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Melatonin 3 mg

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Melatonin 3 mg
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Score83
The 3 mg lozenge provides moderate sleep-onset support, with no sustained-release coverage as the main trade-off.
How scoring works
Quantity:180 Liquid(s) • (180 servings)
Goals:
Sleep Support
Brain Health
Immunity

Score 83

The 3 mg lozenge provides moderate sleep-onset support, with no sustained-release coverage as the main trade-off.
How scoring works

Also available as

1 option
90 servings Melatonin 3 mg • 90 Liquid(s) • 90 servings $4.65 ($0.05 per serving)
$8.70($0.04 per serving)
iHerb
$ 9.17
Walmart
$ 14.85
Amazon
$ 9.17
Vitacost
$ 9.97
Daily Vita
$ 8.70
Report prices

Analysis

Melatonin is supplied at 3 mg in one lozenge. The amount fits a common sleep-onset range, although some users may need less. The clearly listed amount makes dose comparison simple.

The main benefit is support for circadian timing and falling asleep when a delayed schedule is the problem. The format is suited to relatively quick delivery for sleep onset. It does not add a separate pathway for physical tension or daytime stress resilience.

A 180-serving bottle offers an unusually long and economical routine. Vitamin B6 at 3 mg is clearly disclosed but adds little to the focused sleep-timing effect. Melatonin can still cause morning drowsiness or vivid dreams, especially when taken too late.

Who is it for
  • Adults seeking support for sleep timing or delayed onset
  • People who prefer fast bedtime delivery
Best for
  • Sleep-onset support
  • Circadian-timing routines

Pros

  • 3 mg melatonin amount is clearly listed
  • Format supports quick bedtime delivery
  • 180 servings per container
  • Vitamin B6 amount is disclosed separately

Cons

  • No sustained-release feature for nighttime awakenings
  • Covers only the circadian pathway
  • Vitamin B6 adds little sleep-specific value

Warnings

  • The 3 mg melatonin serving may cause next-day drowsiness, vivid dreams, headache, or dizziness.
  • Do not drive or perform safety-sensitive work after taking melatonin or the next morning if alertness is impaired.
  • Alcohol, sleep medicines, and other sedatives can add to melatonin-related drowsiness.

Nutrient quality

83 Highest impact

The liquid or dissolving delivery may support prompt use around bedtime. The moderate 3 mg melatonin amount is well aligned with routine sleep-onset use.

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Ingredient transparency

84 Highest impact

Every supplied active ingredient has a specific amount and understandable name. Serving count is available, but intake directions and inactive ingredients are absent from the supplied label details.

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Customer satisfaction

72 High impact

The supplied aggregate rating is strong and the review volume adds useful statistical stability. No review text is provided to check recurring complaints or product-specific experiences.

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Value for money

91 Highest impact

Serving economics appear very strong relative to the clearly disclosed melatonin amount. Minor extra ingredients do not add much practical value beyond the core melatonin dose.

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Report analysis

Goals

Sleep Support
Sleep Support
Impact
Highest effect
A+ Goal FitA Strength of SupportC+ CoverageA Formula Quality
Melatonin · 3 mg

The 3 mg melatonin dose directly supports circadian timing and may help with falling asleep. Human evidence for melatonin is strongest when sleep difficulty is linked to timing or delayed onset.

The lozenge supports faster delivery, while the label clearly separates melatonin from the small vitamin B6 amount. No sustained-release feature is identified, so the formula is less targeted to nighttime awakenings.

Study evidence
Melatonin Supportive 181 studies
Vitamin B6 Disputed 7 studies
Brain Health
Brain Health
Impact
High effect
C- Goal FitB Strength of SupportD CoverageB+ Formula Quality
Vitamin B6 · 3 mg

Melatonin may support brain health indirectly by improving sleep timing and the conditions for overnight cognitive recovery. It is not a direct nootropic or structural brain nutrient.

The 3 mg lozenge provides a clearly disclosed and physiologically aligned amount with rapid oral delivery. It may still cause morning drowsiness if taken too late or by a sensitive user.

Study evidence
Melatonin Supportive 29 studies
Vitamin B6 Supportive 29 studies
Immunity
Immunity
Impact
Moderate effect
F Goal FitC Strength of SupportF CoverageB- Formula Quality

Melatonin may support restorative sleep, which can indirectly help immune resilience. Vitamin B6 adds a small amount of general nutrient support.

Neither ingredient provides direct barrier or immune-nutrient coverage comparable with vitamin C, vitamin D, or zinc. The formula is narrow and the immune evidence is mostly indirect.

Study evidence
Melatonin Supportive 10 studies

Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxine Hydrochloride)
 3 mg
Melatonin
3 mg
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
Melatonin · 3 mg OverallScore76
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The lozenge format supports rapid onset, though no sustained-release technology is identified. The 3 mg dose is clearly supplied in one lozenge and fits the physiologically aligned range. Cost efficiency is strong, although independent purity certification is not provided.

