Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Meta-analysis: melatonin for the treatment of primary sleep disorders.
Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
Meta-analysis1,683 participants19 studies pooledflagSleep Support forscienceMelatonin
- Exogenous melatonin as a treatment for secondary sleep disorders: A systematic review and meta-analysis.
Li T; Jiang S; Han M; Yang Z; Lv J; Deng C; Reiter RJ; Yang Y · Frontiers in neuroendocrinology · 2019
Meta-analysis205 participants7 studies pooledflagSleep Support forscienceMelatonin
- Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.
Sletten TL; Magee M; Murray JM; Gordon CJ; Lovato N; Kennaway DJ; Gwini SM; Bartlett DJ; Lockley SW; Lack LC; Grunstein RR; Rajaratnam SMW; Delayed Sleep on Melatonin (DelSoM) Study Group · PLoS medicine · 2019
Randomized trial116 participantsflagSleep Support forscienceMelatonin
- Melatonin treatment for age-related insomnia.
Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
Randomized trial30 participantsflagSleep Support forscienceMelatonin
- Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysis.
Salanitro M; Wrigley T; Ghabra H; de Haan E; Hill CM; Solmi M; Cortese S · Neuroscience and biobehavioral reviews · 2022
Meta-analysis1,998 participants34 studies pooledflagSleep Support forscienceMelatonin
- Effects of Melatonin Treatment on Perioperative Sleep Quality: A Systematic Review and Meta-Analysis with Trial Sequential Analysis of Randomized Controlled Trials.
Gao Y; Chen X; Zhou Q; Song J; Zhang X; Sun Y; Yu M; Li Y · Nature and science of sleep · 2022
Meta-analysis725 participants10 studies pooledflagSleep Support forscienceMelatonin
- Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.
Tsukinaga A; Mihara T; Takeshima T; Tomita M; Goto T · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
Meta-analysis516 participants8 studies pooledflagSleep Support forscienceMelatonin
- Unintended consequences: college students' melatonin usage, sleep disturbance, and depressive symptoms.
Peltz JS; Rogge R · Sleep and biological rhythms · 2025
Cohort study331 participantsflagSleep Support forscienceMelatonin
- Melatonin for preventing and treating jet lag.
Herxheimer A; Petrie KJ · The Cochrane database of systematic reviews · 2001
Systematic review10 studies pooledflagGeneral Health forscienceMelatonin
- Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life.
Schroder CM; Malow BA; Maras A; Melmed RD; Findling RL; Breddy J; Nir T; Shahmoon S; Zisapel N; Gringras P · Journal of autism and developmental disorders · 2019
Randomized trial125 participantsflagGeneral Health forscienceMelatonin
- Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials.
Fatemeh G; Sajjad M; Niloufar R; Neda S; Leila S; Khadijeh M · Journal of neurology · 2022
Meta-analysis23 studies pooledflagGeneral Health forscienceMelatonin
- Efficacy of melatonin for chronic insomnia: Systematic reviews and meta-analyses.
Choi K; Lee YJ; Park S; Je NK; Suh HS · Sleep medicine reviews · 2022
Meta-analysis24 studies pooledflagGeneral Health forscienceMelatonin
- Effectiveness of melatonin for the treatment of nocturia: a randomized controlled trial.
Leerasiri P; Pariyaeksut P; Hengrasmee P; Asumpinwong C · International urogynecology journal · 2023
Randomized trial60 participantsflagGeneral Health forscienceMelatonin
- The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
Meta-analysis409 participants8 studies pooledflagSleep Support forscienceMelatonin
- Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
Randomized trial791 participantsflagSleep Support forscienceMelatonin
- Effects of exogenous melatonin on sleep: a meta-analysis.
Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
Meta-analysis284 participants8 studies pooledflagSleep Support forscienceMelatonin
- Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
Randomized trial66 participantsflagSleep Support forscienceVitamin B6
- Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
Randomized trial75 participantsflagSleep Support forscienceVitamin B6
- Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
García-García C; Baik I · Nutrition research and practice · 2022
Randomized trial47 participantsflagSleep Support forscienceVitamin B6
- Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
Randomized trial100 participantsflagSleep Support forscienceVitamin B6
- The effect of pyridoxine administration on melatonin secretion in normal men.
Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
Randomized trial12 participantsflagSleep Support forscienceVitamin B6