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Co-Q10 100 mg

Carlson
4.8
★ ★ ★ ★ ★
(626 ratings)
Coenzyme Q-10 100 mg
Product Image
Score81
CoQ10 at 100 mg provides maintenance CoQ10 support, with unspecified molecular form as the main trade-off.
How scoring works
Quantity:90 Softgel(s) • (90 servings)
Goals:
Heart Health
Anti-Aging
Cardiovascular Support
Energy
Metabolism Boost
Anti-Inflammatory Support

Score 81

CoQ10 at 100 mg provides maintenance CoQ10 support, with unspecified molecular form as the main trade-off.
How scoring works
$42.42($0.47 per serving)
iHerb
$ 42.42
Pure Formulas
$ 42.42
Vitacost
$ 42.42
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Analysis

CoQ10 is supplied at 100 mg in one softgel. The amount fits routine maintenance and moderate support. The softgel format provides a fat-compatible environment for the fat-soluble active.

CoQ10 participates in cellular energy production and may support heart and muscle energy needs. Natural vitamin E appears in a small supporting amount rather than as a separate therapeutic active. The label does not say whether the active is ubiquinone or ubiquinol, which limits form-quality comparison.

The 90-serving supply is practical for a consistent trial, with fair value. The delivery format is appropriate for a fat-soluble compound. Warfarin users need monitoring because CoQ10 can reduce anticoagulant response.

Who is it for
  • Adults seeking maintenance CoQ10 support
  • People who prefer one softgel daily
Best for
  • Mitochondrial energy support
  • Heart and muscle energy routines

Pros

  • 100 mg active amount is clearly listed
  • One-unit serving is easy to use
  • Fat-compatible softgel delivery
  • Includes natural vitamin E

Cons

  • Molecular form is not identified
  • No dosage flexibility within one unit
  • No complementary cardiovascular nutrients

Warnings

  • CoQ10 may reduce warfarin response, so clotting control can change when supplementation starts or stops.
  • CoQ10 may add to blood-pressure-lowering medicines and cause lightheadedness in sensitive users.
  • CoQ10 can cause nausea, loose stools, or insomnia in sensitive users.

Nutrient quality

88 Highest impact

The CoQ10 form is not identified in a meaningful amount. The formula is focused and avoids an obvious excess at the supplied amount.

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Ingredient transparency

77 High impact

Active amounts are clear and no hidden blend is present. The CoQ10 form, daily-use directions, and non-active ingredients are not fully disclosed.

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Customer satisfaction

68 High impact

The available rating is strong and the sample is moderate. Detailed feedback was not supplied, so repeated complaints and alignment with the intended use remain uncertain.

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Value for money

92 Highest impact

The formula and supply provide strong value for the active amount. Unnecessary extras do not materially inflate the cost.

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Report analysis

Goals

Heart Health
Impact
Highest effect
A Goal FitA- Strength of SupportC CoverageA+ Formula Quality
Coenzyme Q-10 · 100 mg

CoQ10 directly supports energy production in heart muscle and antioxidant protection at a meaningful 100 mg amount. The softgel supplies fat and vitamin E, which can aid delivery and protect the oil-based formula.

The molecular form is not identified, so absorption quality cannot be judged as confidently as with disclosed ubiquinol. CoQ10 may reduce warfarin's anticoagulant effect, so clotting control should be monitored when starting or stopping it.

Study evidence
Coenzyme Q-10 Supportive 114 studies
Anti-Aging
Impact
Highest effect
A- Goal FitB Strength of SupportC CoverageA+ Formula Quality
Coenzyme Q-10 · 100 mg

CoQ10 provides 100 mg of targeted mitochondrial-energy and antioxidant support. The fat-containing softgel suits this fat-soluble ingredient, but the label does not identify ubiquinone or ubiquinol.

Its focused design gives good depth for age-related mitochondrial decline without covering structural, inflammatory, or neurological aging pathways. CoQ10 may reduce the effect of warfarin, so anticoagulation monitoring may need review.