View ingredientView products
Loading alternative details
87 Performance

Melatonin Lozenges 3 mg

Life Extension
<p>A clearly disclosed 3 mg melatonin amount matches the original's 3 mg amount. The focused formula and stronger supplied quality profile make it a better-supported option, although the different dose or delivery format may change how it fits individual use.</p>
86 Performance

Melatonin 3 mg Fast Dissolve Strawberry Natural Flavor

Natrol
<p>A clearly disclosed 3 mg melatonin amount matches the original's 3 mg amount. The focused formula and stronger supplied quality profile make it a better-supported option, although the different dose or delivery format may change how it fits individual use.</p>
86 Performance

Fast-Dissolve Melatonin 3 mg Artificial Strawberry Flavor

Spring Valley
<p>A clearly disclosed 3 mg melatonin amount matches the original's 3 mg amount. The focused formula and stronger supplied quality profile make it a better-supported option, although the different dose or delivery format may change how it fits individual use.</p>
87 Budget

Melatonin 1 mg

Nature's Bounty
<p>The 1 mg amount is lower than the original's 3 mg amount and may suit more conservative dosing while lowering the serving cost. The supplied active list stays focused on melatonin without another active ingredient.</p>
84 Budget

Melatonin 1 mg

Spring Valley
<p>The 1 mg amount is lower than the original's 3 mg amount and may suit more conservative dosing while lowering the serving cost. The supplied active list stays focused on melatonin without another active ingredient.</p>
83 Budget

Melatonin 3 mg

Nature Made
<p>The 3 mg amount matches the original's 3 mg amount while lowering the serving cost. The added calcium is not central to the sleep-timing goal.</p>
88 Value

Melatonin 1.0 mg Peppermint Flavor

Source Naturals Sleep Science
<p>The 1 mg melatonin serving combines clear active disclosure with favorable value in the supplied data. It is lower than the original's 3 mg amount and may suit more conservative dosing, so dose fit matters alongside the cost advantage.</p>
83 Value

Melatonin 3 mg

21st Century
<p>The 3 mg melatonin serving combines clear active disclosure with favorable value in the supplied data. It matches the original's 3 mg amount, so dose fit matters alongside the cost advantage.</p>
84 Value

