supplied active ingredient. No proprietary blend hides active doses, while inactive tablet ingredients are not provided.

Customer satisfaction

72 High impact

The supplied aggregate satisfaction metric is favorable, and the large amount of aggregate feedback makes the metric highly stable. No review excerpts were provided, so recurring complaints and purpose-specific experiences cannot be checked.

Value for money

77 High impact

A useful collagen dose supports value, but fo-ti reduces the formula's practical quality. The serving is economical but requires many tablets, while few low-value extras are present, though fo-ti is an unnecessary trade-off.

Report analysis

Goals

Skin Health
Skin Health
Impact
Highest effect
A Goal FitA Strength of SupportB+ CoverageC Formula Quality
Vitamin C · 60 mgCollagen · 5000 mg

Hydrolyzed collagen peptides provide direct structural support, and vitamin C assists normal collagen synthesis. The daily peptide amount is meaningful and aligns well with human skin research.

Biotin adds little unless status is low, while Fo-Ti is not needed for the structural goal. Fo-Ti has been linked to liver injury, making the botanical a meaningful safety drawback for people with liver disease or medicines that affect the liver.

Study evidence
Biotin Supportive 10 studies
Collagen Supportive 62 studies
Vitamin C Supportive 53 studies
Joint Health
Joint Health
Impact
Highest effect
A Goal FitA- Strength of SupportC+ CoverageA- Formula Quality
Collagen · 5000 mg

Hydrolyzed collagen peptides provide structural amino acids, while vitamin C supports the body’s collagen synthesis. The 5 g collagen amount is meaningful and matches the listed protein total.

The animal source, collagen types, and amino-acid profile are not disclosed, which limits joint-specific quality assessment. Fo-Ti does not strengthen the joint strategy and has been linked to liver injury in susceptible users.

Study evidence
Collagen Supportive 49 studies
Vitamin C Disputed 24 studies
Nail Health
Nail Health
Impact
Highest effect
B+ Goal FitA- Strength of SupportB+ CoverageC+ Formula Quality
Collagen · 5000 mgBiotin · 900 mcg

Hydrolyzed collagen provides substantial structural protein, and biotin adds a direct keratin cofactor. Vitamin C supports collagen synthesis, giving the combination useful relevance to brittle or weak nails.

The collagen amount is high and biotin is meaningful, but the exact collagen type and biotin isomer are not specified. Fo-ti has been linked to liver injury, so its inclusion creates a product-specific safety concern without clear nail benefit.

Study evidence
Biotin Supportive 8 studies
Collagen Supportive 4 studies
Vitamin C Supportive 1 study
Anti-Aging
Anti-Aging
Impact
High effect
B+ Goal FitA- Strength of SupportB- CoverageC+ Formula Quality
Collagen · 5000 mg

Hydrolyzed collagen and vitamin C provide meaningful structural support for skin and connective tissue. The 5,000 mg collagen amount is substantial, though its source and collagen types are not disclosed.

Biotin adds a skin and hair cofactor, while Fo-Ti has weak anti-aging evidence and adds avoidable safety uncertainty. Fo-Ti has been linked to liver injury in susceptible users, making the 420 mg extract a product-specific concern.

Study evidence
Collagen Supportive 33 studies
Vitamin C Supportive 30 studies
Bone Health
Bone Health
Impact
High effect
B+ Goal FitB Strength of SupportC CoverageB- Formula Quality
Vitamin C · 60 mgCollagen · 5000 mg

Hydrolyzed collagen provides a meaningful amount of protein building blocks for the flexible bone matrix. Vitamin C supports collagen formation, giving the structural ingredients a sensible pairing.

The formula does not supply calcium, magnesium, vitamin D, or vitamin K for mineralization and calcium handling. Fo-Ti extract has been linked to liver injury in susceptible users, creating a concern unrelated to the collagen benefit.

