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St. John's Wort 700 mg

Nature's Way
4.5
★ ★ ★ ★ ★
(4662 ratings)
St. John's Wort 700 mg
Product Image
Score79
These 700 mg capsules provide a high-dose, full-spectrum approach for those who prefer traditional whole-herb synergy over standardized extracts for emotional balance.
How scoring works
Quantity:100 Capsule(s) • (50 servings)
Goals:
Mood Support

Score 79

These 700 mg capsules provide a high-dose, full-spectrum approach for those who prefer traditional whole-herb synergy over standardized extracts for emotional balance.
How scoring works
$8.55($0.17 per serving)
Vitacost
$ 9.73
Pure Formulas
$ 8.76
iHerb
$ 8.55
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Analysis

Nature’s Way provides 700 mg of St. John's Wort aerial parts to support emotional wellness through traditional herbal methods. Unlike many competitors that use concentrated extracts standardized to specific markers like hypericin, this formula uses the whole plant. This "full-spectrum" approach is designed for users who trust the natural synergy of all the plant's compounds working together rather than isolated active ingredients. While the 700 mg dose is substantial in terms of raw plant weight, the lack of standardization means the levels of active constituents may vary between batches. Because it uses raw powder instead of a concentrated extract, the capsules may be larger than some users expect. However, it remains a highly cost-effective option for baseline daily mood maintenance from a long-standing botanical brand.
Who is it for
  • Adults seeking focused St. John’s wort support
  • People who take no interacting medicines
  • Users who prefer a capsule
Best for
  • Focused mood-support supplementation
  • Whole-herb St. John’s wort use
  • two capsules daily use

Pros

  • Focused single-herb formula
  • Clearly states a 700 mg serving
  • two capsules format

Cons

  • Hypericin and hyperforin are not standardized
  • Extensive medication interactions restrict use
  • Whole-herb potency can vary

Warnings

  • St. John’s wort can sharply reduce the effectiveness of oral contraceptives, warfarin, transplant medicines, HIV medicines, and many other drugs by speeding their clearance.
  • Combining St. John’s wort with SSRIs, SNRIs, MAO inhibitors, triptans, tramadol, or dextromethorphan can cause dangerous serotonin excess.
  • St. John’s wort can increase sensitivity to sunlight, so strong sun or UV exposure may require extra skin and eye protection.

Nutrient quality

79 High impact

The daily herb amount is substantial and directly relevant to mood support. Missing extract and active-marker details limit consistency and precise dose comparison.

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Ingredient transparency

75 High impact

The herb amount is clearly disclosed without a hidden blend. Active-marker strength, complete intake directions, and inactive ingredients are not supplied.

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Customer satisfaction

69 High impact

The supplied average rating is strong. A very large rating base makes the average dependable, but no detailed experience evidence was supplied.

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Value for money

95 Highest impact

Serving economics are highly favorable. Formula quality supports the asking price well.

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Goals

Mood Support
Mood Support
Impact
High effect
B+ Goal FitB+ Strength of SupportD CoverageA Formula Quality

St. John's Wort 700 mg provides 700 mg per serving and uses a St. John's wort extract with incomplete active-marker detail, giving it direct but dose-dependent alignment with mood support.

Customer feedback averages 4.50 from 4660 reviews, while the published label carries medication-interaction cautions and a product-specific independent certification was not confirmed.

Study evidence
St. John's Wort Supportive 97 studies

Ingredients

IngredientAmount per serving
St. John's Wort
700 mg
Gluten Free Adults 18–50 Vegan Dairy Free Sugar Free Women Vegetarian
Report overview
St. John's Wort · 700 mg OverallScore67
F Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyA+ Value

Nature's Way Saint John's Wort 700 mg provides 700 mg per serving and uses plain Saint John's wort without extract or marker details, producing a strong dosage fit under the collection rubric. Customer feedback averages 4.50 from 4660 reviews, while the published label includes a specific interaction warning.

View ingredientView products
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Marker standardization supports consistent extract quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
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St. John's Wort Extract 300 mg

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A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; its extract quality and goal fit provide a clearer option when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
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The named extract supports consistent quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
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St. John's Wort Extract

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Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
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St. John's Wort 300 mg

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Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
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St. John's Wort 300 mg

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A hypericin-standardized extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the lower serving cost improves economy when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
87 Value

St. John's Wort Extract 300 mg

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A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the quality-to-cost balance is favorable when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

St. John's Wort 300 mg

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Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Value

St. John's Wort

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Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression: a randomized double-blind trial in a Brazilian sample.
    Moreno RA; Teng CT; Almeida KM; Tavares Junior H · Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2006
    Randomized trial72 participantsMood Support forSt. John's Wort
  2. The impact of missing data on clinical trials: a re-analysis of a placebo controlled trial of Hypericum perforatum (St Johns wort) and sertraline in major depressive disorder.
    Grobler AC; Matthews G; Molenberghs G · Psychopharmacology · 2014
    Randomized trial340 participantsMood Support forSt. John's Wort
  3. Documentary Analysis of Hypericum perforatum (St. John's Wort) and Its Effect on Depressive Disorders.
    Otero MC; Ceric F; Miranda-Rojas S; Carreño C; Escares R; Escobar MJ; Saracini C; Atala C; Ramírez-Barrantes R; Gordillo-Fuenzalida F · Pharmaceuticals (Basel, Switzerland) · 2025
    Narrative reviewMood Support forSt. John's Wort
  4. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  5. St John's wort for depression--an overview and meta-analysis of randomised clinical trials.
    Linde K; Ramirez G; Mulrow CD; Pauls A; Weidenhammer W; Melchart D · BMJ (Clinical research ed.) · 1996
    Meta-analysis1,757 participants23 studies pooledMood Support forSt. John's Wort
  6. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  7. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  8. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort
  9. [Meta-analysis of effectiveness and tolerability of treatment of mild to moderate depression with St. John's Wort].
    Röder C; Schaefer M; Leucht S · Fortschritte der Neurologie-Psychiatrie · 2004
    Meta-analysis30 studies pooledMood Support forSt. John's Wort
  10. A meta-analysis on the efficacy and safety of St John's wort extract in depression therapy in comparison with selective serotonin reuptake inhibitors in adults.
    Cui YH; Zheng Y · Neuropsychiatric disease and treatment · 2016
    Meta-analysis3,126 participants27 studies pooledMood Support forSt. John's Wort
  11. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort