Choline 500 mg

Choline 500 mg

Nature's Way4.7 (6,028 ratings)
Format:Tablet Quantity: 100 Tablet(s) · 100 servings
Goals
$9.72 $0.09 per serving

Product analysis

75 out of 100

Choline 500 mg offers an affordable way to support choline intake for normal liver fat handling and nerve function. Its nutritional role does not establish extra memory or focus benefits when intake is already adequate.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality56

Choline bitartrate identifies the main nutrient source. That form does not by itself establish an extra cognitive benefit, while other preparation details are limited.

Ingredient Transparency75

Listed amounts make basic serving comparisons possible. Choline bitartrate is named, but the declared material should not automatically be read as the same amount of nutrient choline.

Value For Money88

The choline comparison supports good value for the declared serving. A separate carbohydrate value judgment remains uncertain.

Customer Satisfaction89

Ratings show positive satisfaction across a large number of responses. The broad response provides a more established picture of satisfaction without establishing memory or liver benefits.

Product Focus83

The main role is filling a choline gap for normal nerve function and liver fat handling. The cognitive and focus uses do not establish extra enhancement after nutritional needs are met.

Format
Tablet
Container
100 Tablet(s)
Per serving
$0.09
Customer rating
4.7 · 6,028 ratings
Report analysis

Goals

Liver & Detox
Impact
Highest effect
A+ Ingredient FitC- PathwaysA- EvidenceA+ Formulation Logic
Choline · 500 mg

Choline helps the liver handle and export fat, with nutritional relevance when choline intake is low. The declared 500 mg per serving provides a substantial nutritional amount. This does not establish faster removal of unspecified toxins in someone with adequate intake.

How this product is rated for Liver & Detox

Ingredient fit96

The relevant ingredients sit within a broader formula, so its overall focus extends beyond this goal. The declared amounts fully meet the comparison references; these references do not establish a clinically effective detoxification dose.
Goal fit
The relevant ingredients sit within a broader formula, so its overall focus extends beyond this goal.
Dose adequacy
The declared amounts fully meet the comparison references; these references do not establish a clinically effective detoxification dose.

Pathways59

The main biological connection is liver cell integrity and fat export. One mapped area reaches substantial coverage.
Depth
The strongest mapped connection concerns liver cell integrity and fat export; biological coverage does not itself demonstrate toxin removal.
Breadth
One biological area reaches substantial coverage in the supplied comparison. This indicates concentrated ingredient connections rather than demonstrated clearance of toxins.

Evidence86

Vitamin B4 (Choline) leads the evidence comparison. Specific exposure, nutritional status and preparation distinctions constrain claims about toxin clearance.
Evidence strength
Vitamin B4 (Choline) leads the supplied evidence comparison. The practical interpretation remains limited by the populations, preparations and outcomes described.
Studied preparation
The preparation is accepted in the supplied comparison, although this does not establish routine toxin removal or equivalence across all extracts.

Formulation logic100

The supplied findings identify no unmet partner requirement or configured conflict. Amount thresholds describe the comparison rather than proven detoxification effectiveness.
Partner coverage
The relevant ingredients have no unmet partner requirement in the supplied findings; combining them does not establish an additional detoxification benefit.
Conflicts
No configured ingredient conflict was identified in the supplied findings.
Effective doses
The counted ingredients pass the comparison’s minimum amount threshold, which is not proof of an effective toxin-removal dose.
Study evidence
Choline Supportive 6 studies
Cognitive Support
Impact
Highest effect
A+ Ingredient FitC- PathwaysA- EvidenceA+ Formulation Logic
Choline · 500 mg

Choline is an essential nutrient and a precursor for acetylcholine, a chemical involved in nerve signaling. These roles do not establish routine memory enhancement, and the supplied choline-bitartrate experiments in healthy young adults were negative. The 500 mg serving receives full amount recognition in the saved findings, without proving a cognitive benefit.

How this product is rated for Cognitive Support

Ingredient fit96

Choline is the sole assessed ingredient and receives full amount recognition.
Goal fit
The assessed ingredients are directed toward cognitive support.
Dose adequacy
The relevant declared amount reaches the full saved exposure comparison; this does not establish a proven cognitive dose.