Study evidence
Collagen Supportive 16 studies
Vitamin C Supportive 46 studies
Hair Health
Hair Health
Impact
High effect
B Goal FitB+ Strength of SupportC+ CoverageC- Formula Quality
Biotin · 900 mcgVitamin C · 60 mgCollagen · 5000 mg

Hydrolyzed collagen supplies structural amino acids, while biotin supports keratin production. Collagen has plausible structural support and biotin has a defined biological role, but hair-specific evidence remains conditional.

Five grams of collagen is meaningful, while the biotin amount is moderate for a dedicated hair formula. Hydrolyzed collagen and amounts are disclosed, but collagen source, types, amino acids, and biotin isomer are omitted.

Study evidence
Biotin Supportive 4 studies
Collagen Supportive 3 studies
Vitamin C Mixed 5 studies

Ingredients

IngredientAmount per serving
Calories
20 Calorie(s)
Protein
5 Gram(s)
Vitamin C (Calcium Ascorbate)
 60 mg
Biotin
900 mcg
hydrolyzed Collagen Peptides
5000 mg
Fo-Ti extract
420 mg
Gluten Free Men 18–50 Dairy Free
Report overview
Collagen · 5000 mg OverallScore67
D+ Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyA+ Value

Hydrolyzed collagen peptides and a matching protein declaration support good absorption and label accuracy. The dose is meaningful for structural support, but the animal source, collagen types, branded backing, and amino acid profile are not disclosed. Fo-Ti extract is a product-specific concern because it has been linked to liver injury in susceptible users.

View ingredientView products
Biotin · 900 mcg OverallScore56
B- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyC Value

The formula centers on collagen and supplies only a modest biotin amount for this collection. Biotin is clearly disclosed, but its isomer is not identified and the tablet format is less clean than a capsule or softgel. Fo-ti extract adds a product-specific concern because it has been linked to liver injury, especially for people with liver conditions or those using medicines that affect the liver.

View ingredientView products
Loading alternative details
83 Performance

High Potency Maxi-Collagen 7000

Country Life
A full gram-level combination of hydrolyzed collagen and branded collagen peptides provides strong structural protein support, with vitamin C and biotin as useful complements. It avoids the disclosed fo-ti extract while providing stronger or more focused structural support than the original.
75 Performance

Grass Fed Collagen Beauty Cranberry Pomegranate

Garden of Life
A substantial collagen-peptide serving with vitamin C, silica, and biotin directly supports the intended beauty focus. It avoids the disclosed fo-ti extract while providing stronger or more focused structural support than the original.
75 Performance

Hair Collagen + Keratin

youtheory
Hydrolyzed collagen, keratin, and biotin are all meaningfully dosed for hair and nail support. It avoids the disclosed fo-ti extract while providing stronger or more focused structural support than the original.
87 Budget

Collagen + C 2500 mg

Spring Valley
Branded collagen and vitamin C create a focused structural formula with a meaningful collagen amount and efficient serving value. It costs less per serving and avoids the disclosed fo-ti extract in the original, making the safety and value trade-off easier to justify.
73 Budget

Collagen 1500 + C

Mason Natural
Hydrolyzed bovine collagen, vitamin C, and biotin form a focused beauty formula, but the collagen amount is modest compared with stronger gram-level products. It costs less per serving and avoids the disclosed fo-ti extract in the original, making the safety and value trade-off easier to justify.
58 Budget

Alive! Hair Skin & Nails Gummies Delicious Strawberry Flavored

Nature's Way
Biotin and vitamin C support the beauty positioning, but the collagen amount is far below meaningful gram-level servings. It costs less per serving and avoids the disclosed fo-ti extract in the original, making the safety and value trade-off easier to justify.
80 Value

Maxi-Skin Collagen + C&A Powder Flavorless

Country Life
Branded hydrolyzed collagen peptides and vitamin C provide a focused combination for skin structure, while vitamin A adds a smaller supporting role. It removes the original’s fo-ti concern while balancing meaningful structural support with favorable serving value.
66 Value

