Choline Bitartrate 650 mg

Choline Bitartrate 650 mg

Nutricost4.8 (1,566 ratings)
Format:Capsule Quantity: 240 Capsule(s) · 240 servings
Goals
$16.95 $0.07 per serving

Product analysis

62 out of 100

Choline Bitartrate 650 mg helps supply a nutrient involved in normal nerve signalling and liver fat transport. Its clearest role is meeting choline needs when intake is low.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality20

The specific choline form is not clearly disclosed in the ingredient declaration. Distinct choline preparations cannot be assumed to have matching effects.

Ingredient Transparency63

The choline amount is disclosed, but the nutrient amount and source-compound weight are distinct. The form is not clearly stated in the ingredient declaration, limiting preparation comparisons.

Value For Money100

Choline offers very favorable value for the declared nutrient amount. Its cost advantage does not establish an equivalent cognitive benefit to other choline preparations.

Customer Satisfaction86

Customer feedback is very positive across a large review pool. The volume provides a broad picture of satisfaction without proving effects on memory or focus.

Product Focus74

Choline supports normal nerve signalling and liver fat transport when intake is insufficient. The declared nutrient amount is distinct from the source-compound weight, and the nutritional role does not establish immediate focus or memory enhancement.

Format
Capsule
Container
240 Capsule(s)
Per serving
$0.07
Customer rating
4.8 · 1,566 ratings
Report analysis

Goals

Mental Focus
Impact
High effect
B Ingredient FitD- PathwaysB- EvidenceA+ Formulation Logic
Choline · 650 mg

Choline is a precursor for acetylcholine, a signalling chemical involved in brain function. That normal role does not establish an acute focus improvement when intake is adequate. The declared 260 mg receives partial saved amount recognition and cholinergic coverage, but the supplied healthy-adult context does not demonstrate routine one-serving attention enhancement.

How this product is rated for Mental Focus

Ingredient fit77

Choline is the sole counted ingredient and has a cognitive signalling role.
Goal fit
Choline is the sole counted ingredient and has a cognitive signalling role.
Dose adequacy
The 260 mg declaration receives partial saved amount recognition.

Pathways41

Choline supplies partial cholinergic-signalling coverage. The saved coverage is limited to cholinergic signalling.
Depth
Choline supplies partial cholinergic-signalling coverage.
Breadth
The saved coverage is limited to cholinergic signalling.

Evidence74

Choline leads the single-ingredient finding, but its precursor role does not establish acute enhancement. The choline declaration meets the saved preparation check.
Evidence strength
Choline leads the single-ingredient finding, but its precursor role does not establish acute enhancement.
Studied preparation
The choline declaration meets the saved preparation check.

Formulation logic100

The included ingredients meet the saved partner requirements. No configured ingredient conflict was found in the supplied facts.
Partner coverage
The included ingredients meet the saved partner requirements.
Conflicts
No configured ingredient conflict was found in the supplied facts.
Effective doses
All ingredients counted by this rule meet its minimum amount criterion; this does not establish a proven effective dose.
Study evidence
Choline Supportive 22 studies
Liver & Detox
Impact
High effect
B Ingredient FitD- PathwaysA- EvidenceA+ Formulation Logic
Choline · 650 mg

Choline helps maintain liver cell integrity and fat transport, with the clearest relevance when intake is insufficient. The serving contributes a disclosed amount toward nutritional adequacy and receives partial amount credit. That role should be distinguished from improved toxin clearance in someone with adequate intake. The supplied facts do not establish a general cleanse effect or that a serving reproduces a repeated daily study regimen.

How this product is rated for Liver & Detox

Ingredient fit77

The credited ingredients and declared amounts provide the fit described below, with broader-purpose ingredients affecting how concentrated the formula is.
Goal fit
The credited ingredient is closely concentrated on the assessed role; the product's other linked goals also affect its fit.
Dose adequacy
The serving receives partial amount credit across its credited ingredients, without establishing that those amounts improve toxin clearance.

Pathways40

The strongest mapped role is liver cell integrity and fat export; this is a mechanism finding, not measured toxin elimination. Its coverage is concentrated in one route.
Depth
The strongest mapped role is liver cell integrity and fat export; this is a mechanism finding, not measured toxin elimination.
Breadth
Only one assessed route reaches the saved coverage threshold, leaving the mapped contribution narrow.