Melatonin 1 mg

Natural Factors Stress-Relax
<p>The 1 mg melatonin serving combines clear active disclosure with favorable value in the supplied data. It is lower than the original's 3 mg amount and may suit more conservative dosing, so dose fit matters alongside the cost advantage.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Meta-analysis: melatonin for the treatment of primary sleep disorders.
    Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
    Meta-analysis1,683 participants19 studies pooledSleep Support forMelatonin
  2. Exogenous melatonin as a treatment for secondary sleep disorders: A systematic review and meta-analysis.
    Li T; Jiang S; Han M; Yang Z; Lv J; Deng C; Reiter RJ; Yang Y · Frontiers in neuroendocrinology · 2019
    Meta-analysis205 participants7 studies pooledSleep Support forMelatonin
  3. Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.
    Sletten TL; Magee M; Murray JM; Gordon CJ; Lovato N; Kennaway DJ; Gwini SM; Bartlett DJ; Lockley SW; Lack LC; Grunstein RR; Rajaratnam SMW; Delayed Sleep on Melatonin (DelSoM) Study Group · PLoS medicine · 2019
    Randomized trial116 participantsSleep Support forMelatonin
  4. Melatonin treatment for age-related insomnia.
    Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
    Randomized trial30 participantsSleep Support forMelatonin
  5. Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysis.
    Salanitro M; Wrigley T; Ghabra H; de Haan E; Hill CM; Solmi M; Cortese S · Neuroscience and biobehavioral reviews · 2022
    Meta-analysis1,998 participants34 studies pooledSleep Support forMelatonin
  6. Effects of Melatonin Treatment on Perioperative Sleep Quality: A Systematic Review and Meta-Analysis with Trial Sequential Analysis of Randomized Controlled Trials.
    Gao Y; Chen X; Zhou Q; Song J; Zhang X; Sun Y; Yu M; Li Y · Nature and science of sleep · 2022
    Meta-analysis725 participants10 studies pooledSleep Support forMelatonin
  7. Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.
    Tsukinaga A; Mihara T; Takeshima T; Tomita M; Goto T · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Meta-analysis516 participants8 studies pooledSleep Support forMelatonin
  8. Unintended consequences: college students' melatonin usage, sleep disturbance, and depressive symptoms.
    Peltz JS; Rogge R · Sleep and biological rhythms · 2025
    Cohort study331 participantsSleep Support forMelatonin
  9. Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
    Terao I; Kodama W · Journal of Alzheimer's disease : JAD · 2024
    Meta-analysis4,599 participants10 studies pooledBrain Health forMelatonin
  10. Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
    Mdluli NT; Banda KJ; Chang YC · Age and ageing · 2025
    Meta-analysis516 participants10 studies pooledBrain Health forMelatonin
  11. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
    Wade AG; Farmer M; Harari G; Fund N; Laudon M; Nir T; Frydman-Marom A; Zisapel N · Clinical interventions in aging · 2015
    Randomized trial80 participantsBrain Health forMelatonin
  12. Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule.
    Garofoli F; Asteggiano C; Minniti ML; Accorsi P; Albertini R; Angelini M; Aversa S; Ballante E; Cabini RF; Caporali C; Cociglio S; Franco V; Longo S; Malerba L; Materia V; Mazzocchi L; Naboni C; Palmisani M; Pullega C; Pisoni C; Preda L; Riboli A; Risso FM; Rognone E; Savini G; Simoncelli AM; Villani P; Tzialla C; Pinelli L; Fazzi E; Chiapparini L; Borgatti R; Ghirardello S; Pichiecchio A; Orcesi S · Journal of pineal research · 2026
    Randomized trial54 participantsBrain Health forMelatonin
  13. Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Abouelmagd ME; Aldemerdash MA; Khatatbeh AA; Osman ASA; Abbas A; Allam S; AlEdani EM; Aldemerdash A; Monteith TS · Current pain and headache reports · 2026
    Meta-analysis788 participants9 studies pooledBrain Health forMelatonin
  14. Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.
    Zhang C; Luo J; Yuan C; Ding D · Journal of Alzheimer's disease : JAD · 2021
    Meta-analysis21 studies pooledBrain Health forVitamin B6
  15. Relationship between serum pyridoxal 5'-phosphate concentration and cognitive function in older Japanese.
    Itoh K; Kuwabara A; Otsuka R; Sugimoto T; Sakurai T; Niida S; Ao M; Tanaka K; Takenaka S; Kanouchi H · Journal of clinical biochemistry and nutrition · 2025
    Cross-sectional study266 participantsBrain Health forVitamin B6
  16. A randomized, controlled trial to evaluate the efficacy of pyridoxine and ascorbic acid on cognitive function and quality of life in post-menopausal women.
    Dhivya K; Sarumathy S; Manigandan G · Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Randomized trial180 participantsBrain Health forVitamin B6
  17. Lower Plasma Vitamin B-6 is Associated with 2-Year Cognitive Decline in the Boston Puerto Rican Health Study.
    Palacios N; Scott T; Sahasrabudhe N; Gao X; Tucker KL · The Journal of nutrition · 2020
    Cohort study949 participantsBrain Health forVitamin B6
  18. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review.
    Iolascon G; Gimigliano R; Bianco M; De Sire A; Moretti A; Giusti A; Malavolta N; Migliaccio S; Migliore A; Napoli N; Piscitelli P; Resmini G; Tarantino U; Gimigliano F · The journal of nutrition, health & aging · 2017
    Scoping review12 studies pooledBrain Health forVitamin B6
  19. Exogenous melatonin boosts vaccine-induced immunity in individuals with high pre-existing influenza immunity.
    Oda K; Danko J; Villasante E; Bergmann-Leitner E; Lee R; Wijayalath W · Frontiers in immunology · 2025
    Randomized trialImmunity forMelatonin
  20. Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis.
    Chojnacki C; Wisniewska-Jarosinska M; Walecka-Kapica E; Klupinska G; Jaworek J; Chojnacki J · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · 2012
    Randomized trial60 participantsImmunity forMelatonin
  21. Pineal-opioid system interactions in the control of immunoinflammatory responses.
    Lissoni P; Barni S; Tancini G; Fossati V; Frigerio F · Annals of the New York Academy of Sciences · 1995
    Clinical trial130 participantsImmunity forMelatonin
  22. Influenza vaccine response is predicted by chronotype and differentially associated with pre- and post-vaccination sleep.
    Harrison EM; Lee RU; Porter CK; Isidean SD; Easterling AP; White L; Boulifard DA; DeTizio K; Liang Z; Sedegah M; Danko J; Glickman GL · Brain, behavior, & immunity - health · 2026
    Randomized trialImmunity forMelatonin
  23. Mechanisms and clinical evidence to support melatonin's use in severe COVID-19 patients to lower mortality.
    Tan DX; Reiter RJ · Life sciences · 2022
    Narrative review19 participantsImmunity forMelatonin
  24. The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
    Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
    Meta-analysis409 participants8 studies pooledSleep Support forMelatonin
  25. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
    Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
    Randomized trial791 participantsSleep Support forMelatonin
  26. Effects of exogenous melatonin on sleep: a meta-analysis.
    Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
    Meta-analysis284 participants8 studies pooledSleep Support forMelatonin
  27. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  28. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  29. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  30. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  31. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6