Hydrolyzed Collagen Powder Unflavored

Green Foods
Hydrolyzed bovine collagen with identified types is a suitable form, but the declared collagen amount conflicts sharply with the much larger protein amount. It removes the original’s fo-ti concern while balancing meaningful structural support with favorable serving value.
68 Value

Alive! Hair Skin & Nails Gummies Delicious Strawberry Flavored

Nature's Way
Vitamin C, biotin, and zinc support hair and nail nutrition, but the collagen and silica amounts are small for structural support. It removes the original’s fo-ti concern while balancing meaningful structural support with favorable serving value.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study.
    König D; Oesser S; Scharla S; Zdzieblik D; Gollhofer A · Nutrients · 2018
    Randomized trial131 participantsBone Health forCollagen
  2. Effect of Calcium and Vitamin D Supplementation With and Without Collagen Peptides on Volumetric and Areal Bone Mineral Density, Bone Geometry and Bone Turnover in Postmenopausal Women With Osteopenia.
    Lampropoulou-Adamidou K; Karlafti E; Argyrou C; Makris K; Trovas G; Dontas IA; Tournis S; Triantafyllopoulos IK · Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry · 2022
    Randomized trial51 participantsBone Health forCollagen
  3. The Role of Collagen Supplementation in Bone Metabolism and Structure: A Scoping Review.
    Kuhlman NM; Jagim AR; Blesso C; Jones MT; Chun O; Puglisi M; Fields JB · Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine · 2026
    Scoping review15 studies pooledBone Health forCollagen
  4. Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters.
    Aksac SE; Bilgili SG; Yavuz GO; Yavuz IH; Aksac M; Karadag AS · International journal of dermatology · 2021
    Non-randomized trial60 participantsSkin Health forBiotin
  5. Anti-pollution cosmetic-based one-step formation of w/o/w multiple emulsion containing D-biotin for skin protection: fabrication and in vitro and in vivo evaluation.
    Ali A; Iqbal S; Ilyas A; Khan H; Asad MHHB; Fatima N; Akhtar N · Drug delivery and translational research · 2020
    Non-randomized trial15 participantsSkin Health forBiotin
  6. Interventions for infantile seborrhoeic dermatitis (including cradle cap).
    Victoire A; Magin P; Coughlan J; van Driel ML · The Cochrane database of systematic reviews · 2019
    Systematic review35 participants2 studies pooledSkin Health forBiotin
  7. Exploring the Impact of Hydrolyzed Collagen Oral Supplementation on Skin Rejuvenation: A Systematic Review and Meta-Analysis.
    Dewi DAR; Arimuko A; Norawati L; Yenny SW; Setiasih NL; Perdiyana A; Arkania N; Nadhira F; Wiliantari N · Cureus · 2024
    Meta-analysis967 participants14 studies pooledSkin Health forCollagen
  8. Effects of collagen-based supplements on skin's hydration and elasticity: A systematic review and meta-analysis.
    Danessa G; Notario D; Regina R · Indian journal of dermatology, venereology and leprology · 2025
    Meta-analysis646 participants10 studies pooledSkin Health forCollagen
  9. Efficacy and Safety of Topical or Oral Hydrolyzed Collagen in Women with Dermatoporosis: A Randomized, Double-Blind, Factorial Design Study.
    Guadanhim LRS; Miot HA; Soares JLM; Silva SAM; Leonardi GR; Lopes RD; Bagatin E · Dermatology and therapy · 2023
    Randomized trial56 participantsSkin Health forCollagen
  10. Biotin for the treatment of nail disease: what is the evidence?
    Lipner SR; Scher RK · The Journal of dermatological treatment · 2018
    Narrative reviewNail Health forBiotin
  11. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy.
    Colombo VE; Gerber F; Bronhofer M; Floersheim GL · Journal of the American Academy of Dermatology · 1991
    Other32 participantsNail Health forBiotin
  12. Brittle nails: response to daily biotin supplementation.
    Hochman LG; Scher RK; Meyerson MS · Cutis · 1993
    Case series35 participantsNail Health forBiotin
  13. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort.
    Benito-Ruiz P; Camacho-Zambrano MM; Carrillo-Arcentales JN; Mestanza-Peralta MA; Vallejo-Flores CA; Vargas-López SV; Villacís-Tamayo RA; Zurita-Gavilanes LA · International journal of food sciences and nutrition · 2012
    Randomized trial250 participantsJoint Health forCollagen
  14. The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial.
    Zdzieblik D; Brame J; Oesser S; Gollhofer A; König D · Nutrients · 2021
    Randomized trial180 participantsJoint Health forCollagen
  15. Role of collagen hydrolysate in bone and joint disease.
    Moskowitz RW · Seminars in arthritis and rheumatism · 2001
    Narrative reviewJoint Health forCollagen
  16. Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study.
    Lee M; Kim E; Ahn H; Son S; Lee H · Food & function · 2023
    Randomized trial100 participantsAnti-Aging Skin Health forCollagen
  17. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis.
    de Miranda RB; Weimer P; Rossi RC · International journal of dermatology · 2021
    Meta-analysis1,125 participants19 studies pooledAnti-Aging Skin Health forCollagen
  18. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study.
    Proksch E; Segger D; Degwert J; Schunck M; Zague V; Oesser S · Skin pharmacology and physiology · 2014
    Randomized trial69 participantsAnti-Aging forCollagen
  19. Skin Anti-Aging and Moisturizing Effects of Low-Molecular-Weight Collagen Peptide Supplementation in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
    Lee E; Ahn DK; Kim JH; Lee S; Kim HJ; Lee HK; Shin JH · Journal of microbiology and biotechnology · 2025
    Randomized trial70 participantsAnti-Aging forCollagen
  20. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis.
    Proksch E; Schunck M; Zague V; Segger D; Degwert J; Oesser S · Skin pharmacology and physiology · 2014
    Randomized trial114 participantsAnti-Aging forCollagen
  21. Study on the Multiple Efficacies of Vitamin C Serum in Anti-Glycation, Anti-Carbonylation, Antioxidation, and Anti-Inflammation of Human Skin Based on In Vivo Tests.
    Zi Y; Liu J; Liu Q; Pan Y; Jiang X · Journal of cosmetic dermatology · 2026
    Randomized trial66 participantsAnti-Aging forVitamin C
  22. Evaluation of the anti-wrinkle effect of a lipophilic pro-vitamin C derivative, tetra-isopalmitoyl ascorbic acid.
    Yokota M; Yahagi S · Journal of cosmetic dermatology · 2022
    Randomized trial69 participantsAnti-Aging forVitamin C
  23. The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach.
    Crisan D; Roman I; Crisan M; Scharffetter-Kochanek K; Badea R · Clinical, cosmetic and investigational dermatology · 2015
    Clinical trial60 participantsAnti-Aging forVitamin C
  24. In vivo evaluation of topical ascorbic acid application on skin aging by 50 MHz ultrasound.
    Vergilio MM; Aiello LM; Furlan AS; Caritá AC; Azevedo JR; Bolzinger MA; Chevalier Y; Leonardi GR · Journal of cosmetic dermatology · 2022
    Randomized trial25 participantsAnti-Aging forVitamin C
  25. Clinical Applications of Vitamin C in Dermatology: A Systematic Review.
    Boghosian T; Mendez H; Boghosian N; Sayegh M; Beer J; Tosti A · The Journal of clinical and aesthetic dermatology · 2026
    Systematic review44 studies pooledAnti-Aging forVitamin C
  26. Undenatured type II collagen for knee osteoarthritis.
    Gupta A; Maffulli N · Annals of medicine · 2025
    Systematic review12 studies pooledAnti-Inflammatory Support forCollagen
  27. Anti-inflammatory effect of collagen tripeptide in atopic dermatitis.
    Hakuta A; Yamaguchi Y; Okawa T; Yamamoto S; Sakai Y; Aihara M · Journal of dermatological science · 2018
    Randomized trial17 participantsAnti-Inflammatory Support forCollagen
  28. [Points of undenatured type II collagen application in musculoskeletal pain syndromes treatment].
    Shavlovskaya OA; Gromova OA; Torshin IY · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2022