Evidence86

Choline leads the evidence finding through its nutritional liver-function role, especially when intake is insufficient.
Evidence strength
Choline leads the evidence finding through its nutritional liver-function role, especially when intake is insufficient.
Studied preparation
The saved preparation check is satisfied for qualifying ingredients, without proving a routine toxin-clearance benefit.

Formulation logic100

The credited ingredients meet partner requirements and no configured conflict was recorded. They meet the saved minimum amount threshold.
Partner coverage
The credited ingredients meet the saved partner requirements, with no missing partner recorded.
Conflicts
No configured conflict was recorded in the supplied facts.
Effective doses
All credited ingredients meet the saved minimum amount threshold; that threshold does not establish a clinically effective detoxification dose.
Study evidence
Choline Supportive 6 studies
Cognitive Support
Impact
High effect
B Ingredient FitD- PathwaysA- EvidenceA+ Formulation Logic
Choline · 650 mg

Choline supplies a precursor for acetylcholine, which is involved in nerve signalling. That essential role does not establish routine memory enhancement, and the supplied healthy-young-adult choline-bitartrate experiments were null. The 260 mg serving receives partial amount credit in the saved result, but it cannot inherit cognitive findings from citicoline or Alpha-GPC, which are distinct preparations.

How this product is rated for Cognitive Support

Ingredient fit77

Choline is the sole credited ingredient and receives partial amount coverage.
Goal fit
Choline gives the formula a focused cognitive purpose, alongside links to other goals.
Dose adequacy
The 260 mg serving receives partial saved amount credit; that comparison does not establish memory benefit.

Pathways40

The saved contribution is confined to acetylcholine signalling.
Depth
Choline gives partial saved coverage of acetylcholine signalling.
Breadth
Only acetylcholine signalling meets the saved coverage threshold.

Evidence89

Choline supplies the saved evidence finding, while the supplied context does not establish routine enhancement from generic choline.
Evidence strength
The saved evidence contribution comes from choline; its precursor role does not establish enhanced cognition.
Studied preparation
The saved result gives choline full preparation credit without transferring findings from citicoline or Alpha-GPC.

Formulation logic100

Choline needs no partner for its saved contribution, and no configured conflict was found.
Partner coverage
The saved choline contribution requires no partner ingredient.
Conflicts
None of the configured ingredient conflicts was matched.
Effective doses
Choline passes the saved minimum amount threshold.
Study evidence
Choline Supportive 76 studies

Ingredients

IngredientAmount per servingScore
Choline
260 mg 84
Choline Bitartrate
650 mg 84
Gluten Free Adults 18–50
Report overview
Choline · 260 mg OverallScore84
C+ Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA+ Value
A serving provides 260 mg of choline from 650 mg of choline bitartrate. At the whole-product serving price, that works out to about $0.03 per 100 mg of choline.
How this ingredient is rated

Active Ingredient Quality & Bioavailability68

Choline Bitartrate is a standard choline source. Standard flow agents are noted; no additives of concern were flagged.
Choline Form Efficacy & Bioavailability
Choline Bitartrate is a standard choline source.
Formula Purity & Excipient Quality
Standard flow agents are noted; no additives of concern were flagged.

Dose, Safety & Label Transparency91

The label declares 260 mg of choline per serving and identifies its source.
Choline Dose by Declared Basis
Each serving provides 260 mg of choline, a higher amount.
Elemental Yield Transparency
The label states the choline amount and its source.

Value100

Based on the whole-product serving price, the cost works out to about $0.03 per 100 mg of choline.
Price per 100 mg of Declared Choline Basis
Based on the whole-product serving price, the cost works out to about $0.03 per 100 mg of choline.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.
    De Jesus Moreno Moreno M · Clinical therapeutics · 2003
    Randomized trial261 participantsCognitive Support forCholine
  2. Association of dietary choline intake with incidence of dementia, Alzheimer disease, and mild cognitive impairment: a large population-based prospective cohort study.
    Niu YY; Yan HY; Zhong JF; Diao ZQ; Li J; Li CP; Chen LH; Huang WQ; Xu M; Xu ZT; Liang XF; Li ZH; Liu D · The American journal of clinical nutrition · 2025
    Cohort study125,594 participantsCognitive Support forCholine
  3. Choline intake during pregnancy and child cognition at age 7 years.
    Boeke CE; Gillman MW; Hughes MD; Rifas-Shiman SL; Villamor E; Oken E · American journal of epidemiology · 2013
    Cohort study895 participantsCognitive Support forCholine
  4. Effects of choline alfoscerate on cognitive function and quality of life in type 2 diabetes: A double-blind, randomized, placebo-controlled trial.
    Sohn M; Park YH; Lim S · Diabetes, obesity & metabolism · 2025
    Randomized trial36 participantsCognitive Support forCholine
  5. Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.
    Warton FL; Molteno CD; Warton CMR; Wintermark P; Lindinger NM; Dodge NC; Zöllei L; van der Kouwe AJW; Carter RC; Jacobson JL; Jacobson SW; Meintjes EM · Alcoholism, clinical and experimental research · 2022
    Randomized trial52 participantsCognitive Support forCholine
  6. Choline and contribution to normal liver function of the foetus and exclusively breastfed infants: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Nutrition, Novel Foods and Food allergens (NDA); Turck D; Bohn T; Castenmiller J; De Henauw S; Hirsch-Ernst KI; Knutsen HK; Maciuk A; Mangelsdorf I; McArdle HJ; Naska A; Pentieva K; Thies F; Tsabouri S; Vinceti M; Bresson JL; Fiolet T; Siani A · EFSA journal. European Food Safety Authority · 2024
    Guideline / consensusLiver & Detox forCholine
  7. Adiposity May Moderate the Link Between Choline Intake and Non-alcoholic Fatty Liver Disease.
    Mazidi M; Katsiki N; Mikhailidis DP; Banach M · Journal of the American College of Nutrition · 2020
    Cross-sectional study20,643 participantsLiver & Detox forCholine
  8. Choline and Choline-Related Metabolites in Pediatric Short Bowel Syndrome.
    Hilberath J; Shunova A; Heister L; Poets CF; Bernhard W · Nutrients · 2026
    Observational study80 participantsLiver & Detox forCholine
  9. Choline Supplementation in Cystic Fibrosis-The Metabolic and Clinical Impact.
    Bernhard W; Lange R; Graepler-Mainka U; Engel C; Machann J; Hund V; Shunova A; Hector A; Riethmüller J · Nutrients · 2019
    Single-arm trial10 participantsLiver & Detox forCholine
  10. 1H MR Spectroscopy at 3T for Hepatic Choline Quantification in Healthy Young Women: A Translational Imaging Study with Dietary Correlation.
    Hawesa H; Alghamdi R; Allam H; Alfaifi B; Alrabiah N; Alghumaiz M; Shanawani M; Alshegri H; Hassan MG · Current medical imaging · 2026
    Cohort study88 participantsLiver & Detox forCholine
  11. Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder.
    Wozniak JR; Fink BA; Fuglestad AJ; Eckerle JK; Boys CJ; Sandness KE; Radke JP; Miller NC; Lindgren C; Brearley AM; Zeisel SH; Georgieff MK · Journal of neurodevelopmental disorders · 2021
    Randomized trial31 participantsMental Focus forCholine
  12. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort.
    Poly C; Massaro JM; Seshadri S; Wolf PA; Cho E; Krall E; Jacques PF; Au R · The American journal of clinical nutrition · 2012
    Cohort study1,391 participantsMental Focus forCholine
  13. Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies.
    Obeid R; Derbyshire E; Schön C · Advances in nutrition (Bethesda, Md.) · 2022
    Meta-analysis30 studies pooledMental Focus forCholine
  14. Effect of Choline Supplementation on Neurological, Cognitive, and Behavioral Outcomes in Offspring Arising from Alcohol Exposure During Development: A Quantitative Systematic Review of Clinical and Preclinical Studies.
    Akison LK; Kuo J; Reid N; Boyd RN; Moritz KM · Alcoholism, clinical and experimental research · 2019
    Systematic reviewMental Focus forCholine
  15. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk.
    Ross RG; Hunter SK; McCarthy L; Beuler J; Hutchison AK; Wagner BD; Leonard S; Stevens KE; Freedman R · The American journal of psychiatry · 2013
    Randomized trialMental Focus forCholine