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B-50

NOW
4.7
★ ★ ★ ★ ★
(37741 ratings)
Niacin 50 mg
PABA 25 mg
Vitamin B6 50 mg
Thiamin 50 mg
Riboflavin 50 mg
Vitamin B5 50 mg
Choline 25 mg
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Score77
Complete and economical B-vitamin coverage is offset by conventional forms and a 50 mg vitamin B6 dose that is too aggressive for routine long-term use.
How scoring works
Quantity:250 Capsule(s) • (250 servings)
Goals:
Energy
Metabolism Boost

Score 77

Complete and economical B-vitamin coverage is offset by conventional forms and a 50 mg vitamin B6 dose that is too aggressive for routine long-term use.
How scoring works
$18.99($0.07 per serving)
iHerb
$ 24.49
Vitacost
$ 24.49
Daily Vita
$ 23.10
Amazon
$ 18.99
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Analysis

Thiamine, riboflavin, niacinamide, vitamin B6, folate, vitamin B12, biotin, and pantothenic acid create broad support for normal energy metabolism. Most core B vitamins are supplied at 50 mg or a similarly high multiple of daily needs, so the formula is better described as high potency than balanced maintenance nutrition.

Pyridoxine hydrochloride and cyanocobalamin are conventional forms that require conversion before use. Choline at 25 mg is only a small addition, and PABA and inositol provide limited practical depth beside the main B vitamins.

Folate at 667 mcg DFE is clearly stated and provides substantial coverage. The simple serving and complete disclosure support ease of use, but the dose pattern is more aggressive than most adults need every day.

Who is it for
  • Adults seeking a high-potency B-complex for limited or clinician-directed use
  • People who value a simple once-daily serving
  • Users who have checked total vitamin B6 and folic acid intake from other products
Best for
  • Broad B-vitamin coverage
  • Supporting normal energy metabolism when intake is inadequate
  • Users prioritizing low serving cost over premium coenzyme forms

Pros

  • Includes all core B vitamins with stated amounts
  • Uses non-flushing niacinamide
  • Provides substantial thiamine, riboflavin, and pantothenic acid
  • Simple daily serving is easy to follow

Cons

  • 50 mg pyridoxine is unnecessarily high for a daily maintenance formula
  • Uses conventional cyanocobalamin and pyridoxine hydrochloride
  • Choline is modest at 25 mg
  • PABA and inositol add little to the core energy rationale

Warnings

  • Prolonged use of 50 mg vitamin B6 may cause tingling, numbness, or other nerve symptoms; stop use and seek advice if these occur.
  • Niacinamide at this amount may cause nausea or stomach discomfort in sensitive users.
  • PABA can interfere with sulfonamide antibiotics, so concurrent use should be reviewed with the prescriber.

Nutrient quality

73 High impact

The broad B-vitamin pattern provides substantial, focused coverage. Basic forms and an aggressive B6 amount reduce form quality and long-term balance.

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Ingredient transparency

71 High impact

Active amounts are broadly disclosed without a hidden blend. Repeated vitamin names, missing directions, and absent tablet excipients reduce full clarity.

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Customer satisfaction

71 High impact

The aggregate satisfaction signal is strong and supported by extensive volume. Missing review details prevent assessment of recurring complaints or purpose fit.

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Value for money

96 Highest impact

The large supply delivers broad dosing at excellent serving value. Basic forms and high B6 remain the only major disadvantages against gentler options.

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Goals

Energy
Impact
Highest effect
A- Goal FitB+ Strength of SupportC+ CoverageA Formula Quality
Vitamin B5 · 50 mgRiboflavin · 50 mgThiamin · 50 mgVitamin B12 · 50 mcg

A full high-potency B-complex directly supports carbohydrate metabolism and the enzyme systems involved in cellular energy production. The focused design is most relevant when intake is inadequate and does not provide an immediate stimulant effect.

Amounts are clearly disclosed, although several vitamins use standard forms that require conversion in the body. Prolonged daily intake of the high vitamin B6 amount may cause tingling, numbness, or other nerve symptoms.

Metabolism Boost
Impact
High effect
B- Goal FitB- Strength of SupportD+ CoverageA- Formula Quality
Biotin · 50 mcgNiacin · 50 mgVitamin B12 · 50 mcgRiboflavin · 50 mgThiamin · 50 mgVitamin B5 · 50 mgVitamin B6 · 50 mg

High-potency B vitamins provide a focused set of cofactors for normal cellular energy production. The formula is most relevant when low B-vitamin status is impairing energy metabolism.

No thyroid nutrient, chromium, thermogenic, carnitine, or substantial mitochondrial active broadens the effect. Long-term daily use of the supplied B6 amount may cause tingling, numbness, or other nerve symptoms.

Study evidence
Vitamin B6 Supportive 16 studies

Ingredients

IngredientAmount per serving
Thiamine (Thiamine Hydrochloride, Vitamin B1)
50 mg
Riboflavin (Vitamin B2)
50 mg
Niacin (Niacinamide, Vitamin B3)
50 mg
Vitamin B6 (Pyridoxine Hydrochloride)
50 mg
Folate
667 mcg DFE
Vitamin B12 (Cyanocobalamin)
50 mcg
Biotin
50 mcg
Pantothenic Acid (Calcium Pantothenate)
50 mg
Choline (Choline Bitartrate)
25 mg
PABA
25 mg
Inositol
25 mg
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
B+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyA+ Value

Niacinamide supports general vitamin use, though it is not the form used for lipid-focused goals. The amount fits the usual range for a B-complex, and the broader formula adds nutritional context. Value is excellent for the full formula, while specialized release details and a no-flush statement are not provided.

PABA · 25 mg OverallScore88
A Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB- Value

PABA is clearly named in a standard form, though no pharmaceutical-grade or high-purity claim is supplied, and the delivery format suits the dose. The clearly disclosed 25 mg amount suits a high-potency B-complex, and no targeted additives appear in the supplied ingredient data. PABA-specific cost efficiency is moderate rather than exceptional.

C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Pyridoxine hydrochloride is less direct than active P-5-P, though included riboflavin may support conversion. The 50 mg dose fits the preferred range and comes in one capsule. The large-count B-complex is very economical despite using the synthetic B6 precursor.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives.
    Webster MJ · European journal of applied physiology and occupational physiology · 1998
    Randomized trial6 participantsMetabolism Boost forVitamin B5
  2. Optimum nutrition: thiamin, biotin and pantothenate.
    Bender DA · The Proceedings of the Nutrition Society · 1999
    Narrative reviewMetabolism Boost forVitamin B5
  3. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  4. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  5. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  6. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  7. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  8. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  9. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6