    Narrative reviewAnti-Inflammatory Support forCollagen
  29. Ultrasound Guided Injection of Collagen for Elbow Lateral Epicondylitis - A Pilot Study.
    Porta F; Filippucci E; Barni X; Dinescu SC; Vreju FA · Current health sciences journal · 2026
    Single-arm trial13 participantsAnti-Inflammatory Support forCollagen
  30. Effects of porcine-derived collagen hydrolysates on 24 h blood pressure profiles, markers for endothelial dysfunction and low-grade inflammation and the retinal vasculature in adults with overweight/obesity: a randomized, controlled trial.
    Chavez-Alfaro MA; Mensink RP; Joris PJ; Plat J · Food & function · 2025
    Randomized trial56 participantsAnti-Inflammatory Support forCollagen
  31. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support Joint Health forVitamin C
  32. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  33. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  34. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  35. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  36. Bone turnover and bone collagen maturation in osteoporosis: effects of antiresorptive therapies.
    Byrjalsen I; Leeming DJ; Qvist P; Christiansen C; Karsdal MA · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008
    Randomized trialBone Health forCollagen
  37. A calcium-collagen chelate dietary supplement attenuates bone loss in postmenopausal women with osteopenia: a randomized controlled trial.
    Elam ML; Johnson SA; Hooshmand S; Feresin RG; Payton ME; Gu J; Arjmandi BH · Journal of medicinal food · 2015
    Randomized trial39 participantsBone Health forCollagen
  38. Assessment of Osteoporosis in Lumbar Spine: In Vivo Quantitative MR Imaging of Collagen Bound Water in Trabecular Bone.
    Liu J; Liao JW; Li W; Chen XJ; Feng JX; Yao L; Huang PH; Su ZH; Lu H; Liao YT; Li SL; Ma YJ · Frontiers in endocrinology · 2022
    Methods validation study189 participantsBone Health forCollagen
  39. Effect of calcium and vitamin D supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia.
    Argyrou C; Karlafti E; Lampropoulou-Adamidou K; Tournis S; Makris K; Trovas G; Dontas I; Triantafyllopoulos IK · Journal of musculoskeletal & neuronal interactions · 2021
    Randomized trial51 participantsBone Health forCollagen
  40. Can Dietary Intake of Vitamin C-Oriented Foods Reduce the Risk of Osteoporosis, Fracture, and BMD Loss? Systematic Review With Meta-Analyses of Recent Studies.
    Zeng LF; Luo MH; Liang GH; Yang WY; Xiao X; Wei X; Yu J; Guo D; Chen HY; Pan JK; Huang HT; Liu Q; Guan ZT; Han YH; Zhao D; Zhao JL; Hou SR; Wu M; Lin JT; Li JH; Liang WX; Ou AH; Wang Q; Li ZP; Liu J · Frontiers in endocrinology · 2020
    Meta-analysis19,484 participants17 studies pooledBone Health forVitamin C
  41. Dietary vitamin C intake and the risk of hip fracture: a dose-response meta-analysis.
    Sun Y; Liu C; Bo Y; You J; Zhu Y; Duan D; Cui H; Lu Q · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Meta-analysis6 studies pooledBone Health forVitamin C
  42. Smoking, antioxidant vitamins, and the risk of hip fracture.
    Melhus H; Michaëlsson K; Holmberg L; Wolk A; Ljunghall S · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1999
    Cohort study66,651 participantsBone Health forVitamin C
  43. Micronutrients and the risk of hip fracture: Case-control study.
    Torbergsen AC; Watne LO; Wyller TB; Frihagen F; Strømsøe K; Bøhmer T; Mowe M · Clinical nutrition (Edinburgh, Scotland) · 2018
    Case-control study189 participantsBone Health forVitamin C
  44. Favorable effect of dietary vitamin C on bone mineral density in postmenopausal women (KNHANES IV, 2009): discrepancies regarding skeletal sites, age, and vitamin D status.
    Kim YA; Kim KM; Lim S; Choi SH; Moon JH; Kim JH; Kim SW; Jang HC; Shin CS · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Cross-sectional study1,196 participantsBone Health forVitamin C
  45. A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis.
    Kumar S; Sugihara F; Suzuki K; Inoue N; Venkateswarathirukumara S · Journal of the science of food and agriculture · 2015
    Randomized trialGeneral Health forCollagen
  46. Efficacy and safety of native type II collagen in modulating knee osteoarthritis symptoms: a randomised, double-blind, placebo-controlled trial.
    Luo C; Su W; Song Y; Srivastava S · Journal of experimental orthopaedics · 2023
    Randomized trial101 participantsGeneral Health Joint Health forCollagen
  47. Healing Process, Pain, and Health-Related Quality of Life in Patients with Venous Leg Ulcers Treated with Fish Collagen Gel: A 12-Week Randomized Single-Center Study.
    Mościcka P; Cwajda-Białasik J; Szewczyk MT; Jawień A · International journal of environmental research and public health · 2022
    Randomized trial100 participantsGeneral Health forCollagen
  48. Efficacy and Safety of Dietary Undenatured Type II Collagen on Joint and Motor Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study.
    Shiojima Y; Takahashi M; Takahashi R; Maruyama K; Moriyama H; Bagchi D; Bagchi M; Akanuma M · Journal of the American Nutrition Association · 2023
    Randomized trial64 participantsGeneral Health forCollagen
  49. The use of a collagen matrix in hard-to-heal venous leg ulcers.
    Romanelli M; Mulder G; Paggi B; Macchia M; Panduri S; Dini V · Journal of wound care · 2016
    Randomized trial40 participantsGeneral Health forCollagen
  50. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  51. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  52. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  53. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  54. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  55. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health Nail Health Skin Health forBiotin
  56. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health Skin Health forBiotin
  57. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  58. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  59. Low-Molecular-Weight Collagen Peptide Supplementation Improves Cellulite Severity, Skin Elasticity, and Hair Shaft Diameter: A Clinical Study with Pharmacokinetic Evaluation.
    Hwang S; Won J; Kim S; Kang W; Park M · Journal of medicinal food · 2026
    Randomized trial114 participantsHair Health forCollagen
  60. Calcium and Vitamin D Supplementation with and Without Collagen on Bone Density and Skin Elasticity in Menopausal Women-A Randomized Controlled Study.
    Duangjai A; Srivilai J; Nangola S; Amornlerdpison D · Clinics and practice · 2025
    Randomized trialHair Health forCollagen
  61. Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.
    Biełach-Bazyluk A; Jurga M; Flisiak I; Zbroch E · Nutrients · 2026
    Narrative reviewHair Health forCollagen
  62. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  63. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  64. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  65. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  66. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
    Case reportHair Health forVitamin C
  67. Management and Amelioration of Knee Joint Osteoarthritis in Adults Using a Novel High-Functional Bovine Collagen Peptide as a Nutritional Therapy: A Double-Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five-Arm, Clinical Study to Evaluate the Efficacy, Safety, and Tolerability.
    Devasia S; Joseph JT; P S S; Koizumi S; Clarke L; V T S; Kailas AP; Madhavan S · Cartilage · 2024
    Randomized trial100 participantsJoint Health forCollagen
  68. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.
    Lugo JP; Saiyed ZM; Lane NE · Nutrition journal · 2016
    Randomized trial191 participantsJoint Health forCollagen
  69. [Efficacy and safety of undenatured type II collagen in patients with knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial].