Study evidence
Coenzyme Q-10 Supportive 6 studies
Vitamin E Supportive 19 studies
Cardiovascular Support
Impact
Highest effect
A- Goal FitA- Strength of SupportD+ CoverageA Formula Quality
Coenzyme Q-10 · 100 mgVitamin E · 0.67 mg

CoQ10 supports mitochondrial energy production in heart muscle and has useful evidence in cardiovascular care contexts. The formula is focused and clinically relevant, though it does not address lipids, vascular tone, or homocysteine.

The 100 mg amount is meaningful, and the softgel may improve absorption of fat-soluble ubiquinone. Ubiquinone is less readily absorbed than ubiquinol, while the small vitamin E addition offers only modest oxidation support.

Study evidence
Coenzyme Q-10 Supportive 89 studies
Vitamin E Mixed 79 studies
Energy
Impact
High effect
B- Goal FitB+ Strength of SupportD+ CoverageA Formula Quality
Coenzyme Q-10 · 100 mg

Coenzyme Q10 supports mitochondrial energy production and cellular antioxidant activity at a commonly used amount. The softgel format and small vitamin E addition are logically suited to a fat-soluble compound.

Evidence is more compelling for selected users, including some people taking statins, than for universal daily supplementation. Coenzyme Q10 may reduce warfarin's anticoagulant effect, so users of that medicine need stable, clinician-guided intake.

Study evidence
Coenzyme Q-10 Supportive 32 studies
Metabolism Boost
Impact
High effect
B Goal FitB Strength of SupportC- CoverageA Formula Quality
Coenzyme Q-10 · 100 mg

CoQ10 supports mitochondrial electron transport, a central step in cellular energy production. The disclosed amount provides useful depth, although evidence for raising whole-body metabolic rate is less direct.

The single-active design is transparent and free from label padding. Coverage remains narrow because thermogenesis, glycemic control, thyroid support, and fatty-acid transport are not addressed.

Study evidence
Coenzyme Q-10 Disputed 11 studies
Anti-Inflammatory Support
Impact
High effect
B Goal FitB Strength of SupportC- CoverageA- Formula Quality
Coenzyme Q-10 · 100 mgVitamin E · 0.67 mg

A meaningful CoQ10 dose may support mitochondrial antioxidant defenses and related inflammatory signaling. The full active amount is disclosed, although the specific molecular form is not stated.

The compact formula provides useful depth for one antioxidant pathway without unnecessary additions. Broader support would require complementary actives that address inflammation resolution or other direct pathways.

Study evidence
Coenzyme Q-10 Supportive 46 studies

Ingredients

IngredientAmount per serving
Vitamin E (D-Alpha-Tocopherol)
0.67 mg
Co-Q10
100 mg
Gluten Free Adults 18–50
Report overview
Coenzyme Q-10 · 100 mg OverallScore61
D- Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyC Value