Pathways59

Acetylcholine signaling is the only substantially represented area.
Depth
Acetylcholine signaling is the only substantially represented area.
Breadth
One cognitive area reaches substantial coverage, leaving the other areas unrepresented or less developed.

Evidence89

Choline-bitartrate findings do not establish routine cognitive enhancement.
Evidence strength
Choline-bitartrate findings do not establish routine cognitive enhancement.
Studied preparation
Choline meets the saved preparation comparison.

Formulation logic100

The assessed ingredients need no missing partner and meet the saved minimum amount comparison. No configured conflict was identified.
Partner coverage
The assessed ingredients work alone or have their required partner; no missing partner was identified.
Conflicts
No configured ingredient conflict was identified.
Effective doses
The assessed ingredients meet the saved minimum amount comparison, without establishing a proven cognitive benefit.
Study evidence
Choline Supportive 76 studies
Mental Focus
Impact
High effect
A+ Ingredient FitC PathwaysB- EvidenceA+ Formulation Logic
Choline · 500 mg

Choline is a precursor for acetylcholine, a messenger involved in attention. That normal role does not establish extra focus in adults with adequate intake, and the supplied healthy-adult choline-bitartrate trial did not show acute memory improvement. The declared bitartrate material should not be assumed equivalent to an amount of nutrient choline.

How this product is rated for Mental Focus

Ingredient fit96

Vitamin B4 (Choline) underpin this product’s connection to focus. The amounts meet the saved comparison range.
Goal fit
The relevant ingredients dominate the formula, although it is linked to several goals.
Dose adequacy
The included amounts reach the saved reference range; this is an amount comparison, not proof of a focus benefit.

Pathways60

The main mapped contribution is cholinergic signalling. The mechanism alone does not establish an acute focus benefit.
Depth
Cholinergic signalling is the strongest mapped route. That biological connection does not itself demonstrate acute focus improvement.
Breadth
The meaningful mapped contribution is concentrated in one route, with limited breadth across other aspects of focus.

Evidence74

The supplied evidence is limited for immediate everyday focus, despite the biological roles reflected in the saved findings.
Evidence strength
The leading ingredient supplies the evidence finding, but the supplied science does not establish routine acute focus enhancement.
Studied preparation
The included preparations match those accepted in the saved comparison; this does not extend the trials to different outcomes or populations.

Formulation logic100

The included ingredients have no identified configured conflict. No required partner is missing.
Partner coverage
No required partner is missing for the included ingredients.
Conflicts
No configured ingredient conflict was identified in the supplied findings.
Effective doses
The included ingredients meet the saved minimum amount threshold; that threshold is not a demonstrated effective dose for acute focus.
Study evidence
Choline Supportive 22 studies

Ingredients

IngredientAmount per servingScore
Calories
5 Calorie(s)
Total Carbohydrates
1 Gram(s)
Choline (Choline Bitartrate)
500 mg 81
Gluten Free Adults 18–50 Dairy Free Vegetarian
Report overview
D+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value
Each serving provides 500 mg of choline from choline bitartrate, a larger amount. The available ingredient information also flags additives.
How this ingredient is rated

Active Ingredient Quality & Bioavailability53

The identified source is choline bitartrate, a standard choline form.
Choline Form Efficacy & Bioavailability
The identified source is choline bitartrate, a standard choline form.
Formula Purity & Excipient Quality
The available ingredient information flags additives.

Dose, Safety & Label Transparency100

The stated amount is 500 mg of choline per serving.
Choline Dose by Declared Basis
A serving supplies 500 mg of choline, a larger amount.
Elemental Yield Transparency
The choline amount and its choline bitartrate source are identified.

Value100

At the whole-product price, the cost is about $0.02 per 100 mg of choline.
Price per 100 mg of Declared Choline Basis
The whole-product price corresponds to about $0.02 per 100 mg of choline.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.
    De Jesus Moreno Moreno M · Clinical therapeutics · 2003
    Randomized trial261 participantsCognitive Support forCholine
  2. Association of dietary choline intake with incidence of dementia, Alzheimer disease, and mild cognitive impairment: a large population-based prospective cohort study.
    Niu YY; Yan HY; Zhong JF; Diao ZQ; Li J; Li CP; Chen LH; Huang WQ; Xu M; Xu ZT; Liang XF; Li ZH; Liu D · The American journal of clinical nutrition · 2025
    Cohort study125,594 participantsCognitive Support forCholine
  3. Choline intake during pregnancy and child cognition at age 7 years.
    Boeke CE; Gillman MW; Hughes MD; Rifas-Shiman SL; Villamor E; Oken E · American journal of epidemiology · 2013
    Cohort study895 participantsCognitive Support forCholine
  4. Effects of choline alfoscerate on cognitive function and quality of life in type 2 diabetes: A double-blind, randomized, placebo-controlled trial.
    Sohn M; Park YH; Lim S · Diabetes, obesity & metabolism · 2025
    Randomized trial36 participantsCognitive Support forCholine
  5. Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.
    Warton FL; Molteno CD; Warton CMR; Wintermark P; Lindinger NM; Dodge NC; Zöllei L; van der Kouwe AJW; Carter RC; Jacobson JL; Jacobson SW; Meintjes EM · Alcoholism, clinical and experimental research · 2022
    Randomized trial52 participantsCognitive Support forCholine
  6. Choline and contribution to normal liver function of the foetus and exclusively breastfed infants: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Nutrition, Novel Foods and Food allergens (NDA); Turck D; Bohn T; Castenmiller J; De Henauw S; Hirsch-Ernst KI; Knutsen HK; Maciuk A; Mangelsdorf I; McArdle HJ; Naska A; Pentieva K; Thies F; Tsabouri S; Vinceti M; Bresson JL; Fiolet T; Siani A · EFSA journal. European Food Safety Authority · 2024
    Guideline / consensusLiver & Detox forCholine
  7. Adiposity May Moderate the Link Between Choline Intake and Non-alcoholic Fatty Liver Disease.
    Mazidi M; Katsiki N; Mikhailidis DP; Banach M · Journal of the American College of Nutrition · 2020
    Cross-sectional study20,643 participantsLiver & Detox forCholine
  8. Choline and Choline-Related Metabolites in Pediatric Short Bowel Syndrome.
    Hilberath J; Shunova A; Heister L; Poets CF; Bernhard W · Nutrients · 2026
    Observational study80 participantsLiver & Detox forCholine
  9. Choline Supplementation in Cystic Fibrosis-The Metabolic and Clinical Impact.
    Bernhard W; Lange R; Graepler-Mainka U; Engel C; Machann J; Hund V; Shunova A; Hector A; Riethmüller J · Nutrients · 2019
    Single-arm trial10 participantsLiver & Detox forCholine
  10. 1H MR Spectroscopy at 3T for Hepatic Choline Quantification in Healthy Young Women: A Translational Imaging Study with Dietary Correlation.
    Hawesa H; Alghamdi R; Allam H; Alfaifi B; Alrabiah N; Alghumaiz M; Shanawani M; Alshegri H; Hassan MG · Current medical imaging · 2026
    Cohort study88 participantsLiver & Detox forCholine
  11. Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder.
    Wozniak JR; Fink BA; Fuglestad AJ; Eckerle JK; Boys CJ; Sandness KE; Radke JP; Miller NC; Lindgren C; Brearley AM; Zeisel SH; Georgieff MK · Journal of neurodevelopmental disorders · 2021
    Randomized trial31 participantsMental Focus forCholine
  12. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort.
    Poly C; Massaro JM; Seshadri S; Wolf PA; Cho E; Krall E; Jacques PF; Au R · The American journal of clinical nutrition · 2012
    Cohort study1,391 participantsMental Focus forCholine
  13. Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies.
    Obeid R; Derbyshire E; Schön C · Advances in nutrition (Bethesda, Md.) · 2022
    Meta-analysis30 studies pooledMental Focus forCholine
  14. Effect of Choline Supplementation on Neurological, Cognitive, and Behavioral Outcomes in Offspring Arising from Alcohol Exposure During Development: A Quantitative Systematic Review of Clinical and Preclinical Studies.
    Akison LK; Kuo J; Reid N; Boyd RN; Moritz KM · Alcoholism, clinical and experimental research · 2019
    Systematic reviewMental Focus forCholine
  15. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk.
    Ross RG; Hunter SK; McCarthy L; Beuler J; Hutchison AK; Wagner BD; Leonard S; Stevens KE; Freedman R · The American journal of psychiatry · 2013
    Randomized trialMental Focus forCholine