    Alekseeva LI; Kashevarova NG; Taskina EA; Strebkova EA; Korotkova TA; Sharapova EP; Savushkina NM; Lila AM; Shostak NA; Mazurov VI; Nesterovich II; Dedkova VA; Vasilyuk VB; Egorova NV; Leontyeva MA; Yakupova SP; Vinogradova IB; Sorotskaya VN; Shirokova LY · Terapevticheskii arkhiv · 2024
    Randomized trial212 participantsJoint Health forCollagen
  70. Effects of Multiple Intravenous Doses of Perioperative Vitamin C on Pain Management Following Total Hip Arthroplasty.
    Han G; Ye Y; Kang P · Drug design, development and therapy · 2025
    Randomized trial100 participantsJoint Health forVitamin C
  71. Osteoarthritis prevalence and modifiable factors: a population study.
    Plotnikoff R; Karunamuni N; Lytvyak E; Penfold C; Schopflocher D; Imayama I; Johnson ST; Raine K · BMC public health · 2016
    Cross-sectional study4,733 participantsJoint Health forVitamin C
  72. Anti-Inflammatory Effect of Vitamin C during the Postoperative Period in Patients Subjected to Total Knee Arthroplasty: A Randomized Controlled Trial.
    Ramón R; Holguín E; Chiriboga JD; Rubio N; Ballesteros C; Ezechieli M · Journal of personalized medicine · 2023
    Randomized trial110 participantsJoint Health forVitamin C
  73. Musculoskeletal manifestations of scurvy.
    Fain O · Joint bone spine · 2005
    Narrative reviewJoint Health forVitamin C
  74. Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial.
    Chiavetta A; Mazzurco S; Secolo MP; Tomarchio G; Milani M · Dermatologic therapy · 2020
    Randomized trial50 participantsNail Health forBiotin
  75. Vitamins and minerals: their role in nail health and disease.
    Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
    Narrative reviewNail Health forBiotin
  76. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails.
    Hexsel D; Zague V; Schunck M; Siega C; Camozzato FO; Oesser S · Journal of cosmetic dermatology · 2018
    Single-arm trial25 participantsNail Health forCollagen
  77. Influence of collagen peptide supplementation on visible signs of skin and nail health and -aging in an East Asian population: A double blind, randomized, placebo-controlled trial.
    Vleminckx S; Virgilio N; Asserin J; Prawitt J; Silva CIF · Journal of cosmetic dermatology · 2024
    Randomized trial85 participantsNail Health forCollagen
  78. Nail Supplements: When, How, and Why?
    Zaraa I; Richert B · Skin appendage disorders · 2026
    Narrative reviewNail Health forCollagen
  79. Expanding the COL7A1 mutation database: novel and recurrent mutations and unusual genotype-phenotype constellations in 41 patients with dystrophic epidermolysis bullosa.
    Kern JS; Kohlhase J; Bruckner-Tuderman L; Has C · The Journal of investigative dermatology · 2006
    Observational study41 participantsNail Health forCollagen
  80. Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten Micronutrient.
    Dunleavy KA; Ungaro RC; Manning L; Gold S; Novak J; Colombel JF · Crohn's & colitis 360 · 2023
    Other20 participantsNail Health forVitamin C
  81. Generalized seborrhoeic dermatitis. Clinical and therapeutic data of 25 patients.
    Messaritakis J; Kattamis C; Karabula C; Matsaniotis N · Archives of disease in childhood · 1976
    Non-randomized trial25 participantsSkin Health forBiotin
  82. Holocarboxylase synthetase deficiency: novel clinical and molecular findings.
    Tammachote R; Janklat S; Tongkobpetch S; Suphapeetiporn K; Shotelersuk V · Clinical genetics · 2010
    Case series4 participantsSkin Health forBiotin
  83. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study.
    Kim DU; Chung HC; Choi J; Sakai Y; Lee BY · Nutrients · 2018
    Randomized trial64 participantsSkin Health forCollagen
  84. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  85. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  86. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  87. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  88. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C