The softgel supplies a maintenance amount of CoQ10 in a fat-compatible format. The molecular form is not identified, limiting confidence in absorption quality. Its serving cost is near the collection median and slightly more favorable than the smaller package.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Ubiquinol-10 Intake Is Effective in Relieving Mild Fatigue in Healthy Individuals.
    Mizuno K; Sasaki AT; Watanabe K; Watanabe Y · Nutrients · 2021
    Clinical trial62 participantsEnergy forCoenzyme Q-10
  2. Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies.
    Mehrabani S; Askari G; Miraghajani M; Tavakoly R; Arab A · Complementary therapies in medicine · 2019
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  3. Coenzyme Q10 supplementation increases blood concentrations but shows limited and inconsistent effects on exercise performance: a systematic review and meta-analysis.
    Deng H; Song T; Yin M; Xu K; Zhong Y; Mohd NB; Naharudin MNB; Yusof A; Fan X · The British journal of nutrition · 2026
    Meta-analysis24 studies pooledEnergy forCoenzyme Q-10
  4. A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer.
    Lesser GJ; Case D; Stark N; Williford S; Giguere J; Garino LA; Naughton MJ; Vitolins MZ; Lively MO; Shaw EG; Wake Forest University Community Clinical Oncology Program Research Base · The journal of supportive oncology · 2013
    Randomized trial236 participantsEnergy forCoenzyme Q-10
  5. Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
    Qu H; Guo M; Chai H; Wang WT; Gao ZY; Shi DZ · Journal of the American Heart Association · 2019
    Meta-analysis575 participants12 studies pooledEnergy forCoenzyme Q-10
  6. Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial.
    Sabbatinelli J; Orlando P; Galeazzi R; Silvestri S; Cirilli I; Marcheggiani F; Dludla PV; Giuliani A; Bonfigli AR; Mazzanti L; Olivieri F; Antonicelli R; Tiano L · Nutrients · 2021
    Randomized trial51 participantsHeart Health forCoenzyme Q-10
  7. Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials.
    Lei L; Liu Y · BMC cardiovascular disorders · 2018
    Meta-analysis2,149 participants14 studies pooledHeart Health forCoenzyme Q-10
  8. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.
    Liu Z; Tian Z; Zhao D; Liang Y; Dai S; Liu M; Hou S; Dong X; Zhaxinima; Yang Y · The Journal of clinical endocrinology and metabolism · 2022
    Meta-analysis2,794 participants50 studies pooledHeart Health Cardiovascular Support forCoenzyme Q-10
  9. The Effects of Coenzyme Q10 Supplementation on Blood Pressures Among Patients with Metabolic Diseases: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
    Tabrizi R; Akbari M; Sharifi N; Lankarani KB; Moosazadeh M; Kolahdooz F; Taghizadeh M; Asemi Z · High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2018
    Meta-analysis684 participants17 studies pooledHeart Health forCoenzyme Q-10
  10. The effects of coenzyme Q10 supplementation on lipid profiles among patients with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials.
    Jorat MV; Tabrizi R; Mirhosseini N; Lankarani KB; Akbari M; Heydari ST; Mottaghi R; Asemi Z · Lipids in health and disease · 2018
    Meta-analysis526 participants8 studies pooledHeart Health forCoenzyme Q-10
  11. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension.
    Ho MJ; Li EC; Wright JM · The Cochrane database of systematic reviews · 2016
    Meta-analysis50 participants3 studies pooledHeart Health forCoenzyme Q-10
  12. Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders: A Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Zhao D; Liang Y; Dai S; Hou S; Liu Z; Liu M; Dong X; Zhan Y; Tian Z; Yang Y · Advances in nutrition (Bethesda, Md.) · 2022
    Meta-analysis1,831 participants26 studies pooledHeart Health forCoenzyme Q-10
  13. Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview.
    Mantle D; Hargreaves I · Antioxidants (Basel, Switzerland) · 2020
    Narrative reviewAnti-Aging forCoenzyme Q-10
  14. Coenzyme Q10 Supplementation in Aging and Disease.
    Hernández-Camacho JD; Bernier M; López-Lluch G; Navas P · Frontiers in physiology · 2022
    Narrative reviewAnti-Aging forCoenzyme Q-10
  15. Coenzyme Q10, a cutaneous antioxidant and energizer.
    Hoppe U; Bergemann J; Diembeck W; Ennen J; Gohla S; Harris I; Jacob J; Kielholz J; Mei W; Pollet D; Schachtschabel D; Sauermann G; Schreiner V; Stäb F; Steckel F · BioFactors (Oxford, England) · 1999
    Clinical trialAnti-Aging forCoenzyme Q-10
  16. Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals.
    Pabis K; Wang W; Selvarajoo K; Budovskaya YV; Sorrentino V; Gruber J; Kennedy BK · Aging cell · 2026
    Cross-sectional study4,260 participantsAnti-Aging forCoenzyme Q-10
  17. Coenzyme Q10 supplementation raises plasma levels without improving mitochondrial function in older adults.
    Schmücker M; Tranberg C; Borch J; Kaae MK; Damgaard M; Flensted-Jensen M; Blom I; Morosetti M; Barbarossa S; Orlando P; Tiano L; Dela F; Helge JW; Larsen S · GeroScience · 2026
    Randomized trial40 participantsAnti-Aging forCoenzyme Q-10
  18. Low dietary vitamin E intake is associated with high risk of incident dementia among older adults: The Shanghai Aging Study.
    Liu S; Luo J; Xiao Z; Wu W; Liang X; Ding S; Zhao Q; Zhao X; Wang Y; Ding D · Frontiers in nutrition · 2024
    Cohort study1,550 participantsAnti-Aging forVitamin E
  19. Nutrients and bioactives in green leafy vegetables and cognitive decline: Prospective study.
    Morris MC; Wang Y; Barnes LL; Bennett DA; Dawson-Hughes B; Booth SL · Neurology · 2019
    Cohort study960 participantsAnti-Aging forVitamin E
  20. Low Intake of Vitamin E Accelerates Cellular Aging in Patients With Established Cardiovascular Disease: The CORDIOPREV Study.
    Corina A; Rangel-Zúñiga OA; Jiménez-Lucena R; Alcalá-Díaz JF; Quintana-Navarro G; Yubero-Serrano EM; López-Moreno J; Delgado-Lista J; Tinahones F; Ordovás JM; López-Miranda J; Pérez-Martínez P · The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Observational study1,002 participantsAnti-Aging forVitamin E
  21. The L-shaped link between total antioxidant capacity and phenotypic age acceleration: evidence from NHANES 2003-2010.
    Wu Y; Xiang M; Zhao Y; Zhang Y; Cheng W; Deng J · Biogerontology · 2025
    Cross-sectional study16,395 participantsAnti-Aging forVitamin E
  22. Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults.
    Mangialasche F; Solomon A; Kåreholt I; Hooshmand B; Cecchetti R; Fratiglioni L; Soininen H; Laatikainen T; Mecocci P; Kivipelto M · Experimental gerontology · 2014
    Cohort study140 participantsAnti-Aging forVitamin E
  23. The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients.
    Taghizadeh S; Izadi A; Shirazi S; Parizad M; Pourghassem Gargari B · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2021
    Randomized trial43 participantsAnti-Inflammatory Support forCoenzyme Q-10
  24. The effects of coenzyme Q10 supplementation on metabolic profiles and parameters of mental health in women with polycystic ovary syndrome.
    Karamali M; Gholizadeh M · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2022
    Randomized trial55 participantsAnti-Inflammatory Support forCoenzyme Q-10
  25. Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials.
    Hou S; Tian Z; Zhao D; Liang Y; Dai S; Ji Q; Fan Z; Liu Z; Liu M; Yang Y · Molecular nutrition & food research · 2023
    Meta-analysis1,517 participants31 studies pooledAnti-Inflammatory Support forCoenzyme Q-10
  26. Can coenzyme Q10 supplementation effectively reduce human tumor necrosis factor-α and interleukin-6 levels in chronic inflammatory diseases? A systematic review and meta-analysis of randomized controlled trials.
    Farsi F; Heshmati J; Keshtkar A; Irandoost P; Alamdari NM; Akbari A; Janani L; Morshedzadeh N; Vafa M · Pharmacological research · 2020
    Meta-analysis509 participants9 studies pooledAnti-Inflammatory Support forCoenzyme Q-10
  27. Promising efficacy of coenzyme Q10 supplementation as adjunctive therapy in juvenile idiopathic arthritis: a randomized-controlled pilot study.
    Elsherif N; Shousha G; Sabri NA; Shawki MA · Immunopharmacology and immunotoxicology · 2026
    Randomized trial58 participantsAnti-Inflammatory Support forCoenzyme Q-10
  28. Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial.
    Vrentzos E; Ikonomidis I; Pavlidis G; Katogiannis K; Korakas E; Kountouri A; Pliouta L; Michalopoulou E; Pelekanou E; Boumpas D; Lambadiari V · Cardiovascular diabetology · 2024
    Randomized trial60 participantsCardiovascular Support forCoenzyme Q-10
  29. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial.
    Mortensen SA; Rosenfeldt F; Kumar A; Dolliner P; Filipiak KJ; Pella D; Alehagen U; Steurer G; Littarru GP; Q-SYMBIO Study Investigators · JACC. Heart failure · 2015
    Randomized trial420 participantsCardiovascular Support forCoenzyme Q-10
  30. [Coenzyme Q-10 in the treatment of patients with chronic heart failure and reduced left ventricular ejection fraction: systematic review and meta-analysis].
    Mareev VY; Mareev YV; Begrambekova YL · Kardiologiia · 2022
    Meta-analysis1,139 participants6 studies pooledCardiovascular Support forCoenzyme Q-10
  31. Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial.
    Mortensen AL; Rosenfeldt F; Filipiak KJ · Cardiology journal · 2020
    Randomized trialCardiovascular Support forCoenzyme Q-10
  32. Supplementation with vitamin E alone is associated with reduced myocardial infarction: a meta-analysis.
    Loffredo L; Perri L; Di Castelnuovo A; Iacoviello L; De Gaetano G; Violi F · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2016
    Meta-analysis16 studies pooledCardiovascular Support forVitamin E
  33. Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.
    Chen B; Li Y; Li Z; Hu X; Zhen H; Chen H; Nie C; Hou Y; Zhu S; Xiao L; Li T · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2025
    Randomized trial90 participantsCardiovascular Support forVitamin E
  34. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.
    Lonn E; Bosch J; Yusuf S; Sheridan P; Pogue J; Arnold JM; Ross C; Arnold A; Sleight P; Probstfield J; Dagenais GR; HOPE and HOPE-TOO Trial Investigators · JAMA · 2005
    Randomized trial9,541 participantsCardiovascular Support forVitamin E
  35. Independent and combined associations of dietary antioxidant exposure with all-cause and cause-specific mortality in the general population.
    Liu Z; He Z; Xing Y · Journal of nutritional science · 2026
    Cohort study34,955 participantsCardiovascular Support forVitamin E
  36. Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study.
    Chin SF; Ibahim J; Makpol S; Abdul Hamid NA; Abdul Latiff A; Zakaria Z; Mazlan M; Mohd Yusof YA; Abdul Karim A; Wan Ngah WZ · Nutrition & metabolism · 2011
    Randomized trial62 participantsCardiovascular Support forVitamin E
  37. Coenzyme Q10 Supplementation in Athletes: A Systematic Review.
    Fernandes MSS; Fidelis DEDS; Aidar FJ; Badicu G; Greco G; Cataldi S; Santos GCJ; de Souza RF; Ardigò LP · Nutrients · 2026
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  38. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Tsai IC; Hsu CW; Chang CH; Tseng PT; Chang KV · Frontiers in pharmacology · 2024
    Meta-analysis1,126 participants13 studies pooledEnergy forCoenzyme Q-10
  39. Antifatigue effects of coenzyme Q10 during physical fatigue.
    Mizuno K; Tanaka M; Nozaki S; Mizuma H; Ataka S; Tahara T; Sugino T; Shirai T; Kajimoto Y; Kuratsune H; Kajimoto O; Watanabe Y · Nutrition (Burbank, Los Angeles County, Calif.) · 2008
    Randomized trial17 participantsEnergy forCoenzyme Q-10
  40. Effects of Coenzyme Q10 on Lipid, Glycemic, and Inflammatory Markers in Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Zhang Z; Liu Z; Geng Y; Huang Y; Hu R; Li F; Song Y; Zhang M · Journal of diabetes research · 2026
    Meta-analysis3,422 participants64 studies pooledHeart Health Metabolism Boost forCoenzyme Q-10
  41. Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals.
    Zhang P; Yang C; Guo H; Wang J; Lin S; Li H; Yang Y; Ling W · Journal of clinical lipidology · 2019
    Randomized trial101 participantsHeart Health forCoenzyme Q-10
  42. Coenzyme Q10 supplementation improves adipokine profile in dyslipidemic individuals: a randomized controlled trial.
    Zhang P; Chen K; He T; Guo H; Chen X · Nutrition & metabolism · 2022
    Randomized trial101 participantsMetabolism Boost forCoenzyme Q-10
  43. Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis.
    Hu X; Wang W; Su X; Peng H; Tan Z; Li Y; Huang Y · PeerJ · 2023
    Meta-analysis2,362 participants41 studies pooledMetabolism Boost forCoenzyme Q-10
  44. Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise.
    Diaz-Castro J; Mira-Rufino PJ; Moreno-Fernandez J; Chirosa I; Chirosa JL; Guisado R; Ochoa JJ · Food & function · 2021
    Randomized trial100 participantsMetabolism Boost forCoenzyme Q-10
  45. The effect of coenzyme Q10 intake on metabolic profiles in women candidates for in-vitro fertilization: a randomised trial.
    Ahmadi Asouri S; Asemi R; Aghadavod E; Jamilian M · Annals of medicine and surgery (2012) · 2024
    Randomized trial40 participantsMetabolism Boost forCoenzyme Q-10